Scientific Studies Database PAGE 2

CLICK AICI pt. limba ROmana

Vitamins in alphabetical order

Vitamin A

There is an extensive bibliography on the anti-tumoral action of Vitamin A.

In particular the combined use of Retinoids in the proper proportions (beta-Carotene: retinol = 4 : 1), establishes a synergism which is higher than the sum of the single components.

Studies on Vitamin A and cancer (MANY STUDIES -see NOTES below)

science.naturalnews.com/V/Vitamin_A_and_cancer.html

NOTE 1:

The link above contains multiple studies and the same do many links below( I will try to indicate by ”MANY STUDIES”)

Vitamin A, retinoids and carotenoids as chemopreventive agents for prostate cancer.
2004 The Journal of urology

An international evaluation of the cancer preventive potential of vitamin A.
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Association of dietary vitamin A, carotenoids, and other antioxidants with the risk of ovarian cancer.

2005 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Association of vitamin A, vitamin C and zinc with laryngeal cancer.
2003 Indian journal of cancer

Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study.
2007 The American journal of clinical nutrition

The effect of Vitamin A status in children treated for cancer.
2008 Pediatric hematology and oncology

Oxidant, Vitamin A and angiogenic markers in laryngeal cancer patients.
2003 The Journal of laryngology and otology

The role of antioxidants and Vitamin A in ovarian cancer: results from the Women’s Health Initiative.
2008 Nutrition and cancer

Can Vitamin A modify the activity of docetaxel in MCF-7 breast cancer cells?
2007 Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society

Does Vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?
2004 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Intake of vitamin A-rich foods and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaf consumption.
2007 Asia Pacific journal of clinical nutrition

Vitamin A and apoptosis in prostate cancer.
2002 Endocrine-related cancer

Skin, sun, and vitamin A: from aging to cancer.
2001 The Journal of dermatology

Vitamin A metabolism is impaired in human ovarian cancer.
2009 Gynecologic oncology

Effectiveness of Vitamin A acetate for enhancing the production of lung cancerspecific monoclonal antibodies.
1999 Cytotechnology

A population-based case-control study of carotenoid and Vitamin A intake and ovarian cancer (United States).
2001 Cancer causes & control : CCC

Recent advances in the use of Vitamin A (retinoids) in the prevention and treatment of cancer.
2000 Nutrition (Burbank, Los Angeles County, Calif.)

Fruit, vegetable, Vitamin A intakes, and prostate cancer risk.
2008 Prostate cancer and prostatic diseases

The Vitamin A family can significantly decrease the expression of ERbeta of ERs positive breast cancer cells in the presence or absence of ER ligands and paclitaxel.
2009 Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Induction of apoptosis in maxillary sinus cancer cells by 5-fluorouracil, Vitamin A and radiation (FAR) therapy.
1999 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery

EUROSCAN, a randomized trial of Vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of cancer Head and Neck and Lung cancer Cooperative Groups.
2000 Journal of the National cancer Institute

Rapid HPLC method for the determination of Vitamin A and E and cotinine concentration in human serum in women with CIN and cervical cancer.
2009 Ginekologia polska

Estradiol and tamoxifen differently affects the inhibitory effects of Vitamin A and their metabolites on the proliferation and expression of alpha2beta1 integrins in MCF-7 breast cancer cells.
2009 Advances in medical sciences

Renaissance of the biologically active Vitamin A derivatives: established and novel directed therapies for cancer and chemoprevention.
2003 Current pharmaceutical design

Evaluation of plasma non-enzymatic antioxidants in breast cancer etiology.
2009 Asian Pacific journal of cancer prevention : APJCP

Whole-food sources of Vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate.
2007 The Journal of nutrition

[Chemoprevention and FAR therapy regimen comprised of 5-fluorouracil, Vitamin Aand radiation].
2001 Gan to kagaku ryoho. cancer & chemotherapy

Prostate cancer:

• Vitamin A and apoptosis in prostate cancer. 2002 Endocrine-related cancer
• Fruit, vegetable, Vitamin A intakes, and prostate cancer risk. 2008 Prostate cancer and prostatic diseases
• Vitamin A, retinoids and carotenoids as chemopreventive agents for prostate cancer. 2004 The Journal of urology

Breast cancer:

• The Vitamin A family can significantly decrease the expression of ERbeta of ERs positive breast cancer cells in the presence or absence of ER ligands and paclitaxel. 2009 Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
• Estradiol and tamoxifen differently affects the inhibitory effects of Vitamin A and their metabolites on the proliferation and expression of alpha2beta1 integrins in MCF-7 breast cancer cells. 2009 Advances in medical sciences
• Can Vitamin A modify the activity of docetaxel in MCF-7 breast cancer cells?                                                                                             2007 Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society
• Evaluation of plasma non-enzymatic antioxidants in breast cancer etiology                                                                                                   2009 Asian Pacific journal of cancer prevention : APJCP

Ovarian cancer:

• A population-based case-control study of carotenoid and Vitamin A intake and ovarian cancer (United States).                            2001 Cancer causes & control : CCC
• The role of antioxidants and Vitamin A in ovarian cancer: results from the Women’s Health Initiative.                                              2008 Nutrition and cancer
• Association of dietary vitamin A, carotenoids, and other antioxidants with the risk of ovarian cancer.                                           2005 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
• Vitamin A metabolism is impaired in human ovarian cancer. 2009 Gynecologic oncology

Lung cancer:

• Effectiveness of Vitamin A acetate for enhancing the production of lung cancer specific monoclonal antibodies. 1999 Cytotechnology
• Intake of vitamin A-rich foods and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaf consumption. 2007 Asia Pacific journal of clinical nutrition

Lung, head & neck cancers:

• EUROSCAN, a randomized trial of Vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of cancer Head and Neck and Lung cancer Cooperative Groups.

2000 Journal of the National cancer Institute

Cervical cancer:

• Rapid HPLC method for the determination of Vitamin A and E and cotinine concentration in human serum in women with CIN and cervical cancer. 2009 Ginekologia polska

Gastric cancer:

• Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study.                                                           2007 The American journal of clinical nutrition

Laryngeal cancer:

• Association of vitamin A, vitamin C and zinc with laryngeal cancer. 2003 Indian journal of cancer
• Oxidant, Vitamin A and angiogenic markers in laryngeal cancer patients. 2003 The Journal of laryngology and otology

Children cancer:

• The effect of Vitamin A status in children treated for cancer. 2008 Pediatric hematology and oncology
• Does Vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?                                 2004 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Maxillary sinus cancer :

• Induction of apoptosis in maxillary sinus cancer cells by 5-fluorouracil, Vitamin A and radiation (FAR) therapy. 1999 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery
• [Chemoprevention and FAR therapy regimen comprised of 5-fluorouracil, Vitamin A and radiation].                                                                       2001 Gan to kagaku ryoho. cancer & chemotherapy

Studies on Vitamin A and Antiproliferative

http://science.naturalnews.com/V/Vitamin_A_and_Antiproliferative.html

Studies on Vitamin A and radiation

http://science.naturalnews.com/V/Vitamin_A_and_radiation.html

There is an extensive bibliography on the anti-tumoral action of Vitamin  A cited from LAST PAGE OF THIS DATABASE: 1,3,10,13,14,17,18,23,24,28,34,35,36,45,56,69,73,76,92,93,94,100,106,111,120,121,129,131,137,138,165,187,200,202,203,208,209,21,213,214,216,218,222,235,255,256,257,263,264,265,266,280,282,286,287,288,298,303,304,305,307,313,315,322,324,325,326,334,338,340,341,347,38,352,354,362,363,365,382,383,385,390,398,402,404,405,409,410,420,425,426,427,445,446,447,448,454,457,461,463,468,469,470,471,473,477,48,493,508,512):

This studies conclude  the following about vitamin A:

Anti-tumoral action in general

Vitamin A and retinoids have an anti neoplastic action, shown both in vivo and in vitro, in various tumors: basilomas, scaly carcinomas, melanomes, skin cancers, fungoid mycosis, acute promyelocyte leucemia, ovarian cancer, breast cancer, lung cancer, cancer of the bladder and follicular carcinomas of the thyroid.

Preventative action

Anti-tumoral action has been amply shown indirectly, that is with a preventative purpose. Various  studies have, in fact, shown that low plasmatic levels of beta-Carotene, vitamin C and vitamin E are  connected to an increase in the incidence of lung cancer.

Direct action at a receptor level

Only beta RAR (retinoic acid receptor) seems to be involved. More specifically, vitamin A (and its derivatives) acts by binding with specific receptors. In this way it can both inhibit the proteic synthesis of DNA and RNA, and also perform an anti-promotion  action to determine the return of a cellular differentiation. Furthermore its ability to inhibit oncogenes should be noted.

Apoptosis induction 

Apoptosis means the activation of specific endonucleases which break up the DNA, acting at a level of nucleosomic sites that make up the primary structural unit of the nuclear cromatine of the cell.  Vitamin A and retinoids in general can induce apoptosis in neoplastic cells, by activating intracellular proteolytic enzymes, called caspase 2 and caspase 3, which provoke deterioration  through proteolysis by a transcription factor, called Spl.  If this basal cellular transcription is altered, death is caused by Apoptosis.

In prostate cancer the retinoids intervene by reducing the level of the bcl 2 gene, whose function is to protect the cells from death by Apoptosis.  Carotenoids induced apoptosis in prostate cancer

http://www.erbeofficinali.org/dati/nacci/studi/carotenoidi%20sono%20fattori%20attivi%20contro%20il%20cancro%20della%20prostata.pdf

Inhibition of the cellular cycle

The retinoids block the passage of the cell from phase G1 to phase S (reducing the activity of a protein, called cycline D1): this passage, if not blocked, would lead the cell to mytosis.

Reduction of phosphorilation

Retinoids intervene in cancer causing a reduction in phosphorilation of the pRb, thus increasing survival; this protein is active in suppressing cellular growth.

Synergetic interaction with interferons

A second mechanism, apart from the proteic-enzymatic one, can be traced back to the intervention of interferons which, like retinoids, act as anti-proliferative factors. In practice, acting synergetically, they induce the expression of proteins capable of inhibiting neoplastic cellular proliferation.

The intake of natural carotenoids from food 

There is very little evidence to show that carotenoids taken in from food can increase the levels ofvitamin A: an extra portion a day of green leaf vegetables is not able to increase the hematic level of vitamin A; on the contrary, a mixed diet of foods particularly rich in beta-Carotene will give a  significant increase in vitamin A present in the blood. (627).

If you oblige healthy individuals to eat carrots (270g), broccoli (600g) or tomato juice (180g) it does not establish any significant changes in the hematic levels of the carotenoids: you only find an extremely wide variation (even up to 3-4 times) in the efficiency of gastro-intestinal absorption of  the carotenoids and therefore in their subsequent bio-availability at a hematic level (628) .

Optimal values of anti-oxidants in normal individuals

Vitamin C: >50 microMols/Liter

Vitamin E: >30 microMols/Liter

Vitamin A: >2.2 microMols/Liter

Beta-Carotene: >0.4 microMols/Liter

Association of vitamin A with vitamin E

In an experimental model of a cellular membrane the possibility of a positive interaction between anti-oxidant liposollubles such as beta-Carotene and alpha-Tocopherol has been investigated; the  result showed that there exists a synergetic action between beta-Carotene and alpha-Tocopherol  together which inhibits the processes of lipidic peroxidization compared with when they are used alone (629). THUS:

NOTE 2:

Vitamins , antioxidants and nutrients should be taken from WHOLE, ORGANIC(note below) FOODS (as much as possible) NOT from supplements as they need other vitamins and nutrients for proper usage.

Whole-food sources of Vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate. 2007 The Journal of nutrition

The difference between synthetic vitamins and natural vitamins

The difference between synthetic vitamins and natural ones can be easily exemplified by the experimental case of synthetic beta-Carotene (made up entirely of isomeric trans-beta-Carotene), and of natural beta-Carotene (made up of both isomeric trans-beta-Carotene and isomeric cis-beta- Carotene): the study showed a strong discrimination between the two isomers, with a serious decrease (impoverishment) induced at the level of Lycopene present in the LDLs (…). THUS:

3.It would be better to use the NATURAL (juice) ORGANIC WHOLE foods rich in vitamin A such as  Daucus carota (carrots ), avocados, cantalopues, etc. rather than the synthetic pharmaceutical vitamin products based on Vitamin A.

============================================================================================

B Vitamins 

Studies on Vitamins B and cancer – Natural News Science(MANY STUDIES)

science.naturalnews.com/V/Vitamin_B_and_cancer.html

Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women.
2008 The American journal of clinical nutrition

Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men.
2007 The Journal of nutrition

Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer.
2008 The Journal of nutrition

A prospective study of dietary folate and Vitamin B and colon cancer according to microsatellite instability and KRAS mutational status.
2008 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial.
2008 JAMA : the journal of the American Medical Association

Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer.
2003 Journal of the National cancer InstituteCancer incidence and mortality after treatment with folic acid and vitamin B12.
2009 JAMA : the journal of the American Medical AssociationOne-carbon metabolism-related nutrients and prostate cancer survival.
2009 The American journal of clinical nutritionCirculating concentrations of folate and vitamin B12 in relation to prostate cancerrisk: results from the European Prospective Investigation into cancer and Nutrition study.
2008 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Reduced thiamine (vitamin B1) levels following gastrectomy for gastric cancer.
2002 Gastric cancer : official journal of the International Gastric cancer Association and the Japanese Gastric cancer Association

Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrialcancer among Chinese women.
2007 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation.
2000 Nutrition and cancer

Dietary factors of one-carbon metabolism and prostate cancer risk.
2006 The American journal of clinical nutrition

Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.
2009 BMC cancer

Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women.
2006 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Dietary folate intake and breast cancer risk: results from the Shanghai Breast cancerStudy.
2001 Cancer research

Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies.
2010 JAMA : the journal of the American Medical Association

One-carbon metabolism and prostate cancer risk: prospective investigation of seven circulating B vitamins and metabolites.
2009 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women.
2006 American journal of epidemiology

Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers.
2002 Nutrition and cancer

Association of the B-vitamins pyridoxal 5′-phosphate (B(6)), B(12), and folate with lungcancer risk in older men.
2001 American journal of epidemiology

Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan.
2009 Nutrition and cancer

The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer.
2008 The Journal of antimicrobial chemotherapy

Methylenetetrahydrofolate reductase, diet, and risk of colon cancer.
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study.
2005 International journal of cancer. Journal international du cancer

Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study.
2005 International journal of cancer. Journal international du cancer

Vitamin B(12) and Folate Status in Head and Neck Cancer.
2002 Asian Pacific journal of cancer prevention : APJCP

Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation intocancer and nutrition.
2010 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer.
2008 Carcinogenesis

Vitamin B6 points PC6 injection during acupuncture can relieve nausea and vomiting in patients with ovarian cancer.
2009 International journal of gynecological cancer : official journal of the International Gynecological cancer Society

Studies on Vitamins B and Antineoplastic

http://science.naturalnews.com/V/Vitamin_B_and_Antineoplastic.html

============================================================================================

Vitamin B2 – Riboflavin

Studies on Riboflavin and cancer

science.naturalnews.com/R/Riboflavin_and_cancer.html(MANY STUDIES in this link )

Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer.
2008 The Journal of nutrition

Augmented antioxidant status in Tamoxifen treated postmenopausal women with breast cancer on co-administration with Coenzyme Q10, Niacin and Riboflavin.
2008 Cancer chemotherapy and pharmacology

Anti-angiogenic potential of CoenzymeQ10, Riboflavin and niacin in breast cancerpatients undergoing tamoxifen therapy.
2008 Vascular pharmacology

Biochemical characterization of Riboflavin carrier protein (RCP) in prostate cancer.
2009 Frontiers in bioscience : a journal and virtual library

Effect of coenzyme Q10, Riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy.
2007 Biological & pharmaceutical bulletin

Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), Riboflavin and niacin.
2007 Basic & clinical pharmacology & toxicology

Multidrug transporter ABCG2/breast cancer resistance protein secretes Riboflavin(vitamin B2) into milk.
2007 Molecular and cellular biologyIntracellular processing of Riboflavin in human breast cancer cells.
2008 Molecular pharmaceuticsAmeliorating effect of coenzyme Q10, Riboflavin and niacin in tamoxifen-treated postmenopausal breast cancer patients with special reference to lipids and lipoproteins.
2007 Clinical biochemistry

Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles.
2009 Breast cancer research and treatment

Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery.
2010 Bioorganic & medicinal chemistry letters

Co-enzyme Q10, Riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy.
2008 The British journal of nutrition

Riboflavin deficiency and esophageal cancer: a case control-household study in the Caspian Littoral of Iran.
2005 Cancer detection and prevention

[Apoptosis of human gastric cancer cell induced by photochemical riboflavin].
2003 Ai zheng = Aizheng = Chinese journal of cancer

Riboflavin carrier protein: a serum and tissue marker for breast carcinoma.
2001 International journal of cancer. Journal international du cancer

Studies on Riboflavin and Anti-Angiogenic

http://science.naturalnews.com/R/riboflavin_and_Anti-Angiogenic.html

============================================================================================

Vitamin B3(Niacin)

Studies on Niacin and cancer

Augmented antioxidant status in Tamoxifen treated postmenopausal women with breast cancer on co-administration with Coenzyme Q10, Niacin and Riboflavin.
2008 Cancer chemotherapy and pharmacology

Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin.
2007 Basic & clinical pharmacology & toxicology

Anti-angiogenic potential of CoenzymeQ10, riboflavin and Niacin in breast cancerpatients undergoing tamoxifen therapy.
2008 Vascular pharmacology

Effect of coenzyme Q10, riboflavin and Niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy.

2007 Biological & pharmaceutical bulletin

Anti-invasive activity of Niacin and trigonelline against cancer cells.

2005 Bioscience, biotechnology, and biochemistry

Biochemical assessment of Niacin deficiency among carcinoid cancer patients.

2005 The American journal of gastroenterology

Ameliorating effect of coenzyme Q10, riboflavin and Niacin in tamoxifen-treated postmenopausal breast cancer patients with special reference to lipids and lipoproteins.

2007 Clinical biochemistry

Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles.

2009 Breast cancer research and treatment

Co-enzyme Q10, riboflavin and Niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy.

2008 The British journal of nutrition

Niacin supplementation decreases the incidence of alkylation-induced nonlymphocytic leukemia in Long-Evans rats.

2008 Nutrition and cancer

Niacin and carcinogenesis.

2003 Nutrition and cancer

Other studies:

ANTI-invasive activities of Niacin against cancer  cells; http://science.naturalnews.com/…/3260742_Anti_invasive_activity_of_niacin_and_ trigonelline_against_cancer_cells.html

Studies on Niacin and breast cancer

http://science.naturalnews.com/N/Niacin_and_breast_cancer.html (MANY STUDIES in this link)  

============================================================================================

Vitamin B5 ( pantotenic acid )

Pantothenic Acid for Stage IV Breast Cancer Treatment Information

https://www.medify.com/…/pantothenic–acid-treatment-stage-iv-breast-ca…‎

Vitamins B2, B3,B5 are respiratory vitamins(increasing cellular oxygenation –  see above Otto Wartburg proposals).

============================================================================================

Vitamin B6

Studies on Vitamin B6 and cancer – Natural News Science (MANY STUDIES)

science.naturalnews.com/V/Vitamin_B6_and_cancer.html

Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer.

2003 Journal of the National cancer Institute

Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial.

2008 JAMA : the journal of the American Medical Association

The role of Vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer.

2008 The Journal of antimicrobial chemotherapy

Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.

2009 BMC cancer

Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan.

2009 Nutrition and cancer

Methionine and Vitamin B6 intake and risk of pancreatic cancer: a prospective study of Swedish women and men.

2007 Gastroenterology

Plasma Vitamin B6 and the risk of colorectal cancer and adenoma in women.

2005 Journal of the National cancer Institute

Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts.

2007 Cancer research

Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women.

2006 American journal of epidemiology

Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan.

2005 Nutrition and cancer

Folate and Vitamin B6 intake and risk of colon cancer in relation to p53 expression.

2008 Gastroenterology

Vitamin B6 points PC6 injection during acupuncture can relieve nausea and vomiting in patients with ovarian cancer.

2009 International journal of gynecological cancer : official journal of the International Gynecological cancer Society

Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies.

2010 JAMA : the journal of the American Medical Association

Dietary Vitamin B6 intake and the risk of colorectal cancer.

2008 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Prospective study of plasma Vitamin B6 and risk of colorectal cancer in men.

2009 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Vitamin B6 intake, alcohol consumption, and colorectal cancer: a longitudinal population-based cohort of women.

2005 Gastroenterology

Relationship between dietary and supplemental intake of folate, methionine, Vitamin B6 and folate receptor alpha expression in ovarian tumors.
2010 International journal of cancer. Journal international du cancer

Vitamin B12 

Studies on Vitamin B12 and cancer – Natural News Science(MANY STUDIES)

science.naturalnews.com/V/Vitamin_B12_and_cancer.html

Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. 2011 Cancer causes & control : CCC Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. 2003 Journal of the National cancer Institute Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. 2005 International journal of cancer. Journal international du cancer Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. 2005 International journal of cancer. Journal international du cancer The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteine. 2000 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology Effect of combined folic acid, vitamin B6, and Vitamin B12 on cancer risk in women: a randomized trial. 2008 JAMA : the journal of the American Medical AssociationPlasma Vitamin B12 concentrations and the risk of colorectal cancer: a nested case-referent study. 2008 International journal of cancer. Journal international du cancerDietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women. 2009 BMC cancer Circulating concentrations of folate and Vitamin B12 in relation to prostate cancerrisk: results from the European Prospective Investigation into cancer and Nutrition study. 2008 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. 2009 Nutrition and cancer Cancer incidence and mortality after treatment with folic acid and vitamin B12. 2009 JAMA : the journal of the American Medical Association Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. 2007 Cancer research Plasma homocysteine, folate, and Vitamin B12 levels in patients with laryngeal cancer. 2008 Archives of otolaryngology–head & neck surgery A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. 1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. 2005 Nutrition and cancer Elevated serum Vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. 2000 Journal of pain and symptom management Folate, Vitamin B12 and postmenopausal breast cancer in a prospective study of French women. 2006 Cancer causes & control : CCC Vitamin B12 deficiency: a new risk factor for breast cancer? 1999 Nutrition reviews Toxic epidermal necrolysis related to pemetrexed and carboplatin with Vitamin B12and folic acid supplementation for advanced non-small cell lung cancer. 2009 Onkologie Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status. 2008 World journal of gastroenterology : WJG Efficacy and safety of two doses of pemetrexed supplemented with folic acid andVitamin B12 in previously treated patients with non-small cell lung cancer. 2008 Clinical cancer research : an official journal of the American Association forcancer Research Serum Vitamin B12 and folate status among patients with chemotherapy treatment for advanced colorectal cancer. 2009 Upsala journal of medical sciences Circulating folate, vitamin B12, homocysteine, Vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. 2010 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology Dietary folate and Vitamin B12 intake before diagnosis decreases gastric cancermortality risk among susceptible MTHFR 677TT carriers. 2010 Nutrition (Burbank, Los Angeles County, Calif.) Increased serum CA-15.3 levels in patients with megaloblastic anemia due to Vitamin B12 deficiency. 2004 Oncology

============================================================================================

Vitamin B17(Laetrile/ Amygdalin) (very important vitamin)

Note: “Laetrile” acronym for “LAEvomandeloniTRILE-glucoside”) as Amygdalin:

Laetrile has two molecules of glucose, Amygdalin has more.

Indeed, the chemical structure of Laetrile is D-1 mandelonitrile–beta-glucuronide, while

for Amygdalin it is D-mandelonitrile-bi-glucoside.

B17/ Amygdalin studies science.naturalnews.com/amygdalin.html

How laetrile or B17 from apricot seeds kills only cancer cells ·

apricot studies science.naturalnews.com/apricot.html

Apricot Seeds Kill Cancer Cells without Side Effects

See also:  http://worldwithoutcancer.org.uk/success.html,   http://www.apricotsfromgod.info/journal.htm

Much more details(including treatments & CLINICAL CASES with B17) in my BOOK + DR. Binzel’s FREE EBOOK on this topic + Dr. Nacci’s FREE EBOOK on this topic.

NOTE:

Vitamins(including B group) should be taken from WHOLE FOODS(organic) (as much as possible),NOT from supplements as vitamins and nutrients need other vitamins and nutrients for proper usage within the body.

============================================================================================

Vitamin C (very important vitamin)

Vitamin C   is a respiratory vitamin- it stimulates the body to produce its own hydrogen peroxide (increasing cellular oxygenation –  see above Otto Wartburg proposals).

Therefore, megadoses of vitamin C are administered orally and intravenously by orthomolecular physicians to treat cancer.

60 references to studies published that show the importance of vitamin C:

www.doctoryourself.com / biblio_cameron.html http://www.doctoryourself.com/cancer_hoffer.html.

Even National Institutes of Health is actively sponsoring studies of high-dose intravenous vitamin C therapy.

Other MULTIPLE studies on  vitamin’s C cancer fighting effects: science.naturalnews.com/…/4854330_Vitamin_C_in_alternative_cancer_ treatment_historical_background.html

High doses of vitamin C and cancer :

science.naturalnews.com/…/2387600_High_dose_vitamin_C_supplement_ use_is_associated_with_self.html

Vitamin C and breast cancer studies: science.naturalnews.com / V / Vitamin_C_and_breast_cancer.html

Vitamin C , vitamin E & selenium in breast cancer : science.naturalnews.com/…/1198191_Dietary_beta_carotene_vitamin_C_and _E_intake_and_breast.html science.naturalnews.com/…/3959947_Association_between_breast_cancer_ and_vitamin_C_vitamin_E_and.html

Vitamin C ,vitamin A & zinc  in laryngeal cancer  :

science.naturalnews.com/…/4508069_Association_of_vitamin_A_vitamin_C _and_zinc_with_laryngeal.html

Vitamin C &  gastric cancer:

science.naturalnews.com/…/3603872_Plasma_and_dietary_vitamin_C_levels _and_risk_of_gastric.html science.naturalnews.com/…/3628783_Prediagnostic_plasma_vitamin_C_ levels_and_the_subsequent_risk_of.html science.naturalnews.com/…/4790082_Effect_of_physiological_ concentrations_of_vitamin_C_on_gastric_cancer.html

Also see: http://orthomolecular.org/resources/omns/v04n19.shtml

There is also an extensive bibliography on the anti-tumoral action of vitamin C (25,33,47,54,83,91,122,129,181,197,202,218,244,246,270,299,311,335,339,367,404,405,414,415,416,489,496,510,511)

See the bibliography and studies quoted on last page of databse.

The pioneers of this oncological therapy were Pauling, who received the Nobel Prize for Chemistry, and the Italian Pantellini.

Ascorbic acid is mainly known for its ability to reduce metallic ions in various enzymatic processes and above all for its ability to act as an anti-oxidant agent, thus able to remove free radicals, reducing the damage caused at a genome level.

Furthermore it may be able to block the formation of nitrose at a gastro-intestinal level, as well as carrying out a preventative action on the formation of adenomatose polyps.

Even though ascorbic acid is well known for its collagene forming action, and the well known effect of scurvy in cases of reduction or absence of this acid in the diet, this vitamin is also important, alongside vitamins A and E as a first class anti-tumoral agent.

It is a respiratory vitamin(like vitamins E, B3, B5)  that helps increase cellular oxygen levels.

It reinforces the intercellular bond and forestalls the destructive action of the hyalurons produced by many neoplastic cells.

Vitamin C stimulates the Natural killer lymphocytes, it supports the macrophagic activity, the chemio-tactical mobility of the white corpuscles, the production of antibodies and the response of the T cytotoxic lymphocytes to the antigenes.

Cameron found very low plasmatic levels of vitamin C in cancer patients (0.26 mg/100 mL) compared to normal plasmatic values (54).

In other studies, 154 cancer patients, undergoing analysis, were found to have low levels of vitamin C not only in their plasma (0.31 mg/100 mL), but also in their leucocytes (15.9 mg/10 E+8), with a positive correlation (r = 0.42) between these two values; in particular the authors attributed the alteration in the immune response to the tumor, especially of the phagocytosis, to the low  concentration of vitamin C in the white blood corpuscles.

Already in 1974 Goetz had shown that vitamin C, in vitro, was capable of stimulating the motility and the chemiotaxis of neutrophiles.

The doses advised in literature for anti-neoplastic therapy are about 3-10 grams a day, reaching even 40 grams daily, because the vitamin is not toxic, at high doses it only has a laxative effect.

It would be better to take it by eating fresh fruit, but it is difficult to reach such high doses of the vitamin in this way.

Integrating fresh fruit (kiwi, oranges, lemons and grapefruit) with the juice of sea buckthorn  , Rosa canina (dog rose, wild rose) to reach a daily dosage of at least 5- 8 grams of natural vitamin C, avoiding however, the use of pharmaceutically prepared vitamin C tablets.

Natural vitamin C, rich in its metabolites and other components called bioflavenoids (Citrin, Hesperidin, Campherol, Galangine, Isoamnetin, Rutine, Hyperoxide, Quercitin, Pychnogenol, etc) is more powerful and efficient, and furthermore is devoid of unpleasant gastric effects which are the result of high doses of synthetic vitamin C.

Natural vitamin C is moreover, characterized by a significant reduction in the formation of Calcium oxalate in the kidneys, as opposed to synthetic vitamin C. It is also easier for the intestine to absorb and has greater bio-availability, above all through its most important metabolites such as tronic acid, lixonic acid, xilonic acid etc.

This bio-availability has a critical importance in the immune defense system because the white blood cells tend to absorb Natural vitamin C 4 times more than they absorb synthetic vitamin C.

Recently, Myrciaria paraensis (camu-camu) has appeared on the European market. It is a small exotic fruit, similar to a small orange, but it contains 50 times more natural vitamin C than Citrus aurantium (orange), and it could therefore provide the daily dosage, of at least 3 grams, of vitamin  .

Also Malpighia punicifolia (acerola), a cherry from the Antilles, is very rich in vitamin C, containing 50 to 100 times more than citrus fruits.

Natural vitamin C is therefore efficient because it is naturally associated to the bioflavenoids (Citrin, Hesperidin, Campherol, Galangine, Isoamnetin, Rutine, Hyperoxide, Quercetine,Quercitine, Pychnogenol, etc..) and other molecules, in plants often characterized by an immune  stimulating activity (Echinacea purpurea, Plantago major, Capsicum frutescens)

Note: With very high therapeutic doses (>8-10 grams a day), Magnesium (e.g. Dolomite) must also be taken to avoid the risk of kidney stones.

Here enclosed scientific papers extracted from Catherine Kousmine (“Save your body”, page 129,

“Effects of C vitamin on our body according to Linus Pauling, edition Tecniche Nuove):

“…an intake of 1500 milligrams of ascorbic acid by mouth determines a concentration of 1.5 milligrams of C vitamin for each 100 millilitres of blood. By increasing the intake, the concentration suddenly increases up to 2.5 milligrams and then goes back to 1.5 millilitres for each 100 millilitres blood. There are enzymes which help the conversion of most

ascorbates into useful oxidation products. If the intake remains high, the body increases the amount of enzymes useful to the conversion; otherwise, if the ascorbic acid dose is suddenly reduced for some days, an excess of conversion enzymes and then a too law level of vitamin C in the blood occur. This means a number of disorders, as for example a higher sensibility to infections. The adaptation to a lower proportion takes place by reducing the number of conversion enzymes: it is necessary to gradually decrease the dose of vitamin C. By taking 100 milligrams a day and in presence of a plasmatic level of 1 milligram for every 100 millilitres blood, urines do not contain ascorbic acid because it is reabsorbed by renal tubules. If the intake is higher than 100 milligrams, i.e. 1-2 grams a day, 25% go in urines and the rest is kept by the body. Healthy people, who lack in vitamin C for some months, have to take 2-4 grams in order to eliminate them through urines. In case of cancer patients, who are used to take high doses of ascorbic acid, an interruption of some days requires an intake of 50 grams (fifty grams) of vitamin C so that this one can be found in urines”.

============================================================================================

Vitamin D (very important vitamin)

Cancer prevention by a MINIMUM of 77% cases just by sun exposure(best source of vitamin D): http://www.naturalnews.com/035063_vitamin_D_cancer_facts.html

Cancer treatment with sun exposure(vitamin D): http://www.polymvasurvivors.com/what_you_know.html#Vitamin%20D%20

NOTE:The link above contains multiple studies on sun exposure(vitamin D) and it’s crucial importance in fighting cancer:

Circulating Vitamin D levels in the Blood Dramatically Reduces Death Rate

* For each 10ng/ml increase in the blood level of vitamin D, the death rate from cancer would be reduced by 29%. The relationship between vitamin D and colorectal cancer is particularly strong.

The death rate for colorectal cancer would be reduced by 49%. (30 – Read Supporting Scientific Article on PUBMED)

Vitamin D Levels est during Summer = Improves survival by 40%

* A Norwegian study showed that cancer patients diagnosed in the summer when vitamin D levels are highest had up to 40% better survival rates than patients diagnosed in the winter when vitamin D levels are at their lowest.

(56 – Read Supporting Scientific Article on PUBMED )

Low Vitamin D Levels Greater chance of Death & Metastasis

* Breast cancer patients with low levels of vitamin D followed over eleven years had a 70% greater chance of dying and twice the rate of developing metastasis than patients with high levels of vitamin D.

(90 – Read Supporting Scientific Article )

Lung Cancer Patients Higher levels = Dramatic increase in Survival

* Early stage lung cancer patients who were diagnosed in the summer and had the highest levels of vitamin D had a five-year survival of 73% compared to 30% for those diagnosed in the winter with low vitamin D levels.

(60 – Read Supporting Scientific Article on PUBMED)

Lung – Colon – Prostate – Renal – Endometrial Cancers Higher Vit D levels dramatically decreases Risk

*High vitamin D levels (based on latitude and UV exposure) also correlate with a decreased risk of developing lung cancer, a 45% and 65% reduction in men and women respectively. Similar effects have been demonstrated in colon, prostate, renal and endometrial cancer. (33 – Read Supporting Scientific Article on BMJ(British Medical Journal))

Advanced Colorectal Patients Risk of death greatly Improved

* The risk of death for colorectal cancer patients with advanced disease but with high levels of vitamin D was reduced by over 60% compared to patients with low vitamin D levels. (64 – Read Supporting Scientific Article on PUBMED)

Prostate Cancer Patients

*Prostate Cancer Patients with Vitamin D levels in the mid and high range had a 60% and 85% respectively reduced risk of death from the condition compared to patients with low levels of Vitamin D. This is almost a seven fold increase in the risk of death in those with low vs high vitamin D levels. (152 – Read Supporting Scientific Article on PUBMED)

There is also an extensive bibliography on the anti-tumoral action of vitamin D- see last page of this database:  (28,157,160,188,208,209,231,240,246, 254,302,323,479,489)

Vitamin D is BEST taken from skin exposure to the sun, MINIMUM 30 mins daily,without any sunscreen or protection. Avoid burning and avoid the interval 11 am – 16 pm.

Natural vitamin D, contained in some plants, is however preferable to the synthetic type, because the latter is about 10 times more capable of binding with Magnesium, taking it away from the organism, thus causing all the damage that the loss of this incurs (osteoporosis, kidney stones).

Vitamin D induces the inhibition of neoplastic cellular growth: this has been shown in vitro in neoplastic cellular lines; especially of the hematopoietic system, of the CNS, of the prostate; the  colon, the ovaries and the breasts.

This action is thought to be expressed at various levels, in particular:

a) by means of apoptosis induction, through the activation of p21, that is, the inhibitor of the kinase proteins;

b) the inhibition of neoplastic cellular growth, which would be blocked in the G1 phase because of the action of the IGF1 inhibitor;

c) by means of cellular differentiation.

==========================================================================================================

Vitamin E(respiratory vitamin)

This liposoluble substance consists of a group of various components, called Tocopherols.

Seven of these exist in nature; alpha-Tocopherol, beta-Tocopherol, gamma- Tocopherol, delta-Tocopherol, epsilon-Tocopherol, zetaTocopheros and eta-Tocopherol.

Studies on Vitamin E and cancer

Selenium and Vitamin E supplements for prostate cancer: evidence or embellishment?
2002 Urology

Supplemental Vitamin E intake and prostate cancer risk in a large cohort of men in the United States.
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

The role of Vitamin E in the prevention of cancer: a meta-analysis of randomized controlled trials.

2007 Annals of Saudi medicine

Long-term use of supplemental multivitamins, vitamin C, vitamin E, and folate does not reduce the risk of lung cancer.
2008 American journal of respiratory and critical care medicine

Vitamin E and selenium supplementation and risk of prostate cancer in the Vitamins and lifestyle (VITAL) study cohort.
2008 Cancer causes & control : CCCVitamin E suppresses telomerase activity in ovarian cancer cells.
2007 Cancer detection and preventionEffects of long-term Vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
2005 JAMA : the journal of the American Medical AssociationSupplemental and dietary Vitamin E intakes and risk of prostate cancer in a large prospective study.
2007 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Antioxidants vitamin C and Vitamin E for the prevention and treatment of cancer.
2006 Journal of general internal medicine

Vitamin E: the evidence for multiple roles in cancer.
2003 Nutrition and cancer

Vitamin E supplements and risk of prostate cancer in U.S. men.
2004 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Serum and dietary Vitamin E in relation to prostate cancer risk.
2007 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Association of variants in two Vitamin E transport genes with circulating Vitamin Econcentrations and prostate cancer risk.
2009 Cancer research

Association between breast cancer and vitamin C, Vitamin E and selenium levels: results of a case-control study in India.
2005 Asian Pacific journal of cancer prevention : APJCP

A short-term dietary supplementation with high doses of Vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients.
2007 Cancer immunology, immunotherapy : CII

SELECT: the next prostate cancer prevention trial. Selenum and Vitamin E cancerPrevention Trial.
2001 The Journal of urology

Vitamin C and Vitamin E supplement use and colorectal cancer mortality in a large American cancer Society cohort.
2001 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Vitamin E and breast cancer.
2004 The Journal of nutrition

SELECT: the selenium and Vitamin E cancer prevention trial.
2003 Urologic oncology

The selenium and Vitamin E cancer prevention trial.
2003 World journal of urology

Selenium and Vitamin E cancer prevention trial.
2004 Annals of the New York Academy of Sciences

Selenium and Vitamin E cancer Prevention Trial: a nutrient approach to prostatecancer prevention.
2009 Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer

A nutrient approach to prostate cancer prevention: The Selenium and Vitamin Ecancer Prevention Trial (SELECT).
2010 Nutrition and cancer

Null activity of selenium and Vitamin E as cancer chemopreventive agents in the rat prostate.
2010 Cancer prevention research (Philadelphia, Pa.)

Vitamin E and cancer.
2007 Vitamins and hormones

Clinical models for testing chemopreventative agents in prostate cancer and overview of SELECT: the Selenium and Vitamin E cancer Prevention Trial.
2003 Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer

Cancer Preventive Effects of Vitamin E.
2011 Current pharmaceutical biotechnology

Vitamin E but not St. John’s wort mitigates leukopenia caused by cancerchemotherapy in rats.
2006 Translational research : the journal of laboratory and clinical medicine

Vitamin C and Vitamin E supplement use and bladder cancer mortality in a large cohort of US men and women.
2002 American journal of epidemiology

Review of Vitamin E and selenium in the prevention of prostate cancer: implications of the selenium and Vitamin E chemoprevention trial.
2002 Integrative cancer therapies

Vitamin E and breast cancer prevention: current status and future potential.
2003 Journal of mammary gland biology and neoplasia

Vitamin E and breast cancer prevention: current status and future potential.
2003 Journal of mammary gland biology and neoplasia

Molecular epidemiologic studies within the Selenium and Vitamin E cancerPrevention Trial (SELECT).
2001 Cancer causes & control : CCC

Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer.

2009 Journal of the National cancer Institute

Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E.
2010 The Journal of biological chemistry

Selenium and Vitamin E for prostate cancer: post-SELECT (Selenium and Vitamin Ecancer Prevention Trial) status.
2011 Molecular medicine (Cambridge, Mass.)

Vitamin E and cancer: An insight into the anticancer activities of Vitamin E isomers and analogs.
2008 International journal of cancer. Journal international du cancer

Vitamin E intake, alpha-tocopherol status, and pancreatic cancer in a cohort of male smokers.
2009 The American journal of clinical nutrition

The roles of alpha-vitamin E and its analogues in prostate cancer.
2007 Vitamins and hormones

Combined lycopene and Vitamin E treatment suppresses the growth of PC-346C human prostate cancer cells in nude mice.
2006 The Journal of nutrition

Vitamin E, alpha- and gamma-tocopherol, and prostate cancer.
1999 Seminars in urologic oncology

Synergistic effect of Vitamin E and selenium in human prostate cancer cell lines.
2004 Prostate cancer and prostatic diseases

Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines.
2003 BMC cancer

Vitamin E succinate inhibits colon cancer liver metastases.
2002 The Journal of surgical research

Lycopene and Vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model.
2004 The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Higher baseline serum concentrations of Vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene cancerPrevention Study.
2006 The American journal of clinical nutrition

Alpha-tocopheryl succinate, the most effective form of Vitamin E for adjuvant cancertreatment: a review.
2003 Journal of the American College of Nutrition

gamma-Tocopherol or combinations of Vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis.
2004 Proceedings of the National Academy of Sciences of the United States of America

Experimental basis for cancer prevention by vitamin E.
2000 Cancer investigation

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria.
2007 Molecular aspects of medicine

Vitamin E succinate decreases lung cancer tumor growth in mice.
2005 The Journal of surgical research

RRR-alpha-vitamin E succinate potentiates the antitumor effect of calcitriol in prostatecancer without overt side effects.
2009 Clinical cancer research : an official journal of the American Association forcancer Research

Serum levels of folate, lycopene, ß-carotene, retinol and Vitamin E and prostatecancer risk.
2010 European journal of clinical nutrition

Trace elements and Vitamin E status in Nigerian patients with prostate cancer.
2010 African health sciences

Designing the Selenium and Vitamin E cancer Prevention Trial (SELECT).
2005 Journal of the National cancer Institute

Vitamin E analogues and immune response in cancer treatment.
2007 Vitamins and hormones

Donepezil and Vitamin E for preventing cognitive dysfunction in small cell lungcancer patients: preliminary results and suggestions for future study designs.
2005 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Vitamin E serum levels and gastric cancer: results from a cohort of patients in Tuscany, Italy.
2000 Cancer letters

Donepezil and Vitamin E for preventing cognitive dysfunction in small cell lungcancer patients: preliminary results and suggestions for future study designs.
2005 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Effects of topical L-selenomethionine with topical and oral Vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice.
2003 Journal of the American Academy of Dermatology

Vitamin E and the Y4 agonist BA-129 decrease prostate cancer growth and production of vascular endothelial growth factor.
2002 The Journal of surgical research

Pro-apoptotic mechanisms of action of a novel Vitamin E analog (alpha-TEA) and a naturally occurring form of Vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells.
2004 Nutrition and cancer

Minority recruitment to the Selenium and Vitamin E cancer Prevention Trial (SELECT).
2005 Clinical trials (London, England)

Salubrious effect of vitamin C and Vitamin E on tamoxifen-treated women in breastcancer with reference to plasma lipid and lipoprotein levels.
2000 Cancer letters

Design of Physicians’ Health Study II–a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials.
2000 Annals of epidemiology

Vitamin E succinate promotes breast cancer tumor dormancy.
2000 The Journal of surgical research

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies withVitamin E analogues, inhibitors of complex II.
2007 Journal of bioenergetics and biomembranes

Centralized blood processing for the selenium and Vitamin E cancer prevention trial: effects of delayed processing on carotenoids, tocopherols, insulin-like growth factor-I, insulin-like growth factor binding protein 3, steroid hormones, and lymphocyte viability.
2005 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

The therapeutic and preventive effect of RRR-alpha-vitamin E succinate on prostatecancer via induction of insulin-like growth factor binding protein-3.
2007 Clinical cancer research : an official journal of the American Association forcancer Research

Vitamin E and prostate cancer: is Vitamin E succinate a superior chemopreventive agent?
2005 Nutrition reviews

Aspirin prevents stroke but not MI in women; Vitamin E has no effect on CV disease or cancer.
2006 Cleveland Clinic journal of medicine

Effect of Vitamin E on tamoxifen-treated breast cancer cells.
2006 Surgery

Dietary administration of the proapoptotic Vitamin E analogue alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer.
2006 Cancer research

Combination of Vitamin E and selenium causes an induction of apoptosis of human prostate cancer cells by enhancing Bax/Bcl-2 ratio.
2008 The Prostate

Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E.
2009 Climacteric : the journal of the International Menopause Society

Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth.
2008 Nutrition and cancer

Poly(L-lactide)-vitamin E TPGS nanoparticles enhanced the cytotoxicity of doxorubicin in drug-resistant MCF-7 breast cancer cells.
2010 Biomacromolecules

Vitamin E succinate induced apoptosis and enhanced chemosensitivity to paclitaxel in human bladder cancer cells in vitro and in vivo.
2010 Cancer science

Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway.
2005 Cancer research

Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells.
2007 The Prostate

Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis.
1999 Cancer research

Effects of topical and oral Vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice.
2000 Nutrition and cancer

Synergy between selenium and Vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells.
2003 Cancer research

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancercells by signaling via the mitochondrial pathway.
2005 Biochemical and biophysical research communications

Vitamin E and prostate cancer.
2002 The Urologic clinics of North America

Synergy between selenium and Vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells.
2003 Cancer research

Peptide YY augments gross inhibition by Vitamin E succinate of human pancreaticcancer cell growth.
2000 The Journal of surgical research

Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostatecancer risk.
2006 Journal of the National cancer Institute

Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women’s Health Study: a randomized controlled trial.
2005 JAMA : the journal of the American Medical Association

Dietary intakes of retinol, beta-carotene, vitamin D and Vitamin E in the European Prospective Investigation into cancer and Nutrition cohort.
2009 European journal of clinical nutrition

Mitochondrial targeting of Vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II.
2011 The Journal of biological chemistry

Impact of supplemental site grants to increase African American accrual for the Selenium and Vitamin E cancer Prevention Trial.
2010 Clinical trials (London, England)

The Outcome of Selenium and Vitamin E cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology.
2009 Molecular interventions

Critical roles for JNK, c-Jun, and Fas/FasL-Signaling in Vitamin E analog-induced apoptosis in human prostate cancer cells.
2008 The Prostate

Effect of selenium and Vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E cancer Prevention Trial (SELECT).
2009 JAMA : the journal of the American Medical Association

Tocotrienols, the Vitamin E of the 21st century: its potential against cancer and other chronic diseases.
2010 Biochemical pharmacology

Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity.
2008 European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V

Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release.
2006 Biomaterials

Involvement of JNK/p73/NOXA in Vitamin E analog-induced apoptosis of human breast cancer cells.
2008 Molecular carcinogenesis

Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1.
2005 The Annals of pharmacotherapy

A peptide conjugate of Vitamin E succinate targets breast cancer cells with high ErbB2 expression.
2007 Cancer research

Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention.
2007 The Prostate

The effects of Vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.
2002 World journal of gastroenterology : WJG

The effects of Vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.
2002 World journal of gastroenterology : WJG

Vitamin E succinate and cancer treatment: a Vitamin E prototype for selective antitumour activity.
2003 British journal of cancer

Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
2004 Journal of hepatology

Vitamin E inhibits the high-fat diet promoted growth of established human prostate LNCaP tumors in nude mice.
1999 The Journal of urology

Vitamin E analog alpha-TEA and celecoxib alone and together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis in nude mice.
2004 Breast cancer research and treatment

Development of gamma (gamma)-tocopherol as a colorectal cancer chemopreventive agent.
2003 Critical reviews in oncology/hematology

Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects.

2004 Current cancer drug targets

The role of PC-SPES, selenium, and Vitamin E in prostate cancer.
2002 Oncology (Williston Park, N.Y.)

Differential response of human ovarian cancer cells to induction of apoptosis byVitamin E Succinate and Vitamin E analogue, alpha-TEA.
2004 Cancer research

A short-term dietary supplementation of high doses of Vitamin E increases T helper 1 cytokine production in patients with advanced colorectal cancer.
2002 Clinical cancer research : an official journal of the American Association forcancer Research

Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells.
2003 Nutrition and cancer

High dietary level of synthetic Vitamin E on lipid peroxidation, membrane fatty acid composition and cytotoxicity in breast cancer xenograft and in mouse host tissue.
2003 Cancer cell international

[Roles of ERK1/2 MAPK in Vitamin E succinate-induced apoptosis in human gastriccancer SGC-7901 cells].
2003 Wei sheng yan jiu = Journal of hygiene research

Alpha-vitamin E derivative, RRR-alpha-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells.
2007 Asian journal of andrology

Roles of Fas signaling pathway in Vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.
2002 World journal of gastroenterology : WJG

Mechanisms mediating the antiproliferative and apoptotic effects of Vitamin E in mammary cancer cells.
2005 Frontiers in bioscience : a journal and virtual library

Cellular and molecular effects of alpha-tocopheryloxybutyrate: lessons for the design of Vitamin E analog for cancer prevention.
2004 Anticancer research

Vitamin E and cancer.
2009 Nutrition and cancer

Pentoxifylline and Vitamin E treatment for prevention of radiation-induced side-effects in women with breast cancer: a phase two, double-blind, placebo-controlled randomised clinical trial (Ptx-5).
2009 European journal of cancer (Oxford, England : 1990)

Vitamin E prevents lipid raft modifications induced by an anti-cancer lysophospholipid and abolishes a Yap1-mediated stress response in yeast.
2010 The Journal of biological chemistry

Analogs of Vitamin E epitomized by alpha-tocopheryl succinate for pancreatic cancertreatment: in vitro results induce caution for in vivo applications.
2010 Pancreas

Evaluation of plasma non-enzymatic antioxidants in breast cancer etiology.
2009 Asian Pacific journal of cancer prevention : APJCP

[The study of apoptosis induction effect of Vitamin E succinate on Tca8113 human tongue cancer cells].
2008 Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?
2005 The British journal of nutrition

Double-blind placebo-controlled randomised trial of Vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
2004 Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas inVitamin E succinate-triggered apoptosis.
2000 Nutrition and cancer

Vitamin E and other antioxidants inhibit human prostate cancer cells through apoptosis.
2000 The Prostate

Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis.
2006 International journal of cancer. Journal international du cancer

In vitro and in vivo evaluation of anticancer actions of natural and synthetic Vitamin Eforms.
2008 Molecular nutrition & food research

Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate.
2006 Molecular nutrition & food research

Prospective study of serum Vitamin E levels and esophageal and gastric cancers.
2003 Journal of the National cancer Institute

Systematic review on „vitamin E and prevention of colorectal cancer”.
2010 Pakistan journal of pharmaceutical sciences

Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside?
2009 Molecular nutrition & food research

Vitamin E and cancer: An insight into the anticancer activities of …

science.naturalnews.com/…/1364373_Vitamin_E_and_cancer_An_insight_ into_the_anticancer_activities.html

Studies on Vitamin E and radiation

http://science.naturalnews.com/V/Vitamin_E_and_radiation.html

There is also an extensive bibliography on the anti-tumoral action of vitamin E -see last page of DATABASE (6,19,20,30,45,91,95,112, 125,129,142,165,167,190,202,228,229,246,261,280,332,404,405,452,494)

This liposoluble substance consists of a group of various components, called Tocopherols. Seven of these exist in nature; alpha, beta, gamma, delta, epsilon, zeta and eta.

Alpha-Tocopherol has an anti-oxidant effect on the lipidic membranes in synergy with Melatonin(see below), carrying out a preventative action on the peroxidization of the cellular membrane induced by  ionizing radiation and by chemical carcinogenes.

Vitamin E also carries out an anti-oxidative action in a wider sense, acting as a ‘scavenger’ of the free radicals, similar to vitamin C.

It performs a stimulating activity on the immune system; it induces cellular differentiation; it inhibits, in a selective way, cellular growth intervening at DNA and RNA synthesis level.

Various studies have shown its ability to induce apoptosis in cellular lines of breast carcinomas and lymphoma B.

It is inactivated by Iron, therefore it is essential that any medicines based on Iron are not taken at the same time as vitamin E, but at a distance of at least 10-12 hours.

Aluminum, which is often present in pharmaceutical products, also deactivates vitamin E.

The uncooked oil of Triticum sativum (wheat germ; note: has vitamin B12) contains about twice as much vitamin E as the uncooked oil from the seeds of Helianthus annuus (sunflower) and the latter  contains about five times as much as uncooked olive oil. Furthermore all these seeds are rich in  essential unsaturated fats, an important part of the diet for cancer patients.

In anti-neoplastic therapy much is being discussed about: the raw seeds of Helianthus annuus

(which the author personally considers useful in therapy), wheat shoots (the author is not in favor),

Saccharomyces cerevisiae (yeast, of which the author is not in favor), and the shoots of soya  lecithin (of dubious use and the author is against their use because of the transgenic risk).

Natural vitamins are by far preferable to industrially produced ones: Dracontium loretense, for example, which is considered one of the best  plants for its specific anti-oxidant potential, is of superior quality in its anti-oxidant ability compared to synthetic vitamin E (566). WHOLE, ORGANIC FOODS are BEST due to COMPLEXES of NUTRIENTS !

As an already extracted natural product, together with or without other vitamins, vitamin E must be  given in addition to high quantities of raw seeds of Helianthus annuus (also containing vitamin A,all the vitamin B compounds, vitamin D, Manganese, Zinc and Magnesium) and of high quantities of raw Triticum sativum (which is rich in the precious alpha-lipoic acid): both are also very rich in vitamin B6 (pyridoxin), the latter is important for the immune system, but it is difficult to find in other compatible foods for a suitable diet for cancer patients. Pyridoxin, in fact, is contained especially in Saccharomyces cerevisiae, the latter is a food which the author does not regard favorably for an anti-neoplastic diet, because it contains high quantities of folic acid.

Natural Octacosanol, extracted from the oil of Triticum sativum, has a synergetic action with vitamin E, but it is, in any case, better to consume it with all the uncooked oil of Triticum sativum  and/or Triticum sativum itself rather than taking it already extracted, as a pharmaceutical product  (because it loses its active principles).

Vitamin E is particularly efficient in combination with Selenium, which is contained in Aloe species, Solanum lycopersicum (tomatoes), Equisetum species, Allium cepa (onions).

There is also an extensive bibliography on Selenium (see last page of DATABASE) :

79,108,112,129,133,136,143,156,228,229,276,338,339,364,367,404,405,407,443,452,458,501,510,511)

Both vitamin E and Selenium are in their turn synergetic with Zinc in inhibiting the production of inflammatoryprostoglandins and leukotrienes.

Vitamin E conversion factors

Vitamin E is expressed in milligrams of tocopheral equivalents (T.E.)

1 milligram of Tocopherol is equal to:

= 1 milligram of D-alpha Tocopherol

= 2 milligrams of D-beta Tocopherol

= 5 milligrams of D-gamma Tocopherol

==========================================================================================================

Vitamin F  (very important vitamin-see omega 3)

Polyunsaturated fatty acids :

arachidonic acid, Linoleic cis-cis natural acid (vitamin F1) as: alpha-lipoic acid,  alpha-linolenic acid,etc.

Alpha-lipoic acid

Food Sources: 

spinach, broccoli, tomato, peas, Brussels sprouts, rice bran

Mechanism of action:

Alpha-lipoic acid acts as a lipophilic free radical scavenger. Dihydrolipoic acid (DHLA), a reduced form of lipoic acid, has more potent antioxidant effects. It can assist in repairing oxidative damage and regenerate endogenous antioxidants such as vitamin C, vitamin E, and glutathione.

Both DHLA and lipoic acid also have metal chelating capacities.

As a lipoamide, alpha-lipoic acid functions as a cofactor in various multienzyme systems involved in the decarboxylation of alpha-keto acids such as pyruvate. ^{(13) (14) (15)}

Alpha-lipoic acid caused cell cycle arrest in G0/G1 in FaDu and Jurkat human tumor cell lines ⁽¹⁾.

Alpha lipoic acid was also found to scavenge reactive oxygen species in MCF-7 breast cancer cells ⁽¹⁶⁾.

Reduction of reactive oxygen species was then followed by cancer cell growth arrest and apoptosis ⁽¹⁶⁾.

For studies quoted see http://www.mskcc.org/cancer-care/herb/alpha-lipoic-acid  

Other studies:

Studies on Alpha–Lipoic Acid and cancer –  MANY STUDIES

science.naturalnews.com/A/Alpha–Lipoic_Acid_and_cancer.html

The natural antioxidant Alpha-Lipoic Acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells.
2010 European journal of pharmacology

Restoration of functional defects in peripheral blood mononuclear cells isolated fromcancer patients by thiol antioxidants Alpha-Lipoic Acid and N-acetyl cysteine.
2000 International journal of cancer. Journal international du cancer

alpha-Lipoic acid: the potential for use in cancer therapy.
2008 Neoplasma

Alpha-Lipoic Acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells.
2010 Nutrition research (New York, N.Y.)

Alpha-Lipoic Acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation.
2005 Apoptosis : an international journal on programmed cell death

Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells.
2009 Annals of the New York Academy of SciencesThe long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid/low-dose naltrexone protocol.
2006 Integrative cancer therapiesCytoprotection against Cr(6+)-induced DNA damage by alpha-lipoic acid: implications in reducing occupational cancer risk.
2009 Mutagenesis

Studies on Alpha-Lipoic Acid and Apoptotic

http://science.naturalnews.com/A/Alpha-Lipoic_Acid_and_Apoptotic.html

Alpha-Linolenic Acid(omega 3)

Food sources:flaxseed, avocado, walnuts, almonds, fishoils

Mechanism of action:

The alpha-linolenic acid (vitamin F), for instance, is a cis-polyunsaturated fatty acid that is contained in linseed cold-pressed oil: it is transformed into EPA and DHA (Omega-3 fatty acids) and is quite effective against malignant tumours, as shown by Pardini ( 1647 );

Moreover, Noguchi has proved that Omega-3 fatty acids, unlike Omega-6 fatty acids, help reduce tumour masses, although

Omega-6 fatty acids are unsaturated fatty acids, too ( 1654 ).

see  last page of DATABASE for studies quoted.

Studies on Alpha–Linolenic Acid and cancer –  MANY STUDIES

science.naturalnews.com/A/Alpha–Linolenic_Acid_and_cancer.html

Alpha-Linolenic Acid and the risk of prostate cancer. What is the evidence?
2004 The Journal of urology

Low Alpha-Linolenic Acid content of adipose breast tissue is associated with an increased risk of breast cancer.
2000 European journal of cancer (Oxford, England : 1990)

A prospective study of dietary Alpha-Linolenic Acid and the risk of prostate cancer(United States).
2006 Cancer causes & control : CCC

The relation of Alpha-Linolenic Acid to the risk of prostate cancer: a systematic review and meta-analysis.
2009 The American journal of clinical nutrition

Alpha-Linolenic Acid and risk of prostate cancer: a case-control study in Uruguay.
2000 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, Alpha-Linolenic Acid (ALA; 18:3n-3), in breast cancer cells: the „fat features” of the „Mediterranean diet” as an „anti-HER2 cocktail”.
2006 Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National cancer Institute of MexicoInhibitory effect of conjugated Alpha-Linolenic Acid from bifidobacteria of intestinal origin on SW480 cancer cells.
2009 LipidsProspective studies of dietary Alpha-Linolenic Acid intake and prostate cancer risk: a meta-analysis.
2010 Cancer causes & control : CCC

Dietary Alpha-Linolenic Acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis.
2004 The Journal of nutrition

Growth-inhibitory and proapoptotic effects of Alpha-Linolenic Acid on estrogen-positive breast cancer cells.
2009 Annals of the New York Academy of Sciences

Comparison of stearidonic acid and Alpha-Linolenic Acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures.
2005 The Journal of nutritional biochemistry

Conjugation with Alpha-Linolenic Acid improves cancer cell uptake and cytotoxicity of doxorubicin.
2009 Bioorganic & medicinal chemistry letters

Does Alpha-Linolenic Acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters?
2000 Prostaglandins, leukotrienes, and essential fatty acids

Conjugation with alpha linolenic acid improves cancer cell uptake …

science.naturalnews.com/…/542108_Conjugation_with_alpha_linolenic_acid _improves_cancer_cell_uptake_and.html

Conjugation with alpha linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin.

Inhibitory effect of conjugated alpha linolenic acid from …

science.naturalnews.com/…/2462104_Inhibitory_effect_of_conjugated_alpha _linolenic_acid_from_bifidobacteria_of.html

Inhibitory effect of conjugated alpha linolenic acid from bifidobacteria of intestinal origin on SW480 cancer cells. Publication: Lipids Publication Date: 2009

Growth inhibitory and proapoptotic effects of alpha linolenic acid on …

science.naturalnews.com/…/1637124_Growth_inhibitory_and_proapoptotic_ effects_of_alpha_linolenic_acid_on.html

We tested the anticarcinogenic effect of Alpha–Linolenic Acid (ALA) as a single compound. To test the role of ALA in breast cancer cells (MCF-7), we analyzed …

omega 3 fatty acids on cancer risk: a systematic review.

science.naturalnews.com/…/2859351_Effects_of_omega_3_fatty_acids_on_ cancer_risk_a.html

Effects of omega 3 fatty acids on cancer risk: a systematic review.

Modulation of prostate cancer genetic risk by omega 3 and omega 6 …

science.naturalnews.com/…/3442786_Modulation_of_prostate_cancer_ genetic_risk_by_omega_3_and.html

Modulation of prostate cancer genetic risk by omega 3 and omega 6 fatty acids.

Effect of altering dietary omega 6 omega 3 fatty acid ratios on prostate cancer…

science.naturalnews.com/…/3897405_Effect_of_altering_dietary_omega_6_ omega_3_fatty_acid.html

Effect of altering dietary omega 6 omega 3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase 2, and prostaglandin E2.

Prostate tumor growth and recurrence can be modulated by omega3 intake…

science.naturalnews.com/…/3203424_Prostate_tumor_growth_and_ recurrence_can_be_modulated_by_the.html

Evidence indicates that a diet rich in omega (omega)-6 polyunsaturated fatty acids …prostate cancer (PCa) risk, whereas a diet rich in omega–3 decreases risk.

Beneficial effects of omega 3 long chain fatty acids in breast cancer …

science.naturalnews.com/…/296576_Beneficial_effects_of_omega_3_long_ chain_fatty_acids_in.html

Beneficial effects of omega 3 long chain fatty acids in breast cancer and cardiovascular diseases: voltage gated sodium channels as a common feature?

Fatty fish and fish omega 3 fatty acid intakes decrease the breast cancer risk…

science.naturalnews.com/…/1200161_Fatty_fish_and_fish_omega_3_fatty_ acid_intakes_decrease.html

Although it is believed that fish omega–3 fatty acids may decrease breast cancer risk, epidemiological evidence has been inconclusive. This study examined the …

Omega 3 fatty acid supplements in women at high risk of breast cancer …

science.naturalnews.com/…/759291_Omega_3_fatty_acid_supplements_in_ women_at_high_risk.html

BACKGROUND : Preclinical evidence of the preventive benefits of omega–3 (n-3) polyunsaturated fatty acids (PUFAs) in breast cancer continues to fuel interest …

Decreased severity of ovarian cancer and increased survival with omega 3.

science.naturalnews.com/…/256930_Decreased_severity_of_ovarian_cancer_ and_increased_survival_in_hens.html

Prevention and treatment of pancreatic cancer by omega 3 & curcumin in …

science.naturalnews.com/…/2359858_Prevention_and_treatment_of_ pancreatic_cancer_by_curcumin_in_combination.html

Prevention and treatment of pancreatic cancer by curcumin in combination with omega 3 fatty acids. Publication: Nutrition and cancer. Publication Date: 2008

The importance of the omega 6 omega 3 fatty acid ratio in colorectal cancer…

science.naturalnews.com/…/1101398_The_importance_of_the_omega_6_ omega_3_fatty_acid.html

A ratio of 2.5/1 reduced rectal cell proliferation in patients with colorectal cancer, whereas a ratio of 4/1 with the same amount of omega–3 PUFA had no effect.

Impact of postoperative omega 3 fatty acid supplemented parenteral …

science.naturalnews.com/…/1136096_Impact_of_postoperative_omega_3_ fatty_acid_supplemented_parenteral_nutrition.html

Impact of postoperative omega 3 fatty acid supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients.

Omega 3 reduce colorectal cancer risk in men by 66 percent  …

science.naturalnews.com/…/383170_Calcium_Mobilization_in_Ovarian_ Cancer_Cells_in_Response_to_Lysophospholipids.html

Herbal Remedy Essiac® and Cancer (press release) · Omega–3 fatty acids slash colorectal cancer risk in men by 66 percent · Fatty Acid Blood Tests Help …

Growth of human gastric cancer cells in nude mice is delayed by omega 3…

science.naturalnews.com/…/1201162_Growth_of_human_gastric_cancer_ cells_in_nude_mice_is.html

Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega 3 fatty acids and medium chain triglycerides.

Neuroblastoma studies

science.naturalnews.com/Neuroblastoma.html

Cancer science. Omega–3 fatty acid supplementation delays the progression of neuroblastoma in vivo. International journal of cancer. Journal …

[omega 3 Fatty acid containing diet (Racol) reduces toxicity of chemotherapy…

science.naturalnews.com/…/945592_omega_3_Fatty_acid_containing_diet_ Racol_reduces_toxicity_of.html

omega 3 Fatty acid containing diet (Racol) reduces toxicity of chemoradiation therapy for patients with esophageal cancer].

 

Modulation of lipid rafts by Omega 3 fatty acids in inflammation and …

science.naturalnews.com/…/2597039_Modulation_of_lipid_rafts_by_Omega _3_fatty_acids_in.html

Modulation of lipid rafts by Omega 3 fatty acids in inflammation and cancer: implications for use of lipids during nutrition support.

 

Omega 3, on their own, are crucial for a cancer patient:

-promote optimal functioning of the immune system.

A team of researchers based in China have published results of their work on omega-3 and breast cancer risk in the British Medical Journal (BMJ), stating that a high intake of fatty acids found in fish is associated with a reduction 14 percent risk of breast cancer later in life. To conduct their study, the scientists reviewed and analyzed a group of 26 studies in the United States, Europe and Asia, which included more than 800,000 participants and 20,000 cases of breast cancer.

–promote natural cancer cell death and reduce cancer risk.

After analyzing the data to determine the impact of long chain fats on the risk of breast cancer, the researchers determined the difference between the lowest and highest intake category of marine polyunsaturated fatty acids was associated with a 14 percent reduced risk of disease .

In addition, for an increase of 0.1 grams per day of consumption of omega-3 fatty acids in fish, the risk of breast cancer is reduced by 5 percent. These results clearly demonstrate a significantly reduced risk of affecting the development of breast cancer and future progression of the disease.

The study authors concluded „Our current study provides solid evidence and robust as omega3 are inversely associated with risk of breast cancer. „

Scientists understand from previous studies that omega-3 fats, DHA and EPA, are preferentially accumulated in cell membranes and prevent cancer development through increased transfer of nutrients and oxygen to the cell nucleus.

With DHA metabolism, metabolites are produced that destroy cancer cells. Researchers believe that this mechanism is responsible for reducing the risk of cancers found in this study. (1200-2400 mg EPA / DHA combined daily to reduce the risk associated with breast cancer and other disease lines). Higher doses are required in cancer.

-omega 3 stops spread of cancer

Omega-6, found in most vegetable oils, increased spread of cancer cells in the bone marrow.

Nevertheless, the spread was blocked by omega-3

Comments Dr. Mercola:

„The evidence continues to grow. Not all unsaturated fats are good for you. Even if they come from such healthy foods such as sunflower seeds grown biodynamic. See, most vegetable oils are rich in omega-6 fat and very few people are deficient in these fats.

In addition, omega-3 provides a wonderful benefits for patients with prostate cancer by blocking the functioning of omega-6 fats that cancer cells use them as an energy source. (Therefore, only during cancer your treatment, avoid omega 6 polyunsaturated fats because the thinner blood vessels supply  tumors. thin blood vessels in the body are necessary for optimal functioning, but avoid in cancer high doses of omega-6) This happens at the molecular level when omega-3  (EPA  andDHA), reduces the action of a metabolite of the omega-6 arachidonic acid, prostaglandin E2. The sole point agreed on this study is that scientists have recommended omega 3 as a preventative for prostate cancer as and to stop its development. „

Dr. Clapp compiled a comprehensive program that has achieved national recognition USA. 1990 –was a very successful year of the program – had 16 cures of prostate cancer based on deep cleansing of toxins accumulated in the body and prostate, then flooding the cells with omega 3 fats. „Perhaps the most interesting aspect of this study is clear evidence of the mechanisms that omega-6 fats stimulate the growth of prostate cancer, clearly debunking industry hypethat  vegetable oils are good for our health. „

We saw dramatically reduced overall inflammation (measured by CRP testing) and especially in reducing enlarged prostate, reducing also any tumor mass, monitored / evaluated by Doppler sonograms.

-Omega 3 promote apatosis(programmed cell death) in cancer cells

Two new studies suggest that omega-3 fatty acids may inhibit the growth of liver cancer cells, suggesting that this may be an effective therapy to treat and prevent liver cancer.

Like vitamin B17/laetrile,and other natural substances(turmeric, ginger) omega 3 trigger apatosis.

The first study examined the effects of omega-3 and omega-6 fats in hepatocellular carcinoma cells .

Carcinoma represent 90 percent of all cases of liver cancer and is usually rapidly fatal. Omega-6 had no effect on cancer cells, but omega-3 – as  (DHA) and (EPA) – induced apoptosis (programmed cell death).

In the second study, omega-3 fats have been shown as effective in the treatment of cholangiocarcinoma tumor cells, an aggressive and fatal type of cancer that forms in the liver bile ducts.

Researchers said omega-3 fatty acids may not only be an effective treatment for liver cancer, but could also protect the liver from hepatic steatosis, chronic liver disease thought to be a precursor to cancer.

These above are just a few specific examples of cancer and Omega3 .Omega are great in any cancer.

Omega-3 Builds Muscle Mass in Cancer Patients, thus PREVENT and HELP IN CACHEXIA: http://articles.mercola.com/sites/articles/archive/2011/03/24/omega3-builds-muscle-mass-in-cancer-patients.aspx

Omega 3 fats are highly recommended and among the few fats accepted in cancer (either from seeds, nuts, avocado or fish, although fish oils might be contaminated with heavy metals from the fish )

These and many other roles that help in cancer, including stimulation of the immune system, reducing inflammation , direct relationship to sun tolerance by the body and regulation of vitamin D levels (often those with cancer can not tolerate the sun, therefore can not benefit either its energy or the important natural Vitamin D, the sun being main source of vitamin D, but omega 3 fixes this, also regulating levels of vitamin D)

http://articles.mercola.com/sites/articles/archive/2010/07/27/omega3s-reduce-your-risk-of-breast-cancer.aspx

See also:

For prostate cancer risk and omega3 controversy see this articles:

http://articles.mercola.com/sites/articles/archive/2013/07/31/omega-3-fats.aspx

http://articles.mercola.com/sites/articles/archive/2001/07/21/flaxseed-part-two.aspx

The relation of alpha linolenic acid to the risk of prostate cancer: a …

science.naturalnews.com/…/520717_The_relation_of_alpha_linolenic_acid_ to_the_risk_of.html

The relation of alpha linolenic acid to the risk of prostate cancer: a systematic review and meta analysis.

Prostate tumor growth and recurrence can be modulated by omega3 intake…

science.naturalnews.com/…/3203424_Prostate_tumor_growth_and_ recurrence_can_be_modulated_by_the.html

Evidence indicates that a diet rich in omega (omega)-6 polyunsaturated fatty acids …prostate cancer (PCa) risk, whereas a diet rich in omega–3 decreases risk.

Much more about  OMEGA 3 as well a POWERFUL (stage IV) cancer treatment based on AWARDED 2 NOBEL PRIZES  in my book.

============================================================================================

Vitamin K

 (i.e: in algae, greens, grapes, etc) Also see antagonists such as cinnamon, etc,

Studies on Vitamin K and cancer (MANY STUDIES)

science.naturalnews.com/V/Vitamin_K_and_cancer.html

Dietary Vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into cancer and Nutrition (EPIC-Heidelberg).
2010 The American journal of clinical nutrition

Dietary intake of Vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into cancer and Nutrition (EPIC-Heidelberg).
2008 The American journal of clinical nutrition

Serum undercarboxylated osteocalcin as biomarker of Vitamin K intake and risk of prostate cancer: a nested case-control study in the Heidelberg cohort of the European prospective investigation into cancer and nutrition.
2009 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology

Vitamin K and childhood cancer: analysis of individual patient data from six case-control studies.
2002 British journal of cancer

Vitamin K and childhood cancer: a report from the United Kingdom Childhoodcancer Study.
2003 British journal of cancer

Long-term use of Vitamin K antagonists and incidence of cancer: a population-based study.
2011 BloodCancer prevention and Vitamin K antagonists: an overview.
2010 Thrombosis researchSorafenib combined Vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways.

2010 Journal of cellular physiology

Efficacy of low- molecular- weight- heparin versus Vitamin K antagonists for long term treatment of cancer-associated venous thromboembolism in adults: a systematic review of randomized controlled trials.
2009 Thrombosis research

A resected case of metachronous liver metastasis from lung cancer producing alpha-fetoprotein (AFP) and protein induced by Vitamin K absence or antagonist II (PIVKA-II).
2004 Hepato-gastroenterology

Low-molecular-weight heparins are superior to Vitamin K antagonists for the long term treatment of venous thromboembolism in patients with cancer: a cochrane systematic review.
2008 Journal of experimental & clinical cancer research : CR

Oxygen free radical generating mechanisms in the colon: do the semiquinones ofVitamin K play a role in the aetiology of colon cancer?
2001 Biochimica et biophysica acta

A study of the prevalence of Vitamin K deficiency in patients with cancer referred to a hospital palliative care team and its association with abnormal haemostasis.
2008 Journal of clinical pathology

Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K2 trigger apoptosis in human ovarian cancer TYK-nu cells.
2006 Apoptosis : an international journal on programmed cell death

Vitamin K2-mediated apoptosis in cancer cells: role of mitochondrial transmembrane potential.
2008 Vitamins and hormones

Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells.
2007 International journal of oncology

Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis.
2008 International journal of molecular medicine

A resected case of metachronous liver metastasis from lung cancer producing alpha-fetoprotein (AFP) and protein induced by Vitamin K absence or antagonist II (PIVKA-II).2004 Hepato-gastroenterology

Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells.2007 International journal of oncology

Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K2 trigger apoptosis in human ovarian cancer TYK-nu cells. 2006 Apoptosis : an international journal on programmed cell death

Vitamin K2-mediated apoptosis in cancer cells: role of mitochondrial transmembrane potential. 2008 Vitamins and hormones Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis. 2008 International journal of molecular medicine

Vitamin K antagonists

Cancer prevention and Vitamin K antagonists: an overview.

2010 Thrombosis research

Long-term use of Vitamin K antagonists and incidence of cancer: a population-based study.

2011 Blood

Efficacy of low- molecular- weight- heparin versus Vitamin K antagonists for long term treatment of cancer-associated venous thromboembolism in adults: a systematic review of randomized controlled trials.

2009 Thrombosis research

Low-molecular-weight heparins are superior to Vitamin K antagonists for the long term treatment of venous thromboembolism in patients with cancer: a cochrane systematic review.

2008 Journal of experimental & clinical cancer research : CR

<<PREVIOUS PAGE            NEXT PAGE>>

Reclame