CLICK AICI pt. limba ROmana
Vitamins in alphabetical order
Vitamin A
There is an extensive bibliography on the anti-tumoral action of Vitamin A.
In particular the combined use of Retinoids in the proper proportions (beta-Carotene: retinol = 4 : 1), establishes a synergism which is higher than the sum of the single components.
Studies on Vitamin A and cancer (MANY STUDIES -see NOTES below)
NOTE 1:
The link above contains multiple studies and the same do many links below( I will try to indicate by ”MANY STUDIES”)
Vitamin A, retinoids and carotenoids as chemopreventive agents for prostate cancer.
2004 The Journal of urology
An international evaluation of the cancer preventive potential of vitamin A.
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
2005 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Association of vitamin A, vitamin C and zinc with laryngeal cancer.
2003 Indian journal of cancer
Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study.
2007 The American journal of clinical nutrition
The effect of Vitamin A status in children treated for cancer.
2008 Pediatric hematology and oncology
Oxidant, Vitamin A and angiogenic markers in laryngeal cancer patients.
2003 The Journal of laryngology and otology
The role of antioxidants and Vitamin A in ovarian cancer: results from the Women’s Health Initiative.
2008 Nutrition and cancer
Can Vitamin A modify the activity of docetaxel in MCF-7 breast cancer cells?
2007 Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society
Does Vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?
2004 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Intake of vitamin A-rich foods and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaf consumption.
2007 Asia Pacific journal of clinical nutrition
Vitamin A and apoptosis in prostate cancer.
2002 Endocrine-related cancer
Skin, sun, and vitamin A: from aging to cancer.
2001 The Journal of dermatology
Vitamin A metabolism is impaired in human ovarian cancer.
2009 Gynecologic oncology
Effectiveness of Vitamin A acetate for enhancing the production of lung cancerspecific monoclonal antibodies.
1999 Cytotechnology
A population-based case-control study of carotenoid and Vitamin A intake and ovarian cancer (United States).
2001 Cancer causes & control : CCC
Recent advances in the use of Vitamin A (retinoids) in the prevention and treatment of cancer.
2000 Nutrition (Burbank, Los Angeles County, Calif.)
Fruit, vegetable, Vitamin A intakes, and prostate cancer risk.
2008 Prostate cancer and prostatic diseases
The Vitamin A family can significantly decrease the expression of ERbeta of ERs positive breast cancer cells in the presence or absence of ER ligands and paclitaxel.
2009 Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Induction of apoptosis in maxillary sinus cancer cells by 5-fluorouracil, Vitamin A and radiation (FAR) therapy.
1999 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery
EUROSCAN, a randomized trial of Vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of cancer Head and Neck and Lung cancer Cooperative Groups.
2000 Journal of the National cancer Institute
Rapid HPLC method for the determination of Vitamin A and E and cotinine concentration in human serum in women with CIN and cervical cancer.
2009 Ginekologia polska
Estradiol and tamoxifen differently affects the inhibitory effects of Vitamin A and their metabolites on the proliferation and expression of alpha2beta1 integrins in MCF-7 breast cancer cells.
2009 Advances in medical sciences
Renaissance of the biologically active Vitamin A derivatives: established and novel directed therapies for cancer and chemoprevention.
2003 Current pharmaceutical design
Evaluation of plasma non-enzymatic antioxidants in breast cancer etiology.
2009 Asian Pacific journal of cancer prevention : APJCP
Whole-food sources of Vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate.
2007 The Journal of nutrition
[Chemoprevention and FAR therapy regimen comprised of 5-fluorouracil, Vitamin Aand radiation].
2001 Gan to kagaku ryoho. cancer & chemotherapy
Prostate cancer:
- Vitamin A and apoptosis in prostate cancer. 2002 Endocrine-related cancer
- Fruit, vegetable, Vitamin A intakes, and prostate cancer risk. 2008 Prostate cancer and prostatic diseases
- Vitamin A, retinoids and carotenoids as chemopreventive agents for prostate cancer. 2004 The Journal of urology
Breast cancer:
- The Vitamin A family can significantly decrease the expression of ERbeta of ERs positive breast cancer cells in the presence or absence of ER ligands and paclitaxel. 2009 Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Estradiol and tamoxifen differently affects the inhibitory effects of Vitamin A and their metabolites on the proliferation and expression of alpha2beta1 integrins in MCF-7 breast cancer cells. 2009 Advances in medical sciences
- Can Vitamin A modify the activity of docetaxel in MCF-7 breast cancer cells? 2007 Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society
- Evaluation of plasma non-enzymatic antioxidants in breast cancer etiology 2009 Asian Pacific journal of cancer prevention : APJCP
Ovarian cancer:
- A population-based case-control study of carotenoid and Vitamin A intake and ovarian cancer (United States). 2001 Cancer causes & control : CCC
- The role of antioxidants and Vitamin A in ovarian cancer: results from the Women’s Health Initiative. 2008 Nutrition and cancer
- Association of dietary vitamin A, carotenoids, and other antioxidants with the risk of ovarian cancer. 2005 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Vitamin A metabolism is impaired in human ovarian cancer. 2009 Gynecologic oncology
Lung cancer:
- Effectiveness of Vitamin A acetate for enhancing the production of lung cancer specific monoclonal antibodies. 1999 Cytotechnology
- Intake of vitamin A-rich foods and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaf consumption. 2007 Asia Pacific journal of clinical nutrition
Lung, head & neck cancers:
2000 Journal of the National cancer Institute
Cervical cancer:
- Rapid HPLC method for the determination of Vitamin A and E and cotinine concentration in human serum in women with CIN and cervical cancer. 2009 Ginekologia polska
Gastric cancer:
- Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study. 2007 The American journal of clinical nutrition
Laryngeal cancer:
- Association of vitamin A, vitamin C and zinc with laryngeal cancer. 2003 Indian journal of cancer
- Oxidant, Vitamin A and angiogenic markers in laryngeal cancer patients. 2003 The Journal of laryngology and otology
Children cancer:
- The effect of Vitamin A status in children treated for cancer. 2008 Pediatric hematology and oncology
- Does Vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer? 2004 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Maxillary sinus cancer :
- Induction of apoptosis in maxillary sinus cancer cells by 5-fluorouracil, Vitamin A and radiation (FAR) therapy. 1999 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery
- [Chemoprevention and FAR therapy regimen comprised of 5-fluorouracil, Vitamin A and radiation]. 2001 Gan to kagaku ryoho. cancer & chemotherapy
Studies on Vitamin A and Antiproliferative
http://science.naturalnews.com/V/Vitamin_A_and_Antiproliferative.html
Studies on Vitamin A and radiation
http://science.naturalnews.com/V/Vitamin_A_and_radiation.html
There is an extensive bibliography on the anti-tumoral action of Vitamin A cited from LAST PAGE OF THIS DATABASE: 1,3,10,13,14,17,18,23,24,28,34,35,36,45,56,69,73,76,92,93,94,100,106,111,120,121,129,131,137,138,165,187,200,202,203,208,209,21,213,214,216,218,222,235,255,256,257,263,264,265,266,280,282,286,287,288,298,303,304,305,307,313,315,322,324,325,326,334,338,340,341,347,38,352,354,362,363,365,382,383,385,390,398,402,404,405,409,410,420,425,426,427,445,446,447,448,454,457,461,463,468,469,470,471,473,477,48,493,508,512):
This studies conclude the following about vitamin A:
Anti-tumoral action in general
Vitamin A and retinoids have an anti neoplastic action, shown both in vivo and in vitro, in various tumors: basilomas, scaly carcinomas, melanomes, skin cancers, fungoid mycosis, acute promyelocyte leucemia, ovarian cancer, breast cancer, lung cancer, cancer of the bladder and follicular carcinomas of the thyroid.
Preventative action
Anti-tumoral action has been amply shown indirectly, that is with a preventative purpose. Various studies have, in fact, shown that low plasmatic levels of beta-Carotene, vitamin C and vitamin E are connected to an increase in the incidence of lung cancer.
Direct action at a receptor level
Only beta RAR (retinoic acid receptor) seems to be involved. More specifically, vitamin A (and its derivatives) acts by binding with specific receptors. In this way it can both inhibit the proteic synthesis of DNA and RNA, and also perform an anti-promotion action to determine the return of a cellular differentiation. Furthermore its ability to inhibit oncogenes should be noted.
Apoptosis induction
Apoptosis means the activation of specific endonucleases which break up the DNA, acting at a level of nucleosomic sites that make up the primary structural unit of the nuclear cromatine of the cell. Vitamin A and retinoids in general can induce apoptosis in neoplastic cells, by activating intracellular proteolytic enzymes, called caspase 2 and caspase 3, which provoke deterioration through proteolysis by a transcription factor, called Spl. If this basal cellular transcription is altered, death is caused by Apoptosis.
In prostate cancer the retinoids intervene by reducing the level of the bcl 2 gene, whose function is to protect the cells from death by Apoptosis. Carotenoids induced apoptosis in prostate cancer
Inhibition of the cellular cycle
The retinoids block the passage of the cell from phase G1 to phase S (reducing the activity of a protein, called cycline D1): this passage, if not blocked, would lead the cell to mytosis.
Reduction of phosphorilation
Retinoids intervene in cancer causing a reduction in phosphorilation of the pRb, thus increasing survival; this protein is active in suppressing cellular growth.
Synergetic interaction with interferons
A second mechanism, apart from the proteic-enzymatic one, can be traced back to the intervention of interferons which, like retinoids, act as anti-proliferative factors. In practice, acting synergetically, they induce the expression of proteins capable of inhibiting neoplastic cellular proliferation.
The intake of natural carotenoids from food
There is very little evidence to show that carotenoids taken in from food can increase the levels ofvitamin A: an extra portion a day of green leaf vegetables is not able to increase the hematic level of vitamin A; on the contrary, a mixed diet of foods particularly rich in beta-Carotene will give a significant increase in vitamin A present in the blood. (627).
If you oblige healthy individuals to eat carrots (270g), broccoli (600g) or tomato juice (180g) it does not establish any significant changes in the hematic levels of the carotenoids: you only find an extremely wide variation (even up to 3-4 times) in the efficiency of gastro-intestinal absorption of the carotenoids and therefore in their subsequent bio-availability at a hematic level (628) .
Optimal values of anti-oxidants in normal individuals
Vitamin C: >50 microMols/Liter
Vitamin E: >30 microMols/Liter
Vitamin A: >2.2 microMols/Liter
Beta-Carotene: >0.4 microMols/Liter
Association of vitamin A with vitamin E
In an experimental model of a cellular membrane the possibility of a positive interaction between anti-oxidant liposollubles such as beta-Carotene and alpha-Tocopherol has been investigated; the result showed that there exists a synergetic action between beta-Carotene and alpha-Tocopherol together which inhibits the processes of lipidic peroxidization compared with when they are used alone (629). THUS:
NOTE 2:
Vitamins , antioxidants and nutrients should be taken from WHOLE, ORGANIC(note below) FOODS (as much as possible) NOT from supplements as they need other vitamins and nutrients for proper usage.
Whole-food sources of Vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate. 2007 The Journal of nutrition
The difference between synthetic vitamins and natural vitamins
The difference between synthetic vitamins and natural ones can be easily exemplified by the experimental case of synthetic beta-Carotene (made up entirely of isomeric trans-beta-Carotene), and of natural beta-Carotene (made up of both isomeric trans-beta-Carotene and isomeric cis-beta- Carotene): the study showed a strong discrimination between the two isomers, with a serious decrease (impoverishment) induced at the level of Lycopene present in the LDLs (…). THUS:
3.It would be better to use the NATURAL (juice) ORGANIC WHOLE foods rich in vitamin A such as Daucus carota (carrots ), avocados, cantalopues, etc. rather than the synthetic pharmaceutical vitamin products based on Vitamin A.
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B Vitamins
Studies on Vitamins B and cancer – Natural News Science(MANY STUDIES)
2008 The American journal of clinical nutrition
2007 The Journal of nutrition
2008 The Journal of nutrition
2008 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
2008 JAMA : the journal of the American Medical Association
2003 Journal of the National cancer InstituteCancer incidence and mortality after treatment with folic acid and vitamin B12.
2009 JAMA : the journal of the American Medical AssociationOne-carbon metabolism-related nutrients and prostate cancer survival.
2009 The American journal of clinical nutritionCirculating concentrations of folate and vitamin B12 in relation to prostate cancerrisk: results from the European Prospective Investigation into cancer and Nutrition study.
2008 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Reduced thiamine (vitamin B1) levels following gastrectomy for gastric cancer.
2002 Gastric cancer : official journal of the International Gastric cancer Association and the Japanese Gastric cancer Association
Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrialcancer among Chinese women.
2007 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation.
2000 Nutrition and cancer
Dietary factors of one-carbon metabolism and prostate cancer risk.
2006 The American journal of clinical nutrition
Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women.
2006 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Dietary folate intake and breast cancer risk: results from the Shanghai Breast cancerStudy.
2001 Cancer research
Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies.
2010 JAMA : the journal of the American Medical Association
One-carbon metabolism and prostate cancer risk: prospective investigation of seven circulating B vitamins and metabolites.
2009 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women.
2006 American journal of epidemiology
Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers.
2002 Nutrition and cancer
Association of the B-vitamins pyridoxal 5′-phosphate (B(6)), B(12), and folate with lungcancer risk in older men.
2001 American journal of epidemiology
Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan.
2009 Nutrition and cancer
The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer.
2008 The Journal of antimicrobial chemotherapy
Methylenetetrahydrofolate reductase, diet, and risk of colon cancer.
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study.
2005 International journal of cancer. Journal international du cancer
Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study.
2005 International journal of cancer. Journal international du cancer
Vitamin B(12) and Folate Status in Head and Neck Cancer.
2002 Asian Pacific journal of cancer prevention : APJCP
Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation intocancer and nutrition.
2010 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer.
2008 Carcinogenesis
Vitamin B6 points PC6 injection during acupuncture can relieve nausea and vomiting in patients with ovarian cancer.
2009 International journal of gynecological cancer : official journal of the International Gynecological cancer Society
Studies on Vitamins B and Antineoplastic
http://science.naturalnews.com/V/Vitamin_B_and_Antineoplastic.html
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Vitamin B2 – Riboflavin
2008 The Journal of nutrition
2008 Cancer chemotherapy and pharmacology
2008 Vascular pharmacology
2009 Frontiers in bioscience : a journal and virtual library
2007 Biological & pharmaceutical bulletin
2007 Basic & clinical pharmacology & toxicology
2007 Molecular and cellular biologyIntracellular processing of Riboflavin in human breast cancer cells.
2008 Molecular pharmaceuticsAmeliorating effect of coenzyme Q10, Riboflavin and niacin in tamoxifen-treated postmenopausal breast cancer patients with special reference to lipids and lipoproteins.
2007 Clinical biochemistry
Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles.
2009 Breast cancer research and treatment
Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery.
2010 Bioorganic & medicinal chemistry letters
Co-enzyme Q10, Riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy.
2008 The British journal of nutrition
Riboflavin deficiency and esophageal cancer: a case control-household study in the Caspian Littoral of Iran.
2005 Cancer detection and prevention
[Apoptosis of human gastric cancer cell induced by photochemical riboflavin].
2003 Ai zheng = Aizheng = Chinese journal of cancer
Riboflavin carrier protein: a serum and tissue marker for breast carcinoma.
2001 International journal of cancer. Journal international du cancer
Studies on Riboflavin and Anti-Angiogenic
http://science.naturalnews.com/R/riboflavin_and_Anti-Angiogenic.html
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Vitamin B3(Niacin)
Studies on Niacin and cancer
Augmented antioxidant status in Tamoxifen treated postmenopausal women with breast cancer on co-administration with Coenzyme Q10, Niacin and Riboflavin.
2008 Cancer chemotherapy and pharmacology
2007 Basic & clinical pharmacology & toxicology
2008 Vascular pharmacology
Other studies:
ANTI-invasive activities of Niacin against cancer cells; http://science.naturalnews.com/…/3260742_Anti_invasive_activity_of_niacin_and_ trigonelline_against_cancer_cells.html
Studies on Niacin and breast cancer
http://science.naturalnews.com/N/Niacin_and_breast_cancer.html (MANY STUDIES in this link)
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Vitamin B5 ( pantotenic acid )
Pantothenic Acid for Stage IV Breast Cancer Treatment Information
https://www.medify.com/…/pantothenic–acid-treatment-stage-iv-breast-ca…
Vitamins B2, B3,B5 are respiratory vitamins(increasing cellular oxygenation – see above Otto Wartburg proposals).
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Vitamin B6
2010 International journal of cancer. Journal international du cancer
Vitamin B12
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Vitamin B17(Laetrile/ Amygdalin) (very important vitamin)
Note: “Laetrile” acronym for “LAEvomandeloniTRILE-glucoside”) as Amygdalin:
Laetrile has two molecules of glucose, Amygdalin has more.
Indeed, the chemical structure of Laetrile is D-1 mandelonitrile–beta-glucuronide, while
for Amygdalin it is D-mandelonitrile-bi-glucoside.
B17/ Amygdalin studies science.naturalnews.com/amygdalin.html
How laetrile or B17 from apricot seeds kills only cancer cells · |
apricot studies science.naturalnews.com/apricot.html
Apricot Seeds Kill Cancer Cells without Side Effects |
See also: http://worldwithoutcancer.org.uk/success.html, http://www.apricotsfromgod.info/journal.htm
Much more details(including treatments & CLINICAL CASES with B17) in my BOOK + DR. Binzel’s FREE EBOOK on this topic + Dr. Nacci’s FREE EBOOK on this topic.
NOTE:
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Vitamin C (very important vitamin)
Vitamin C is a respiratory vitamin- it stimulates the body to produce its own hydrogen peroxide (increasing cellular oxygenation – see above Otto Wartburg proposals).
Therefore, megadoses of vitamin C are administered orally and intravenously by orthomolecular physicians to treat cancer.
60 references to studies published that show the importance of vitamin C:
www.doctoryourself.com / biblio_cameron.html http://www.doctoryourself.com/cancer_hoffer.html.
Even National Institutes of Health is actively sponsoring studies of high-dose intravenous vitamin C therapy.
Other MULTIPLE studies on vitamin’s C cancer fighting effects: science.naturalnews.com/…/4854330_Vitamin_C_in_alternative_cancer_ treatment_historical_background.html
High doses of vitamin C and cancer :
science.naturalnews.com/…/2387600_High_dose_vitamin_C_supplement_ use_is_associated_with_self.html
Vitamin C and breast cancer studies: science.naturalnews.com / V / Vitamin_C_and_breast_cancer.html
Vitamin C , vitamin E & selenium in breast cancer : science.naturalnews.com/…/1198191_Dietary_beta_carotene_vitamin_C_and _E_intake_and_breast.html science.naturalnews.com/…/3959947_Association_between_breast_cancer_ and_vitamin_C_vitamin_E_and.html
Vitamin C ,vitamin A & zinc in laryngeal cancer :
science.naturalnews.com/…/4508069_Association_of_vitamin_A_vitamin_C _and_zinc_with_laryngeal.html
Vitamin C & gastric cancer:
science.naturalnews.com/…/3603872_Plasma_and_dietary_vitamin_C_levels _and_risk_of_gastric.html science.naturalnews.com/…/3628783_Prediagnostic_plasma_vitamin_C_ levels_and_the_subsequent_risk_of.html science.naturalnews.com/…/4790082_Effect_of_physiological_ concentrations_of_vitamin_C_on_gastric_cancer.html
Also see: http://orthomolecular.org/resources/omns/v04n19.shtml
There is also an extensive bibliography on the anti-tumoral action of vitamin C (25,33,47,54,83,91,122,129,181,197,202,218,244,246,270,299,311,335,339,367,404,405,414,415,416,489,496,510,511)
See the bibliography and studies quoted on last page of databse.
The pioneers of this oncological therapy were Pauling, who received the Nobel Prize for Chemistry, and the Italian Pantellini.
Ascorbic acid is mainly known for its ability to reduce metallic ions in various enzymatic processes and above all for its ability to act as an anti-oxidant agent, thus able to remove free radicals, reducing the damage caused at a genome level.
Furthermore it may be able to block the formation of nitrose at a gastro-intestinal level, as well as carrying out a preventative action on the formation of adenomatose polyps.
Even though ascorbic acid is well known for its collagene forming action, and the well known effect of scurvy in cases of reduction or absence of this acid in the diet, this vitamin is also important, alongside vitamins A and E as a first class anti-tumoral agent.
It is a respiratory vitamin(like vitamins E, B3, B5) that helps increase cellular oxygen levels.
It reinforces the intercellular bond and forestalls the destructive action of the hyalurons produced by many neoplastic cells.
Vitamin C stimulates the Natural killer lymphocytes, it supports the macrophagic activity, the chemio-tactical mobility of the white corpuscles, the production of antibodies and the response of the T cytotoxic lymphocytes to the antigenes.
Cameron found very low plasmatic levels of vitamin C in cancer patients (0.26 mg/100 mL) compared to normal plasmatic values (54).
In other studies, 154 cancer patients, undergoing analysis, were found to have low levels of vitamin C not only in their plasma (0.31 mg/100 mL), but also in their leucocytes (15.9 mg/10 E+8), with a positive correlation (r = 0.42) between these two values; in particular the authors attributed the alteration in the immune response to the tumor, especially of the phagocytosis, to the low concentration of vitamin C in the white blood corpuscles.
Already in 1974 Goetz had shown that vitamin C, in vitro, was capable of stimulating the motility and the chemiotaxis of neutrophiles.
The doses advised in literature for anti-neoplastic therapy are about 3-10 grams a day, reaching even 40 grams daily, because the vitamin is not toxic, at high doses it only has a laxative effect.
It would be better to take it by eating fresh fruit, but it is difficult to reach such high doses of the vitamin in this way.
Integrating fresh fruit (kiwi, oranges, lemons and grapefruit) with the juice of sea buckthorn , Rosa canina (dog rose, wild rose) to reach a daily dosage of at least 5- 8 grams of natural vitamin C, avoiding however, the use of pharmaceutically prepared vitamin C tablets.
Natural vitamin C, rich in its metabolites and other components called bioflavenoids (Citrin, Hesperidin, Campherol, Galangine, Isoamnetin, Rutine, Hyperoxide, Quercitin, Pychnogenol, etc) is more powerful and efficient, and furthermore is devoid of unpleasant gastric effects which are the result of high doses of synthetic vitamin C.
Natural vitamin C is moreover, characterized by a significant reduction in the formation of Calcium oxalate in the kidneys, as opposed to synthetic vitamin C. It is also easier for the intestine to absorb and has greater bio-availability, above all through its most important metabolites such as tronic acid, lixonic acid, xilonic acid etc.
This bio-availability has a critical importance in the immune defense system because the white blood cells tend to absorb Natural vitamin C 4 times more than they absorb synthetic vitamin C.
Recently, Myrciaria paraensis (camu-camu) has appeared on the European market. It is a small exotic fruit, similar to a small orange, but it contains 50 times more natural vitamin C than Citrus aurantium (orange), and it could therefore provide the daily dosage, of at least 3 grams, of vitamin .
Also Malpighia punicifolia (acerola), a cherry from the Antilles, is very rich in vitamin C, containing 50 to 100 times more than citrus fruits.
Natural vitamin C is therefore efficient because it is naturally associated to the bioflavenoids (Citrin, Hesperidin, Campherol, Galangine, Isoamnetin, Rutine, Hyperoxide, Quercetine,Quercitine, Pychnogenol, etc..) and other molecules, in plants often characterized by an immune stimulating activity (Echinacea purpurea, Plantago major, Capsicum frutescens)
Note: With very high therapeutic doses (>8-10 grams a day), Magnesium (e.g. Dolomite) must also be taken to avoid the risk of kidney stones.
Here enclosed scientific papers extracted from Catherine Kousmine (“Save your body”, page 129,
“Effects of C vitamin on our body according to Linus Pauling, edition Tecniche Nuove):
“…an intake of 1500 milligrams of ascorbic acid by mouth determines a concentration of 1.5 milligrams of C vitamin for each 100 millilitres of blood. By increasing the intake, the concentration suddenly increases up to 2.5 milligrams and then goes back to 1.5 millilitres for each 100 millilitres blood. There are enzymes which help the conversion of most
ascorbates into useful oxidation products. If the intake remains high, the body increases the amount of enzymes useful to the conversion; otherwise, if the ascorbic acid dose is suddenly reduced for some days, an excess of conversion enzymes and then a too law level of vitamin C in the blood occur. This means a number of disorders, as for example a higher sensibility to infections. The adaptation to a lower proportion takes place by reducing the number of conversion enzymes: it is necessary to gradually decrease the dose of vitamin C. By taking 100 milligrams a day and in presence of a plasmatic level of 1 milligram for every 100 millilitres blood, urines do not contain ascorbic acid because it is reabsorbed by renal tubules. If the intake is higher than 100 milligrams, i.e. 1-2 grams a day, 25% go in urines and the rest is kept by the body. Healthy people, who lack in vitamin C for some months, have to take 2-4 grams in order to eliminate them through urines. In case of cancer patients, who are used to take high doses of ascorbic acid, an interruption of some days requires an intake of 50 grams (fifty grams) of vitamin C so that this one can be found in urines”.
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Vitamin D (very important vitamin)
Cancer prevention by a MINIMUM of 77% cases just by sun exposure(best source of vitamin D): http://www.naturalnews.com/035063_vitamin_D_cancer_facts.html
Cancer treatment with sun exposure(vitamin D): http://www.polymvasurvivors.com/what_you_know.html#Vitamin%20D%20
NOTE:The link above contains multiple studies on sun exposure(vitamin D) and it’s crucial importance in fighting cancer:
Circulating Vitamin D levels in the Blood Dramatically Reduces Death Rate
* For each 10ng/ml increase in the blood level of vitamin D, the death rate from cancer would be reduced by 29%. The relationship between vitamin D and colorectal cancer is particularly strong.
The death rate for colorectal cancer would be reduced by 49%. (30 – Read Supporting Scientific Article on PUBMED)
Vitamin D Levels est during Summer = Improves survival by 40%
* A Norwegian study showed that cancer patients diagnosed in the summer when vitamin D levels are highest had up to 40% better survival rates than patients diagnosed in the winter when vitamin D levels are at their lowest.
(56 – Read Supporting Scientific Article on PUBMED )
Low Vitamin D Levels Greater chance of Death & Metastasis
* Breast cancer patients with low levels of vitamin D followed over eleven years had a 70% greater chance of dying and twice the rate of developing metastasis than patients with high levels of vitamin D.
(90 – Read Supporting Scientific Article )
Lung Cancer Patients Higher levels = Dramatic increase in Survival
* Early stage lung cancer patients who were diagnosed in the summer and had the highest levels of vitamin D had a five-year survival of 73% compared to 30% for those diagnosed in the winter with low vitamin D levels.
(60 – Read Supporting Scientific Article on PUBMED)
Lung – Colon – Prostate – Renal – Endometrial Cancers Higher Vit D levels dramatically decreases Risk
*High vitamin D levels (based on latitude and UV exposure) also correlate with a decreased risk of developing lung cancer, a 45% and 65% reduction in men and women respectively. Similar effects have been demonstrated in colon, prostate, renal and endometrial cancer. (33 – Read Supporting Scientific Article on BMJ(British Medical Journal))
Advanced Colorectal Patients Risk of death greatly Improved
* The risk of death for colorectal cancer patients with advanced disease but with high levels of vitamin D was reduced by over 60% compared to patients with low vitamin D levels. (64 – Read Supporting Scientific Article on PUBMED)
Prostate Cancer Patients
*Prostate Cancer Patients with Vitamin D levels in the mid and high range had a 60% and 85% respectively reduced risk of death from the condition compared to patients with low levels of Vitamin D. This is almost a seven fold increase in the risk of death in those with low vs high vitamin D levels. (152 – Read Supporting Scientific Article on PUBMED)
There is also an extensive bibliography on the anti-tumoral action of vitamin D- see last page of this database: (28,157,160,188,208,209,231,240,246, 254,302,323,479,489)
Vitamin D is BEST taken from skin exposure to the sun, MINIMUM 30 mins daily,without any sunscreen or protection. Avoid burning and avoid the interval 11 am – 16 pm.
Natural vitamin D, contained in some plants, is however preferable to the synthetic type, because the latter is about 10 times more capable of binding with Magnesium, taking it away from the organism, thus causing all the damage that the loss of this incurs (osteoporosis, kidney stones).
Vitamin D induces the inhibition of neoplastic cellular growth: this has been shown in vitro in neoplastic cellular lines; especially of the hematopoietic system, of the CNS, of the prostate; the colon, the ovaries and the breasts.
This action is thought to be expressed at various levels, in particular:
a) by means of apoptosis induction, through the activation of p21, that is, the inhibitor of the kinase proteins;
b) the inhibition of neoplastic cellular growth, which would be blocked in the G1 phase because of the action of the IGF1 inhibitor;
c) by means of cellular differentiation.
Vitamin E(respiratory vitamin)
This liposoluble substance consists of a group of various components, called Tocopherols.
Seven of these exist in nature; alpha-Tocopherol, beta-Tocopherol, gamma- Tocopherol, delta-Tocopherol, epsilon-Tocopherol, zetaTocopheros and eta-Tocopherol.
Studies on Vitamin E and cancer
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
The role of Vitamin E in the prevention of cancer: a meta-analysis of randomized controlled trials.
2008 American journal of respiratory and critical care medicine
2008 Cancer causes & control : CCCVitamin E suppresses telomerase activity in ovarian cancer cells.
2007 Cancer detection and preventionEffects of long-term Vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
2005 JAMA : the journal of the American Medical AssociationSupplemental and dietary Vitamin E intakes and risk of prostate cancer in a large prospective study.
2007 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Antioxidants vitamin C and Vitamin E for the prevention and treatment of cancer.
2006 Journal of general internal medicine
Vitamin E: the evidence for multiple roles in cancer.
2003 Nutrition and cancer
Vitamin E supplements and risk of prostate cancer in U.S. men.
2004 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Serum and dietary Vitamin E in relation to prostate cancer risk.
2007 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Association of variants in two Vitamin E transport genes with circulating Vitamin Econcentrations and prostate cancer risk.
2009 Cancer research
Association between breast cancer and vitamin C, Vitamin E and selenium levels: results of a case-control study in India.
2005 Asian Pacific journal of cancer prevention : APJCP
A short-term dietary supplementation with high doses of Vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients.
2007 Cancer immunology, immunotherapy : CII
SELECT: the next prostate cancer prevention trial. Selenum and Vitamin E cancerPrevention Trial.
2001 The Journal of urology
Vitamin C and Vitamin E supplement use and colorectal cancer mortality in a large American cancer Society cohort.
2001 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Vitamin E and breast cancer.
2004 The Journal of nutrition
SELECT: the selenium and Vitamin E cancer prevention trial.
2003 Urologic oncology
The selenium and Vitamin E cancer prevention trial.
2003 World journal of urology
Selenium and Vitamin E cancer prevention trial.
2004 Annals of the New York Academy of Sciences
Selenium and Vitamin E cancer Prevention Trial: a nutrient approach to prostatecancer prevention.
2009 Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
A nutrient approach to prostate cancer prevention: The Selenium and Vitamin Ecancer Prevention Trial (SELECT).
2010 Nutrition and cancer
Null activity of selenium and Vitamin E as cancer chemopreventive agents in the rat prostate.
2010 Cancer prevention research (Philadelphia, Pa.)
Vitamin E and cancer.
2007 Vitamins and hormones
Clinical models for testing chemopreventative agents in prostate cancer and overview of SELECT: the Selenium and Vitamin E cancer Prevention Trial.
2003 Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
Cancer Preventive Effects of Vitamin E.
2011 Current pharmaceutical biotechnology
Vitamin E but not St. John’s wort mitigates leukopenia caused by cancerchemotherapy in rats.
2006 Translational research : the journal of laboratory and clinical medicine
Vitamin C and Vitamin E supplement use and bladder cancer mortality in a large cohort of US men and women.
2002 American journal of epidemiology
Review of Vitamin E and selenium in the prevention of prostate cancer: implications of the selenium and Vitamin E chemoprevention trial.
2002 Integrative cancer therapies
Vitamin E and breast cancer prevention: current status and future potential.
2003 Journal of mammary gland biology and neoplasia
Vitamin E and breast cancer prevention: current status and future potential.
2003 Journal of mammary gland biology and neoplasia
Molecular epidemiologic studies within the Selenium and Vitamin E cancerPrevention Trial (SELECT).
2001 Cancer causes & control : CCC
Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer.
2009 Journal of the National cancer Institute
Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E.
2010 The Journal of biological chemistry
Selenium and Vitamin E for prostate cancer: post-SELECT (Selenium and Vitamin Ecancer Prevention Trial) status.
2011 Molecular medicine (Cambridge, Mass.)
Vitamin E and cancer: An insight into the anticancer activities of Vitamin E isomers and analogs.
2008 International journal of cancer. Journal international du cancer
Vitamin E intake, alpha-tocopherol status, and pancreatic cancer in a cohort of male smokers.
2009 The American journal of clinical nutrition
The roles of alpha-vitamin E and its analogues in prostate cancer.
2007 Vitamins and hormones
Combined lycopene and Vitamin E treatment suppresses the growth of PC-346C human prostate cancer cells in nude mice.
2006 The Journal of nutrition
Vitamin E, alpha- and gamma-tocopherol, and prostate cancer.
1999 Seminars in urologic oncology
Synergistic effect of Vitamin E and selenium in human prostate cancer cell lines.
2004 Prostate cancer and prostatic diseases
Vitamin E succinate inhibits colon cancer liver metastases.
2002 The Journal of surgical research
Lycopene and Vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model.
2004 The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Higher baseline serum concentrations of Vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene cancerPrevention Study.
2006 The American journal of clinical nutrition
Alpha-tocopheryl succinate, the most effective form of Vitamin E for adjuvant cancertreatment: a review.
2003 Journal of the American College of Nutrition
gamma-Tocopherol or combinations of Vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis.
2004 Proceedings of the National Academy of Sciences of the United States of America
Experimental basis for cancer prevention by vitamin E.
2000 Cancer investigation
Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria.
2007 Molecular aspects of medicine
Vitamin E succinate decreases lung cancer tumor growth in mice.
2005 The Journal of surgical research
RRR-alpha-vitamin E succinate potentiates the antitumor effect of calcitriol in prostatecancer without overt side effects.
2009 Clinical cancer research : an official journal of the American Association forcancer Research
Serum levels of folate, lycopene, ß-carotene, retinol and Vitamin E and prostatecancer risk.
2010 European journal of clinical nutrition
Trace elements and Vitamin E status in Nigerian patients with prostate cancer.
2010 African health sciences
Designing the Selenium and Vitamin E cancer Prevention Trial (SELECT).
2005 Journal of the National cancer Institute
Vitamin E analogues and immune response in cancer treatment.
2007 Vitamins and hormones
Donepezil and Vitamin E for preventing cognitive dysfunction in small cell lungcancer patients: preliminary results and suggestions for future study designs.
2005 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Vitamin E serum levels and gastric cancer: results from a cohort of patients in Tuscany, Italy.
2000 Cancer letters
Donepezil and Vitamin E for preventing cognitive dysfunction in small cell lungcancer patients: preliminary results and suggestions for future study designs.
2005 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Effects of topical L-selenomethionine with topical and oral Vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice.
2003 Journal of the American Academy of Dermatology
Vitamin E and the Y4 agonist BA-129 decrease prostate cancer growth and production of vascular endothelial growth factor.
2002 The Journal of surgical research
Pro-apoptotic mechanisms of action of a novel Vitamin E analog (alpha-TEA) and a naturally occurring form of Vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells.
2004 Nutrition and cancer
Minority recruitment to the Selenium and Vitamin E cancer Prevention Trial (SELECT).
2005 Clinical trials (London, England)
Salubrious effect of vitamin C and Vitamin E on tamoxifen-treated women in breastcancer with reference to plasma lipid and lipoprotein levels.
2000 Cancer letters
Design of Physicians’ Health Study II–a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials.
2000 Annals of epidemiology
Vitamin E succinate promotes breast cancer tumor dormancy.
2000 The Journal of surgical research
Mitocans as anti-cancer agents targeting mitochondria: lessons from studies withVitamin E analogues, inhibitors of complex II.
2007 Journal of bioenergetics and biomembranes
Centralized blood processing for the selenium and Vitamin E cancer prevention trial: effects of delayed processing on carotenoids, tocopherols, insulin-like growth factor-I, insulin-like growth factor binding protein 3, steroid hormones, and lymphocyte viability.
2005 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
The therapeutic and preventive effect of RRR-alpha-vitamin E succinate on prostatecancer via induction of insulin-like growth factor binding protein-3.
2007 Clinical cancer research : an official journal of the American Association forcancer Research
Vitamin E and prostate cancer: is Vitamin E succinate a superior chemopreventive agent?
2005 Nutrition reviews
Aspirin prevents stroke but not MI in women; Vitamin E has no effect on CV disease or cancer.
2006 Cleveland Clinic journal of medicine
Effect of Vitamin E on tamoxifen-treated breast cancer cells.
2006 Surgery
Dietary administration of the proapoptotic Vitamin E analogue alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer.
2006 Cancer research
Combination of Vitamin E and selenium causes an induction of apoptosis of human prostate cancer cells by enhancing Bax/Bcl-2 ratio.
2008 The Prostate
Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E.
2009 Climacteric : the journal of the International Menopause Society
Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth.
2008 Nutrition and cancer
Poly(L-lactide)-vitamin E TPGS nanoparticles enhanced the cytotoxicity of doxorubicin in drug-resistant MCF-7 breast cancer cells.
2010 Biomacromolecules
Vitamin E succinate induced apoptosis and enhanced chemosensitivity to paclitaxel in human bladder cancer cells in vitro and in vivo.
2010 Cancer science
Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway.
2005 Cancer research
Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells.
2007 The Prostate
Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis.
1999 Cancer research
Effects of topical and oral Vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice.
2000 Nutrition and cancer
Synergy between selenium and Vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells.
2003 Cancer research
Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancercells by signaling via the mitochondrial pathway.
2005 Biochemical and biophysical research communications
Vitamin E and prostate cancer.
2002 The Urologic clinics of North America
Synergy between selenium and Vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells.
2003 Cancer research
Peptide YY augments gross inhibition by Vitamin E succinate of human pancreaticcancer cell growth.
2000 The Journal of surgical research
Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostatecancer risk.
2006 Journal of the National cancer Institute
Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women’s Health Study: a randomized controlled trial.
2005 JAMA : the journal of the American Medical Association
Dietary intakes of retinol, beta-carotene, vitamin D and Vitamin E in the European Prospective Investigation into cancer and Nutrition cohort.
2009 European journal of clinical nutrition
Mitochondrial targeting of Vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II.
2011 The Journal of biological chemistry
Impact of supplemental site grants to increase African American accrual for the Selenium and Vitamin E cancer Prevention Trial.
2010 Clinical trials (London, England)
The Outcome of Selenium and Vitamin E cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology.
2009 Molecular interventions
Critical roles for JNK, c-Jun, and Fas/FasL-Signaling in Vitamin E analog-induced apoptosis in human prostate cancer cells.
2008 The Prostate
Effect of selenium and Vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E cancer Prevention Trial (SELECT).
2009 JAMA : the journal of the American Medical Association
Tocotrienols, the Vitamin E of the 21st century: its potential against cancer and other chronic diseases.
2010 Biochemical pharmacology
Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity.
2008 European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release.
2006 Biomaterials
Involvement of JNK/p73/NOXA in Vitamin E analog-induced apoptosis of human breast cancer cells.
2008 Molecular carcinogenesis
Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1.
2005 The Annals of pharmacotherapy
A peptide conjugate of Vitamin E succinate targets breast cancer cells with high ErbB2 expression.
2007 Cancer research
Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention.
2007 The Prostate
The effects of Vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.
2002 World journal of gastroenterology : WJG
The effects of Vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.
2002 World journal of gastroenterology : WJG
Vitamin E succinate and cancer treatment: a Vitamin E prototype for selective antitumour activity.
2003 British journal of cancer
Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
2004 Journal of hepatology
Vitamin E inhibits the high-fat diet promoted growth of established human prostate LNCaP tumors in nude mice.
1999 The Journal of urology
Vitamin E analog alpha-TEA and celecoxib alone and together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis in nude mice.
2004 Breast cancer research and treatment
Development of gamma (gamma)-tocopherol as a colorectal cancer chemopreventive agent.
2003 Critical reviews in oncology/hematology
Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects.
2004 Current cancer drug targets
The role of PC-SPES, selenium, and Vitamin E in prostate cancer.
2002 Oncology (Williston Park, N.Y.)
Differential response of human ovarian cancer cells to induction of apoptosis byVitamin E Succinate and Vitamin E analogue, alpha-TEA.
2004 Cancer research
A short-term dietary supplementation of high doses of Vitamin E increases T helper 1 cytokine production in patients with advanced colorectal cancer.
2002 Clinical cancer research : an official journal of the American Association forcancer Research
Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells.
2003 Nutrition and cancer
High dietary level of synthetic Vitamin E on lipid peroxidation, membrane fatty acid composition and cytotoxicity in breast cancer xenograft and in mouse host tissue.
2003 Cancer cell international
[Roles of ERK1/2 MAPK in Vitamin E succinate-induced apoptosis in human gastriccancer SGC-7901 cells].
2003 Wei sheng yan jiu = Journal of hygiene research
Alpha-vitamin E derivative, RRR-alpha-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells.
2007 Asian journal of andrology
Roles of Fas signaling pathway in Vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.
2002 World journal of gastroenterology : WJG
Mechanisms mediating the antiproliferative and apoptotic effects of Vitamin E in mammary cancer cells.
2005 Frontiers in bioscience : a journal and virtual library
Cellular and molecular effects of alpha-tocopheryloxybutyrate: lessons for the design of Vitamin E analog for cancer prevention.
2004 Anticancer research
Vitamin E and cancer.
2009 Nutrition and cancer
Pentoxifylline and Vitamin E treatment for prevention of radiation-induced side-effects in women with breast cancer: a phase two, double-blind, placebo-controlled randomised clinical trial (Ptx-5).
2009 European journal of cancer (Oxford, England : 1990)
Vitamin E prevents lipid raft modifications induced by an anti-cancer lysophospholipid and abolishes a Yap1-mediated stress response in yeast.
2010 The Journal of biological chemistry
Evaluation of plasma non-enzymatic antioxidants in breast cancer etiology.
2009 Asian Pacific journal of cancer prevention : APJCP
[The study of apoptosis induction effect of Vitamin E succinate on Tca8113 human tongue cancer cells].
2008 Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?
2005 The British journal of nutrition
Double-blind placebo-controlled randomised trial of Vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
2004 Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas inVitamin E succinate-triggered apoptosis.
2000 Nutrition and cancer
Vitamin E and other antioxidants inhibit human prostate cancer cells through apoptosis.
2000 The Prostate
Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis.
2006 International journal of cancer. Journal international du cancer
In vitro and in vivo evaluation of anticancer actions of natural and synthetic Vitamin Eforms.
2008 Molecular nutrition & food research
Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate.
2006 Molecular nutrition & food research
Prospective study of serum Vitamin E levels and esophageal and gastric cancers.
2003 Journal of the National cancer Institute
Systematic review on „vitamin E and prevention of colorectal cancer”.
2010 Pakistan journal of pharmaceutical sciences
Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside?
2009 Molecular nutrition & food research
Studies on Vitamin E and radiation
There is also an extensive bibliography on the anti-tumoral action of vitamin E -see last page of DATABASE (6,19,20,30,45,91,95,112, 125,129,142,165,167,190,202,228,229,246,261,280,332,404,405,452,494)
This liposoluble substance consists of a group of various components, called Tocopherols. Seven of these exist in nature; alpha, beta, gamma, delta, epsilon, zeta and eta.
Alpha-Tocopherol has an anti-oxidant effect on the lipidic membranes in synergy with Melatonin(see below), carrying out a preventative action on the peroxidization of the cellular membrane induced by ionizing radiation and by chemical carcinogenes.
Vitamin E also carries out an anti-oxidative action in a wider sense, acting as a ‘scavenger’ of the free radicals, similar to vitamin C.
It performs a stimulating activity on the immune system; it induces cellular differentiation; it inhibits, in a selective way, cellular growth intervening at DNA and RNA synthesis level.
Various studies have shown its ability to induce apoptosis in cellular lines of breast carcinomas and lymphoma B.
It is inactivated by Iron, therefore it is essential that any medicines based on Iron are not taken at the same time as vitamin E, but at a distance of at least 10-12 hours.
Aluminum, which is often present in pharmaceutical products, also deactivates vitamin E.
The uncooked oil of Triticum sativum (wheat germ; note: has vitamin B12) contains about twice as much vitamin E as the uncooked oil from the seeds of Helianthus annuus (sunflower) and the latter contains about five times as much as uncooked olive oil. Furthermore all these seeds are rich in essential unsaturated fats, an important part of the diet for cancer patients.
In anti-neoplastic therapy much is being discussed about: the raw seeds of Helianthus annuus
(which the author personally considers useful in therapy), wheat shoots (the author is not in favor),
Saccharomyces cerevisiae (yeast, of which the author is not in favor), and the shoots of soya lecithin (of dubious use and the author is against their use because of the transgenic risk).
Natural vitamins are by far preferable to industrially produced ones: Dracontium loretense, for example, which is considered one of the best plants for its specific anti-oxidant potential, is of superior quality in its anti-oxidant ability compared to synthetic vitamin E (566). WHOLE, ORGANIC FOODS are BEST due to COMPLEXES of NUTRIENTS !
As an already extracted natural product, together with or without other vitamins, vitamin E must be given in addition to high quantities of raw seeds of Helianthus annuus (also containing vitamin A,all the vitamin B compounds, vitamin D, Manganese, Zinc and Magnesium) and of high quantities of raw Triticum sativum (which is rich in the precious alpha-lipoic acid): both are also very rich in vitamin B6 (pyridoxin), the latter is important for the immune system, but it is difficult to find in other compatible foods for a suitable diet for cancer patients. Pyridoxin, in fact, is contained especially in Saccharomyces cerevisiae, the latter is a food which the author does not regard favorably for an anti-neoplastic diet, because it contains high quantities of folic acid.
Natural Octacosanol, extracted from the oil of Triticum sativum, has a synergetic action with vitamin E, but it is, in any case, better to consume it with all the uncooked oil of Triticum sativum and/or Triticum sativum itself rather than taking it already extracted, as a pharmaceutical product (because it loses its active principles).
Vitamin E is particularly efficient in combination with Selenium, which is contained in Aloe species, Solanum lycopersicum (tomatoes), Equisetum species, Allium cepa (onions).
There is also an extensive bibliography on Selenium (see last page of DATABASE) :
79,108,112,129,133,136,143,156,228,229,276,338,339,364,367,404,405,407,443,452,458,501,510,511)
Both vitamin E and Selenium are in their turn synergetic with Zinc in inhibiting the production of inflammatoryprostoglandins and leukotrienes.
Vitamin E conversion factors
Vitamin E is expressed in milligrams of tocopheral equivalents (T.E.)
1 milligram of Tocopherol is equal to:
= 1 milligram of D-alpha Tocopherol
= 2 milligrams of D-beta Tocopherol
= 5 milligrams of D-gamma Tocopherol
Vitamin F (very important vitamin-see omega 3)
Polyunsaturated fatty acids :
arachidonic acid, Linoleic cis-cis natural acid (vitamin F1) as: alpha-lipoic acid, alpha-linolenic acid,etc.
Alpha-lipoic acid
Food Sources:
spinach, broccoli, tomato, peas, Brussels sprouts, rice bran
Mechanism of action:
Alpha-lipoic acid acts as a lipophilic free radical scavenger. Dihydrolipoic acid (DHLA), a reduced form of lipoic acid, has more potent antioxidant effects. It can assist in repairing oxidative damage and regenerate endogenous antioxidants such as vitamin C, vitamin E, and glutathione.
Both DHLA and lipoic acid also have metal chelating capacities.
As a lipoamide, alpha-lipoic acid functions as a cofactor in various multienzyme systems involved in the decarboxylation of alpha-keto acids such as pyruvate. (13) (14) (15)
Alpha-lipoic acid caused cell cycle arrest in G0/G1 in FaDu and Jurkat human tumor cell lines (1).
Alpha lipoic acid was also found to scavenge reactive oxygen species in MCF-7 breast cancer cells (16).
Reduction of reactive oxygen species was then followed by cancer cell growth arrest and apoptosis (16).
For studies quoted see http://www.mskcc.org/cancer-care/herb/alpha-lipoic-acid
Other studies:
2010 European journal of pharmacology
2000 International journal of cancer. Journal international du cancer
2008 Neoplasma
2010 Nutrition research (New York, N.Y.)
2005 Apoptosis : an international journal on programmed cell death
2009 Annals of the New York Academy of SciencesThe long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid/low-dose naltrexone protocol.
2006 Integrative cancer therapiesCytoprotection against Cr(6+)-induced DNA damage by alpha-lipoic acid: implications in reducing occupational cancer risk.
2009 Mutagenesis
Studies on Alpha-Lipoic Acid and Apoptotic
http://science.naturalnews.com/A/Alpha-Lipoic_Acid_and_Apoptotic.html
Alpha-Linolenic Acid(omega 3)
Food sources:flaxseed, avocado, walnuts, almonds, fishoils
Mechanism of action:
The alpha-linolenic acid (vitamin F), for instance, is a cis-polyunsaturated fatty acid that is contained in linseed cold-pressed oil: it is transformed into EPA and DHA (Omega-3 fatty acids) and is quite effective against malignant tumours, as shown by Pardini ( 1647 );
Moreover, Noguchi has proved that Omega-3 fatty acids, unlike Omega-6 fatty acids, help reduce tumour masses, although
Omega-6 fatty acids are unsaturated fatty acids, too ( 1654 ).
see last page of DATABASE for studies quoted.
2004 The Journal of urology
2000 European journal of cancer (Oxford, England : 1990)
2006 Cancer causes & control : CCC
2009 The American journal of clinical nutrition
2000 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
2006 Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National cancer Institute of MexicoInhibitory effect of conjugated Alpha-Linolenic Acid from bifidobacteria of intestinal origin on SW480 cancer cells.
2009 LipidsProspective studies of dietary Alpha-Linolenic Acid intake and prostate cancer risk: a meta-analysis.
2010 Cancer causes & control : CCC
Dietary Alpha-Linolenic Acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis.
2004 The Journal of nutrition
Growth-inhibitory and proapoptotic effects of Alpha-Linolenic Acid on estrogen-positive breast cancer cells.
2009 Annals of the New York Academy of Sciences
Comparison of stearidonic acid and Alpha-Linolenic Acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures.
2005 The Journal of nutritional biochemistry
Conjugation with Alpha-Linolenic Acid improves cancer cell uptake and cytotoxicity of doxorubicin.
2009 Bioorganic & medicinal chemistry letters
Does Alpha-Linolenic Acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters?
2000 Prostaglandins, leukotrienes, and essential fatty acids
Conjugation with alpha linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin.
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Inhibitory effect of conjugated alpha linolenic acid from bifidobacteria of intestinal origin on SW480 cancer cells. Publication: Lipids Publication Date: 2009
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We tested the anticarcinogenic effect of Alpha–Linolenic Acid (ALA) as a single compound. To test the role of ALA in breast cancer cells (MCF-7), we analyzed …
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Effects of omega 3 fatty acids on cancer risk: a systematic review.
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Modulation of prostate cancer genetic risk by omega 3 and omega 6 fatty acids.
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Effect of altering dietary omega 6 omega 3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase 2, and prostaglandin E2.
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Evidence indicates that a diet rich in omega (omega)-6 polyunsaturated fatty acids …prostate cancer (PCa) risk, whereas a diet rich in omega–3 decreases risk.
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Beneficial effects of omega 3 long chain fatty acids in breast cancer and cardiovascular diseases: voltage gated sodium channels as a common feature?
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Although it is believed that fish omega–3 fatty acids may decrease breast cancer risk, epidemiological evidence has been inconclusive. This study examined the …
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BACKGROUND : Preclinical evidence of the preventive benefits of omega–3 (n-3) polyunsaturated fatty acids (PUFAs) in breast cancer continues to fuel interest …
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Prevention and treatment of pancreatic cancer by curcumin in combination with omega 3 fatty acids. Publication: Nutrition and cancer. Publication Date: 2008
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A ratio of 2.5/1 reduced rectal cell proliferation in patients with colorectal cancer, whereas a ratio of 4/1 with the same amount of omega–3 PUFA had no effect.
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Impact of postoperative omega 3 fatty acid supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients.
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Herbal Remedy Essiac® and Cancer (press release) · Omega–3 fatty acids slash colorectal cancer risk in men by 66 percent · Fatty Acid Blood Tests Help …
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Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega 3 fatty acids and medium chain triglycerides.
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Cancer science. Omega–3 fatty acid supplementation delays the progression of neuroblastoma in vivo. International journal of cancer. Journal … |
omega 3 Fatty acid containing diet (Racol) reduces toxicity of chemoradiation therapy for patients with esophageal cancer].
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Modulation of lipid rafts by Omega 3 fatty acids in inflammation and cancer: implications for use of lipids during nutrition support.
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-promote optimal functioning of the immune system.
A team of researchers based in China have published results of their work on omega-3 and breast cancer risk in the British Medical Journal (BMJ), stating that a high intake of fatty acids found in fish is associated with a reduction 14 percent risk of breast cancer later in life. To conduct their study, the scientists reviewed and analyzed a group of 26 studies in the United States, Europe and Asia, which included more than 800,000 participants and 20,000 cases of breast cancer.
–promote natural cancer cell death and reduce cancer risk.
After analyzing the data to determine the impact of long chain fats on the risk of breast cancer, the researchers determined the difference between the lowest and highest intake category of marine polyunsaturated fatty acids was associated with a 14 percent reduced risk of disease .
In addition, for an increase of 0.1 grams per day of consumption of omega-3 fatty acids in fish, the risk of breast cancer is reduced by 5 percent. These results clearly demonstrate a significantly reduced risk of affecting the development of breast cancer and future progression of the disease.
The study authors concluded „Our current study provides solid evidence and robust as omega3 are inversely associated with risk of breast cancer. „
Scientists understand from previous studies that omega-3 fats, DHA and EPA, are preferentially accumulated in cell membranes and prevent cancer development through increased transfer of nutrients and oxygen to the cell nucleus.
With DHA metabolism, metabolites are produced that destroy cancer cells. Researchers believe that this mechanism is responsible for reducing the risk of cancers found in this study. (1200-2400 mg EPA / DHA combined daily to reduce the risk associated with breast cancer and other disease lines). Higher doses are required in cancer.
-omega 3 stops spread of cancer
Omega-6, found in most vegetable oils, increased spread of cancer cells in the bone marrow.
Nevertheless, the spread was blocked by omega-3
Comments Dr. Mercola:
„The evidence continues to grow. Not all unsaturated fats are good for you. Even if they come from such healthy foods such as sunflower seeds grown biodynamic. See, most vegetable oils are rich in omega-6 fat and very few people are deficient in these fats.
In addition, omega-3 provides a wonderful benefits for patients with prostate cancer by blocking the functioning of omega-6 fats that cancer cells use them as an energy source. (Therefore, only during cancer your treatment, avoid omega 6 polyunsaturated fats because the thinner blood vessels supply tumors. thin blood vessels in the body are necessary for optimal functioning, but avoid in cancer high doses of omega-6) This happens at the molecular level when omega-3 (EPA andDHA), reduces the action of a metabolite of the omega-6 arachidonic acid, prostaglandin E2. The sole point agreed on this study is that scientists have recommended omega 3 as a preventative for prostate cancer as and to stop its development. „
Dr. Clapp compiled a comprehensive program that has achieved national recognition USA. 1990 –was a very successful year of the program – had 16 cures of prostate cancer based on deep cleansing of toxins accumulated in the body and prostate, then flooding the cells with omega 3 fats. „Perhaps the most interesting aspect of this study is clear evidence of the mechanisms that omega-6 fats stimulate the growth of prostate cancer, clearly debunking industry hypethat vegetable oils are good for our health. „
We saw dramatically reduced overall inflammation (measured by CRP testing) and especially in reducing enlarged prostate, reducing also any tumor mass, monitored / evaluated by Doppler sonograms.
-Omega 3 promote apatosis(programmed cell death) in cancer cells
Two new studies suggest that omega-3 fatty acids may inhibit the growth of liver cancer cells, suggesting that this may be an effective therapy to treat and prevent liver cancer.
Like vitamin B17/laetrile,and other natural substances(turmeric, ginger) omega 3 trigger apatosis.
The first study examined the effects of omega-3 and omega-6 fats in hepatocellular carcinoma cells .
Carcinoma represent 90 percent of all cases of liver cancer and is usually rapidly fatal. Omega-6 had no effect on cancer cells, but omega-3 – as (DHA) and (EPA) – induced apoptosis (programmed cell death).
In the second study, omega-3 fats have been shown as effective in the treatment of cholangiocarcinoma tumor cells, an aggressive and fatal type of cancer that forms in the liver bile ducts.
Researchers said omega-3 fatty acids may not only be an effective treatment for liver cancer, but could also protect the liver from hepatic steatosis, chronic liver disease thought to be a precursor to cancer.
These above are just a few specific examples of cancer and Omega3 .Omega are great in any cancer.
Omega-3 Builds Muscle Mass in Cancer Patients, thus PREVENT and HELP IN CACHEXIA: http://articles.mercola.com/sites/articles/archive/2011/03/24/omega3-builds-muscle-mass-in-cancer-patients.aspx
Omega 3 fats are highly recommended and among the few fats accepted in cancer (either from seeds, nuts, avocado or fish, although fish oils might be contaminated with heavy metals from the fish )
These and many other roles that help in cancer, including stimulation of the immune system, reducing inflammation , direct relationship to sun tolerance by the body and regulation of vitamin D levels (often those with cancer can not tolerate the sun, therefore can not benefit either its energy or the important natural Vitamin D, the sun being main source of vitamin D, but omega 3 fixes this, also regulating levels of vitamin D)
See also:
http://articles.mercola.com/sites/articles/archive/2013/07/31/omega-3-fats.aspx
http://articles.mercola.com/sites/articles/archive/2001/07/21/flaxseed-part-two.aspx
The relation of alpha linolenic acid to the risk of prostate cancer: a systematic review and meta analysis.
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Evidence indicates that a diet rich in omega (omega)-6 polyunsaturated fatty acids …prostate cancer (PCa) risk, whereas a diet rich in omega–3 decreases risk.
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Much more about OMEGA 3 as well a POWERFUL (stage IV) cancer treatment based on AWARDED 2 NOBEL PRIZES in my book.
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Vitamin K
2010 The American journal of clinical nutrition
2008 The American journal of clinical nutrition
2009 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
2002 British journal of cancer
2003 British journal of cancer
2011 BloodCancer prevention and Vitamin K antagonists: an overview.
2010 Thrombosis researchSorafenib combined Vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways.
2010 Journal of cellular physiology
Efficacy of low- molecular- weight- heparin versus Vitamin K antagonists for long term treatment of cancer-associated venous thromboembolism in adults: a systematic review of randomized controlled trials.
2009 Thrombosis research
A resected case of metachronous liver metastasis from lung cancer producing alpha-fetoprotein (AFP) and protein induced by Vitamin K absence or antagonist II (PIVKA-II).
2004 Hepato-gastroenterology
Low-molecular-weight heparins are superior to Vitamin K antagonists for the long term treatment of venous thromboembolism in patients with cancer: a cochrane systematic review.
2008 Journal of experimental & clinical cancer research : CR
Oxygen free radical generating mechanisms in the colon: do the semiquinones ofVitamin K play a role in the aetiology of colon cancer?
2001 Biochimica et biophysica acta
A study of the prevalence of Vitamin K deficiency in patients with cancer referred to a hospital palliative care team and its association with abnormal haemostasis.
2008 Journal of clinical pathology
Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K2 trigger apoptosis in human ovarian cancer TYK-nu cells.
2006 Apoptosis : an international journal on programmed cell death
Vitamin K2-mediated apoptosis in cancer cells: role of mitochondrial transmembrane potential.
2008 Vitamins and hormones
Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells.
2007 International journal of oncology
Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis.
2008 International journal of molecular medicine
A resected case of metachronous liver metastasis from lung cancer producing alpha-fetoprotein (AFP) and protein induced by Vitamin K absence or antagonist II (PIVKA-II).2004 Hepato-gastroenterology
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