Scientific Studies DATABASE PAGE 7

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  • Scientific studies on Anticarcinogenic natural substances
  • Hundreds of studies about NATURAL substances with DEMONSTRATED chemopreventive effect:
  • Hundreds of studies about NATURAL substances with DEMONSTRATED Chemotherapeutic effect:
  • APOPTOSIS & hundreds of studies about NATURAL substances with DEMONSTRATED APOPTOTIC effect
  • Hundreds of studies about NATURAL substances with DEMONSTRATED ANTIPROLIFERATIVE effect
  • Scientific studies on Anti-Angiogenic
  • Immune therapy & studies about NATURAL substances with DEMONSTRATED immune strengthening effect

Scientific studies on Anticarcinogenic natural substances

Anticarcinogenic- reduces the occurrence of cancers, reduces the severity of cancers that do occur, or acts against cancers that do occur
The study of antioxidant and anticarcinogenic green tea and black tea.
Pakistan journal of biological sciences: PJBSAdherence and anticarcinogenic effects of Bacillus polyfermenticus SCD in the large intestine.
Letters in applied microbiologyAntioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays.
Journal of agricultural and food chemistryAnticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum.
Journal of natural medicines

Reactive oxygen species abrogate the anticarcinogenic effect of eicosapentaenoic acid in Atm-deficient mice.
Nutrition and cancer

Anti-inflammatory and anticarcinogenic effect of genistein alone or in combination with capsaicin in TPA-treated rat mammary glands or mammary cancer cell line.
Annals of the New York Academy of Sciences

Anticarcinogenic and antimitotic effects of Turkish propolis and mitomycin-C on tissue cultures of bladder cancer.
Natural product research

Cytotoxic and anticarcinogenic activity of the ent-kaurene diterpenoid, melissoidesin, from Isodon wightii (Bentham) H. Hara.
Natural product research

Preparation of Disubstituted Phenyl Propargyl Alcohols, their Use in Oxathiolene Oxide Synthesis, and Evaluation of the Oxathiolene Oxide Products as Anticarcinogenic Enzyme Inducers.
Letters in organic chemistry

Chemopreventive and anticarcinogenic effects of Momordica charantia extract.
Asian Pacific journal of cancer prevention : APJCP

Influence of anticarcinogenic metalloporphyrin Cu(II)TOEPyP(4) on DNA thermostability in vitro.
Georgian medical news

Anticarcinogenic effects of Solanum lycopersicum fruit extract on Swiss albino and C57 Bl mice.
Asian Pacific journal of cancer prevention : APJCP

Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells.

Determination of anticarcinogenic and rescue therapy drugs in urine by photoinduced spectrofluorimetry using multivariate calibration: comparison of several second-order methods.
Analytical and bioanalytical chemistry

4-hydroxynonenal, a lipid peroxidation product of dietary polyunsaturated fatty acids, has anticarcinogenic properties in colon carcinoma cell lines through the inhibition of telomerase activity.
The Journal of nutritional biochemistry

Chemopreventive efficacy of gallic acid, an antioxidant and anticarcinogenic polyphenol, against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.
Investigational new drugs

Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves.
Journal of veterinary science

Anticarcinogenic effects of polyphenolics from mango (Mangifera indica) varieties.
Journal of agricultural and food chemistry

Superior anticarcinogenic activity of trans,trans-conjugated linoleic acid in N-methyl-N-nitrosourea-induced rat mammary tumorigenesis.
Journal of agricultural and food chemistry

Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie

Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450.
Toxicological sciences : an official journal of the Society of Toxicology

Mechanisms and anticarcinogenic effects of diet-related apoptosis in the intestinal mucosa.
Nutrition research reviews

Extraction and chromatographic separation of anticarcinogenic fractions from cacao bean husk.
BioFactors (Oxford, England)

Simultaneous and rapid determination of the anticarcinogenic proteins Bowman-Birk inhibitor and lectin in soybean crops by perfusion RP-HPLC.
Journal of chromatography. A

Application of a functional mathematical index for antibacterial and anticarcinogenic effects of tea catechins.
Journal of agricultural and food chemistry

Structure-activity relationships of tea compounds against human cancer cells.
Journal of agricultural and food chemistry

Studies on the neuroprotective role of Piper longum in C6 glioma induced rats.
Investigational new drugs

Selenium and anticarcinogenesis: underlying mechanisms.
Current opinion in clinical nutrition and metabolic care

The Tg.AC Transgenic Mouse as a Screening Tool for Anticarcinogens: Broccoli Juice Protected Against 12-O-Tetradecanoylphorbol-13-Acetate (TPA) But Not Benzo[a]Pyrene (B[a]P)-Induced Skin Tumors.
Toxicology mechanisms and methods

Hundreds of studies about NATURAL substances with DEMONSTRATED chemopreventive effect:

chemopreventive-prevent the development of cancer

Chemopreventive studies(hundreds of scientific studies – only first page quoted below- go to link for many more)
Chemopreventive effect of raw and cooked lentils (Lens culinaris L) and soybeans (Glycine max) against azoxymethane-induced aberrant crypt foci.
Nutrition research (New York, N.Y.)Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials.
Current medicinal chemistryFlavones as colorectal cancer chemopreventive agents–phenol-o-methylation enhances efficacy.
Cancer prevention research (Philadelphia, Pa.)Mechanisms of cancer chemopreventive agents: a perspective.
Planta medica

APC10.1 cells as a model for assessing the efficacy of potential chemopreventive agents in the Apc(Min) mouse model in vivo.
European journal of cancer (Oxford, England : 1990)

Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol.

Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.
Investigational new drugs

The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer.

Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity.
Toxicology and applied pharmacology

The selenium analog of the chemopreventive compound S,S’-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer.
Chemico-biological interactions

Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death.

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals.
Planta medica

Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.
Chinese medicine

Induction of cytochromes P450 in small intestine by chemopreventive compounds.
Neuro endocrinology letters

Chemopreventive effects of natural dietary compounds on cancer development.
Chemical Society reviews

Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

Chemopreventive Effect of Curcuma longa Linn on Liver Pathology in HBx Transgenic Mice.
Integrative cancer therapies

Clove (Syzygium aromaticum L.), a potential chemopreventive agent for lung cancer.

Identification, synthesis, and enzymology of non-natural glucosinolate chemopreventive candidates.
Chembiochem : a European journal of chemical biology

Chemopreventive effects of honokiol on UVB-induced skin cancer development.
Anticancer research

Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells.
Molecular carcinogenesis

Chemopreventive Properties and Molecular Mechanisms of the Bioactive Compounds in Hibiscus Sabdariffa Linne.
Current medicinal chemistry

Chemopreventive and antioxidant efficacy of (6)-paradol in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis.
Pharmacological reports : PR

Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie

The chemopreventive effects of Carpesium abrotanoides are mediated by induction of phase II detoxification enzymes and apoptosis in human colorectal cancer cells.
Journal of medicinal food

Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice.
Cancer prevention research (Philadelphia, Pa.)

Chemopreventive effects of fermented brown rice and rice bran against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice.
Oncology reports

Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin.
Nutrition and cancer

Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease.
Clinical cancer research : an official journal of the American Association for Cancer Research

Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: a long-term experiment.
Phytotherapy research : PTR

Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent.
Journal of agricultural and food chemistry

Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents.
Planta medica

Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products.
The Journal of nutrition

Antioxidant and chemopreventive properties of polyphenolic compounds derived from Greek legume plant extracts.
Journal of agricultural and food chemistry

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Hundreds of studies about NATURAL substances with DEMONSTRATED Chemotherapeutic effect:

Chemotherapeutic-selectively destructive to malignant cells
Chemotherapeutic agents in low noncytotoxic concentrations increase immunogenicity of human colon cancer cells.
Cellular oncologyResveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents.
Laboratory investigation; a journal of technical methods and pathologyAn anti-transferrin receptor antibody enhanced the growth inhibitory effects of chemotherapeutic drugs on human non-hematopoietic tumor cells.
International immunopharmacologyMechanisms of chemotherapeutic drug resistance in cancer therapy–a quick review.
Taiwanese journal of obstetrics & gynecology

Subcutaneous wash-out procedure (SWOP) for the treatment of chemotherapeutic extravasations.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Dynamics of Ku80 in living hamster cells with DNA double-strand breaks induced by chemotherapeutic drugs.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science

Low-dose chemotherapeutic agents regulate small Rho GTPase activity in dendritic cells.
Journal of immunotherapy (Hagerstown, Md. : 1997)

The effect of chemotherapeutic agents on contaminated titanium surfaces: a systematic review.
Clinical oral implants research

[Correlation between the expression of PCDGF in serum and the chemotherapeutic sensitivity in NSCLC].
Zhonghua zhong liu za zhi [Chinese journal of oncology]

The effects of environmental low-dose irradiation on tolerance to chemotherapeutic agents.
Environmental toxicology and chemistry / SETAC

Augmentation of Chemotherapeutic Infusion Effect by TSU-68, an Oral Targeted Antiangiogenic Agent, in a Rabbit VX2 Liver Tumor Model.
Cardiovascular and interventional radiology

Small interfering RNA targeting 14-3-3? increases efficacy of chemotherapeutic agents in head and neck cancer cells.
Molecular cancer therapeutics

Modification of 2-deoxy-D-glucose on radiation-and chemotherapeutic drug-induced chromosomal aberrations.
Journal of cancer research and therapeutics

The value of new chemotherapeutic agents for metastatic colorectal cancer.
Archives of internal medicine

Immediate type hypersensitivity to chemotherapeutic agents in pediatric patients.
Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand

Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation.
Cancer letters

C60(Nd) nanoparticles enhance chemotherapeutic susceptibility of cancer cells by modulation of autophagy.

The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs.
Leukemia & lymphoma

[Synergistic effects and mechanisms of combined tumor necrosis factor-related apoptosis-inducing ligand and chemotherapeutic drugs or radiotherapy in killing laryngeal squamous carcinoma cells in vitro].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin.
Molecular cancer therapeutics

Aminopyrimidinimino isatin analogues: design of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques

Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs.
Annals of the New York Academy of Sciences

Additive cytotoxic effect of apoptin and chemotherapeutic agents paclitaxel and etoposide on human tumour cells.
Basic & clinical pharmacology & toxicology

[A meta-analysis of the curative effects of carboplatin-based and cisplatin-based chemotherapeutic regimens on advance non-small cell lung cancer].
Zhonghua yi xue za zhi

Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

Expression of Daxx sensitizes Jurkat T-cells to the apoptosis-inducing effect of chemotherapeutic agents.
Pharmacological research : the official journal of the Italian Pharmacological Society

Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation.
International journal of cancer. Journal international du cancer

Can serum cystatin C reflect the glomerular filtration rate accurately in pediatric patients under chemotherapeutic treatment? A comparative study with Tc-99m DTPA two-plasma sample method.
Nuclear medicine communications

The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo.
Cancer chemotherapy and pharmacology

miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines.
Acta biochimica et biophysica Sinica

Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid.
Cell death & disease

Chemotherapeutic drugs inhibit ribosome biogenesis at various levels.
The Journal of biological chemistry

An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer.
PloS one

Pharmacology and pharmacogenetics of chemotherapeutic agents.
Cancer investigation

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Phyto medicines with a Bio-Chemo-Therapy action:

Plants which have a “suicide affect” on Cancer.

Fresh plants contain thousands of vitamins which are able to activate our immune system against germs, viruses or tumour cells, or even to induce apoptosis (cell suicide or programmed cell death –SEE note) in tumour cells.


As known to Ayurvedic Indian Medicine for thousands of years, patients affected by malignant tumours must never take plant SPROUTS, as they usually contain ALL 9 ESSENTIAL AMINO ACIDS, FOLIC ACID and Vitamin B12, a fact that WESTERN MEDICINE also discovered recently.

The plant with anti-cancer properties (apoptosis and/or immunostimulation) must not damage human organs or tissues and must therefore be eaten fresh, as a real PHYTOTHERAPIC PRODUCT.

In many cases, it can also be taken in the form of INFUSION (TEA or DECOCTION), with or without the addition of other substances, for example alcoholic ones, according to EXPERTS’ prescriptions.

It is generally advisable to eat raw fresh plants that kill cancer cells with the addition of honey(to make them 15-17 times more efficient), provided that they have no toxic side effects, as for example the Salvia species, which must be taken in the form of TEA in order to eliminate the very dangerous Thujone

ORGANIC RAW HONEY is also  important because it protects the precious vitamins from air oxidation and gastric juices and allows them to be absorbed by patients’ intestinal walls. Furthermore, honey is a powerful antiseptic preventing germs from destroying vitamins. Several types of honey also have  real healing properties as they are obtained from flowers of medicinal plants.

Amounts of vitamins needed to induce apoptosis in a certain number of tumour cells in the laboratory without damaging healthy human cells are really very small.

The following is a report of several scientific studies showing the actual ability of these vitamins to induce cell suicide in various tumours. Amounts needed are measurable in a few dozens of micromoles/litre, i.e. picomoles/microlitres.

For apoptosis-inducing vitamins – Tatman’s fundamental scientific study is higly recommended. His book lists about 180 different isoprenoids (Tatman H., Cancer Letters 175, 2002, pp. 129-139).

The following is a collection of significant scientific papers which can help doctors choose the most  suitable plants for healing each malignant tumour

The papers, almost all of them available in PDF format, can be found in the scientific literature and indicate the amounts of vitamins which are needed to induce APOPTOSIS in the cancerous cell line considered. The amounts are measurable in micromoles, i.e. micromoles/litre, i.e. nanomoles/millilitre, i.e picomoles/microlitre.The studies generally demonstrate that these plants almost never have side effects on healthy cells.

PLEASE NOTE: Reading the articles will make it clear that the amounts of vitamins needed to induce APOPTOSIS can change depending on tissular Ph, on oxygen quantity and above all on the time they remain in the tumour…

 Aloe arborescens, maybe the most famous plant among those currently studied, contains Emodin, a fluorescent anthraquinone inducing a selective apoptosis only in tumour cells.

Please find three PDFs attached at the end of this work, including Palù G.: Aloe-Emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors, Cancer Research, 60, pp. 2800-2804, 2000. [PDF  ]



 By apoptosis we mean the activation of specific endonuclease which break up DNA, acting at the level of the nucleosomic sites which make up the primary structural unit of the nuclear chromatin of the cell. The induction molecules, in general deriving from plants (phyto-chemical), induce apoptosis in neoplastic cells, by activating proteolytic intracellular enzymes, which cause the deterioration by proteolysis of the vital sequence of the DNA, thus causing the death of the cell through apoptosis. In anti-neoplastic therapy these molecules have to reactivate the suicide command in the tumor cells, without causing damage to the healthy cells. Initial clinical experience has already found in Emodine, contained in Aloe, a good example of a particularly selective  molecule for certain types of human tumor, like vitamins A, D and E.

The deliberate attempt on the part of companies producing GMO to deactivate (with Fortilin, Bcl-2, Bcl-xl) this precious natural mechanism contained in plants is very serious. This phenomenon of blocking apoptosis (anti-apoptosis action), already introduced experimentally into tobacco plants by means of a virus (748,751), is according to the author a deliberate act of damage inflicted on the ecosystem by GMO: a damage which, if it is propagated to plants commonly used in the food chain, could render the cure of tumors and other serious illnesses completely impossible using the method proposed in this study.



There are also vegetable substances (and perhaps even, by means of chemical synthesis, of pharmaceutical origin) which have the ability to be absorbed by membrane molecules exclusively present in certain human tumor cells, and therefore introduced to the inside of the diseased cell.

Since all cellular membranes have the same structure, these molecules also become absorbed at the level of the lysosomial membrane, damaging it. De Duve (84) had defined lysosomes as “suicide vesicles”, and, if their membrane is damaged by toxic agents, it becomes permeable to enzymes contained in it, which thus digest the cell itself. This phenomenon is partly reminiscent of apoptosis: in practice, a cellular suicide induced by enzymes present in the DNA itself of the cell, that is to say, the activation of specific endonucleases which break up the DNA, acting at the level of nucleosomic sites which make up the primary structural unit of the nuclear chromatin of the cell (SEE also:Emodine-Aloe). But, in this case, they are extraneous molecules which interfere with the integrity of the membrane of the lysosomes, and not with the DNA structure, as for example in the case of the berries of Pittosporum tobira and Chamerops excelsa (84).


 Another form of apoptosis was discovered by a Japanese study in the case of neuroblastomas, which tend to regress when a certain amount of H-Ras protein has accumulated in cells (1042-43)

It probably occurs also in the case of glioblastomas (astrocytomas of III or IV degree of malignancy). It was observed that this kind of tumour regressed in human beings after administering plant extracts inducing the production of the same vitamin (H-Ras) in glioblastomas.(1173)

In the case of brain tumours, Morinda citrifolia extracts are particularly important (1043). which induced RAS expression and caspase-independent Neuroblastoma cell death.

Other plants such as Hypericum perforatumMelissa officinalisMomordica carantia, Betula alba,Yucca schidigera (1118and Gardenia species are currently being studied (1061),%20contenuto%20nel%20frutto%20di%20Gardenia,%20fa%20suicidare%20cellule%20del%20tumore%20del%20cervello.pdf.

Alpha-Bisabolol, a sesquiterpene alcohol in Chamomile (Matricaria chamomilla) essential oil, could be considered as a promising inducer of apoptosis in highly malignant glioma cells (1568)

A significant effect on the treatment of glioma was reported using Elemene which is found in small amounts in many essential oils: it prolonged quality survival time of 40 patients with glioma (1574)

(Tan P.: Clinical study on treatment of 40 cases of malignant brain tumor by Elemene emulsion injection, Chin. J.

Integ. Trad. Western Med, 20, pp.: 645-648, 2000)

Note: Morinda citrifolia is inhibition of angiogenic initiation and disruption of newly established human vasculary vesels (1172).

The term Pseudo-Apoptosis, may better differentiate this mechanism from Apoptosis proper, as described above.


One particular aspect concerns medicines, phyto-medicines, vitamin substances or minerals, or of other types, which have a selective anti-tumoral action on cancer cells alone, by means of inducing apoptosis or pseudo-apoptosis like (from:

The cruciferous vegetables (809)

Glucosinolates (1137)

Volatile isoprenoid constituents of fruit, vegetables and herbs, for leukaemia and melanoma (1141)

Bioflavonoids for Leukaemia (1130)

Baicalin and Baicalein (718, 1563,1564).

Quercetin for Leukaemia (1146, 1561)

Quercetin for oral cancer (1370)

Quercetin for oesophageal adenocarcinoma (1560) and colonrectal cancer (1562)

Limonene induces the formation of apoptotic bodies on BCG-823 gastric cancer cells in a dose-and time –dependent manner (1565) and induced significant reductions of hepatocellular carcinomas (1566).

Limonene showed anti-angiogenic and pro-apoptotic effects on human gastric cancer implanted in nude mice, thus inhibiting tumor growth and metastasis (1577).

Essential oil of lemon balm (Melissa officinalis) was found to be effective against a series of human cancer cell lines (1567).


Artemisia annua induced apoptosis of hepatocarcinoma (Li Y.: Induction of apoptosis of cultured hepatocarcinoma cell by essential oil of Artemisia annua (1569)

Eucalyptol (Eucalyptus globulesElettaria cardamomum) on human leukaemia HL-60 cells showed induction of apoptosis (1570)

The essential oil of Melaleuca alternifolia and its major monoterpene alcohol (terpinen 4-ol) were able to induce caspase – dependent apoptosis in human melanoma cells (1571).

The essential oil of Tetraclinis articulate (conifer tree) showed the hallmarks of apoptosis when tested on a number of human cancer cell lines including melanoma, breast and ovarian cancer in addition to peripheral blood lymphocytes (1572)

 Cudrania tricuspidata induces apoptosis in human leukaemia (1573)

Pomegranate seed oil (Punica granatum) contains a coniugated trienoic fatty acid as a principal ingredient, which can induce apoptosis in several cancer cell (1576)

Alisma plantago acquatica induces apoptosis in human acute lymphoblastic leukaemia and human fibrosarcoma (1559-1600)

Ellipticine of Ochrosia elliptica for breast cancer (1135)

Carnosic acid (712).

Diosmin (as Tribulus terrestris) induce apoptosis on osteosarcoma (1134)’OSTEOSARCOMA.pdf

Betulinic acid for melanoma, neuroblastoma, leukaemia, malignant brain-tumors (1036-1041,1127,1128,1166, 1603)


Mimosa species (1142)

The berries of Pittosporum tobira and Chamerops excelsa (84).

Emodine-Aloe (333,487,715)

Flavonoids (1122)

Catechin (1123,1186),

Vitamins A, D and E

Citrus limonum (693)

Allium sativum (694,696,1369)

Rosmarinus officinalis (1062).

Sutherlandia frutescens (1147)

 Uncaria tomentosa and Uncaria guianensis (714, 1606)

Acacetin (1165)

Two bioflavonoids (Apigenin and Quercetin) inhibit metastatic potential of melanoma (1609)

The metanolic extract of the flowers of Hypericum perforatumVaccinium vitis idaea, Bacopamonnieri (640),

Various flavenoids (Wagonin, Fisetin) for human hepatic-carcinoma (713).

 Capsicum frutescens, fasciculatum or annuum on leukaemia and prostate cancer (1351,1598)

Curcumina induce apoptosis in lung cancer (1133)

It’s in Curcuma longa and Curcuma zedoaria , currently under experiment in vitro only on leukaemia [690], but already mentioned by Castore Durante even in 1617; inhibition of metastases (1161).

Many other plants, still being studied to verify their possible toxicity according to dosage, such as:

halictrum acutifolium for lung cancer (711).

Sophora flavescens for leukaemia (716)

Hibiscus sabdaiffa, experimented in vitro only on human leukaemia (692),

Ursolic acid(700)

Altholactone induced apoptosis on leukaemia (1125 )

Elemene (Curcuma zedoaria and another plants), induced apoptosis in leukaemia (1409).

Organic Germanium on lung cancer (269)

Carotenoids induced apoptosis in prostate cancer (1366)

Cianidine 3Glucoside and Peonidine 3-Glucoside induced apoptosis on cancer (1368)

Flavonoids and Isoflavonoids (1129)

Alkaloides of Gelsemium sempervirens induced apoptosis on liver cancer (699)

Essential oils of plants induced apoptosis on cancer and leukaemia ( 1371)

Manganese Superoxide Dismutasis induced apoptosis on mesotelioma (1365)

Curcumina and Quercitina induced apoptosis on adenoma (1410)’intestino.pdf

Curcumina and Isothiocyanates (PEITC) induced apoptosis on prostate cancer (1352)

Pereskia bleo for breast cancer (1144)

Panax ginseng (1170,1171)

Resveratrol (1162) in the Polygonum cuspidatumVitis vinifera and in Yucca schidigera (1118) whichis characterized by its apoptotic activity p53-dependent on Melanoma, by depolarizing

mitochondrial membranes (activating Caspase-9 ) in Acute Leukaemia (1121,1148,1605), in the Breast cancer (1608) and also its anti-angiogenese properties (695)

Gordonia axillaris, tested on human tumors (698)

The rhizome of Atractylodes ovata tested on leukaemia (704).

Solanum lyratum for cancer of the liver (705)

Lepidozamia peroffskyana (1044).

Boswellia carterii tested on leukaemia (704).

Drinaria fortunei which has proven effective against human osteoclast (717), and according to the

author should be tried on osteolithic bone metastasis or Multiple Myeloma.

Phyllanthus urinaria against lung cancer (720)

Salvia miltiorrhiza is still being evaluated for its possible toxic effects (Tujone), but apoptosis on

epatocarcinoma (708,1115,1116)

and Leukaemia (1575)

Camellia sinensis (173,1123,1124, 1159, 1160,1164,1186)

Tartary buckwheat flavonoid activates caspase 3 and induces apoptosis in cancer (1064).

Zingiber officinale (6-paradol) activates caspase 3 (1143)

Sesquiterpene lactone parthenolide, the principal active component in medicinal plants (es.:

Tanacetum parthenium), induced apoptosis in toumors, depletion of Glutathione, generation of

reactive oxygen species, activation of Caspases 7,8,9, overexpression of GADD153, an anticanceragent inducibile gene, and subsequent apoptotic cell death. (701)

Goniothalamin of Goniothalamus species (1138,1139)

Boswellic acid induces apoptosis in metastatic melanoma and fibrosarcoma (1131)

Citrus species induced apoptosis in cancer, with beta Cryptoxanthin and Hesperidin (1063)

In Calabria (Italy) Citrus aurantium bergamia (Bergamot orange) is being cultivated.

In the following work, many food plants included in the diet of several people and having

advantageous medical properties are reported (1149-1153).

Spinaches also have effects on papillomas (1154)

Equally important is organic Selenium (1155)

Alpinia oxyphylla (Zingiberaceae) in human promielocytic leukaemia (1156)

Another process of apoptosis induced by woodfordin I in human leukaemia K562 cells (1157)

Chlorophyllin and chlorophyll are modulation of apoptosis (1158)

Pentacyclic triterpenes from Chrysobalanaceae species have cytotoxicity on leukaemia (1167).

Inhibition of human breast cancer growth by Genistein (1168)

Several major ingredients of Chinese herbal medicines are under study in human hepatoma (1169).

Even alcohol perillico induces apoptosis of tumors, cancers that both leukemias (1556-1559)

Even the root extract of Solanum dulcamara has been shown to cause apoptosis in prostate cancer and its metastases (1655)

Among the many Indoles, is to remember the glucobrassicin, contained in the Brassicaceae, which determines apoptosis in breast cancer. In particular, it is contained in Isatis dyeing (1656)

Many other plants exist, and have been collected in particular extracts for therapeutic use, not only as plants with potential apoptotic and pseudo apoptotic use but also as immune stimulating plants (chap.9) and/or with an anti-oxidative action

On the basis of recent discoveries about the apoptotic induction of the seeds of Momordica charantia (639), particular interest is currently being shown to the seeds of other plants such as Helianthus annuus (sunflower); Citrus paradisi (grapefruit); Cucumis melo (melon); Cucumis sativus (cucumber); Citrullus vulgaris (water melon, red melon); Solanum lycopersicum (tomato); Solanum melongena (aubergine/eggplant); Rubus idaeus (raspberry); Actinidia chinensis (kiwi);Citrus aurantium (orange) and Vitis vinifera. 

A matter of grave concern is that large GMO seed firms are putting on the global agricultural market fruits with no seeds inside, in particular the following: Cucumis meloCitrus limonumCitrullus vulgarisSolanum lycopersicumVitis vinifera.

Seeds are deemed significant anti-cancer agents essentially because they contain the well-known vitamin B17.

Another modifications are: GMO-Brassica rapa (turnip, 968), GMO-Brassica oleracea botrytis (cauliflower,968), Prunus domestica (1013), Citrus paradisi (1014),etc….

Pueraria species induced apoptosis on human toumors for the contents of Antocyanin (apoptosis on toumors) but the contents of Antocyanin of the Pueraria GMO were dramatically decreased by 40% (1119)

Other hundreds of studies about NATURAL substances with DEMONSTRATED APOPTOTIC effect:
[Evaluation of morphologically determined apoptotic index].
Acta medica Croatica : c?asopis Hravatske akademije medicinskih znanosti
Apoptotic cell-mediated immunoregulation of dendritic cells does not require iC3b opsonization.
Journal of immunology (Baltimore, Md. : 1950)Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.
NaturePhagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax.

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research

Gene expression in mouse preimplantation embryos affected by apoptotic inductor actinomycin D.
The Journal of reproduction and development

Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?
Arthritis research & therapy

Anti-apoptotic Bcl-XL protein in complex with BH3 peptides of pro-apoptotic Bak, Bad, and Bim proteins: comparative molecular dynamics simulations.

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells.
Journal of immunology (Baltimore, Md. : 1950)

IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)

Effect of hypoxia on expression of apoptotic proteins in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets: the role of nuclear Ca++ -influx.
Neurochemical research

Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)

Apoptotic cell death is initiated during normothermic ischemia in human kidneys.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

A deficiency in the in vivo clearance of apoptotic cells is a feature of the NOD mouse.
Journal of autoimmunity

Cuts can kill: the roles of apoptotic nucleases in cell death and animal development.

Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies.
The Journal of clinical investigation

Apoptotic lymphocytes treated with IgG from Trypanosoma cruzi infection increase TNF-alpha secretion and reduce parasite replication in macrophages.
European journal of immunology

N-acetylcysteine inhibits RhoA and promotes apoptotic cell clearance during intense lung inflammation.
American journal of respiratory and critical care medicine

Human oral cancers have altered expression of Bcl-2 family members and increased expression of the anti-apoptotic splice variant of Mcl-1.
The Journal of pathology

Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin.
PloS one

C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)

The role of nucleotides in apoptotic cell clearance: implications for disease pathogenesis.
Journal of molecular medicine (Berlin, Germany)

HIPK2 modulates p53 activity towards pro-apoptotic transcription.
Molecular cancer

Different immunophenotypical apoptotic profiles characterise megakaryocytes of essential thrombocythaemia and primary myelofibrosis.
Journal of clinical pathology

Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling.
Current biology : CB

TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation.
American journal of physiology. Lung cellular and molecular physiology

Clearance of apoptotic neutrophils is diminished in cord blood monocytes and does not lead to reduced IL-8 production.
Pediatric research

An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response.
Cell death and differentiation

Apoptotic cells protect mice against lipopolysaccharide-induced shock.
Journal of immunology (Baltimore, Md. : 1950)

Cigarette Smoke Inhibits Engulfment of Apoptotic Cells by Macrophages through Inhibition of Actin Rearrangement.
American journal of respiratory cell and molecular biology

Ro 60 functions as a receptor for beta(2)-glycoprotein I on apoptotic cells.
Arthritis and rheumatism

Anti-apoptotic genes in the survival of monocytic cells during infection.
Current genomics

Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase.
Journal of cell science

Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells.
Journal of pineal research

Next Page »

Scientific studies on Antiproliferative

Scientific studies on Anti-Angiogenic

Immune therapy

Immune therapy is the immune response against tumors, carried out by means of gamma delta T

Lymphocytes, cytotoxic T Lymphocytes, killer lymphocytes and Natural Killers, real guide systems of a complete immune response of the patient against the tumor itself (start of the Immune Cascade).

There are different scientific studies on this subject:

JAMA, 278: 1972-1981, 1997; Crit. Rev. Oncol.-Hematol, 22, pp.: 213-228, 1996;

Semin. immunol., 8, pp. 295-302, 1996; Sem. Oncol., 23, pp.: 101-107, 1996;

Springer Semin. Immunopath. 18, pp.: 185-198, 1996; Cancer Met Rev., 15, pp:329-349, 1996;

Ann. Rev. Immunol., 12, pp.: 337-365, 1994; Adv Immunol. 35, pp.: 89-122, 1984.

Brain cancer : J. Neurosurgery 77, pp 757-762, 1992;

Cellular Immunology, 178, pp: 101-107, 1997; J. Neuro- Oncology, 32, pp.: 29-38, 1997.

Breast cancer : Cancer Gene Therapy, 4, pp.: 157-166, 1997; Surgery, 122, pp.: 228-234, 1997.

Per tumori del Colon: Blood 89, pp: 2529-2536, 1997;

Leukaemia: Progress Cancer Research and Therapeutics, 22, pp: 127-133, 1982;

Liver cancer: J. Immunology, 161, pp.: 5133-5137, 1998;

Lung cancer: Blood 89, pp.: 2529-2536, 1997; J. Immunology 147, pp: 729-737, 1991; J. Immunology 143, pp.:740-748, 1989.

Melanoma: Cancer Immunology, Immunotherapy, 42, pp.: 237-245, 1996; J. Immunotherapy, 13, pp.: 153-165, 1993.

The Immune Cascade, induced to fight the tumor, is carried out by means of the use of phytotherapy (plant therapy), because it is considered safer compared to the complex methodology of extracting Lymphocytes from the tumor, cultivating them in a sterile environment, and then reinjecting them, intravenously, into the patient, as Rosemburg and other authors [see: Pizza

Giancarlo: Immunotherapy of metastatic kidney cancer, Int. J. Cancer, 94, pp.109-120, 2001]).

There have been many studies carried out on the search for natural substances which have an antineoplastic immune-modulating action (9, 11, 32, 44, 50, 53, 61, 67, 82, 105, 126, 132, 144, 145, 146, 180, 196, 198, 225, 236, 278, 279, 306, 310, 319, 331, 346, 351, 359, 368, 372-381, 387, 388, 394, 395, 406, 412, 418, 419, 430, 444, 456, 462, 472, 474, 500, 516, 517, 520, 577). (see last page of darabase  for regerences)

The majority of tumoral antigen markers, which were well thought of during the 1980s as specific tumoral antigens, are in fact differentiating antigens, that is, antigens which appear along the maturing lines of the cell as embryonal antigens.

Not all tumoral cells express the same antigens at the same time and irrespective of the cellular cycle, it is thought that these antigens can cause a weak cytotoxic reaction mediated by the lymphocytes, perhaps because of carbohydrate structures screening the protein structures, which are the real determining antigens;(507).

The activation of the T lymphocyte suppressors is caused by the weak immune response to the

tumor: in the case, that is, of a spontaneously arising tumor, the presence at the beginning of a low number of cells favors rather than inhibits its growth by means of a mechanism mediated by the T suppressors.

It is still much debated whether the regional lymph nodes form an immune or even only a mechanic barrier to the spread of the metastasis.

The lymph nodes next to the tumor often do not contain tumoral cells but they show a hyper-plastic reaction which suggests the existence of a reaction of the host against the tumor or its derivatives.

The theory has also been proposed that the lymph nodes have a limited capacity to eliminate neoplastic cells.

It is thought that the limit of this action is exactly connected to the number of malignant cells which reach the lymph node, a value which has to be less than 500-1.000 cells to avoid the onset of a metastasis.

The destruction of metastasizing cells is started, above all, by the histiocyte macrophages of the breasts with a hyper-plastic reaction of these, which is then followed by an active infiltration of the tumoral micro-metastasis caused by cytotoxic T lymphocytes and Natural-Killers (NK) (507).

These are thought to have a spontaneous reactivity against both primary and metastasis cancerous  cells, without any manifestation of histocompatability or of specific types for the function of the interaction of the cells.

Rats with a low level of NK, if treated with Beta-estradiol increase their NK quite significantly,with significant reductions in the number of metastases(507).

Even the neutrophils of peripheral human blood have been shown, in vitro, capable of inhibiting the growth of cancerous cells of either human or murine origin, with a strength ratio of 40 to1 between effector cells and neo-plastic cells; and always if the latter are covered by antibodies (507).

Macrophage-Monocytes show cytotoxity of a phagocytic type on neo-plastic cells even in the absence of precise stimulation; their cytotoxity is thought to occur by means of a bond, favored by the receptor for the FC portion of the antibody and of the complement, to the antigen target covered by antibodies with a strength ratio of 1 to 1, after which the cells may be destroyed (507).

Recently, there has also been notable interest regarding T Lymphocytes, which might be activated  by particular substances, such as lecithin, which is contained in Aloe for example (499).

The following plants might also be useful, because they are forerunners of Prostaglandin and therefore they assist in the Immune Cascade: oil of Borrago officinalis (Borragine [note; eliminate  the fine down which covers it]); oil of Oenothera biensis (Enotera); the leaves of Nelumbium speciosum (Kamala), which contain two essential unsaturated fatty acids (vitamin F): gammalinolenic acid and linolenic acid: the two acids cis-linolenic and gamma linolenic introduce a number of essential fatty acids into the human biochemical complex; then, the delta 6 desaturated block is overcome through gamma-linolenic acid (GLA) encouraging the production of Protaglandin and so setting off the first phase of the Immune Cascade.

The immune response to the tumor is fully demonstrated by the use of other phytotherapeutic

substances(621,773,793,794) such as extract of Viscum album (Mistletoe) and above all by a variety of

combinations of European, Asian, American, Australian and African herbs, or by using them

individually: Echinacea purpureaAstragalus membranaceusPanax ginsengRhodiola rosea,

Morinda citrifoliaCampanula latifoliaTribulus terrestrisUncaria tomentosaSida cordifolia,

Arctium lappaRumex acetosaRumex crispusBacopa monnieriRheum palmatum or officinale,

Trifolium pratensaeCalendula officinalisAchillea filipendulinaUrtica dioicaAcalypha indicaTaraxacum officinaleMalva silvestris or vulgarisEpilobium angustifolium or parviflorumArtemisia abrotanum or dracunculus, Salvia officinalis or lavandulifoliaEquisetum arvense Crocus sativusPolygala senegaThymus vulgarisCitrullus colocynthis, Primula veris or officinalisAilanthus glandulosaThymus serpillumSysymbrium officinaleAquilaria agallochaEclipta albaLarrea mexicanaViola tricolorDrosera rotundifolia or anglica, or intermediaArgemone mexicanaSambucus nigraSmilax sarsaparilla or utilitisMyrica ceriferaRosmarinus officinalisCinnamomum zeylanicumAdiantum capillus venerisLuffa operculataTephorosia purpureaNepeta catariaMomordica charantiaTrigonella foenum graecumVerbascum thapsus or densiflorumSerenoa repensSempervivum montanumAjuga reptans or piramidalisGnafalium supinumCitrus aurantium bergamiaDraba aizoidesHieracium pilosellaCicerbita alpinaHypericum richeriAngelica archangelicaLeucanthemopsis alpinaPrimula hirsutaSaxifraga oppositifoliaCerastium alpinumCirsium spinosissimumPedicularis rostrato-capitataPotentilla grandifloraAnnona squamosaGentiana germanicaSaxifraga aizoidesAntennaria dioicaArgyreia speciosa (o Lettsomia nervosa), Moringa pterygospermaAntyllis alpestrisHypoxishemerocallideaEupatorium perfoliatum or purpureumEuspongia officinalisGlycyrrhiza glabraLycopodium clavatumGalphimia glaucaAlbizzia lebbekSticta pulmonaria or Lobaria pulmonariaHolarrhena antidysentericaSutherlandia frutescensChimaphila umbellataMyristica fragrans or sebiferaGrindelia camporum or squarrosaAlthaea officinalisGuajacum officinalis,Boswellia serrataMyroxylon balsamumErithrea antauriumPulmonaria officinalis or angustifoliaPeucedanum ostruthiumBambusa arundinaceaOcimum basilicumsanctum or tenuiflorumCeanothus americanusCassia angustifoliaCentaurea erythreumRhamnus sagrada or purshianaAralia racemosaRhamnus frangula (or Frangula alnus), Curcuma longaTerminalia chebulaLepidium meyeniiMahonia aquifoliumStachys arvensisAbuta grandifoliaPolygonum

aviculareAilantus glandulosaGeranium robertianumMarasdenia cundurangoMelissa monarda or officinalisAlchimilla alpina or vulgarisAsparagus racemosusApium graveolensLamium albumPimpinella majorLysimachia nummulariaMarrubium vulgareAcorus calamus, Galium aparine, Lapsana communisGlechoma hederaceumMyrtus communisCinchona calisaya or succirubraMeum mutellinaPicramnia antidesmaAzadirachta indicaAchyrocline satureoidesPolypodium lepidopterisAnacardium occidentaleBidens pilosaBixa orellanaCarapa guianensisScutellaria baicalensis latifloraNelumbo nucifera, Boerhaavia diffusaCalendula silvestris, Cassia occidentalisHouttuynia cordata, Cayaponia tayuyaCissampelos pareiraAsparagus cochinensis, Copaifera officinalisCynara scolymusErythrina mulunguErythroxylum catuaba, Ilex paraguariensis, Inesinae caleaLepidium meyeniiMaytenus krukovitMaytenus illicifolia, Myroxylon balsamum or pereiraePfaffia paniculataPhyllantus niruriPhysalis angulata or Muehenbeckia volcanicaPsidium guajavaSchinus molleSolanum paniculatum, and many other (see below)

Other plants with an immune stimulating activity

There are about sixty other immune modulating plants from North America and Europe, with an

action which is partially similar to Aloe Arborescens(see below), seven of which can be included in the composition termed Essiac ( the formula of Renè Caisse see below) which is particularly effective (517, 520,1047- 1060, 1438-1496).

There are also some interesting combinations of about 200 Indian plants and herbs of ancient Vedic,

Chinese tradition (608-609), of Africa and of Sud-America, used today in modern western plant

therapy which has revalued their importance (621,773,793,794).

Abuta grandifolia Acalypha indica Achyrocline satureoides Adiantum capillus veneris Ailanthus glandulosa Althaea officinalis Albizzia lebbek Anacardium occidentale Angelica archangelica Annona squamosa or muricata Apium graveolens  Aralia racemosa Argemone mexicana Argyreia speciosa

Asparagus cochinensis Artemisia abrotanum Artemisia dracunculus Astragalus membranaceus Aquilaria agallocha Bambusa arundinacea Bidens pilosa  Bixa orellana Boerhaavia diffusa Boswellia serrata Calendula silvestis Calendula officinalis Campanula latifolia Carapa guianensis Cassia occidentalis Cassia angustifolia. Cayaponia tayuya Ceanothus americanus. Chimaphila umbellata Cinnamomum zeylanicum Cissampelos pareira Citrus aurantium bergamia Citrullus colocynthis Copaifera officinalis Cynara scolymus Cucurma longa Drosera rotundifolia, or anglica, or intermedia Echinacea purpurea, angustifolia, pallida Eclipta alba Equisetum arvense Epilobium angustifolium Erithrea antaurium Eupatorium perfoliatum Eupatorium purpureum Euspongia officinalis Erythrina mulungu Erythroxylum catuaba Frangula alnus Grindelia camporum or squarrosa Glycyrrhiza glabra Holarrhena antidysenteric Hypoxis hemerocallidea Houttuynia cordata Ilex paraguariensis Inesinae calea Larrea mexicana Lepidium meyenii Lettsomia nervosa Lobaria pulmonaria fraxineuem Lycopodium clavatum Luffa operculata Maytenus krukovit Maytenus illicifolia Myroxylon balsamum aut pereirae  Momordica charantia Moringa pterygosperma Morinda citrifolia Myrica cerifera Myristica fragrans or sebifera Nelumbo nucifera Nepeta cataria Ocimum sanctum or enuiflorum Ocimum basilicum Picramnia antidesma Pfaffia paniculata Phyllantus niruri Physalis angulata aut Muehenbeckia volcanica  Psidium guajava Plantago major Polygala senega Primula veris or officinalis Rhamnus sagrada or purshiana Rhamnus frangula Rhodiola rosea Rosmarinus officinalis Rumex crispus Scutellaria baicalensis o latiflora a Sambucus nigra

Salvia officinalis Schinus molle Serenoa repens Smilax aspera, sarsaparilla or utilitis Solanum paniculatum Sticta pulmonaria Sysymbrium officinale Taraxacum officinalis Terminalia chebula Tephorosia purpurea Thymus vulgaris Thymus serpillumTribulus terrestris Ulmus rubra or fulva Uncaria tomentosa. Urtica dioica Verbascum densiflorum or thapsus  Viola tricolor Xanthoxilum  and others in random order: Acorus calamus Ajuga reptans or piramidalis Alchimilla alpina or vulgaris Azadirachta indica Antennaria dioica Antyllis alpestris Bacopa monnieri Capsella bursa pastoris Cerastium alpinum Centaurea erythreum  Cetraria islandica Cicerbita alpina monogyna Cinchona calisaya or succirubra Crataegus oxyacantha or Draba aizoides Galphimia glauca Galium aparine Gentiana germanica Glechoma hederaceum Gnafalium supinum Hypericum richeri Hieracium pilosella Lamium album Lepidium meyenii Leucanthemopsis alpina graecum Larrea Lapsana communis Lichen islandicus divaricata Lysimachia nummularia Marasdenia Marrubium vulgare balsamum Mahonia aquifolium Melissa monarda or officinalis Melaleuca alternifoglia or Meum mutellina cundurango Myrtus communis Myroxylon Peucedanum ostruthium Pedicularis rostrato-capitata Pimpinella major Polygonum aviculare Potentilla grandiflora Primula hirsuta Pulmonaria officinalis Pulmonaria angustifolia Stachys arvensis Sutherlandia frutescens  Tabebuia impetiginosa Trigonella foenum Sempervivum montanum Saxifraga oppositifolia Saxifraga aizoides 

For studies referred  above see last page for the bibliography with over 1600 scientific papers quoted in the book studies.


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