APOPTOSIS

CLICK AICI pentru limba ROmana(traducerea “aproximativa” utilizand google translate).

Phyto medicines with a Bio-Chemo-Therapy action:

Plants which have a “suicide affect” on Cancer.

Fresh plants contain thousands of vitamins which are able to activate our immune system against germs, viruses or tumour cells, or even to induce apoptosis (cell suicide or programmed cell death –SEE note) in tumour cells.

PLEASE NOTE:

As known to Ayurvedic Indian Medicine for thousands of years, patients affected by malignant tumours must never take plant SPROUTS, as they usually contain ALL 9 ESSENTIAL AMINO ACIDS, FOLIC ACID and Vitamin B12, a fact that WESTERN MEDICINE also discovered recently.

The plant with anti-cancer properties (apoptosis and/or immunostimulation) must not damage human organs or tissues and must therefore be eaten fresh, as a real PHYTOTHERAPIC PRODUCT.

In many cases, it can also be taken in the form of INFUSION (TEA or DECOCTION), with or without the addition of other substances, for example alcoholic ones, according to EXPERTS’ prescriptions.

It is generally advisable to eat raw fresh plants that kill cancer cells with the addition of honey(to make them 15-17 times more efficient), provided that they have no toxic side effects, as for example the Salvia species, which must be taken in the form of TEA in order to eliminate the very dangerous Thujone

ORGANIC RAW HONEY is also important because it protects the precious vitamins from air oxidation and gastric juices and allows them to be absorbed by patients’ intestinal walls. Furthermore, honey is a powerful antiseptic preventing germs from destroying vitamins. Several types of honey also have real healing properties as they are obtained from flowers of medicinal plants.

Amounts of vitamins needed to induce apoptosis in a certain number of tumour cells in the laboratory without damaging healthy human cells are really very small.

The following is a report of several scientific studies showing the actual ability of these vitamins to induce cell suicide in various tumours. Amounts needed are measurable in a few dozens of micromoles/litre, i.e. picomoles/microlitres.

For apoptosis-inducing vitamins – Tatman’s fundamental scientific study is higly recommended. His book lists about 180 different isoprenoids (Tatman H., Cancer Letters 175, 2002, pp. 129-139).

http://www.erbeofficinali.org/dati/nacci/studi/TATMAN%20(%20ARTICOLO%SUGLI%20%20ISOPRENOIDI).pdf

The following is a collection of significant scientific papers which can help doctors choose the most suitable plants for healing each malignant tumour http://www.erbeofficinali.org/dati/nacci/allpdf.php

The papers, almost all of them available in PDF format, can be found in the scientific literature and indicate the amounts of vitamins which are needed to induce APOPTOSIS in the cancerous cell line considered. The amounts are measurable in micromoles, i.e. micromoles/litre, i.e. nanomoles/millilitre, i.e picomoles/microlitre.The studies generally demonstrate that these plants almost never have side effects on healthy cells.

PLEASE NOTE: Reading the articles will make it clear that the amounts of vitamins needed to induce APOPTOSIS can change depending on tissular Ph, on oxygen quantity and above all on the time they remain in the tumour…

Aloe arborescens, maybe the most famous plant among those currently studied, contains Emodin, a fluorescent anthraquinone inducing a selective apoptosis only in tumour cells.

Please find three PDFs attached at the end of this work, including Palù G.: Aloe-Emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors, Cancer Research, 60, pp. 2800-2804, 2000. [PDF http://www.erbeofficinali.org/dati/nacci/allpdf.php ]

More details about ALOE ARBORESCENS and a strong (for stage IV cancers ) supplement that can be easily at home from ALOE ARBORESCENS also in my book.

Apoptosis

By apoptosis we mean the activation of specific endonuclease which break up DNA, acting at the level of the nucleosomic sites which make up the primary structural unit of the nuclear chromatin of the cell. The induction molecules, in general deriving from plants (phyto-chemical), induce apoptosis in neoplastic cells, by activating proteolytic intracellular enzymes, which cause the deterioration by proteolysis of the vital sequence of the DNA, thus causing the death of the cell through apoptosis. In anti-neoplastic therapy these molecules have to reactivate the suicide command in the tumor cells, without causing damage to the healthy cells. Initial clinical experience has already found in Emodine, contained in Aloe, a good example of a particularly selective molecule for certain types of human tumor, like vitamins A, D and E.

The deliberate attempt on the part of companies producing GMO to deactivate (with Fortilin, Bcl-2, Bcl-xl) this precious natural mechanism contained in plants is very serious. This phenomenon of blocking apoptosis (anti-apoptosis action), already introduced experimentally into tobacco plants by means of a virus (748,751), is according to the author a deliberate act of damage inflicted on the ecosystem by GMO: a damage which, if it is propagated to plants commonly used in the food chain, could render the cure of tumors and other serious illnesses completely impossible using the method proposed in this study.

Pseudo-Apoptosis

There are also vegetable substances (and perhaps even, by means of chemical synthesis, of pharmaceutical origin) which have the ability to be absorbed by membrane molecules exclusively present in certain human tumor cells, and therefore introduced to the inside of the diseased cell.

Since all cellular membranes have the same structure, these molecules also become absorbed at the level of the lysosomial membrane, damaging it. De Duve (84) had defined lysosomes as “suicide vesicles”, and, if their membrane is damaged by toxic agents, it becomes permeable to enzymes contained in it, which thus digest the cell itself. This phenomenon is partly reminiscent of apoptosis: in practice, a cellular suicide induced by enzymes present in the DNA itself of the cell, that is to say, the activation of specific endonucleases which break up the DNA, acting at the level of nucleosomic sites which make up the primary structural unit of the nuclear chromatin of the cell (SEE also:Emodine-Aloe). But, in this case, they are extraneous molecules which interfere with the integrity of the membrane of the lysosomes, and not with the DNA structure, as for example in the case of the berries of Pittosporum tobira and Chamerops excelsa (84).

Another form of apoptosis was discovered by a Japanese study in the case of neuroblastomas, which tend to regress when a certain amount of H-Ras protein has accumulated in cells (1042-43)

http://www.erbeofficinali.org/dati/nacci/studi/articolo%20sul%20NONU%20(morinda%20citrifolia)%20attiva%20contro%20tumore%20al%20cervello_2.pdf

It probably occurs also in the case of glioblastomas (astrocytomas of III or IV degree of malignancy). It was observed that this kind of tumour regressed in human beings after administering plant extracts inducing the production of the same vitamin (H-Ras) in glioblastomas.(1173)

http://www.erbeofficinali.org/dati/nacci/studi/Suicidio%20di%20cellule%20tumorali%20del%20cervello%20(glioblastomi)%20e%20del%20cancro%20gastrico%20via%20APOPTOSI-INDIPENDENTE.pdf

In the case of brain tumours, Morinda citrifolia extracts are particularly important (1043). which induced RAS expression and caspase-independent Neuroblastoma cell death.

http://www.erbeofficinali.org/dati/nacci/studi/articolo%20sul%20NONU%20(morinda%20citrifolia)%20attiva%20contro%20tumore%20al%20cervello_2.pdf

Other plants such as Hypericum perforatum, Melissa officinalis, Momordica carantia, Betula alba,Yucca schidigera (1118) and Gardenia species are currently being studied (1061)

http://www.erbeofficinali.org/dati/nacci/studi/Geniposide,%20contenuto%20nel%20frutto%20di%20Gardenia,%20fa%20suicidare%20cellule%20del%20tumore%20del%20cervello.pdf.

Alpha-Bisabolol, a sesquiterpene alcohol in Chamomile (Matricaria chamomilla) essential oil, could be considered as a promising inducer of apoptosis in highly malignant glioma cells (1568)

A significant effect on the treatment of glioma was reported using Elemene which is found in small amounts in many essential oils: it prolonged quality survival time of 40 patients with glioma (1574)

(Tan P.: Clinical study on treatment of 40 cases of malignant brain tumor by Elemene emulsion injection, Chin. J.

Integ. Trad. Western Med, 20, pp.: 645-648, 2000) http://www.mednat.org/cancro/cancro_cervello.pdf

Note: Morinda citrifolia is inhibition of angiogenic initiation and disruption of newly established human vasculary vesels (1172).

http://www.erbeofficinali.org/dati/nacci/studi/articolo%20sul%20NONU%20(morinda%20citrifolia)%20attiva%20contro%20tumore%20al%20cervello.pdf

The term Pseudo-Apoptosis, may better differentiate this mechanism from Apoptosis proper, as described above.

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One particular aspect concerns medicines, phyto-medicines, vitamin substances or minerals, or of other types, which have a selective anti-tumoral action on cancer cells alone, by means of inducing apoptosis or pseudo-apoptosis like (from: http://www.erbeofficinali.org/dati/nacci/allpdf.php

The cruciferous vegetables (809)

http://www.erbeofficinali.org/dati/nacci/studi/INDOLI%20e%20ISOTIOCIANATI%20delle%20crucifere%20o%20%20brassicacee.pdf

Glucosinolates (1137) http://www.erbeofficinali.org/dati/nacci/studi/Glucosinolati.pdf

Volatile isoprenoid constituents of fruit, vegetables and herbs, for leukaemia and melanoma (1141)

http://www.erbeofficinali.org/dati/nacci/studi/TATMAN%20(%20ARTICOLO%SUGLI%20%20ISOPRENOIDI).pdf

Bioflavonoids for Leukaemia (1130)http://www.erbeofficinali.org/dati/nacci/studi/azione%20di%20antileucemia%20dei%20bioflavonoidi_2.pdf

Baicalin and Baicalein (718, 1563,1564).

Quercetin for Leukaemia (1146, 1561)

http://www.erbeofficinali.org/dati/nacci/studi/Quercitina%20apoptosi%20su%20LEUCEMIA.pdf

Quercetin for oral cancer (1370) http://www.erbeofficinali.org/dati/nacci/studi/quercetina.pdf

Quercetin for oesophageal adenocarcinoma (1560) and colonrectal cancer (1562)

Limonene induces the formation of apoptotic bodies on BCG-823 gastric cancer cells in a dose-and time –dependent manner (1565) and induced significant reductions of hepatocellular carcinomas (1566).

Limonene showed anti-angiogenic and pro-apoptotic effects on human gastric cancer implanted in nude mice, thus inhibiting tumor growth and metastasis (1577).

Essential oil of lemon balm (Melissa officinalis) was found to be effective against a series of human cancer cell lines (1567).

Artemisia annua induced apoptosis of hepatocarcinoma (Li Y.: Induction of apoptosis of cultured hepatocarcinoma cell by essential oil of Artemisia annua (1569)

Eucalyptol (Eucalyptus globules, Elettaria cardamomum) on human leukaemia HL-60 cells showed induction of apoptosis (1570)

The essential oil of Melaleuca alternifolia and its major monoterpene alcohol (terpinen 4-ol) were able to induce caspase – dependent apoptosis in human melanoma cells (1571).

http://www.erbeofficinali.org/dati/nacci/studi/terpenoide%20di%20olio%20di%20Melaleuca%20alternifolia%20induce%20apoptosi%20su%20MELANOMA.pdf

The essential oil of Tetraclinis articulate (conifer tree) showed the hallmarks of apoptosis when tested on a number of human cancer cell lines including melanoma, breast and ovarian cancer in addition to peripheral blood lymphocytes (1572)

Cudrania tricuspidata induces apoptosis in human leukaemia (1573)

Pomegranate seed oil (Punica granatum) contains a coniugated trienoic fatty acid as a principal ingredient, which can induce apoptosis in several cancer cell (1576)

Alisma plantago acquatica induces apoptosis in human acute lymphoblastic leukaemia and human fibrosarcoma (1559-1600) http://www.erbeofficinali.org/dati/nacci/studi/ALISMA%20PLANTAGO-AQUATICA.pdf

Ellipticine of Ochrosia elliptica for breast cancer (1135)

http://www.erbeofficinali.org/dati/nacci/studi/Ocrosia%20elliptica%20induce%20apoptosi%20su%20cancro%20della%20mammella.pdf

Carnosic acid (712).

Diosmin (as Tribulus terrestris) induce apoptosis on osteosarcoma (1134)

http://www.erbeofficinali.org/dati/nacci/studi/DIOSGENINA%20fa%20suicidare%20cellule%20dell’OSTEOSARCOMA.pdf

Betulinic acid for melanoma, neuroblastoma, leukaemia, malignant brain-tumors (1036-1041,1127,1128,1166, 1603) http://www.erbeofficinali.org/dati/nacci/studi/betulla_1.pdf

http://www.erbeofficinali.org/dati/nacci/studi/betulla_2.pdf http://www.erbeofficinali.org/dati/nacci/studi/betulla_3.pdf

http://www.erbeofficinali.org/dati/nacci/studi/Acido%20betulinico%20induce%20apoptosi%20su%20tumori%20neuroectodermali.pdf

Mimosa species (1142) http://www.erbeofficinali.org/dati/nacci/studi/MIMOSA%20fa%20suicidare%20cellule%20tumorali.pdf

The berries of Pittosporum tobira and Chamerops excelsa (84).

Emodine-Aloe (333,487,715)

http://www.erbeofficinali.org/dati/nacci/allpdf.php

http://www.aloearborescens.tripod.com/studi.htm

Flavonoids (1122)

http://www.erbeofficinali.org/dati/nacci/studi/Flavonoidi%20promettenti%20agenti%20anticancro.pdf

Catechin (1123,1186),

Vitamins A, D and E

Citrus limonum (693)

http://www.erbeofficinali.org/dati/nacci/FLAVONOIDI%20contenuti%20nel%20Limone20%provocano%20APOPTOSI.pdf

Allium sativum (694,696,1369) http://www.erbeofficinali.org/dati/nacci/studi/aglio_provoca_apoptosi_del_cancro_del_polmone.pdf

http://www.erbeofficinali.org/dati/nacci/studi/AGLIO%20provoca%20apoptosi%20in%20cancro%20della%20PROSTATA_2.pdf

http://www.erbeofficinali.org/dati/nacci/studi/aglio%20induce%20apoptosi%20sulla%20leucemia%20mieloide%20cronica.htm

http://www.erbeofficinali.org/dati/nacci/studi/DIFFERENZA%20fra%20ALLINASI%20di%20AGLIO%20FRESCO%20ed%estratto.pdf

Rosmarinus officinalis (1062).

Sutherlandia frutescens (1147) http://www.erbeofficinali.org/dati/nacci/studi/sutherlandia%20frutescens.pdf

Uncaria tomentosa and Uncaria guianensis (714, 1606) http://www.erbeofficinali.org/dati/nacci/studi/Uncaria_species.pdf

http://www.erbeofficinali.org/dati/nacci/studi/Uncaria_species%20azione%20antiproliferativa%20degli%20acidi%20uncarinici%20di%20Uncara.pdf

Acacetin (1165)

http://www.erbeofficinali.org/dati/nacci/studi/ACACETINA%20induce%20APOPTOSI%20su%20cancro%20del%20fegato.pdf

Two bioflavonoids (Apigenin and Quercetin) inhibit metastatic potential of melanoma (1609)

http://www.erbeofficinali.org/dati/nacci/studi/allpdf.php

The metanolic extract of the flowers of Hypericum perforatum, Vaccinium vitis idaea, Bacopamonnieri (640),

Various flavenoids (Wagonin, Fisetin) for human hepatic-carcinoma (713).

Capsicum frutescens, fasciculatum or annuum on leukaemia and prostate cancer (1351,1598)

http://www.erbeofficinali.org/dati/nacci/studi/peperoncino%20efficace%20su%20leucemia.pdf http://www.erbeofficinali.org/dati/nacci/studi/Capsaicina%20(peperoncino)%20induce%20APOPTOSI%20in%20cellule%20del%20cancro%20della%20prostata%20sia%20androgeno-positive%20che%20androgeno-negative.pdf

Curcumina induce apoptosis in lung cancer (1133)

http://www.erbeofficinali.org/dati/nacci/studi/curcuma%20provoca%20APOPTOSI%20(SUICIDIO)%20di%20cellule%20del%20cancro%20del%20polmone.pdf

It’s in Curcuma longa and Curcuma zedoaria , currently under experiment in vitro only on leukaemia [690], but already mentioned by Castore Durante even in 1617; inhibition of metastases (1161).

Many other plants, still being studied to verify their possible toxicity according to dosage, such as:

halictrum acutifolium for lung cancer (711).

Sophora flavescens for leukaemia (716)

http://www.erbeofficinali.org/dati/nacci/studi/Sophora%20flavescens%20induce%20apoptosi%20su%20leucemia.htm

Hibiscus sabdaiffa, experimented in vitro only on human leukaemia (692),

http://www.erbeofficinali.org/dati/nacci/studi/ibisco_induce_apoptosi_su_leucemia_e_retinoblastoma.pdf

Ursolic acid(700)

http://www.erbeofficinali.org/dati/nacci/studi/Acido%20ursolico%20(Asparago)%20induce%20apoptosi.htm

Altholactone induced apoptosis on leukaemia (1125 )

http://www.erbeofficinali.org/dati/nacci/studi/altolactone%20induce%20apoptosi%20su%20leucemia.pdf

Elemene (Curcuma zedoaria and another plants), induced apoptosis in leukaemia (1409).

http://www.erbeofficinali.org/dati/nacci/studi/elemene_zedoaria_provoca_apoptosi_nella_leucemia.pdf

Organic Germanium on lung cancer (269)

http://www.erbeofficinali.org/dati/nacci/studi/Germanium%20132%20un%20caso%20clinico%20di%20cancro%20polmonare.pdf

Carotenoids induced apoptosis in prostate cancer (1366)

http://www.erbeofficinali.org/dati/nacci/studi/carotenoidi%20sono%20fattori%20attivi%20contro%20il%20cancro%20della%20prostata.pdf

Cianidine 3–Glucoside and Peonidine 3-Glucoside induced apoptosis on cancer (1368)

http://www.erbeofficinali.org/dati/nacci/studi/Riso%20indiano%20(CIANIDINE)%20inducono%20APOPTOSI%20su%20cellule%20del%20cancro.pdf

Flavonoids and Isoflavonoids (1129) http://www.erbeofficinali.org/dati/nacci/studi/azione%20di%20antileucemia%20dei%20bioflavonoidi_1.pdf

Alkaloides of Gelsemium sempervirens induced apoptosis on liver cancer (699)

http://www.erbeofficinali.org/dati/nacci/studi/alcaloidi%20del%20Gelsemio%20inducono%20apoptosi%20su%20cellule%20tumorali.htm

Essential oils of plants induced apoptosis on cancer and leukaemia ( 1371)

http://www.erbeofficinali.org/dati/nacci/studi/gli%20olii%20essenziali%20.pdf

Manganese Superoxide Dismutasis induced apoptosis on mesotelioma (1365)

http://www.erbeofficinali.org/dati/nacci/studi/Manganese-Superossido%20Desmutasi-%20apoptosi%20del%20mesotelioma%20pleurico.pdf

Curcumina and Quercitina induced apoptosis on adenoma (1410)

http://www.erbeofficinali.org/dati/nacci/studi/cipolla%20e%20curcuma%20efficaci%20contro%20i%20polipi%20precancerosi%20dell’intestino.pdf

Curcumina and Isothiocyanates (PEITC) induced apoptosis on prostate cancer (1352)

http://www.erbeofficinali.org/dati/nacci/studi/curcuma%20longa%20e%20isotiocianati%20(Crucifere).pdf

Pereskia bleo for breast cancer (1144)

http://www.erbeofficinali.org/dati/nacci/studi/PERESKIA%20induce%20apoptosi%20su%20cancro%20della%20mammella.pdf

Panax ginseng (1170,1171)

http://www.erbeofficinali.org/dati/nacci/studi/GINSENG/%20pianta%20che%20induce%20apoptosi%20su%20molti%20tumori%20maligni_1.pdf

http://www.erbeofficinali.org/dati/nacci/studi/GINSENG/%20pianta%20che%20induce%20apoptosi%20su%20molti%20tumori%20maligni_2.pdf

Resveratrol (1162) in the Polygonum cuspidatum, Vitis vinifera and in Yucca schidigera (1118) whichis characterized by its apoptotic activity p53-dependent on Melanoma, by depolarizing

mitochondrial membranes (activating Caspase-9 ) in Acute Leukaemia (1121,1148,1605), in the Breast cancer (1608) and also its anti-angiogenese properties (695)

http://www.erbeofficinali.org/dati/nacci/studi/resveratrolo_2.pdf

http://www.erbeofficinali.org/dati/nacci/studi/resveratrolo%20induce%20apoptosi%20su%20melanoma.pdf

http://www.erbeofficinali.org/dati/nacci/studi/resveratrolo_1.pdf

http://www.erbeofficinali.org/dati/nacci/studi/Resveratrolo%20induce%20apoptosi%20sulla%20Leucemia.pdf

http://www.erbeofficinali.org/dati/nacci/studi/allpdf.php

Gordonia axillaris, tested on human tumors (698) http://www.erbeofficinali.org/dati/nacci/studi/camellina%20B_(english).pdf

The rhizome of Atractylodes ovata tested on leukaemia (704).

Solanum lyratum for cancer of the liver (705)

http://www.erbeofficinali.org/dati/nacci/studi/apoptosi%20di%20cancro%del%20fegato%20con%20varie%20piante%20cinesi_1.pdf

Lepidozamia peroffskyana (1044).

Boswellia carterii tested on leukaemia (704).

Drinaria fortunei which has proven effective against human osteoclast (717), and according to the

author should be tried on osteolithic bone metastasis or Multiple Myeloma.

Phyllanthus urinaria against lung cancer (720)

http://www.erbeofficinali.org/dati/nacci/studi/PHYLLATHUS%20provoca%20APOPTOSI%20su%20tumori.pdf

Salvia miltiorrhiza is still being evaluated for its possible toxic effects (Tujone), but apoptosis on

epatocarcinoma (708,1115,1116) http://www.erbeofficinali.org/dati/nacci/studi/salvia%20%20induce%20apoptosi%20su%20tumori.pdf

and Leukaemia (1575)

Camellia sinensis (173,1123,1124, 1159, 1160,1164,1186)http://www.erbeofficinali.org/dati/nacci/studi/the%20verde_2.pdf

http://www.erbeofficinali.org/dati/nacci/studi/the%20verde_3.pdf

Tartary buckwheat flavonoid activates caspase 3 and induces apoptosis in cancer (1064).

Zingiber officinale (6-paradol) activates caspase 3 (1143)

http://www.erbeofficinali.org/dati/nacci/studi/Zenzero%20induce%20APOPTOSI%20su%20LEUCEMIA%20con%206-paradolo%20e%206gingerolo.pdf

Sesquiterpene lactone parthenolide, the principal active component in medicinal plants (es.:

Tanacetum parthenium), induced apoptosis in toumors, depletion of Glutathione, generation of

reactive oxygen species, activation of Caspases 7,8,9, overexpression of GADD153, an anticanceragent inducibile gene, and subsequent apoptotic cell death. (701)

http://www.erbeofficinali.org/dati/nacci/studi/PARTENOLIDE%20induce%20APOPTOSI%20su%20diversi%20tipi%20di%20tumori%20maligno.pdf

Goniothalamin of Goniothalamus species (1138,1139)

http://www.erbeofficinali.org/dati/nacci/GONIOTALAMINA%20induce%20APOPTOSI%20su%20cellule%20della%20LEUCEMIA_1.pdf

http://www.erbeofficinali.org/dati/nacci/GONIOTALAMINA%20induce%20APOPTOSI%20su%20cellule%20della%20LEUCEMIA_2.pdf

Boswellic acid induces apoptosis in metastatic melanoma and fibrosarcoma (1131)

http://www.erbeofficinali.org/dati/nacci/studi/acido%20boswellico%20induce%20apoptosi%20su%20cellule%20del%20melanoma%20e%20del%20fibrosarcoma.pdf

Citrus species induced apoptosis in cancer, with beta Cryptoxanthin and Hesperidin (1063)

http://www.erbeofficinali.org/dati/nacci/studi/Ciproxantina%20e%20Esperidina.pdf

In Calabria (Italy) Citrus aurantium bergamia (Bergamot orange) is being cultivated.

In the following work, many food plants included in the diet of several people and having

advantageous medical properties are reported (1149-1153).

Spinaches also have effects on papillomas (1154)

http://www.erbeofficinali.org/dati/nacci/studi/spinaci%20sono%20efficaci%20su%20papillomi_(english).php

Equally important is organic Selenium (1155)

http://www.erbeofficinali.org/dati/nacci/studi/Selenio%20induce%20APOPTOSI%20su%20cellule%20del%20carcinoma.pdf

Alpinia oxyphylla (Zingiberaceae) in human promielocytic leukaemia (1156)

http://www.erbeofficinali.org/dati/nacci/studi/alpinia%20species%20induce%20apoptosi%20su%20leucemia%20promielocitica.pdf

Another process of apoptosis induced by woodfordin I in human leukaemia K562 cells (1157)

http://www.erbeofficinali.org/dati/nacci/studi/EPILOBIO%20Chamaenerion%20angustifolium%20(woodfordin%201)%20induce%20apoptosi%20su%20leucemia.pdf

Chlorophyllin and chlorophyll are modulation of apoptosis (1158)

http://www.erbeofficinali.org/dati/nacci/studi/clorofilla%20e%20clorofillina%20inducono%20APOPTOSI.pdf

Pentacyclic triterpenes from Chrysobalanaceae species have cytotoxicity on leukaemia (1167).

Inhibition of human breast cancer growth by Genistein (1168)

http://www.erbeofficinali.org/dati/nacci/studi/GENISTEINA%20fa%20suicidare%20cellule%20del%20cancro%20della%20mammella.pdf

Several major ingredients of Chinese herbal medicines are under study in human hepatoma (1169).

http://www.erbeofficinali.org/dati/nacci/studi/apoptosi%20di%20cancro%del%20fegato%20con%20varie%20piante%20cinesi_2.pdf

Even alcohol perillico induces apoptosis of tumors, cancers that both leukemias (1556-1559)

http://www.erbeofficinali.org/dati/nacci/studi/Perillyl%20alcohol%20(Monoterpene)%20against%20cancer.pdf

http://www.erbeofficinali.org/dati/nacci/studi/Perillyl%20alcohol%20(Monoterpene)%20induces%20APOPTOSIS%20on%20CARCINOMA.pdf

http://www.erbeofficinali.org/dati/nacci/studi/Perillyl%20alcohol%20inhibits%20human%20breast%20cancer.pdf

http://www.erbeofficinali.org/dati/nacci/studi/Anti-leukaemia%20effects%20of%20Perillyl%20alcohol.pdf

Even the root extract of Solanum dulcamara has been shown to cause apoptosis in prostate cancer and its metastases (1655)

http://www.erbeofficinali.org/dati/nacci/studi/Dulcamara%20solanacea%20induce%20apoptosi%20nel%20cancro%20della%20prostata.pdf

Among the many Indoles, is to remember the glucobrassicin, contained in the Brassicaceae, which determines apoptosis in breast cancer. In particular, it is contained in Isatis dyeing (1656)

http://www.erbeofficinali.org/dati/nacci/studi/Isatis%20tinctoria%20(glucobrassicina)%20induce%20apoptosi%20nel%20cancro.pdf

Many other plants exist, and have been collected in particular extracts for therapeutic use, not only as plants with potential apoptotic and pseudo apoptotic use but also as immune stimulating plants (chap.9) and/or with an anti-oxidative action

On the basis of recent discoveries about the apoptotic induction of the seeds of Momordica charantia (639), particular interest is currently being shown to the seeds of other plants such as Helianthus annuus (sunflower); Citrus paradisi (grapefruit); Cucumis melo (melon); Cucumis sativus (cucumber); Citrullus vulgaris (water melon, red melon); Solanum lycopersicum (tomato); Solanum melongena (aubergine/eggplant); Rubus idaeus (raspberry); Actinidia chinensis (kiwi);Citrus aurantium (orange) and Vitis vinifera.

A matter of grave concern is that large GMO seed firms are putting on the global agricultural market fruits with no seeds inside, in particular the following: Cucumis melo, Citrus limonum, Citrullus vulgaris, Solanum lycopersicum, Vitis vinifera.

Seeds are deemed significant anti-cancer agents essentially because they contain the well-known vitamin B17.

Another modifications are: GMO-Brassica rapa (turnip, 968), GMO-Brassica oleracea botrytis (cauliflower,968), Prunus domestica (1013), Citrus paradisi (1014),etc….

Pueraria species induced apoptosis on human toumors for the contents of Antocyanin (apoptosis on toumors) but the contents of Antocyanin of the Pueraria GMO were dramatically decreased by 40% (1119) http://www.mednat.org/alimentazione/PUERARIA.pdf

Other hundreds of studies about NATURAL substances with DEMONSTRATED APOPTOTIC effect:

Apoptotic studies – science.naturalne… – Natural News

science.naturalnews.com/Apoptotic.html

Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17.
Arthritis and rheumatism

The human lung surfactant proteins A (SP-A) and D (SP-D) interact with apoptotic target cells by different binding mechanisms.
Immunobiology

[Evaluation of morphologically determined apoptotic index].
Acta medica Croatica : c?asopis Hravatske akademije medicinskih znanosti

Dendritic cells are able to produce IL-12p70 after uptake of apoptotic cells.
Immunobiology

Natural IgM and innate immune collectin SP-D bind to late apoptotic cells and enhance their clearance by alveolar macrophages in vivo.
Molecular immunology

Apoptotic cell-mediated immunoregulation of dendritic cells does not require iC3b opsonization.
Journal of immunology (Baltimore, Md. : 1950)Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.
NaturePhagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax.
OncogeneBcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer ResearchGene expression in mouse preimplantation embryos affected by apoptotic inductor actinomycin D.
The Journal of reproduction and development

Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?
Arthritis research & therapy

Anti-apoptotic Bcl-XL protein in complex with BH3 peptides of pro-apoptotic Bak, Bad, and Bim proteins: comparative molecular dynamics simulations.
Proteins

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells.
Journal of immunology (Baltimore, Md. : 1950)

IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)

Effect of hypoxia on expression of apoptotic proteins in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets: the role of nuclear Ca++ -influx.
Neurochemical research

Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)

Apoptotic cell death is initiated during normothermic ischemia in human kidneys.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

A deficiency in the in vivo clearance of apoptotic cells is a feature of the NOD mouse.
Journal of autoimmunity

Cuts can kill: the roles of apoptotic nucleases in cell death and animal development.
Chromosoma

Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies.
The Journal of clinical investigation

Apoptotic lymphocytes treated with IgG from Trypanosoma cruzi infection increase TNF-alpha secretion and reduce parasite replication in macrophages.
European journal of immunology

N-acetylcysteine inhibits RhoA and promotes apoptotic cell clearance during intense lung inflammation.
American journal of respiratory and critical care medicine

Human oral cancers have altered expression of Bcl-2 family members and increased expression of the anti-apoptotic splice variant of Mcl-1.
The Journal of pathology

Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin.
PloS one

C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)

The role of nucleotides in apoptotic cell clearance: implications for disease pathogenesis.
Journal of molecular medicine (Berlin, Germany)

HIPK2 modulates p53 activity towards pro-apoptotic transcription.
Molecular cancer

Different immunophenotypical apoptotic profiles characterise megakaryocytes of essential thrombocythaemia and primary myelofibrosis.
Journal of clinical pathology

Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling.
Current biology : CB