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Suplimente, medicamente si ‘alicamente’ bazice impotriva cancerului: sinergia si cocktailuri pentru o strategia integrala

Suplimente, medicamente si ‘alicamente’ bazice impotriva cancerului: sinergia si cocktailuri pentru o strategia integrala

 

Traducere facuta de Nicoleta

 

Poate fi frustranta sarcina de a decide intre cantitatea mare de suplimente disponibile pe piata. La aceasta trebuie sa adaugam cantitatea mare de marci, prezentari si doze ale fiecareia, ceea ce face foarte complicat sa alegem suplimentele cele mai eficiente, doza cea mai potrivita cat si brand-urile cu cel mai bun raport calitate / pret. Inainte de a propune o lista de suplimente anticancer despre care cred ca indeplinesc parametrii de calitate si eficacitate, voi explica pe ce ma bazez pentru a le propune. Orice decizie trebuie sa provina dintr-o reflexie anterioara, o colectie de date aprofundate si o strategie elaborata plecand de la acestea. Acea alegere poate sa nu fie cea mai exacta si nici nu intentionez sa fie exhaustiva (i se pot adauga zeci de ierburi si multe alte suplimente), dar se bazeaza pe un rationament bine fundamentat. Desigur, as fi incantat de orice corecturi sau adaugari. 

  1. Dieta alimentatia ANTIcancer este cea mai importanta

Suplimentele ANTIcancer nu ar trebui sa inlocuiasca dieta ANTIcancer, ci doar sa o sustina, furnizand alte molecule care au fost demonstrate a fi eficace in doze mari(care nu pot fi obtinuti in doze adecvate din dieta precum vitamina C IntraVenos(30-50 grame zilnic administrate in interval de 90 minute) sau vitamina C lipozomala, vitamina D3 (5000-20000, UI mai ales iarna)melatonina (6-50 mg, seara) , suplimente imunitare (ciuperci medicinale (ABM, AHCC,reishi , maitake ,shiitake ,chaga, cordyceps, etc) , Transfer factor,  imunomodulatori precum 714 X, etc) , suplimente deparazitare, minerale puternic alcalinizante precum Clorura de cesiu (chiar si calciu si potasiu, seleniu,etc) , omega 3 in doze mari(asa cum include dieta dr Budwig alte grasimi permise in cancer) si compusi care nu sunt de obicei gasiti intr-o dieta tipic occidentala sau nu pot fi procurati in dozele necesare pentru efect anticancerigen din alimente integrale. Pe cat posibil, o mare parte dintre suplimente ar trebui sa consiste din alimente, fie sub forma de extract, fie sub forma de uleiuri sau infuzii care sa asigure toate substantele nutritive esentiale ale alimentului sau ale plantei din care provin insa in doza mai mare si in cantitate mai mica. Chiar si in astfel de cazuri, nu ar trebui sa inlocuiasca produsele alimentare, ci sa o consolideze pe aceasta. De fapt, lista suplimentelor include, de asemenea, unele alimente care ar trebui sa fie consumate, cred ca, aproape in fiecare zi deoarece pot fi considerate medicamente autentice, prin urmare,  de aici numele sau de „alicamente”. In realitate, intr-o  dieta ANTIcancer, ar trebui sa nu fie introdus nici un aliment care sa nu poate fi numit asa in masura mai mare sau mai mica.

Desi s-au identificat molecule naturale de actiune antitumorala, trebuie sa luam in considerare faptul ca un produs alimentar contine, de asemenea, tot ceea ce „noi nu stim ca nu stim”, adica, mii de posibili compusi cu o eficacitate terapeutica datorita factorilor inca necunoscuti. Exceptiile sunt vitamine, minerale, antioxidanti si molecule specifice, care s-au dovedit a fi eficiente, fie in probe solide, fie datorita elementelor care demonstreza un potential beneficiu si absenta efectelor sale secundare.

2. Sinergia

Cel mai important cuvant atunci cand se planifica o strategie/protocol ANTIcancer este sinergie. Definitia grafica  a sinergiei este 1 + 1 > 2 , adica doua substante care, luate impreuna, furnizeaza o valoare terapeutica mai mare decat ar furniza-o individual. In timp ce masurile conventionale se aplica, in general, din una in una, datorita efectelor sale secundare, dieta si suplimente au avantajul de a fi instrumente terapeutice inofensive sau cu putine efecte secundare. Este adevarat ca deja se aplica linii terapeutice din 2 medicamente sau un medicament impreuna cu o doza de radiatie, dar asta e tot ce isi poate permite medicina alopata. Exista studii, desi inca off-label, care cerceteaza strategii similare cu cele propuse aici, dar cu medicamentele conventionale. Este vorba de un multidrog utilizat pentru alte boli si cu putine efecte secundare, aplicate concomitent cu dozele de chimioterapie metronomice (doze mici, dar zilnice) care „par” promitatoare. Cu toate acestea, foarte putini medici indraznesc sa le prescrie pacientilor lor (studiile sunt preliminare) si prefera sa se aplice tratamentul standard , previzibil si neproblematic ( pentru ei ). Principala critica impotriva strategiei de suplimente alimentare este ca „nu este dovedita”. Un argument inutil, din moment ce nimeni nu poate pretinde ca un bolnav sa stea cu mainile in san in timp ce i comunica ca nimic nu se mai poate face pentru el.

 Si pentru ca  trebuie sa asteptam mult  pana sa se faca aceasta probe, finantate de companii farmaceutice (cand ?!) , (de fapt, nu se va face niciodata daca paradigma actuala nu se schimba, pentru ca nimeni nu va investi banii necesari pentru a obtine date semnificative statistic pentru lucruri din care nu se paote obtine profit substatial), nu avem nici o alta alternativa decat sa ne bazam pe studii in vitro, pe animale sau in cel mai bun caz, pe un numar limitat de pacienti sau feedback pacienti (MARTURII). Desigur, in unele cazuri, dovezile sunt suficient de solide pentru a justifica studii pe scara larga. 

O alta critica folosita impotriva suplimentelor este ca studiile stiintifice care sunt bazate pe anumite doze terapeutice, sunt foarte greu de realizat cu prezentari comerciale obisnuite. In timp ce acest lucru este adevarat, in unele cazuri, este de asemenea adevarat ca:

  • Apar prezentari comerciale cu doze din ce in ce mai mari
  •  Sinergia, despre care am vorbit, permite ca doua suplimente, luate in doze relativ mici, sa se sustin reciproc si sa produca un efect considerabil sporit- exemple : piperina pontenteaza biodisponibilitatea cucurminei pina la 2000%; catechinele din ceaiul verde si curcumina din curcuma se sustin reciproc. Acelasi lucru este valabil si cu unele suplimente de biodisponibilitate scazuta, care cresc cu mai multe ordine de marime daca sunt consumate impreuna cu anumite alimente, care pot fi considerate de la sine ca medicamente. De exemplu, berberina si scortisoara. 

Ca de obicei, diferenta dintre o buna si o proasta decizie sunt rezultatul cunostiintelor si al informatiilor: cateva suplimente izolate, luate fara a urma nici o regula, in doze aleatorii sunt putin probabil sa aiba efect, si da,  sunt multi care il vor folosi ca argument de catre cei care neaga ca aceasta strategie ar pentru avea vreo eficacitate

3. Cocktail

Al doilea cuvant pe care trebuie sa il retinem este cocktail: trebuie sa profitam de efectele secundare minime sau inexistente pentru a suplimenta cu cat mai multe substante, de forma agresiva si sub forma de multe abordari biochimice, dar intotdeauna cu aceeasi focalizare: de a folosi ceea ce s-a dovedit a nu avea nici un efect secundar sau foarte putine si care ofera un avantaj, desi aparent „indirect”. 

In acest moment pot aparea intrebari rezonabile: Si cum stii ca nu exista interactiuni nedorite intre unele dintre aceste suplimente? De unde stii ca rezultatul final nu va fi mai rau? Raspunsul meu este: Nu stiu. Nu pretind a fi sigur de eficienta lor, dar nu voi sta fara sa fac nimic asteptand  sa fie testate toate combinatiile de molecule, pentru ca acea zi nu va veni niciodata.  Acest rezultat negativ prin combinarea multe suplimente este posibil, dar putin probabil pentru ca vorbim de lucruri naturale : ma concentrez pe studii care au demonstrat ca sinergia este benefica in anumite combinatii de molecule. Si, de asemenea, ma bazez pe experienta anterioara a persoanelor care au aplicat protocoale similare si au obtinut rezultate excelente. Este evident ca nu toate combinatiile posibile de substante pot fi fost testate, dar epidemiologia si istoria ne invata ca fiecare molecula prezenta in natura, a fost supusa unui test „dublu-orb”, care a durat mii de ani, in timpul careia observarea si bunul simt au declarat eficacitatea si siguranta lor relativa. Eu cred ca vorbesc cu oameni inteligenti. Oameni capabili sa ia o decizie cu responsabilitate, inclusiv cu deplina cunostinta,  care s-a informat in mod liber si care sunt capabili de a cantari echilibrul intre posibile riscuri si beneficii. Persoanele care isi asuma responsabilitatea cu privire la ceea ce se intampla in viata lor si decid sa ia fraiele vietii lor. Sarcina mea este de a informa si de a oferi uneltele pentru ca astfel de decizii sa poata fi facute cu mai multa incredere si responsabilitate. Este posibil, desigur, ca dozele sa fie prea mari sau sa apara interactiuni nedorite si inca necunoscute, dar aceste probleme sunt aproape intotdeauna usoare si trecatoare. 

4. Orice substanta eficienta trebuie luata in considerare

Este important sa nu avem prejudicii atunci cand se studiaza orice actiune sau molecula. Bunul simt ar trebui sa prevaleze intotdeauna si nu trebuie sa ne pierdem motivarea de ce facem acest lucru: sa construim o strategie de actiuni practice care sa conduca la remisie, fara sau cu minime efecte secundare. Din acest motiv, lista pe care o voi prezenta, va include unele medicamente conventionale, dar care au demostrat un amestec de eficacitate si tolerabilitate. Pentru ca nu sunt impotriva drogurilor/medicamentelor sintetice in sine, ci numai impotriva celor otravitoare si ineficiente. 

5. Bani

Stiu din experienta cat de scump poate fi un plan de suplimente. Daca adaugam achizitionarea de alimente ecologice, costul lunar poate fi destul de mare. Nu am nici o solutie pentru acest lucru, din pacate. Nici chiar acolo unde sistemul public de sanatate nu a fost jefuit, statul nu isi asuma aceste cheltuieli.  Incercati sa gasiti marci si formulari cu cel mai bun raport calitate / pret, dar chiar si asa, costul final va fi mare pentru un buzunar de mijloc. 

Lista de suplimente impotriva cancerului

Am pregatit o liste cu explicatii alegerii fiecarui supliment, deoarece consider esential sa clarific motivele deciziilor luate, precum si datele pe care ma bazez. Problema este ca documentul deja are 30 de pagini, ceea ce il face imposibil de gestionat iar eu as intarzia foarte mult in a-l termina, asa ca voi publicat doua liste de informatii sumare, insa voi dezvolta in viitor, in alte articole, toate motivele pentru care sfatuiesc fiecare supliment precum si studiile in care ma bazez.

In ceea ce priveste cele doua liste:

  • Una este o lista de suplimente in care explic dozele, reguli de administrare si posibile marci propuse
  • A doua este o lista de suplimente si medicamente pe care este bine sa le avem la indemana si pe care inca nu le luam, dar  care ar putea fi interesante pentru altii. Sugerez ca fiecare cititor sa investigheze pe cont propriu, daca considera util vreun medicament si sa il introduca in planul lui de tratament. 
  • In aceste liste, voi prezenta terapiile pe care le consider cele mai promitatoare si sper ca pot dezvolta mai tarziu,  insa repet avertismentul: nu am, desigur, certitudinea ca aceasta combinatie este cea mai eficienta. Toata lumea ar trebui sa cantareasca ce-l poate ajuta cel mai bine. Nu am nimic de-a face cu niciunul dintre brandurile de suplimente pe care le sugerez. Am pus doar ca un exemplu ceea ce noi am ales si, cu toate ca, in unele cazuri, sunt destul de sigur ca am ales bine, in altele, cum ar fi extractul de ceai verde, nu am incredere ca calitatea acestuia coincide cu ceea ce producatorul spune si orice sugestie este bine venita. 

Clasificarea suplimentele

A- molecule naturale izolate sau extracte de alimente care fac parte din grupul pe care noi il intelegem ca suplimente.

B- Alicamente: produse alimentare care urmeaza sa fie luate intr-un mod similar medicamentelor insa in anumite doze minime pentru proprietatile sale benefice intrinseci si a capacitatii sale de a potenta alte masuri.

C- Medicamente disponibile, care au demonstrat un beneficiu in studii preliminare fara a produce efecte adverse sau cu efecte secundare usoare. In aceasta lista vor exista medicamente care pot fi obtinute printr-o achizitie on-line.

 D- Protocoale standard: propuse de companii private si / sau medici privati, indepartati de curentul oficial si care par a fi tratamente anticancer eficiente.

E- Medicamente care se pot obtine cu retete, cu relative putine efecte secundare si care pot fi prescrise numai de catre un medic.

 F- Molecule sintetice care inca nu sunt disponibile sau cu o disponibilitatea foarte dificila, dar cu o foarte mare eficacitate potentiala. 

Lista 1: suplimentele principale

Naltrexona in doze mici sau LDN (low dose naltrexone)

Tip: C

Brand: BuyLDN (a se vedea lista tarilor in care se trimite)

Doza: 4,5 mg / zi: 1 capsula pe zi, inainte de culcare.

Posibil efect: stimulare imunitatii. 

Comentarii: Primul supliment in aceasta lista nu este o molecula naturala, ci sintetica: un medicament in doze mari, adesea prescrise impotriva alcoolismului. In doze mici, nu are efecte secundare si s-a dovedit cu pacientii reali, ca are o eficacitatea antitumorala extraordinara (numai in doze mici. Cresterea dozei se va anula efectele pozitive). Este un obligatoriu in orice strategie de suplimentarea impotriva cancerului un supliment imunitar.

Nota mea: Alte suplimente imunitare NATURALE:ciuperci medicinale (ABM, AHCC,reishi , maitake ,shiitake ,chaga, cordyceps, etc), MGN3, BIOBRAN, BetaGlucani, Transfer factor,  imunomodulatori precum 714 X, etc.

 

Coriolus versicolor (PSP50)

Tip: A

Doza: 3 capsule pe zi, 1 mic dejun – 1 pranz – 1 cina

Brand: Oriveda

Posibile mecanisme de actiune: Folosit in tratamentul conventional in tari precum Japonia, este un excelent immunopotentiator.

Nota mea: alt brand bun de ciuperci(de la bolnavi stiut): https://www.hawlik-vitalpilze.de/

Nu uitati ca imunitatea tine si de starea emotionala a bolnavului, sanatatea florei intestinale, echilibrul hormonal, odihna adecvata noaptea, expunerea la soare ziua, LIPSA DE PARAZITI A ORGANELOR(suplimente deparazitare)  si de alti parametrii.

 

Ulei de peste sau de krill 

Tip: A

Brand: Enerzona

Doza: minim de 6 grame pe zi. Acesta doza poate fi mult mai mare in cazul in care o analiza AA de sange / EPA determina aceasta nevoie.

Doza: 2 linguri la micul dejun.

Posibile mecanisme de actiune: posibila actiune antitumorala, antiinflamatorie.

Comentarii: Unul dintre cele mai studiate suplemente si a carei eficienta a fost demonstrata.

Nota mea: NEAPARAT de inclus 6-8 linguri ulei de in ecologic zilnic (asa cum include dieta dr Budwig ) si  alte grasimi permise in cancer(ulei de canepa, de canabis si alte uleirui permise; nu uitati minim 2-3 punmi de nucifere samburi si seminte GERMINATE zilnic(exceptie caju si arahide)

 

Ulei de nuca de cocos

Tip: B

Brand: Coconoil

Doza: 3-6 lingurite pe zi, 1-2 lingurite la fiecare masa

Posibile mecanisme de actiune: multiple (antitumoral, facilitator al cetoza, etc.)

Nota mea: poate fi de asemenea folosite pentru gatit, in plus fata de doza prescrisa aici si suplimentat cu ulei de masline virgin.

 

Vitamina D3

Tipul: A

Brand: Puritan’s Pride

Doza: 10.000UI / zi la inceput. Se reduce la 2.000-5.000UI / zi cand se ajunge la un nivel de sange intre 80 si 100 ng / ml

Doze: 2 capsule la micul dejun

Posibile mecanisme de actiune: multiple

Comentarii: unul dintre cele mai studiate suplimente si a carei eficienta a fost demonstrata

vitamina D3 (5000-20000, UI mai ales iarna;stat la saore zilnic minim 30 minute NECESAR)

 

Melatonina

Tip: A

Brand: Pure Encapsulations

Doza: 20 mg / zi, 1 cu 1 ora inainte de culcare

Posibile mecanisme de actiune: modularea sistemului imunitar si al inflamatie.

Comentarii: hormon foarte studiat, de a carei eficacitate exista dovezi foarte puternice.

Nota mea: melatonina (6-50 mg, seara)

 

Vitamina K2

Tip : A

Brand: Now Foods

Doza: este legata de consumul de vitamina D3. Aproximativ 100 de mcg / zi pentru fiecare 1000 UI de D3 consumat. In cazul in care se iau alte suplimente si alimente din aceasta lista care sunt surse abundente de K2, se poate lua doar 300mcg / zi.

Se iau 3 capsule pe zi. 1 mic dejun, 1 pranz, 1 cina, sau  toate 3, la un moment dat sau doar 1 pe zi in cazul in care capsula este de  300mcg.

Posibile mecanisme de actiune: multiple.

Comentarii: se prezinta ca o vitamina cu o actiune la fel de importanta ca si D3 si care permite sa se moduleze efectele potentiale asociate cu consumul excesiv de D3.

Nota mea: Atentie ca multe alimente verzi si lactate din dieta Budwig contin deja vitamina K si excesul de vitamina K NU este recomandat

 

Bisglicinatul de magneziu (inlocuieste calciu, magneziu si zinc)

Tip: A

Doza: 1500 mg pe zi, 3 comprimate: 1 mic dejun – 1 pranz – 1 cina

Brand: Bulk Powders

Posibile mecanisme de actiune: Magneziul este implicat intr-un numar foarte mare de reactii in organism si lucreaza sinergic cu vitaminele D3 si K2.

 

Glicina

Tip: A

Doza: 15-20g pe z,  3 comprimate: 1 mic dejun – 1 pranz – 1 cina

Brand: Bulk Powders

Posibile mecanisme de actiune: S-a dovedit a fi un aminoacid antiangiogenetic care permite sa se obtina glutation din metionina.

 

Lizina

Tip: A

Doza: 30g pe zi, 1 mic dejun – 1 pranz – 1 cina

Posibile mecanisme de actiune: Este unul dintre cei doi aminoacizi cetogeni care se poate transforma in cetone, nu in glucoza, cu ajutorul caruia se intra mai bine in cetoza. In plus, si-a dovedit capacitatea de a creste imunitatea. 

Nota mea: Prolina si ceai verde extract (EGCG) sunt parte din formula Dr Rath din carte si e bine sa luati aceasta formula a Dr Matias Rath

 

 Extract de ceai verde

Tip: A

Brand: Puritan’s Pride

Doza: trebuie asigurat un minim intre 1500 si 3000 mg pe zi (in aceasta prezentare, 6 capsule pe zi, 2 mic dejun – 2 masa – 2 cina ).

Posibile mecanisme de actiune: face dificila glutaminoliza tumorala si creste eficienta insulinei. 

Comentarii: Nu sunt sigur ca am ales bine brand-ul. Este marca cu cea ai mare cantitate de catechine pe capsula pe care am gasit-o, dar culoarea nu arata asa cum ar trebui sa aiba un extract de calitate si pretul sau este, de asemenea, suspect de scazut. As aprecia orice sugestii.

 

Curcuma

Tip: A

Brand: Theracurmin

Doza: In aceasta prezentare, 1200mg, 2 capsule pe zi, 1 mic dejun – 1 cina

Mecanisme de actiune posibile: multiple (anti-inflamatoare, directe anti-tumorale)

Comentarii: Multiple studii sustin eficacitatea sa, desi biodisponibilitatea curcuminei este foarte scazuta. Dintre toate observatiile de piata (lipozomi, nanoparticule, etc.), cu diferite solutii pentru a creste o astfel de utilizare a metabolitilor, Theracurmin pare a fi cel mai puternic, dar din aprilie 2015, a fost introdus pe piata Novasolcurcumin care sustine ca a crescut biodisponibilitatea. 

Are o puternica actiune sinergica cu ulei de peste si resveratrol, printre altele. Creste efectul sau daca se consuma in paralel cu piperul negru pina la 2000%(cucurmin 95)

 

Scortisoara 

Tip: B

Doza: aproximativ 3 grame pe zi (unele persoane pot experimenta o iritatie gastrica atunci cand este luata in exces si trebuie redusa doza atunci cand apare acest disconfort. In unele studii, scortisoara este considerata un protector al stomacului). Se ia ¼ lingurita la fiecare masa si inainte de alte suplemente.

Posibile mecanisme de actiune: impiedica sa fie utilizat zaharul, limiteza varfurile glucozei, limiteaza autofagia tumorala.

Comentarii: imbunatateste absortia berberinei. Este un antimalaric si de asemenea, un antitumoral.

 

Piperul negru

Tip: B

Doza: aproximativ 3 grame pe zi (unele persoane pot experimenta iritatie gastrica atunci cand sunt luate in exces si trebuie redusa doza in cazul in care se produce acest disconfort). Se ia ¼ lingurita cu fiecare masa si inainte de celelalte suplemente.

Posibile mecanisme de actiune: antitumorala directa.

Comentarii: Piperul negru este un cunoscut intensificator de mai multe medicamente si molecule. De exemplu, creste in mai mult de 1000 de ori absorbtia curcumei.

Nota mea: Ghimbir si alte condimente anticancerigene de asemenea , in special integrate in  tratamente cu miere 

Nu uitati de miere si Aloe Arborescens ,excelent pentru imunitate

Resveratrol

Tip: A

Brand: Terraternal

Doza: In aceasta prezentare, 150-300mg / zi, echivalentul a 200 de ori o doza orala de resveratrol, 1 sau 2 capsule pe zi

Posibile mecanisme de actiune: face dificila glicoliza tumorala si autofagia tumorala

Comentarii : probabil cel mai scump supliment, insa unul dintre cele mai studiate, care blocheaza mecanisme de baza ale unei tumori si a carei eficienta este dincolo de orice indoiala, cu conditia ca formulele folosite sa fie cele pe care organismul le poate utiliza. 

Are, probabil, o buna absorbtie insa nu este folosit 100% (desi exista un studiu care sugereaza ca acest lucru nu este asa si ca utilizarea este mult mai mare decat se credea anterior).

Acest supliment se administreaza sublingual pentru a fie metabolizat prin membranele mucoase ale cavitatii bucale. In acest mod creste foarte mult biodisponibilitatea.  Din acesta este motiv este atat de scump. 

Asa cum se intampla si cu curcumina, creste si mai mult disponibilitatea resveratrolului prin consumul de piper negru. Trebuie sa folosim formule care utilizeaza Trans-resveratrol si nu Cis-resveratrol. 

resveratrol + pterostilben este mai efecient decat resveratrol trans

Nota mea: recomand consumul de alimente bogate in resveratrol, precum struguri negrii NUMAI pe stomacul gol

 

Vitamina B6, B12 si B9 (acid folic)

Tip:A

Brand: Vitamina B6Vitamina B12 si Folati

Dozare: 100-200 mg de B6, 800-1600 micrograme de folati, de la 1000 la 2000 de micrograme de vitamina B12 pe zi, pana cand o analiza  a homocisteinei sangelui arata niveluri mai mici la 6 micromoli / l. 

Odata atinse aceste nivele, continuati cu 100 mg de B6, 800 mcg de folati si 1000 micrograme de vitamina B12 pe zi: 1 sau 2 tablete pe zi.

Posibile mecanisme de actiune: favorizeaza metilarea si ulterioara sinteza a antioxidanti endogeni glutation si SAM. Studiile sugereaza ca reduc expansiunea si agresivitatea celulelor tumorale, singure sau ca adjuvant la chimioterapiei.

Comentarii: cele 3 vitamine sunt implicate in procese similare, prin urmare, ele sunt grupate intr-o singura achizitie. A fost foarte studiat relatia lor cu homocisteina si cu toate bolile cronice, inclusiv cancerul.

Este important sa fugim de formele sintetice  oxidate ale vitaminelor si sa folosim pe cele biologic active (piridoxal-5-fosfat pentru vitamina B6, methylcobalamin pentru vitamina B12 desi exista si alte modalitati de valide -L-5-methylenetetrahydrofolate pentru B9). In cazul folatilor, daca trebuie utilizati pentru perioade lungi de timp, este indicata forma oxidat a vitaminei B9 deoarece acidul folic poate conduce la aparitia de mai multe probleme decat beneficii.

 

Probiotice (mai ales in si dupa chimio terapie)

Tip: A

Brand: Nutrition Now

Doza: pentru acea prezentare, 3 comprimate pe zi: dimineata si la pranz .

Posibile mecanisme de actiune: intarirea sistemului imunitar.

Comentariile: este indicat sa se combine suplimentarea cu alimentele integrale care fermenteaza. Sunt tot mai multe studii care sustin ca exista o stransa legatura intre sistemul imunitar si microbiome intestinale sanatoase precum si intre rezistenta sistemului imunitar si cancerul.

In plus, probiotice ar putea rezolva problemele proastei absortii nutritive ale unor pacienti, astfel incat pot fi considerate ca stimulatori puternici ale altor suplimente. Trebuie alese branduri cu mai mult de 10 de tulpini diferite de bacterii, mai mult de 10.000 de milioane de organisme vii, atunci cand sunt ingerate si, de asemenea, care contin prebiotice, cum ar fi inulina. 

 

Probiotice

Tip: B

Doza: mancati, daca este posibil, in fiecare zi, cantitati rezonabile de chefir, varza acra (sau alte legume fermentate NATURAL si NU in otet) si muraturi naturale(fermentatie , nu in otet).dieta Budwig  este excelenta si aici.

Posibile mecanisme de actiune: intarirea sistemului imunitar.

Observatii: Este un aspect atat de important  incat consider ca este necesar ca actiunea probiotica trebuie sa se „prescrie” pe doua fronturi: cu suplimente si alimente.

 

Enzime proteolitice si pancreatice

Tip: A

Brand: Zymactive (sau Wobenzym)

Doza: In aceasta prezentare, un minim de 3 capsule pe zi, inainte de micul dejun si intre mese, pentru a evita pe cat posibil, sa fi utilizate de stomac in timpul digestiei si pentru a ajunge in fluxul sanguin.

Posibile mecanisme de actiune: neclare.  Posibil sa dizolve membranele tumorale, stimuleaza sistemul imunitar si impiedica angiogeneza.

Comentariile: s-au efectuat teste pe grupuri reduse de pacientii cu adenocarcinoame pancreatice, a caror timp de supravietuire s-a triplat prin utilizarea enzimelor la doze mari (adica minim 60 pilule pe zi, 10 cu o ora inainte de fiecare masa si 10 cu mese) 

 

Berberina

Tip: A

Brand: LeanerLiving

Doza: 1500-2000mg pe zi,  3 comprimate pe zi, 1 la scurt timp inainte de fiecare masa. Indicat cu scortisoara (explicatia mai jos).

Mecanisme posibile de actiune: creste eficienta insulinei, reduce inflamatia, reduce activitatea enzimelor tumorale, are o directa eficacitate antiproliferativa.

Comentarii: un alt indispensabil. Berberina are o biodisponibilitate scazuta, dar creste odata cu utilizarea concomitenta a scortisoarei. 

 

Chlorella (Nota mea: Spirulina de asemenea, AFA pentru ficat; Kombu si Kelp si cele brune sunt si mai bune)

Tip: A

Brand:  Source Naturals

Doza: intre 2 si 5 grame pe zi (poate provoca diaree la inceputul tratamentului pentru ca este un puternic detoxifiant  de impuritati si metale grele. In cazul in care se intampla acest lucru, se reduce doza initiala pana dispare problema). Se iau: 4 la 9 comprimate pe zi, 2-3 inainte de micul dejun si 0-3 intre mese. Se poate cumpara si sub forma de pulbere.

Posibile mecanisme de actiune: potentiator imunitar, antialergic (histamina este un promotor puternic al cancerului), efect probiotic. 

Comentarii: suplimentul ar trebui sa provina din agricultura ecologica si „“Broken Cell  Wall” sau organismul o nu poate folosi. Sinergie cu curcuma si spirulina.

 

Spirulina

Tip: A

Brand: Solgar

Doza: intre 2 si 5 grame pe zi, de la 4 la 9 sau mai multe comprimate pe zi, 2-3 inainte de micul dejun si 0-3 intre mese. Se poate cumpara si sub forma de pulbere.

Posibile mecanisme de actiune: excelent potentator al celulelor NK (natural killer) ale sistemului imunitar, efect probiotic.

Comentarii: Este o sursa foarte mare de beta-caroten, precursor ale vitaminei A. In plus, contine doze mari de vitamina B12.

 

 R-alfa-acid lipoic

Tip: A

Brand: AOR

Doza: 600-1200mg / zi, (pentru aceasta marca, 2-4 pe zi), ultima doza mica se ia impreuna cu naltrexona (LDN) si melatonina.

Posibile mecanisme de actiune: blocarea glicolizei, similar cu dicloracetat de sodiu.

Comentarii: are o puternica sinergie cu LDN si Hydroxycitrate (extract din Garcinia Cambogia), s-a fost folosit in unele teste, cu pacientii bolnavi de cancer avansat si s-a obtinut o crestere in mod spectacular a mediei de supravietuire si, in unele cazuri, remisii complete si durabile. Este convenabil sa se utilizeze forma naturala a acidului R-lipoic care este mai bine utilizata de catre organism.

 

Hydroxycitrate (extract din Garcinia Cambogia)

Tip: A

Brand: Pure Body Naturals

Doza:. 3 grame / zi, (aceasta marca 1-2 capsule inainte de fiecare masa).

Posibile mecanisme de actiune: nu sunt sigur inca. 

Comentarii: asa cum am spus, are o puternica sinergie cu acid alfa-lipoic. A a fost testat pe unii pacienti cu cancer avansat, cu rezultate foarte bune. 

 

Extract de usturoi invechit

Tip: A

Brand: Kyolic

Doza: 2400-3600mg / zi (pentru aceasta marca, 4-6 capsule pe zi in timpul meselor)

Posibile mecanisme de actiune: anti-inflamator, amplificator al sistemului imunitar, efect antiproliferativ direct.

Comentarii : are o puternica sinergie cu LDN. Usturoiul invechit are un procentaj mai mari de diferite molecule decat usturoi normal, dar nu are alicina(si alicina e foarte importanta). De aceea, este recomandabil sa se consume cantitati mari de usturoi, ulei de usturoi si / sau usturoi incoltit in fiecare zi. 

 

Vitamina C in doze mari (Nota mea: vitamina C IntraVenos(30-50 grame zilnic administrate in interval de 90 minute) sau liposomala)

Tip: A

Doza: Depinde de starea pacientului si de tolerabilitatea (excesul cauzeaza diaree si trebuie redusa doza). Daca se administreaza intravenos, se incepe cu o doza intre 30 si 50 de grame pe zi, dar se poate ajunge la 2g / kg greutate corporala. Daca se ia lipozomi de inalta calitate, se spune ca aproximativ 6 grame de vitamina C (continuti in aproximativ 30 de mililitri de lipozomi), este echivalentul a 50 de grame injectat, dar ar fi mult de discutat pentru ca ambele tipuri de administrare a vitaminei C au mecanisme diferite, astfel incat este dificil sa se stabileasca echivalente. Se pot lua 3-6 doze pe zi de lipozomi de inalta calitate, pentru a ajunge la 30-50 ml pe zi (6-10 grame de vitamina C). Este important sa fiti constanti si sa distribuiti pe tot parcursul zilei.

Posibile mecanisme de actiune: citostatic direct prin generarea peroxidului de hidrogen.

Comentarii: aplicarea sa a dat rezultate aparent extraordinare in clinici medicale din intreaga lume care ofera tratamente complementare, in special cu DHA (acid docosahexaenoic, un omega 3). Problema este ca, datorita absorbtiei intestinale inferioare ale formelor orale conventionale, pana in prezent a fost aplicata doar intravenos, care cere ajutor medical si impiedica aplicarea autonoma de catre pacient. In prezent au fost testate formule orale lipozomale (care pot fi fabricate la domiciliu, folosind un agent de curatare cu ultrasunete, si in conformitate cu doua posibile „retete”), cu o capacitate de absorbtie mult mai mare. 

 

Lamaie

Tip: B

Doza: cel putin doua lamai organice pe zi, suc sau apa si stevie/miere si bicarbonat sodiu. Se poate bea oricand insa intotdeauna una in dimineata cu micul dejun

Posibile mecanisme de actiune: antitumoral direct, limiteaza varfurile glucozei

Comentarii: este recomandabil sa se foloseasca din agricultura ecologica. Se poate utiliza, de asemenea si coaja rasa pentru gatit.

 

Lista 2: suplimentele complementare

Sunt suplimentele care ar putea face parte din orice strategii de suplimentarea impotriva cancerului. Pentru aceste nu am inca referinte de marci.  De asemenea, sunt incluse aici si medicamentele care au nevoie de retete prescrise si protocoale farmacologice non-standard. 

 

Maitake MD

Alt extract de ciuperci, in acest caz Maitake, cu efecte similare. 

 

Extract de struguri

Tip: A

Multe studii in vitro si pe soareci confirma eficacitatea sa ca potential supresor tumoral. 

repet : includeti struguri negri pe stomacul gol sau in posturi ca cel Brandt dar nu mai mult de 3 zile

 

Quercetina

Tip: A

Si mai multe studii au confirmat eficacitatea sa antitumoral si prezinta sinergie cu ceai verde si, mai presus de toate, poate fi folosit ca un mijloc de crestere a nivelurilor exploatabile ale resveratrolului. 

 

Coenzima Q10 (Nota mea: 400-1200 mg pe zi)

Tip: A

Un cofactor prezent in membranele interioare ale mitocondriilor, ale caror niveluri scazute sunt asociate cu prezenta a numeroase boli cronice.

 

Boswellia

Tip: A

Un efect citotoxic direct, anti-inflamatorii si un bun agent anti-edem in tumorile cerebrale.

 

MCP (modified citrus pectin)

Tip: A

Este vorba de pectina din citrice modificata pentru ca organismului sa o poata absorbi. Unele studii recunoaste eficacitatea acesteia pentru a preveni sau pentru a impiedica metastaza, reducand agresivitatea unor forme de cancer. 

 

Extract de crucifere

Tip: A

Plantele din familia varzei contin molecule studiate pe larg ca potent antitumoral cu o citotoxicitate directa iar studii recente sugereaza ca poate reduce nivelul proteinei CXCR4 implicate in fenomenele de metastaze.

Este indicat sa se consume de cat mai multe ori pe saptamana gulii, varza de Bruxelles, varza, conopida, broccoli insa nu ar fie rau sa se ia si un bun extract din aceste plante.

 

Silimarina(din ciulinul laptelui)

Tip: A

Protector si detoxifiant hepatic puternic, cu multiple actiuni anti-tumorale directe, anti-inflamatorii si anti-angiogenice. Un bun adjuvant in cazul in care se ia in timpul chimioterapiei pentru a spori eficacitatea acesteia, protejand in acelasi timp, intr-o anumita masura, organismul sanatos (in special ficatul) de reactii adverse.

 

Canabis(inclusiv ulei)

Tip:A

Unul dintre cei mai promitatori compusi, supus cercetarilor in intreaga lume. Exista un zgomot de fond foarte important, cu oameni care pretind ca s-au vindecat utilizand canabinoidele. Este o veste plina de speranta insa trebuie sa fie luata cu precautie. 

 

Asthaxantin

Tip:A

Un carotenoid natural intalnit ca pigment in animale carora le confera culoarea rosie caracteristica: microalge, creveti, somon, unele pasari. 

Este considerat cel mai puternic antioxidant exogen si sunt suspicii ca ar modula inflamatia si sistemul imunitar.

 

Infuziile, sucuri si extracte de diferite plante

Tipuri: B

S-ar putea dedica mai multe articole care sa prezinte nenumaratele plante care au aratat un grad mai mare sau mai mic de eficacitate antitumorala : Artesimin, Astragalus, cimbru, Graviola(NU se ia cu dieta Budwig), aloe vera si mai ale ARBORESCENS, papadie, vasc etc.

 

DCA (dicloracetat de sodiu)

Tip: C

Va fi tratat pe larg intr-un viitor articol.

 

GC-MAA

Tip: D

Este un activator de macrofage, celule ale sistemului imunitar innascut, care actioneaza, in ceea ce priveste cancerul, ca un fel de Dr.Jeckyl si Mr. Hyde.

 In cazul in care datele privind eficacitatea acestuia sunt adevarate, am putea vorbi despre un avans foarte important pentru ca macrofagele sunt excelente dr Jekyll, aliati ai corpului sanatos. Aceasta informatie ne avertizeaza cu privire la avantajele de a activa macrofagele cu alimentele naturale, cum ar fi laptele fermentat (de ex. chefir).

 

Clorochina

Tip: E

Un medicament folosit in mod traditional impotriva malariei (cauzata de un parazit), care blocheaza autofagia tumorala si dificulteaza metastazele. In colaborare cu chimioterapie, dar, de asemenea, si cu alte masuri naturale, la soareci a demonstrat o mare capacitate sinergica. 

 

Plerixaforul

Tip: E

Un medicament imunostimulator, cu efecte secundare reduse, utilizate pentru a consolida imunitatea in transplanturi de maduva osoasa in pacientii cu leucemie, care dovedeste (din nou), rolul decisiv al sistemului imunitar in controlul cancerului. 

Este unul dintre mecanismele de actiune care pare sa blocheze proteina CXCR4, vitala pentru recurenta si metastaze. In acelasi timp, este unul dintre cel mai util medicament atunci cand se combina cu chimioterapia sau cu alte strategii mai putin agresive propuse aici.

 

3-brompiruvat

Tip: F

Probabil astazi, molecula cea mai promitatoare cu o gama de actiune mai larga si puternica, care ar putea revolutiona tratamentul cancerului, mai ales daca sunt aplicate cu amplificatori ai sistemului imunitar precum GC -Maf

Nota mea: https://tratamenteanticancer.wordpress.com/2015/08/10/nagalaza-testare-sange-detectie-si-monitorizare-tratament-cancer-si-alte-boli-asociate-cu-deficiente-ale-sistemului-imunitarautism-boli-virale-etc/ si terapiile adjuvante, cum ar fi dieta si LDN.

Este un puternic blocant al glicolizei si a demonstrat rezultate spectaculoase in soareci si in unii pacient stadiu IV care au reusit o remisie completa. 

 

2-deoxyglucose

Tip: F

Este un analog al glucozei, folosit pentru a marca tumorilor in timpul testelor de tomografie cu emisie de pozitroni (PET), care a demonstrat o eficacitate antitumorala prin blocarea drumului glucozei catre tumoare.

 

Fenilbutirat

Tip: F

Blocheaza glutaminoliza.

 

Concluzii

In definitiv, o strategie integrala care combina dieta cetonica cu suplemente ale carei obiective sunt:

 

Articol original pe cancerintegral.com. modificat putin de mine insa e interesant cum oameni din tari diferite, ajung la concluzii similare.

 

Doamne ajuta!

Antioxidantii si multirezistenta cancer ; Beneficiile dietei paleo-ketogenica si suplementelor naturale in lupta impotriva cancerului

Antioxidantii si  multirezistenta  cancer ;  Beneficiile dietei paleo-ketogenica si suplementelor naturale in lupta impotriva cancerului

articol tradus de Nicoleta

Una dintre temele asupra careia sunt de acord un numar mare de oncologi este “pericolul” de a folosi antioxidanti in timpul tratamentului impotriva cancerului. Practic toti avertizeaza bolnavul despre suplementarea cu “antioxidanti” pentru ca pot “interfera  negativ” cu chimioterapia si radioterapia.(de fapt chair interfereaza in sensul ca protejeaza celula de la stressul oxidativ al chimio si radio ‘terapiilor’)

Unii chiar propun ca pacientul sa manace junk food pe perioada tratamentului “pentru a evita posibile interactiuni”.

In acest articol vom prezenta date care demonstreaza cat de antistiintifica si contraproductiva este aceasta ideie si vom explica una dintre marile probleme cu care se confrunta ocologii: multirezistenta la tratamente alopate cancer de care sufera o mare parte dintre bolnavii de cancer(pe langa multe alte probleme). In loc de a ramane impasibili, asteptand sa se produca inevitabilul, vom aduna date stiintifice (peste 60 de referinte in acest articol) si vom elabora o strategie pentru a face fata problemelor, cu solutii practice, atat nivelul dietei anticancer cat si suplementelor anticancer  care ajuta in lupta impotriva cancerului, cu 2 obiective clare:

  1. De a reduce sau elimina efectele secundare ale tratamentelor aloapte cancer
  2. De a creste drastic  efecienta tratamentelor anti cancer.

 

Ce e starea redox? Oxidare(stress oxidativ) si antioxidanti

Radicalii liberi sunt deseuri provenite din procesele metabolice carora le lipseste un electron, ceea ce ii face foarte reactivi si instabili: “ataca” alte molecule stabile pentru a inlocui acesti electroni lipsa, transformand in acelasi timp moleculele atacate in radicali liberi si producand asa o reactie in lant de oxidare.

Diferiti atomi si molecule pot fi radicali liberi; de exemplu, ionul superoxid (O2-) sau ionul hidroxil (HO-).

Exista de asemenea oxidanti reactivi care nu sunt radicali liberi, de tipul peroxidului de hidrogen (H2O2) sau oxidul nitric (NO). Oxidantii reactivi pot afecta structura celulara producand anomalii in lipidele membranelor sau proteinelor. Aceste modificari structurale se pot traduce in probleme functionale ale celulei si pot conduce la o multime de probleme de sanatate. In continuare vom vedea care sunt. Elementele reactive derivate ale oxigenului (ROS  in engleza) sunt oxidanti, radicali liberi sau nu, a carei reactivitate se focalizeaza in atomul de oxigen, desi de multe ori include altii care reactioneaza cu atomul de nitrogen si clor. ROS-ii cei mai abundenti sunt ionii de superoxid (O2-) si oxidul nitric (NO).

Antioxidantii sunt molecule care se unesc cu radicalii si ii neutralizeaza sau opresc lantul de reactii pe care acesti il initiaza, ‘dandu-le poamana’ /donandu-le electroni si eliminand reactivitatea lor insa fara ca ei insasi se se transforme in radicali liberi.

 

Tipul de antioxidanti

 

Putem face o prima clasificare de antioxidanti in exogeni si endogeni.

Antioxidantii exogeni trebuie luati din alimente:

  • Vitamine precum C, E, A (retinoizi  proveniti din alimente de origine animala) si betacaroteni precursori ai vitaminei A si proveniti din alimente vegetale
  • Alti carotenoizi precum zeaxantina, astraxantina sau luteina
  • Polifenoli precum catechine din ceaiul verde
  • Alti compusi precum izotiocianați(isotiocianatos) din legume crucifere sau compusi sulfurosi din usturoi si ceapa

 

Antioxidantii endogeni pot fi proportionati de dieta insa se sintetizeaza in corp in special plecand de la urmatoarele elemente:

  • Superoxidul dismutasa
  • Catalasa
  • Glutation peroxidasa si glutation reductasa
  • Glutation
  • Acidul alfa lipoic
  • Coenzina Q10
  • Acidul uric
  • Melatonina
  • Etc

 

Se poate face si o alta clasificare:

  1. Antioxidanti enzimatici sunt aceia care elimina radicalii:
    • Superoxidul dismutasa
    • Catalasa
    • Glutation peroxidasa si glutation reductasa
  2. Antioxidanti ne-enzimatici sunt cei ce opresc reactiile lant pe care le produc elementele reactive oxidante: glutation, acidul alfa lipoic, vitamina C, polifenolii etc.

 

Multiplele functii ale antioxidantilor

 

Cand medicii vorbesc, in general, de antioxidanti, par sa uite sau sa ignore ca functia lor nu este doar de a neutraliza elementele reactive ci sunt responsabili si de alte sarcini suplimentare care beneficiaza bolnavul cancer in lupta impotriva cancerului. Sa vorbim doar despre capacitatea antioxidanta este o reducere absurda si contraproductiva.

De exemplu, vitamina C este un bun imunostimulator insa contribuie si la producerea colagenului si la respiratia celulara, coenzima Q10 colaboreaza si in cresterea imunitatii sau in obtinerea energiei.  Chiar si glutation, antioxidantul cel mai puternic dintre toti antioxidantii si pe care il vom analiza in acest articol, a carei functie principala este de a proteja membrana celulara sau mitocontriala impotriva oxidari, colaboreaza in alte functii de extrema importanta ((Ref)) precum eliminarea de toxine intracelulare si metale grele, participa in metabolismul leucotriene sau extrogenilor, la fabricarea …..(bilei) sau la sinteza proteinelor care contin cisteina. Antioxidantii endogeni sunt in general mai puternici ca cei exogeni in momentul neutralizarii elementelor reactive. Desi toti sunt necesari pentru produce sinergii comune, glutation este, fara indoiala, cel mai puternic si cel care determina cu mai mare flexibilitate, balanta redox al celulei. Vom vorbi in special de el in acest articol pentru ca are o importanta capitala in tratamentul anticancer.

 

Nevoia de radicali liberi si de homeostazia redox

Totul in natura are un scop. Radicalii liberi ai oxigenului pot avea functii benefice sau daunatoare in functie de cantitatea  absoluta sau relativa la nivelul antioxidantilor. Aceasta balanta redox permite ca celula sa obtina o homeostaza sanatoasa iar dezechilibrul ei poate conduce la aparitia diferitelor boli. In realitate, fara radicalii liberi nu putem trai. Asa cum se intampla si in alte procese biologice, un component nu este rau sau bun in sine, ci in relatie cu altii care il complementeaza. Un anumit nivel de ROS are efecte benefice intracelulare in timp ce nivele ridicate contribuie la moartea celulara (Ref).. Aceasta moarte poate fi necesara (asa cum vom vedea in continuare) pentru eliminarea celulelor posibil periculoase sau poate fi indusa din cauza unei starei de dezechilibru si prin urmare, nedorita si patologica. In definitiv, echilibrul intre oxidanti si antioxidanti este foarte complex si nu poate fi inteles usor plecand de la articole publicate in presa.

 

Mitocondria si echilibrul dificil intre apoptoza si proliferare celulara

 

Cu putin timp in urma, s-a descoperit rolul pe care il joaca mitocondria in reglarea homeostaziei celulare. Ea este cea care produce procesul de apoptoza sau sinuciderea celulara si o face generand radicali liberi in forma de elemente reactive ale oxigenului sau ROS (Ref). Apoptoza este un mecanism programat, auto-destructiv, normal pe care celula il activeaza cand se descopera vreo problema care ar putea pune in pericol buna functionare a acesteia: un dezechilibru biochimic, o problema structurala, daca celula s-a desprins din matricea ei extracelulara (in acest caz creste pericolul de a se produce o metastaza; acest tip de suicid se chiama Anoikis), din cauza toxinelor, sau in general, orice alteratie pe care o poate produce un comportament anormal al celulei. Semnalele care conduc la apoptoza pot fi extrinseci sau intrinseci (exterioare celulei sau interioare celulei). Cand are loc unul dintre aceste semnale, se incepe procesul destinat ca celula defecta sa fie eliminata (mult mai curat decat alte forme de moarte celulara precum necroza care conduce la inflamatii locale destul de periculoase) pentru ca in acest fel sa se mentina echilibrul intre celulele sanatoase care prolifereaza. O celula trebuie sa moara pentru ca alta sa traiasca si altfel organismul sa prolifereze.

În cazul unor semnale intrinseci care duc la nevoia de sinucidere, mitocondria celulei utilizeaza ROS ca elemente de semnalizare care initiaza o cascada de proteine ce trimit semnale la nucleul celulei, se dezactiveaza procesul de proliferare iar celula moare de o forma “curata”. ROS-urile generate in circumstante fiziologice nu sunt prejudiciale si au un rol important in semnalizarea celulara iar situatii de tipul hipoxia (nivel scazut oxigen) sau stres chimic pot creste productia lor (Ref). Este usor de vazut ca un exces de ROS motocondrial poate impune moartea in celulele sanatoase, ceea ce conduce la boli precum Alzheimer sau Parkinson.

 

Stresul oxidativ, mitocondria si cancerul

 

Insa ce se intampla cand problema afecteaza chiar mitocondriile, cand se altereaza permeabilitatea membranei mitocondriala si nu poate “comunica” cu nucleul?
In aceasta situatie se produce ROS mitocondrial care nu conduce la un suicid. In felul aceste, avem de a face cu o celula care a devenit nemuritoare (redevine mortala doar daca i se induce moartea celulara, programata sau nu). Mitocondria se ocupa de asemenea de a proportiona marea parte din energia celulara de care celula are nevoie, oxidand
piruvatul care s-a produs in citosol plecand de la glucoza.

Ce se intampla cand mitocondria deteriorata NU poate sa isi faca treaba precum centrala de energie?

Celula trebuie sa o obtina din alta parte si acest lucru se obtine cu ajutorul procesului de glicoliza anaerobica sau efectul Warburg: fermenteaza mari cantitati de glucoza in citosol fara a folosi oxigen desi in jur exista suficient oxigen (foloseste de 100 de ori mai multa glucoza ca o celula normala care  oxideaza glucoza in mitocondriile ei nedefectuoase si genereaza mai mult ATP in fiecare molecula de glucoza). Glicoliza produce acid lactic in cantitate mare care ajunge in jurul extracelular si il acidifica. Celula care nu se poate sinucide, se inmulteste fara control, mai repede decat vasele sangvine care ar trebui sa se formeze ca sa o alimenteze, in felul aceste, noile celule apar intr-un mediu slab alimentat si oxigenat. In aceste circumstante creste proteina HIF-1 alfa, sau factor de crestere prin hipoxie pe care celulele sanatoase o folosesc in situatii adverse, de exemplu in timpul unei ischieme: se inmultesc repede pentru a preveni moartea tesutului sanatos. In acest caz, in schimb, aceasta inmultire se termina intr-o situatie patologica: cresterea, datorita hipoxiei, a unei mase celulare care nu se poate sinucide. Hipoxia se relationeaza apoi cu numarul mare de factori angiogentici care formeaza vase sangvine noi pentru a alimenta aceasta masa care creste de forma necontrolata si care este in realitate un cancer.  Drumul de la problemele produse de oxidare, inflamatie si cancer este destul de clar (Ref). Acest stres poate fi provocat de o dieta (plina de glucoza) care nu aduce suficienti antioxidanti si nu premite nici  corpului sa ii produca, si/sau virus sau metale grele si care rup echilibrul redox.

 

Glutation si proportia intre reducere si oxidare ca masura a stresului oxidativ

 

Glutation (GSH) este o tripeptida formata din 3 aminoacizi: glicina, cisteina si glutamatul iar sinteza lor se produce in 2 pasi: intai se uneste glutamatul cu cisteina cu ajutorul unei enzime care se chiama glutamat-cisteina ligasa (GCL) si acesta este primul pas in sinteza glutation la care apoi se uneste glicinia prin intermediul enzimei glutation sintetasa.

Se produce in toate celulele din corp insa in special in ficat, care se pare ca este centrul de producere si distribuire a glutationului-iata de ce de multe ori inainte de cancer ficatul a suferit, asa cum a observat si  dr Max Gerson . Un fapt important: mitocondria poate genera ROS insa nu poate genera glutation si e nevoie sa il importe cu ajutorul cistolului prin intermediul membranei sale: reusita de a evita acest pas transmembrana poate fi o forma de a modifica balanta redox intracelulara tumorala fata de stresul oxidativ.

Mai târziu vom vedea cum să profitam de aceasta informatie.

Cand glutation (GSH) in stadiul redus realizeaza functiile sale antioxidante, el însuși este oxidat si trece in stadiul de glutation oxidat sau GSSG. Starea redox din celula depinde in realitate, nu atat de nivelul absolut de GSH cat de proportia dintre glutation redus si oxidat: GSH\GSSG. Un raport mai mare inseamna o stare putin predispusa la oxidare in timp ce un raport scazut sugereaza ca celula sau organul va fi supus stresului oxidativ. Aceasta proportie este direct legata de capacitatea celulei de a induce Apoptoza (Ref1, Ref2)si inclusiv alt tip de moarte celulara precum la necroza sau autofagia(Ref)

Dupa cum am vazut, ROS-ii sunt cei care initiaza procesul insa sunt controlati de proportia sau raportul glutation-ului redus/oxidat care reprezinta un aspect important in controlul homeostatic celular.

 

Diferenta echilibrului redox din celula sanatoasa si  din celula cancerigena

 

Din ce am vazut pana acum:

  • Exista o relatie directa intre excesul de oxidare si aparitia cancerului
  • Oxidantii promoveaza apoptoza sau sucidiul celular in timp ce un exces de antioxidanti il opreste
  • Celulele canceroase nu se pot sinucide pentru ca desi produc un exces de oxidanti, compenseaza cu un exces de antioxidanti

Inseamna asta ca un surplus de glutation (GSH) protejeaza celula sanatoasa impotriva cancerului insa acest surplus intr-o celula canceroasa serveste pentru a proteja tumoarea?

Raspunsul e DA (Ref), si in plus, organele sanatoase ale unui bolnav de cancer prezinta in general o proportie scazuta de GSH\GSSG, adica un inalt stres oxidativ, in timp ce celulele dintr-o tumoare prezinta o proportie sau un raport crescut de GSH\GSSG, adica un nivel scazut al stresului oxidativ(mai pe romaneste cele sanatoase sunt predispuse sa devina canceroase in timp ce cele canceroase sunt protejate de antioxidantul glutation GSH).  
Efectele si rolul chimioterapiei si influenta stadiului redsupraexpresiaox

 

Practic, toate chimioterapiile se bazeaza pe niste principii simple: generare ROS care ataca celulele care produc diviziune celulara. Asta inseamna ca chimioterapia va fi mai eficace cu cat este mai mare diviziunea celulara si cu cat este mai mica protectia antioxidanta a tumorei. In acest sens, nivelul de glutation si proportia GSH\GSSG sunt direct relationate cu agresivitatea unei celule si cu capacitatea ei de rezistenta la chimioterapie (Ref1, Ref2). Aceasta inseamna ca cu cat agresivitatea este mai mare, cu atat mai mare este nivelul de antioxidanti  endogeni si mai mare va fi capacitatea tumorei de a resista stresului oxidativ (al chimioterapiei). In plus exista o relatie directa, aproape liniară (și, prin urmare, formează o serie de relații cauză-efect de simplicitate extraordinara, deoarece acestea pot fi puternice obiective terapeutice pentru a opri punctele slabe ale acestui lanț de evenimente) intre gradul de moarte mitocondriala, gradul de glicoliza si glutaminoliza, cantitatea de acid lactic produs, aciditatea extratumorala, hipoxie, …..supraexpresia factorilor inflamatorii si angiogenetici si …..supraexpresia glutation.

Cand o tumora devine mai agresiva, ea devine, de asemenea, mai hipoxica (și invers este de asemenea adevărat), ceea ce face dificilă generarea de specii de oxigen reactive, care, la rândul lor, sa compenseze, chiar si în mai mică măsură, antioxidanti în exces pe care tumora ii sintetizeaza. 

Din contra, celulele sanatoase care de asemenea se divid rapid (de exemplu mucoasa intestinala), …microbiota, sistemul imunitar, celulele reproducatoare, foliculii pilosi vor fi supusi unui puternic stres oxidativ. Aici avem o reteta pentru dezastru daca nu complementam chimioterapia cu actiuni aditionale:

  • Pe de o parte, corpul sanatos al bolnavului de cancer, oxidat si incapabil de a se apara de stresul aditional al chimioterapiei
  • Pe de alta parte, celulele din tumoare dispuse a produce un surplus de antioxidanti pentru a face fata atacurilor externe ale chimio terapie

Pe cine suprinde acum aspectul unui bolnav de cancer, cu intestinele si sistemul imunitar distrus, fara par si convinsi ca probabil micul timp castigat prin chimioterapie, nu compenseaza aceasta pierdere a calitatii de viata?

Multi oncologi folosesc o logica binara care porneste de la realitati foarte putin empatice  si in acelasi timp extrem de antistiintifice: ma intereseaza sa prelungesc cat de cat viata, reducand momentan dimensiunea tumoarei in defavoarea organelor sanatoase. Chiar daca vor reusi sa induca un stres considerabil in tumoare, stiu ca chimio va vindeca intr-un procentaj scandalos de mic si ca tumoarea va reaparea insa de data aceasta va prezenta rezistenta la tratament. In acelasi timp,  corpul bolnavului va avea imunitatea profund afectata si va fi incapabil de a opune mai mult decat o usoara rezistenta agresivitatii tumorei. Desi tratamentul alopat „a prelungit putin viata” in comparatie cu cine nu se trateaza (si de fapt este exact invers), lunile „castigate” vor fi extrem de dificile. Logica oncologului este: cum tumoarea contine o cantitate mare de antioxidanti, nu vom face lucrurile mai usoare ca prin mancare, corpul sa ii poata fabrica. Arunca o moneda in aer si spera ca corpul  sa nu moara inaintea tumoarei. Insa daca asa se intampla, daca pacientul moare din cauza tratamentului alopat (si de obicei ASTA se intampla), nimeni nu o sa il acuze ca au accelerat de fapt moartea pacientului bolnav cancer. La urma urmei, ei aplica doar tratamentele alopate standard pe care „stiinta” le permite, cea bazata exclusiv in studii in faza III platite de marile corporatii farmaceutice.

Intrebarea pe care trebuie sa ne-o punem este putem proteja corpul sanatos crescand nivelul de glutation in celulele sanatoase si in acelasi timp sa scadem nivelul de antioxidanti in celulele tumorale astfel incat sa le facem mai vulnerabile?

Raspunsul este DA.

Relatia intre glution si metilare. Importanta dietei in cancer

 

Metilarea este un mecanism complex de o extraordinara importanta care participa intr-o lista interminabila de procese biochimice corporale si este unul dintre principalele mecanisme epigenetice, adica “aprinde” sau “stinge” mii de gene (data viitoare cand auziti vorbindu-se de importanta mutatiilor genetice in cancer, va sfatuiesc ca intai sa izbucniti in ras apoi sa intrebati daca nu ar fi convenabil sa se studieze inainte mecanismele epigenetice). Este un proces ciclic care “incepe” cu aminoacidul metionina si “termina” cu alt aminoacid, homecisteina, si cu producerea de antioxidanti endogeni precum SAM-e si glutation.

Un exces de ambele datorita unei deficiente de metilare (in special homocisteina, un analog al cisteinei, ambele toxice in cantitati excesive) sta in spatele unei infinitati de procese patalogice iar cancerul se afla printre ele (Ref).

Intr-o metilare corecta intervin o multime de aminoacizi, vitamine si alti cofactori, si unii dintre cele mai importanti sunt: metionina (paradoxul este ca se produce mai mult glutation cand se genereaza o cantitate mai mica de metionina ( Ref) , vitaminele B6, B12, folati (B9), glicinia, cisteina, colina sau betaina. Daca vom  cauta care sunt sursele cele mai importante ale acestor compusi, probabil unii se vor surprinde: ficat, piele, oase, albus…insa un moment, parca ascult…”nu urmam o dieta vegetariana care este plina de antioxidanti?  Pai, sunt pline de antioxidanti exogeni insa daca vorbim de o dieta care sa permita corpului sa produca o multime de de antioxidanti endogeni (cei mai potenti), alimentele de origine animala sunt cele mai indicate.

Este adevărat, totuși, că antioxidanți exogeni lucrează împreună sinergic pentru a consolida reciproc și pentru reciclarea glutationului oxidat, crescând nivelurile sale. Ceva deosebit de evident mai ales în cazul vitaminei C (Ref). . Aceasta este, în avans o parte din concluziile la care ajungem la sfârșitul acestui articol: știința susține omnivorism, nu vegetarianismul strict, ca cel mai bun promotor al sănătății.

Cum este nevoie sa reducem metionina (Ref) pentru a creste productia de glutation, trebuie sa reducem consumul de carne provenita de la muschi si sa crestem consumul de organe interne si in special de colagen. Punctul in comun cu dietele vegetariane si de care trebuie sa tinem cont, este ca trebuie sa reducem proteinele insa dietele vegetariene de obicei sunt deficiente in glicina (in afara de vitamina B12) asa ca trebuie sa echilibram de forma adecvata aminoacizii crescand consumul de colagen.

 

Ducand dieta anticancer putin mai departe: cetoza /ketoza(energia din GRASIMI permise in cancer)

Se pare ca deja am garantat productia suficienta de antioxigeni endogeni care protejeaza corpul sanatos de chimioterapie, reducand proteinele si crescand consumul de organe interne si in special de colagen (piele, oase, cartilaje, moluste etc).

Vom vedea daca putem imbunatati si mai mult aceast aspect. Dieta ketonica se bazeaza pe principiu ca infometand tumoarea (prin limitarea de glucide), scadem dramatic nivelele de glucoza si cresc corpii ketonici care au efecte toxice asupra tumorii (Ref)..

Insa cum afecteaza dieta Ketogenica nivelele de antioxidani endogeni in celulele sanatoase si canceroase?

Un studiu facut de Universitatea din Colorado a aratat ca dieta ketogenica creste nivelul glutation-ului in celulele sanatoase (Ref), si scade nivelul peroxidului de oxigen (H2O2).

Pe de alta parte, departamentul de radiooncologie  din cadrul Universitatii din Iowa (Ref) a studiat avantajele antitumorale ale  ketozei (Ref si au mers mai departe de efectele terapeutice asociate stresului metabolic pentru ca din punctul lor de vedere, aceasta termina cu un stres oxidativ selectiv in celulele tumorale.

De fapt, propun ca metabolismul glicolitic este maniera prin care celula scapa de stresul oxidativ anterior.

Mecanismul pe care il propun pentru a explica efectele oxidative ale dietei ketogenice in celulele tumorale are legatura cu producerea de coenzima NADPH care este un puternic reductor al GSSG, transformand din nou forma oxidata a glutation in forma sa redusa (DSH).

Concluzia este  ca, blocand selectiv producerea de NADPH in celulele tumorale, dieta ketogenica  dezechilibreaza proportia GSH\GSSG tumorala(din tumoi) si potenteaza forma oxidata cu ajutorul careia  se creste stresul oxidativ(in tumori).

Cum celulele tumorale contin o concentratie mai mare de ROS decat celulele sanatoase, orice oxidare are efecte crescute in ele, superioara cantitatii pe care ar produce-o o celula sanatosa si multiplica efectul chimioterapiei. De fapt asa cum se intampla in multe alte procese biologice, NADPH  mentine un echilibru cu NSDP+ si proportia NAD+\NADH joaca un rol extrem de important in evolutia cancerului (Ref1, Ref2).

O proportie redusa implica un stres oxidativ mai mic si o malignitate crescuta. De fapt, studiul sustine ca obiectiv terapeutic principal ar trebuie sa fie sa se trateze bolnavul cancer  cu promotori NAD+. Ceea ce e bun din dieta, e ca produce acelasi efect insa de forma selectiva. Chiar si unul dintre oncologii cei mai recalcitranti cu care m-am intalnit pana acum, mi-a recunoscut acum cateva luni in urma, ca bolnavii care veneau sa faca tratamentul alopat dupa ce au renuntat la micul dejun 2-3 zile inainte, suportau mult mai bine efectele secundare ale chimioterapiei si obtineau mai bune rezultate. Am fost pe punctul de a ii raspunde cu sarcasm pentru a ii reaminti ca “observatiile lui sunt anecdotice si statisticamente nesemnificative” asa cum raspunde el cand ii este prezentat un studiu preclinic insa m-am abtinut la timp. Este interesant cum observatiile personale bazate in putine cazuri, sunt mai puternice ca orice statistica si cum activeaza intuitia, un aliat puternic al inteligentei in a elabora ipoteze. Ceea ce este mai rau din aceasta istorie este ca mai mult ca sigur ca doctorul nu cunoaste fundamentul metabolic al renuntatii la micul dejun si ca poate sustine pana la un punct efectele lui tinand o dieta ketogenica. De asemenea nu cunoaste ca observatiile lui sunt compatibile cu toate aceste cercetari carora niciodata nu le-a acordat atentie.

 

Actiuni terapeutice aditionale cu efecte in glutation tumoral

In afara de dieta ketogenica, stim ca exista anumite medicamente si molecule naturale care au ca obiectiv glutation si care au o buna eficacitate antitumorala facand o buna sinergie cu chimioterapia.

Moleculele sintetice vin insotite de marea problema a absentei selectivitatii si drept urmare, de multe efecte secundare (asupra celulelro sanatoase) ceea ce ne obliga a sfatui sa se inceapa cu moleculele naturale si sa se apeleze la medicamente doar in situatii de urgenta.

 

Medicamente

 

Sulfasalazina este un antiinflamator folosit in tratarea bolilor precum colitis ulceroasa si actioneaza asupra transportatorului cisteinei. In acest fel impiedica sa se folosesca acest aminoacid pentru a se produce glutation (Ref1, Ref2).. Trebuie luat in considerare ca cisteina este toxica si ca este rar intalnita in dieta noastra, motiv pentru care corpul are tendinta de a retine aceasta toxicitate folosind-o imediat in a fabrica glutation. Daca o impiedicam, concentratia in sange a cisteinei va creste si va produce efecte secundare. Desi pare o optiune punctuala la care putem apela in caz de urgenta, exista optiuni naturale mult mai bune.

 

Butionina Sulfoximina (BSO) foloseste alta cale de a reduce glutation din celulele canceroase si prezinta o buna sinergie cu chimioterapia. Intr-un studiu preclinic pe mieloma multiple, s-a observat o crestere semnificativa in media de supravetuire in grupul tratat cu BSO plus chimioterapie (Ref)

 

Verapamil este in inhibator al calciului si este utilizat in cazuri de hipertensiune si angina in piept. S-a descoperit ca va creste efectele chimioterapiei prin reducerea  glutation din celulele canceroase (Ref).. Face parte din cocteilul de medicamente cu ajutorul carora cativa pacienti au obtinut rezultate exceptionale insa trebuie luate in considerare efectele secundare care pot fi grave si intereactiunea cu alte medicamente.

 

Diphenyliodonium blocheaza NOX, care reduce sinteza NAPDH y prin urmare conduce la cresterea stresului oxidativ tumoral si impiedica raspandirea (Ref).. In ciuda bunelor rezultate, are efecte secundare nedorite care il transforma intr-o arma cu dubla taiere (Ref) si in consecinta e un medicament putin recomandabil.

 

Trioxido de arsenic (As2O3) a condus in vitro la remisia completa a celulelor cancerigene in cazul leucemiei, cu o aparenta minima toxicitate, scazand nivelul glutation in tumoare (Ref)

 

Molecule naturale

 

Resveratrol s-a devedit a fi efecient in producerea apoptozei celulelor tumorale (Ref):: in loc de a creste productia de ROS, actioneaza asupra membranei mitocondriei, facilitand circularea GSH-ului care a intrat in ea si dificultand intrarea noului glutation de la citosol catre mitocondrie, de forma specifica in celulele tumorale si fara efecte secundare. Are in schimb problema putinei biodisponibilitati si cum sa atingem in subiecti umani nivelele terapeutice pe care le-au folosit studiile preclinice si in acest sens ar trebui sa ne indreptam atentia catre noile formule de nanoparticule si lipozomi care pot revolutiona aministrarea de medicamente crescand potenta, selectivitatea si sinergia lor.

 

Curcuma, omniprezenta molecula cu multiple efecte antitumorale, creste de asemenea productia de ROS motocondrial in celule tumorale. Desi nu pare sa aiba un efect direct asupre glutation, dezechilibreaza balanta redoxului tumoral. La fel ca si resveratrol, prezinta problema putinei biodisponibilitati si ar trebuie sa se utilizeze nanoparticule sau curcuma lipozomala.

 

L-glutamina – este complet contraintuitiv ca suplimentarea cu glutamina este benefica bolnavului de cancer datorita faptului ca celulele tumorale consuma o cantitate mare de acest aminoacid in timpul procesului chemat glutaminoliza. Totusi glutamina si oxidarea sa pare sa concureze cu glutation  care intra in mitocondrie si pare sa favorizeze faptul ca merge spre citosol scazand nivelele de GSH mitocondrial (Ref). Sunt multe studii care confirma beneficiile suplimentarii cu glutamina a bolnavilor de cancer (Ref) deoarece reduce de forma semnificativa efectele secundare ale chimioterapiei si radioterapiei (Ref) fara sa intervina in efecticienta tratamentului alopat. In plus, glutamina para sa combata casexia care afecteaza bolnavii cu cancere avansate. Amintim : casexia nu tine neaparat de pierderea de grasimi ci de pierderea de masa musculara si energie deoarece tumoarea se alimenteaza cu glutamina ramasa libera. Se poate spune ca tumoarea va obtine glutamina de oriunde din organismul sanatos asa ca este mai bine sa i-o proportionam noi pentru a evita astfel deteriorarea organismului si asa acesta sa poata face fata luptei cu cancerul. Un motiv in plus ca consumam supe din oase frecvent.

 

Piperlongumina, molecula obtinuata din planta Piper Longum L, s-a dovedit a avea capacitatea de a reduce nivelele de GSH si de a creste nivelele de GSSG, scazand proportia de GSH/GSSG mitocondrial din celulele tumorale si in acest fel, facandu-le mai sensibile la chimio si radio (Ref1, Ref2),, fara efecte adverse in celulele normale.

 

Potentilla fulgens, extractul din radacinile acestei plante (de obicei face parte din arsenalul terapeutic al medicinei indiene) si-a dovedit capacitatea de a goli depozitele de glutation redus dintr-o tumoare (GSH) cel putin in vitro Ref1, Ref2.

 

Extract de usturoi, componentele lui sulfurice cresc nivelul de glutation in celulele sanatoase (Ref) si il reduc in celulele tumorale (Ref)

 

Isotiocianatos din verdeturile crucifere, compusi sulfuricicare in acelasi mod ca si cei din usturoi si ceapa, reduc GHS din celulele tumorale si induc un puternic stres oxidativ Ref

 

Seleniul este un cofactor care intervine in ciclul de sinteza a glutation si nivelele lui in sange sunt direct relationate cu acest antioxidant. (Ref).

Totusi desi pare sa creasca nivelele de glutation in celulele tumorale, reduce proportia GSH\GSSG si induce un stres oxidativ in tumoare. Formele de Selenitul de sodiu si Seleniometionina au demonstrat eficacitate antitumorala (Ref). Sunt cateva studii care se indoiesc ca suplimentarea cu Seleniometionina ar ajuta in prevenirea cancerului (Ref)

 

Vitamina C are un efect prooxidant si dezechilibreaza, prin intermediul unui mecanism elegant si curat, echilibrul redox, numai in celulele tumorale.

 

Problema multirezistentei la tratament si la medicamente. Pozitia oficiala a oncologiei

 

Dintre toate cosmarurile oncologiei, multirezistenta este cea mai temuta. Nu e nevoie sa fii un geniu pentru a intelege ca asa cum este fundamentata investigatia oncologica-paradigma pe  care aceasta o sustine-este logic sa se intample asa. Ceea ce rezulta mai putin curios este cum toate aceste cosmaruri sunt percepute de catre oncologi ca inevitabile. Medicamentele sunt supuse la proble clinice in faza III pentru a vedea daca ceva functioneaza sau nu iar medicii pot recomanda doar ceea ce a fost supus acestei probe. Experimentele sunt lungi si costisitoare si sunt finantate doar de marile corporatii asa ca se experimenteaza doar cu ceea ce intereseaza din punct de vedere economic. Cum exista o multime de molecule promitatoare insa cu  care nu se experimenteaza in faza III, vor zace in taramul posibililor iar oncologii nu le vor putea trece pe reteta in ciuda potentialului enorm datorita “lipsei de dovezi si a posibilelor interactiuni cu chimio”. Aceeasi chimio ‘terapie’ care (si asta se poate demonstra cu date) va esua  mai devreme sau mai tarziu dupa ce va lasa urme de distrugere in corpul sanatos al pacientilor sai.

 

Conceptul de multirezistenta la medicamente

Multirezistenta la medicamente (MDR) este un mecanism in care sunt implicati multi factori Ref, Starea de redox (definita asa cum am vazut  prin nivelele de glutation oxidat si redus cat si prin nivelele de ROS mitocondrial) este unul dintre ele asa ca punand in practica ceea ce am aflat pana acum, se poate reduce rezistenta macar in parte. O tumora cu nivele crescute de glutation va fi mai rezistenta la chimioterapie.

Sunt si alti factori care intervin in aceasta rezistenta: acum putin timp in urma s-au descoperit niste glicoproteine numite trasportatori ABC (de moment s-au identificat  49) a carei functie principala este e a expulza din celule tot ce este toxic in tratamentul de chimioterapie. Datorita actiunii lor, o mare parte din chimioterapie nu ramane in celulele tumorale timp suficient pentru a realiza functia sa citostatica care are loc cand celula se divide. S-au cercetat diferite medicamente care au ca obiectiv blocarea acestor transportatori insa pana acum au demonstrat o eficacitate limitata iar efectele toxice ridicate.

 

Hormeza si factorul Nrf2

 

Hormeza poate fi definita ca raspunsul adaptativ a unui organism la o mica doza de stres, ceea ce ii permite sa faca fata viitoarelor doze puternice in viitor. In mici doze, veninul poate fi benefic si sa ajuea organismul sa capete rezistenta la doze superioare care inainte de aceasta adaptare, ar fi fost letale. Factorul NRF2 este o proteina care reguleaza raspunsul antioxidant al organismului la nivele moderate de stres oxidativ.

 

Homehormeza sunt chiar fitochimici antioxidanti?

 

In ultimul timp, numerose studii pun la indoiala ca fitochimicii ar fi antioxidanti si sustin ca , capacitatea antioxidanta a plantelor provine din capacitatea noastra de a reactiona in fata unei oxidari moderate: factorul Nrf2 activeaza apararea antioxidanta  cand ne intalnim cu atacuri oxidante ale fitochimicilor. La urma urmei, fitochimicii sunt moleculele pe care le produc plantele pentru a se proteja. Plantele nu vor ca noi si animalele sa ne alimentam de ele pt ca ele nu obtin nici un beneficiu si in acest sens au pregatit un adevarat atac chimic destinat celui care indrazneste sa le manance. Raspunsul organismului va fi pe masuta atacului chimic. Prin urmare cu cat e mai mic atacul fitochimic al plantelor, cu atat mai mica este activarea antioxidantilor, datorita factorului Nrf2 si mai mica  capacitatea de a raspunde la stres va acumula organismul nostru. De-a lungul evolutiei, am reusit sa ne adaptam la otrăvurile lor opunand o rezistența care in cele din urma, e posibil sa fi beneficiat  toti. Un echilibru a fost rupt insa în ultimele decenii din cauza solurilor sărace și tratamentelor  industriale: plante nu mai au nevoie de protecție împotriva insectelor, pentru că elemente externe o fac pentru ele și, din acest motiv, plantele din culturi de câmp industriale produc între 5 și 10 ori mai puțin fitochimice sălbatice (și o cantitate la fel de mică de vitamine și minerale). Răspunsul organismului este proporțională atacului chimic. Prin urmare, cu cat plantele au o cantitate mai mica de fitochimici,  cu atat mai mica este activitatea antioxidanta, datorită factorului Nrf2 si cu atat va fi mai mica capacitatea organismului nostru de a raspunde la stres.(personal nu prea imi suna ok teoria aceasta)

 

Factorul Nrf2 si cancerul

Dupa cum am vazut pana acum, un nivel adecvat de Nrf2 permite sa se produca antioxidanti endogeni care sa se opuna stresului oxidativ, asa ca pare corect sa presupunem ca ajuta a preveni ciclul de initiere a cancerului. Dar si niveluri excesive perturba echilibrul catre formele reduse, ceea ce poate conduce la dificultăți de diferențiere și problemelor similare celor constatate cand ne intalnim cu un exces de forme oxidate (Ref).

 Nu este de mirare ca exista o relatie directa intre factorul Nrf2 si gradul de malignitate pentru ca va avea mai multe facilitati de a sintetiza glutation redus care imbunatateste raportul GSH\GSSG si permite tumorii sa devina mai rezistenta la tratament alopat.

 

Problema aditionala a hipoxiei(deficitului de oxigen)

 

Alt factor care contribuie la multirezistenta este hipoxia. Cresterea rapida a unei tumori conduce la dezvoltarea de zone hipoxice cu diferente caracteristice de restul celulelor tumorale, mai bine oxigenate.  Probabil creșterea unora dintre celule hipoxice sa se realizeze la fel de repede ca și restul insa prin caracteristicile sale biochimice sunt mai agresive si in acest fel devin rezistente la tratament alopat si predispus la recidive. Mecanismul glicoliza creste in zonele hipoxice si consecinta este ca produce mai mult acid lactic care ajunge de la citosolul celulei in spatiul extratumoral prin transportatorii monocarboxilati (MCT). Acest acid lactic acidifica spatiul extracelular al tumorii (ph mai mic) ceea ce obliga interiorul celulei tumorale sa se apere si mai mult (ph mai mare) si sa ridice o bariera fizico-chimica care sa opreasca pasul medicamentelor in zona tumorala (Ref)

Asa ca in afara de a oxigena tesuturile, trebuie sa impiedicam sa se verse acidul lactic din interiorul celulei cancerigene (cercetatorii de la Universitatea din Minnisota au creat mici molecule biodisponibile care au acest efect) Ref

 

Natura in salvarea multirezistentei

 

In acest capitol vom  vedea cum putem incorpora legumele si alte substante naturale de forma inteligenta pentru a distruge multirezistenta tumorala a tratamentului alopat. Stiinta a inceput sa se intereseze de acele molecule care pot fi selective si eficace, si multe studii au confirmat potentialitatea diferitelor fitochimicale(‘chimicale’ din plante) ca inhibitori ai tranportatorilor ABC, MCT si al factorului Nrf2 (desi e  dificil de crezut ca vor fi supusi testelor asa cum sunt supuse medicamentele in ciuda efectelor negative).  Unele dintre aceste molecule au demonstrat eficacitatea lor (se pot lua in suplemente insa includ si sursa de aliment):

 

  • Gamma-tocotrienol: este una dintre cele 8 forme ale vitaminei E care se regaseste in uleiul de  palmier si in uleiul de cocos
  • Quercetina: cacao, ceapa, ardei, ardei iute
  • EGCG epipalocatequingat: ceai cerde si cacao
  • Luteolina: telina, ulei de masline extravirgen, ardei, lamaie, cimbru, anghinare
  • Apigenina: romanita, patrunjel, telina, coriandru, spanac, rosmarin, oregan, busuioc, cimbru
  • Baicalina si oroxilina: radacina plantei Scutellaria Baicalensisi folosita in medicina chinezeasca
  • Silimarina: ciulinul laptelui Milk Thistle
  • Galangina: din planta Rhizoma Alpinae Officinarum
  • Piperina si cafeina: piper negru si cafe organica (fara lapte)

Lista compusilor naturali cu o activitate antitumorala mai mare sau mai mica si cu efecte de reducere a multirezistentei este foarte larga si este posibil ca sinergiile pozitive ale multor combinatii ale acestor compusi sa faca mai eficiente alte terapiilor conventionale si chiar sa poata conduce la disparitia completa a tumorei. Este simplu sa facem combinatiile  cu aceste molecule promitatoare si sa determinam gradul de sinergie sau antagonism, folosind o unealta de tipul Cosbosyn care permite preconizarea cu precizie comportamentul diferitelor combinatii ale unui coctail de molecule si care sunt cele mai indicate in a crea o sinergie. Acest program utilizeaza metoda de Chou-Talalay pentru a atribui un indice de sinergie a acestor combinatii. Desi un sistem matematic de acest tip nu poate fi utilizat pentru a crea unui cocktail de molecule precis, acesta poate fi folosit pentru a face o verificare a ceea ce se amesteca inainte de a fi testate si pentru a castiga timp si resurse atunci cand ne intalnim cu un numar mare de combinații posibile care ar putea fi obtinute cu toate fitochimicale si molecule naturale cunoscute și necunoscute. Până în prezent, este dificil sa gasim un studiu care testeaza mai mult de doua molecule la un moment dat. Atunci cand se gasesc studii care foloseste sinergia promitatoare a doua molecule care reduc rata de progresie a tumorilor in mod semnificativ (la soareci, eu știu că nu se poate extrapola la om insa asta e situatia), mă întreb ce s-ar întâmpla dacă am putea găsi un cocktail de 4, 5, 6 sau 40 de substanțe naturale care sa reduca sa conduca la remisia cancerului in mod obisnuit ? 

 

Chimioterapia in doze mici

 

Dacă prin utilizarea inteligent a dietei si suplimentelor (ceea ce am studiat pana acum in acest articol), putem face ca chimioterapie sa fie mai eficientă și mai puțin toxica pentru organism sănătos, atunci am putea lua în considerare reducerea dozei.  Trebuie sa fie pe termen lung, atacand in continuu tumoarea cu un asediu chimic contant si pe multiple fronturi.  Chimioterapia in doze mai mici insa constante poate fi aplicata in mai multe cicluri fata de dozificarea standard in asa fel incat corpul sanatos sa aiba aiba imunitate iar tumoarea sa nu aiba perioade in care sa nu fie atacata de drog. Aceasta prezenta insinuoasa si permanenta are efecte antiangiogenetice pe langa cele citostatice. Atat studiile pe tema aceasta cat si simtul comun zice ca cea mai buna strategie impotriva tumorii e cea mai putin toxica pentru pacient.

 

Rezumand: dieta paleoKetogenica, nu strict vegana , suplemente naturale, antioxidanti si anumite medicamente  in apararea organismului si in lupta impotriva cancerului

 

Rezumatul masurile dietetice ce par cele mai razonabile in lupta cu cancerul:

  • Reducerea proteinelor si in special a metioninei (datorita capacitatii de a creste antioxidantii in corpul sanatos)
  • Cresterea colagenului, reducerea carbohidratilor cu alta densitate energetica si cresterea grasimilor sanatoase(in special a GRASIMILOR PERMISE IN CANCERin special  OMEGA 3 _)
  • Cresterea consumului de legume cu un alt procentaj de fitochimice potentatoare a terapiilor conventionale si inhibatori ai multirezistentei

 

Rezultatul este o lista de alimente care formeaza o dieta paleo cu varianta sa redusa-carbohidrati insa cu un ridicat nivel de macronutrienti. Este o dieta oarecum atipica pentru ca elimina aproape complet carnea din muschi si recomanda organele interne, parti cartilaginoase, piele, oase, moluste, peste albastru si oua ca aport proteic. Se recomanda grasimi sanatoasa si multe legume, alge si ciuperci.

articol original:http://cancerintegral.com/antioxidantes-multirresistencia-cancer/

 

Si in final, adaug si eu cea mai buna dieta ANTI cancer elaborata pina in prezent ramane tot dieta Dr Budwig(care este si ketogenica si creste si oxigenarea celulara!!! si nu numai), dieta care poate fi completata cu cele de mai sus!

luati in calcul si recomandarile dr Budwig cancere avansate

si multa credinta , nadejde dragoste ca nu traim vesnic oricum pe acest pamant stricacios 🙂

Sanatate multa si DOAMNE AJUTA!

sanatate tatalui Nicoletei , multumim pentru traducere

 

Vitamina C liposomală  

Pentru acei dintre dvs care opteaza pentru folosirea de vitamina C si optiunea Vitamina C IntraVenoasa este una costisitoare sau nu are cine sa o adminsitreze, iata o alternativa buna: vitamina C lipozomala

AUTOR: Blake Graham, nutriţionist Clinic

Am folosit recent un produs denumit vitamina C liposomală, produsă de LivOn Laboratories. Vitamina C liposomală este vitamina C încapsulată în molecule lipidice numite liposomi. Acest sistem de transport permite o absorbţie mult îmbunătăţită, plus absorbţie celulară foarte eficientă. Rezultatul este o eficienţă net superioară. Un doctor în medicina integrativă binecunoscut în SUA este Thomas Levy, M.D., J.D. Este specialist cardiolog, are o titulatură în biologie şi alta în drept. Este cunoscut în special pentru eforturile sale extinse în ce priveşte vitamina C, folosind atât IV vitamin C,  cât şi megadoze orale de vitamina C. IV vitamin C este un excelent tratament pentru infecţiile cronice, deşi beneficiile pe termen lung necesită folosirea la intervale regulate. De exemplu dacă administ…

Citeşte mai mult: www.alergicblog.ro/2015/04/vitamina-c-forma-liposomala/ © traducere: Alergic Blog

Vitamina C si CITRINA(vitamina P)

Buna seara,

Doresc sa fac o corectie legat de administrarea de vitamina C in doze MARI.pentru a o tolera , organismul are nevoie de CITRINA(bioflavonoid din complexul numit vitamina P):

Uncovered by the Nobel prize-winning biochemist who also discovered vitamin C,1 Albert Szent-Gyorgyi, these brightly colored nutrients are also known as citrin, vitamin C-2, flavones, flavonols, and flavonones.2 Let’s take a brief look at some of the names used to identify the bioflavonoids, and what they mean: Bioflavonoids are nutrients with vitaminlike qualities; they are water soluble and always occur in combination with vitamin C. Bioflavonoids could be defined as compounds that perform biological functions in the human body.

Within citrin are hesperidin and other bioflavonoids. Hesperidin is a bioflavonoid found in the skins and peels of citrus fruits. Quercetin and rutin are names for two individual members of the bioflavonoid family. Rutin, which occurs in buckwheat, is sometimes sold separately. Trioexethyl-rutin is a rutin-related flavonoid effective in the treatment of hemorrhoids. Vitamin C complex or C-2 is used to describe the inseparable partnership of the flavones and vitamin C. Vitamin P symbolizes the positive effects that bioflavonoids have on the permeability of the capillaries. Confused?

And last but not least, vitamin P, a group of elements called bioflavonoids with names like rutin, citrin, hesperidin, and quercetin.

Atentie, CITRINA(din citrice) , NU citrulina(din coaja pepene verde)(desi nici citrulina nu va dauna, ci din contra, va fi transformata de cele mai multe tipuri de cancer (cu exceptia hepatocarcinoamelor , melaniamelor si cancerelor renale) in arginina si mai departe in Oxid Nitric cu rol anticnacerigen (imunomodulator , antiproliferativ, respiratia celulara,etc)

Cautati vitamina C cu Bioflavonoide ce includ CITRINA daca doriti sa beneficiati de efectele vitamina C in doze RIDICATE.

Toate cele bune!

Multumesc celui ce m-a intrebat referitor la diferenta Citrina si Citrulina

Cancer – chimioterapie sau vitamine?

 

  Cancer – chimioterapie sau vitamine?

imi cer scuze pentru perioada de „inacivitate „de pe acest site.Este insa o perioada in care s-au pus in plan si s-au si materializat mai mutle proiecte mai mari in domeniul sanatati alternative ROMANAI si EUROPA DE EST – sper eu sa se materializeze si restul – am sa va anunt la momentul respectiv pentru ca e drum lung, dar sper eu si avem aprte si de ajutor .Pina un a alta, va anunt despre – o nouă conferință la Timișoara  , Fundatia de sanatate Dr. Rath Romania
info@dr-rath-foundation.org, organizatie ce are produse de calitate ce pot completa un protocol bun 
 
 
 
Dr. Rath Health Foundation - Responsibility for Health, Peace and Social Justice
 
Fundatia de sanatate Dr. Rath Romania 12 iunie 2014
 

CANCER: Chimioterapie sau vitamine? – o nouă conferință la Timișoara

Fundaţia de Sănătate Dr. Rath – România organizează pe data de 25 iunie 2014, la Timișoara, o nouă conferinţă ce face parte din campania “Mişcarea Vieţii”.

Prezentarea va fi susţinută de Paul Anthony Taylor, Directorul executiv al Fundaţiei de Sănătate Dr. Rath.

Conferința va fi tradusă în limba română.

Tema conferinţei:

CANCER: CHIMIOTERAPIE SAU VITAMINE?

Află rezultatele cercetărilor din domeniul sănătăţii naturale care au demonstrat ştiintific faptul că toate mecanismele-cheie care fac din cancer o boală mortală pot fi blocate

Încă de la începutul istoriei, omenirea a fost bântuită de o boală care a rămas esenţialmente incurabilă – cancerul. Timp de aproape un secol, această boală a fost ţinta unei afaceri de investiţii, industria farmaceutică transformând această epidemie într-o afacere în valoare de multe miliarde de dolari.

Rezultatul era previzibil: astăzi, la începutul secolului XXI, cancerul se răspândeşte la scară globală; în cazul celor mai multe tipuri de cancer, rata anuală a mortalităţii este în continuă creştere, iar costurile astronomice ale acestei boli ruinează financiar milioane de bolnavi de cancer, sufocând economia unor întregi naţiuni.

Semnificativ este faptul că, pentru ca omenirea să câștige lupta împotriva cancerului, nu a fost necesară inventarea unor noi abordări de înaltă tehnologie. Descoperirea revoluţionară decisivă în ceea ce priveşte prevenirea eficientă, controlul şi în ultimă instanţă eliminarea cancerului se bazează pe înţelegerea rolului crucial al microelementelor nutritive.

 

TIMIȘOARA

Miercuri 25 iunie 2014, orele 18.00-20.00

Hotel Best Western Ambassador (Sala Ambassador)

Str. Mangalia nr.3, Timișoara

PARTICIPAREA ESTE GRATUITĂ

IMPORTANT: Numărul de locuri este limitat. Dacă doriţi să participaţi la conferinţă, vă rugăm să vă înregistraţi până vineri 20 iunie trimiţând un scurt mesaj de confirmare, pe adresa de email:

fundatia.dr.rath@gmail.com

Vom rezerva rânduri pentru cei care s-au înregistrat. Persoanele care nu s-au înregistrat dinainte vor fi îndrumate spre locurile rămase disponibile. 

Puteți înscrie și persoane care doresc să participe dar nu au acces la email, trimițându-le numele pe această adresă de e-mail.

Radu Oancea, 
Communication Officer, 

Fundația de Sănătate Dr.Rath – România
021-589.74.23 / 0737.19.17.82

Informaţiile despre conferinţă sunt disponibile şi pe site-ul fundaţiei: 

WWW4RO.DR-RATH-FOUNDATION.ORG

Cu multe urari de bine

Fundatia de Sanatate Dr. Rath Romania

Dr. Rath Health Foundation

Fundația de Sănătate Dr. Rath – România
Phoenix Center – Calea Buzești nr 75-77 et.6 cam.54
București 011013 România
Website: www4ro.dr-rath-foundation.org

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sau trimite-ne un email pe adresa: 
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Vitamin B 17 (Laetrile)

CLICK AICI pentru  limba ROmana(traducerea „aproximativa” utilizand google translate).

Vitamin B17 was thoroughly studied by Japanese researchers in the early 1970s. Vitamin B17 is found especially in apricot (Prunus armeniaca) kernels.

It is also found in the bitter seeds of wild almonds (Prunus amygdalus), of cherries (Prunus avium), of plums (Prunus domestica), of peaches (Prunus persica), of blackthorns (Prunus spinosa), of acerolas (Malpighia punicifolia), of quinces (Cydonia oblonga), as well as in the seeds and/or pulp of many other fruits like apples, grapes , berries(see table below).

This vitamin is very useful for cancer therapy. Indeed, it takes advantage of cancer cell metabolism, which is different from healthy cell metabolism in human beings.

Neoplastic cells, and especially anaerobiotic neoplastic cells, have a high concentration of beta-

Glucosidase, without Rhodanese. Therefore, they immediately phagocyte vitamin B17, and divide it by hydrolysis into two poisons: benzaldehyde and cyanide ions. On the contrary, healthy cells are normo-oxygenated and rich in Rhodanese, so they quickly convert these two poisons into benzoic acid and thiocyanates respectively.
 Both of them are harmless for healthy cells; actually, they are useful for them.

According to Kanematsu Sugiura, a Japanese researcher, beta-Glucosidase is found in the cells of breast, stomach, womb, mesentery and gullet cancer, in much higher concentrations compared to healthy cells.

On the contrary, the Rhodanese enzyme is not present in cancer cells (514, 515,774-787).

The modern history of vitamin B17 started in 1830, when two French scientists, Roubiquet and Bontron-Chariand, purified for the first time a vitamin later called Amygdalin or vitamin B17 (1187).

Seven years later two German scientists, Von Liebig and Woehier, discovered that this vitamin could be found in all fruit seeds (apart from citrus fruits) and could be divided into Cyanide ions,

Benzaldehyde and Glucose by only one specific enzyme.

The use on human beings for medical purposes and cancer therapy followed shortly after.

In 1845, fifteen years after the first French scientific experiences, the French scientific journal “Gazette Medicale de Paris”, (1188) and afterwards the German journal “Journal für die Chirurgie und Augenheil-kunde”(1189), described the first case of metabolic therapy with vitamin B17 to “cure cancer”, created by Russian doctor Inosmetzeff, professor at the Imperial University of Russia in Moscow. Therapy was performed on a twenty-one-year-old boy affected by cancer, and consisted of 46 grams of Amygdalin administered for 3 months. Inosmetzeff had also cured a 48-year-old woman with extended metastases due to womb cancer. In 1845 this woman was still alive, 11 years after metabolic therapy with Amygdalin. In both cases, Inosmetzeff said that he never noticed any side effects with vitamin B17.

This vitamin was only used again for cancer therapy after more than a century, that is in 1950, when US researcher Ernest Krebs started using vitamin B17 again. After boiling it, evaporating it in alcohol, and then settling it in small white crystals, he called the result “Laetrile”.

The term “Laetrile” is the acronym for “LAEvomandeloniTRILE-glucoside”. It is almost the same  as Amygdalin (which is naturally present in fruit bitter seeds). The only difference is in chemical structure: Laetrile has two molecules of glucose, Amygdalin has more.

Indeed, the chemical structure of Laetrile is D-1 mandelonitrile–beta-glucuronide, while for Amygdalin it is Dmandelonitrile- bi-glucoside.

There are at least a dozen other cyanogenetic glucosides (nitrosilides) similar to Amygdalin, that

can be found in vegetables, fruit (including lemons), cassava, legumes and cereals (1190).

Vitamin B 17 is a stable, chemically inert molecule, and it is not noxious if taken in the right quantity under a doctor’s supervision.

The initial recommended dosage in adults is 4-5 bitter seeds per day for apricot bitter seeds (quantity has to be higher or lower if seeds are of a different fruit) for the first week.

In the following week, the doctor can decide whether dosage can be increased or diminished. The values that have to be reached must be carefully calculated according to the following parameters: the biological half-life of vitamin B17, urine analysis (the presence of Sodium Thiocyanate and hippuric acid in certain quantities could mean that the quantity of seeds taken is too high), the patient’s hematic and body mass, the patient’s good or bad liver, kidney (and other organs’) function, the possible massive colliquation of cancer mass with possible death due to irreversible kidney failure, etc…

The pharmaco-cynetics of vitamin B17 are complex and must be taken into account.

In medical and/or phitotherapic literature, episodes of deadly poisoning of children have been reported. Death occurred after they ate food that was particularly rich in vitamin B17, such as peculiar berries, traditionally not eaten and therefore extremely interesting for cancer therapy, or bitter almond seeds, which are notoriously richer in vitamin B17 than apricot bitter seeds. Death in children is easier because the concentration of vitamin B17 is higher in a smaller body. Moreover, their liver mass is smaller: this organ is essential to detoxify blood from vitamin B17. Finally, liver enzymes in children could be less functional.

Treatment has to be interrupted from time to time under a doctor’s supervision. Seeds must be chewed very well or previously ground.

Therapy has to be stopped immediately if sickness arises.

Seeds must never be taken all together, but during the whole day. It is better to eat them on a full stomach, in order to avoid the partial hydrolysis of vitamin B17 by hydrochloric acid.

It is forbidden to take more than six apricot bitter seeds in one hour, even if health conditions are good; as far as peach seeds are concerned, a dosage of no more than half seed per one hour can be taken.

Vitamin B17 poisoning is not the only possible one.

Other natural vitamins, too, can cause death if taken in excess. For instance, medicine books still report an episode that took place at the beginning of the 20th century. A group of arctic explorers died because of vitamin A poisoning: they had eaten huge quantities of polar bear liver, that they had taken for survival.

The only vitamin that seems NOT to cause poisoning is said to be vitamin C. It can be taken in quantities higher than 50 grams per day.

Back to vitamin B17, Krebs discovered that this vitamin reacts to enzyme Beta-glucosidase. The latter is found in many tumors, and is virtually absent in healthy cells. In the reaction, the enzyme splits the innocuous vitamin B17 into two powerful poisons: Cyanide ions and Benzaldehyde. The latter is a strong painkiller. These two substances are produced in small quantities by cancer cells themselves, and combine in cancer cells producing an extremely toxic substance that kills cells in a sort of pseudo-apoptosis.

Small quantities of this poison can still be active even after cancer cells died and can go into circulation, cancer generally having many blood vessels.

On the contrary, healthy cells have another enzyme, called Rhodanese. It is found in cells in quantities that are inversely proportional to those of Beta-glucosidase.

If vitamin B17 comes intocontact with healthy cells, Rhodanese neutralizes Cyanide ions and oxidizes Benzaldehyde. Two products are obtained: Thiocyanate and benzoic acid, which are good nutrition for healthy cells. If these two products are in excess, they are eliminated through the urine.

It is clear then that the enzyme Beta-glucosidase produces Cyanide ions from nitriloside food.

Notice that Cyanide ions have to be freed from vitamin B17 or from Laetrile. Cyanide ions are not found freely in food: they are only produced in cancer cells, because the specific enzyme for this (Beta-glucosidase) can only be found in cancer cells.

In 1947, Fishman and Aniyan wrote in the important medical journal Journal Biol. Chem. (1191):

“…Tissue excised from malignant noeplasms (cancers) of various organs, including breast, uterus, stomach, abdominal wall and esophagus were found to contain 200 to 3600 percent more betaglucosidase activity than uninvolved adjacent tissue. Metastases to lymph nodes from cancers originating in various organs contained beta-glucosidase in higher concentrations than the uninvolved lymph nodes”. http://www.mednat.org/cancro/FISHMAN%201947.pdf

In the same year, they wrote in the notorious journal Science (1192): “…high Beta-glucosidase is probably a characteristic feature of cancer cells”.

In his book “Nitrilosides (Laetriles)”, pages 189-204, Krebs writes:

http://www.mednat.org/cancro/Nitrilosides_Plants_Animals.pdf

In addition to their high levels of Beta-glucosidase, malignant lesions are characterised by a generally profound deficiency of Rhodanese, as was reported by Homberger, Mendel, Rodney and Bowman. Rosenthal reported an 80% decrease in Rhodanese in cancerous liver tissue, and a similar decrease was found in the leukemic invasion of tissues”(1187).

Researcher James South explains the essential biochemistry of what happens when a person eats nitriloside food or takes vitamin B17 in pharmaceutical form, either as Laetrile or as Amygdalin:

“…These two properties of cancel cells – an excess of Laetrile-splitting Beta-glucosidase and a deficiency of cyanide-detoxifiying Rhodanese – are presumed to provide the explanation of both why Laetrile kills cancer cells, and why it is preferentially split by cancer cells into Cyanide ions, Benzaldehyde and sugar. They will then be poisoned, since cancer cells lack the Cyanidedetoxifying enzyme Rhodanese. If some Cyanide “spills out” from the cancer cells, adjacent normal cells will then be able to detoxify it through their Rhodanese enzymes.” (1187).

http://www.mednat.org/cancro/JAMES_SOUTH.pdf

If quantities do not exceed liver (and other organs’) function of purifying blood from this poison, it is the doctor’s task to assess how the metabolic therapy is going from blood and urine tests and rom the patient’s general check-up.

The Rhodanese enzyme destroys hydrocyanic acid and produces a non-toxic substance:

Thiocyanate.

As Oke notes:

“…Rhodanese is widely distributed in all the tissues with the highest concentrations in the liver.

Detoxification can therefore take place in all parts of the body, but with the liver as the chief site.

When hydrocyanic acid (Cyanide) is converted to thiocyanic acid (Thiocyanate) there is a 200-fold reduction in toxicity”(1190). http://www.mednat.org/cancro/OKE.pdf

When Beta-glucosidase destroys Laetrile, Benzaldehyde and Cyanide ions are released in cancer cells.

Several studies on humans used Benzaldehyde itself as a drug against cancer (1193,1194). In 1980-

1985 Kochi wrote: “ …no toxic effects were reported, including hematologic or biochemical disorders, even when Benzaldehyde was repeatedly administered for long periods.”

http://www.mednat.org/cancro/benzaldehyde_derivative.pdf

Tatsumura used an average total dose of 393 grams of a substance similar to Benzaldehyde, that subsequently changed into Benzaldehyde, and obtained a positive reaction rate of about half the patients who were given treatment:

“…Careful monitoring showed no toxic action of the drug at these large doses. Complete necrotic liquefaction of tumour was seen in 2 of 3 cases in which histological examination was feasible” (1195). http://www.mednat.org/cancro/TATSUMURA.pdf

During the Seventh International Congress of Chemotherapy in Prague, in 1971, Dean Burk said:

In vitro tests with Ehrlich ascites carcinoma (a type of cancer cell culture) revealed that, where  cyanide alone killed one percent of the cells and Benzaldehyde alone killed twenty percent, a combination of the two was effective against all the cells. Amygdalin with Beta-glucosidase added also succeeded in killing 100 percent of the ascites tumor cells, due to the same two chemicals” (1187).

But Krebs soon realized that he had clashed with huge economic interests. Chemo-pharmaceutical multinationals could not obtain a registration nor have exclusive rights on vitamin B17. Thus, they began a long defamatory campaign against apricot bitter seeds, and they convinced the whole American population that these are allegedly dangerous.

At the moment, cancer treatment with Laetrile is forbidden by law in the USA, even if under a doctor’s supervision. That is why dozens of thousands of American citizens get treatment in expensive private hospitals just beyond the Mexican border, in Bahamas, and in other places, where they officially go “on holiday”.

For instance, doctor Francisco Contreras, the current managing director of the Oasis of Hope hospital in Tijuana, Mexico, treated more that 60,000 patients with a vegetarian therapy and vitamin B17 in 35 years of activity (1187). http://www.mednat.cancro/Contreras.pdf

Doctor Ernesto Contreras has been using Laetrile since 1963, and thinks that

“…The majority of most frequent cancers, such as lung, breast, colon, ovarian, stomach,esophagus, prostate cancer, and lymphoma, can improve dramatically with Laetrile” (1187).

Clinical Case history

 

Amygdalin taken orally has been known to be a poison since ancient times, though amygdalin-laden black and brown bitter seeds were described as antitumor agents in the pharmacopeia of ancient China (1497)

Egyptian, Greek, Roman and Arabic physicians also used amygdalin to treat tumors (1498).

In a study conducted in 1958, Prof Marco Tasca, head of the radiology department of the Civil Hospital in Sanremo, treated 21 Italian terminally ill patients – 3 suffering from seminomas, 4 from breast cancers, 1 from womb cancer, 2 from laryngitis cancers, 7 from lung cancers, 1 from cancer of the oesophagus, 2 from stomach cancers, 1 from Hodgkin’s disease – with intramuscular injections of Laetrile. He noticed that patients showed good drug tolerance, their clinical conditions improved during the entire treatment period and only one month – on average – after the interruption of the therapy the neoplastic pathology resumed its progression. He pointed out only two complications:

hemorrhage and icterus. The former probably caused by necrotic eschars coming off the tissues, the latter induced by a direct toxic action on hepatic cells, which rarely happens though (5% of his case histories). The article is available in PDF format (1373) at http://www.fiocco59.altervista.org/images/tasca.pdf  or http://www.mednat.org/cancro/tasca.pdf.

In the 1966 report, Proceedings of the Ninth International Cancer Congress, Rossi cites a ten-year trial in Europe involving 150 patients that found „50 percent of all cases in treatment showed objective improvement” and concluded that laetrile was „an extremely useful chemotherapeutic drug.”(1382) http://fiocco59.altervista.org/vitamina_b_17.htm

In 1994, professor Dr .Binzel published the results he obtained treating patients with Laetrile between 1974 and 1991. His case history included 180 patients with primary cancer (with no metastasis and limited to only one organ or tissue). 131 patients were still alive in 1991, when the report was published. At that time, 58 patients had been followed for 2 to 4 years, while 80 of them had had a medical follow-up for 5 to 18 years. Out of the 42 patients that had died by 1991, 23 had died from cancer, 12 from “unrelated causes” and 7 of “unknown causes” (Binzel E.P.: “Alive and Well”). http://www.mednat.org/cancro/ALIVE_AND_WELL.pdf

Among patients with metastasis, 32 out of 108 had died from their disease, 6 from “unrelated causes” and 9 from “unknown causes”. Out of the 61 patients that were still alive in 1991, 30 had had a medical follow-up of 2-4 years, 31 had been followed for 5-18 years.

Doctor John A. Richardson’s case history of 1976 reports over 6,000 cases that show a positive effect of vitamin B17 against cancer. (1187)

There are 4,800 cases reported and carefully studied by doctor Ernesto Contreras. Those were

selected among 10,000 case sheets collected in 14 years of experiences with Laetrile.

Doctor Paul Wedel from Oregon reported about 4,000 cases of metabolic treatment. He survived cancer himself with vitamin B17 and a diet similar to the gersonian one (1187).

1,000 cases were reported by doctor Manuel Navarro of Santo Tomas University in Manila, the Philippines. The Mexican government is even monitoring about 100 patients that are being treated with metabolic therapy and vitamin B17, under the guidance of doctor Mario Soto de Leon, medical director of the Cydel Clinic in Tijuana (1187).

In Germany, doctor Hans Nieper reported about 1,000 cases. (http://www.mwt.net/~drbrewer  )

It is interesting to notice that cases such as that of Mr. Glen Rutherford from Kansas, who healed completely in Tijuana, are recorded in tribunal archives as “cures” (1187).

Clinical Trial of Chemotherapeutic treatment of advanced cancers with Leatrile

Guidetti Ettore

Rossi Benedetto

Deckers Christian

Presented at the 9th International Cancer Congress in Tokyo, October 1966

From 1954 to 1966 we gave 150 patients the above-mentioned therapy, chiefy at San Cottolengo Hospital, Turin; DosioHospital, Milan; and Louvain University Cancer Institute. All patients were in the terminal stage of the disease, the majority of them prey to cachezia, and all other therapies had failed.

The following table summarizes the cases treated, classified according to the site of the tumor, and showing the number of patients for each degree of reaction to therapy. We use the sign ++ to denote patients who reacted in an objectively favourable manner, by which we mean diminution of volume of the tumor or at least all interruption of its evolution, improvement in the roentgenographic picture, and improvement in laboratory findings. The mark + and + indicates patients who showed a more or less distinct subjective improvement, and the mark – those who reacted negatively to the treatment.

Cases corresponding to ++ represent about 20% of those treated.

We again underline the fact that the majority of these cases were simultaneously subjected to an immunotype therapy, which might have some bearing on the number of positive results observed, grouped under the signs ++ and + totalling about half the number of cases treated.

Cancer Site        No. cases            ++    +    +-          

Toruli tactiles                    26                           5             6             6             9

Breast                                  25                           3             8             7             7

Uterus                                 24                           7             7             4             6

Rectum                                               20                           2             9            2             7

Ovary (with infusion)    10                           2             2             2             4

Other types                       30                           9             7             2             12

Totals                                   135                        28           39           23           45

We have separately considered neoplasms of the pleura with effusion (15 cases), where the product was used direct by injection in the pleural cavity. In these cases we observed our best results, as generally we obtained reduction and then on occasion complete disappearance of the effusion, associated with a distinct improvement in the patients’ condition.

Conclusion:

On the basis of our clinical trial, we are able to state that L-mandelonitrile-beta-diglucoside may be considered an

extremely useful chemotherapeutic drug for palliative medical treatment of malign neoplasms, from the standpoint both of its therapeutic effect and its very low toxicity.

Amygadin metabolic liver aspects

Detoxification of cyanide can take place in all tissues of the body, but principally in the liver. The dosage levels and toxicity of amygdalin (Laetrile) in laboratory animals and humans is well established and documented.

No evidence of acute or accumulative toxicity was observed in any animals giving doses in excess of 100 times the maximum intravenous dose usually given in humans.

These findings coincide with that mentioned by Otto Jacobsen in 1887, Davidson in 1944 and Dr. Dean Burk (National Cancer Institute) in 1968: „Amygdalin is impressively nontoxic from the pharmacological point of view„, and „non-hydrolyzed amygdalin is less toxic than glucose„. The oral toxicity of amygdalin was found to be 39 to 44 times greater than the intramuscular route, and more toxic than intravenous route (parentenal route). Amygdalin is less tolerable by oral administration because of the hydrolysis of amygdalin by the gastric juices. On the other hand amygdalin, in dosages of 20-40/mg/kg orally (for a 200 lb human this would translate to 16 -500mg laetrile/B17 tablets, daily), used in humans, is 10 to 20 times less than the minimum toxic dosage in dogs. The biological half life of amygdalin is only 80 minutes.

Over 80% of the amygdalin administered is excreted from the body in 4 hours.

The usual metabolic approach to amygdalin (laetrile) therapy is to provide the patient with adequate nutritional support, with relatively nontoxic high doses of vitamins and minerals, and other active natural substances.

Amygdalin (laetrile) has been administered in dosages of up to 70 grams (70,000 miligrams-mg) per day in adult humans by combined oral and parentenal routes without adverse effects.

Ever since the days of Louis Pasteur (1822-1895) and Paul Ehrlich (1854-1915), cancer victimshave hoped for the „wonder vaccine” or the „magic bullet”.

Amygdalin (laetrile) does NOT come under the heading of either of these dramatic therapies. There are a number of factors that enter into the cancer treatment complex.

The type of cancer involved is an important factor. Some types of cancer tend to be more sensitive to treatment than other.

Amygdalin (laetrile) is NOT equally effective in all types of cancers.

Rubin (1977) found in their clinical investigations in Israel that Amygdalin (laetrile) was most effective against Adeno-carcinoma and Hodgkin’s disease, somewhat less effective in certain other of the Sarcomas and Melanomas, and relatively poor results were achieved with the Leukaemia. Similar results have been obtained by other clinicians in the United States and elsewhere.

The best results with Amygdalin (laetrile) therapy have been achieved with Lung, Prostate, Breast, Lymphomas, Liver and Brain cancer.

The chemical quality of the Amygdalin (Laetrile) also has a bearing on the clinical therapeutic results.

Only the laevo isomer of Amydalin (Laetrile) has been found to be therapeutically active. A high quality Amygdalin is now produced in Mexico and some products are currently under investigation in the United States and Germany . It is therefore of the utmost importance that quality products be utilized. Failure to recognize this point can result in inadequate dosage levels and false negative therapeutic results (Krible, 1912; Levi, et al, 1965; Rubin, 1978).

Other factors relating directly tothe administration of Amygdalin (Laetrile) concern the dosage.

In the past, most physicians have tended toward administering too low a dosage. Therefore the frequency of administration, the route of administration, and the dosage are of the utmost importance if adequate blood levels are to be maintained. In the past, most errors of administration have been made on the side of too little, rather than too much. However, it should be kept in mind that the most effective routes are by parenteral injection (I.M or I.V.) and the physician should not attempt to achieve the necessary dosage levels by the oral route. Rubin (1978) reports administering 70 gr. per day to each patient with no ill effects.

Another aspect that will have a bearing on the recovery of a patient depends upon the  degree of tissue damage caused by excessive radiation and toxicity resulting from Chemo-Therapy.

It is presently estimated in the United States, Mexico, and elsewhere, that about 90% or more of the patients begin using Amygdalin (Laetrile) only after all other types of cancer therapies have failed.

Most metabolic physicians are of the opinion that if the patient were to begin Metabolic Therapy earlier in the course of the disease, it would improve the patient’s chances of Cancer Control.

The adequacy of liver functions is of the utmost importance in cancer therapy. The liver has varied, intricate and extremely complex metabolic functions. Among other things the liver is concerned with fat, carbohydrate and protein metabolism.

The liver has a propensity for storing vitamins, especially A, D and B 12, and Iron in the form of ferritin. The liver forms a large proportion of the blood constituents: Fibrinogen, Prothrombin,

Accelerator Globulin, Factor VII, and other coagulation factors. The liver is involved in vitamin K metabolism. The liver is concerned with the vascular storage and filtration of blood, with about 1,000 ml of blood flowing from the portal vein through the liver sinusoids each minute, and an additional 400 ml flows into the sinusoid from the hepatic artery. Thus when the liver or kidneys are damaged due to a primary or metastatic malignancy, it may adversely affect the entire metabolism of the body.

The studies conducted thus far on Amygdalin (Laetrile) indicate that there is no damage to the liver or kidney function. Much of the effort of metabolic therapy is dedicated toward sustaining adequate liver and kidney functions, and to attempt to minimize the detoxification load placed upon them.

It should be emphasized that Amygdalin (Laetrile) therapy is most effective when used in conjunction with a comprehensive METABOLIC approach. Most physicians using this form of therapy provide adequate nutritional support with the use of proper vitamin and mineral supplements. The patient is placed on a complete vegetarian diet with a reduction of proteins, fats, refined sugars, and processed foods. All tobacco, alcohol, caffeinated drinks, and most toxic medications are eliminated. The patient is placed on a high intake of select fruit juices, fresh fruits and vegetables. A program of Detoxification is required. A minimum of 9 gr of Amygdalin (Laetrile) per day is administered, largely by the parenteral route, but even higher levels may be given if indicated.

Patients that refuse to follow the general Metabolic Program are discouraged from taking Amygdalin (Laetrile)

 

 

 

 Amygdalin poisoning: medical aspects

1) Effect: quick tissue anoxia due to intracellular respiratory failure and toxic lesion of respiratory centres.

2) Amygdalin plasmatic half-life: about 80 minutes.

3) Clinical symptoms: asthenia, torpor, somnolence, headache, vertigo, coma, dyspnea, apnea, polypnea, heart rhythm disorders (bradycardia, atrial fibrillation). Vomit and diarrhea are possible as well. High abdominal pain. Not associated with cyanotic coloration.

Basic therapy

1) Artificial breathing with 100% oxygen.

2) Hypotension needs to be treated with sympathomimetic amines (if it is of cardiogenic origin) or with liquid infusion (if it is of hypovolemic origin).

3) Electrolytes and acid-base balance have to be checked (risk for lactic acidosis).

Antidotal therapy

1) Inhalation of gauze pads soaked with a vial of amile nitrate for 15-30 seconds, to be repeated every 2-3 minutes using another vial.

2) Slow endovenous infusion (3-5 minutes) of 10 millilitres of 3% sodium nitrite solution.

3) Endovenous infusion of 50 millilitres of 25% sodium thiosulfate.

Clinical observation must be intense for at least 24 hours. Medical treatment should be corrected according to methaemoglobin monitoring (it should not be more than 40%).

 

Therapeutic dosage of vitamin B17

The various kinds of seeds or food contain adequate quantities of vitamin B17. But, unfortunately, it is not possible to calculate the bioavailability of these foods for absorption of vitamin B17 by intestinal walls, and this depends on many factors. Empirically, in adult patients weighing about 70 kg, it can be lethal to administrate daily 15 (fifteen) bitter almond seeds, or 30 (thirty) peach bitter seeds, or 300 (three hundred) apricot bitter seeds.

On the contrary, even a quantity as small as 2-3 bitter almond seeds is deadly for a child.

4 Tables showing the quantity of vitamin B17 found in 100 grams of fruit, the quantity of vitamin B17 found in 100 grams of seeds , quantity of vitamin B17 found in 100 grams of various types of leaves & the quantity of vitamin B17 found in 100 grams of various types of tubers are in my book.

Various sources report a very low biological half-life of about 80 minutes. This confirms that it is possible to administrate a maximum dose of about 5-7 apricot bitter seeds every hour for adults.

Some American doctors that have been working in Mexican clinics for the past 30 years claim that a safe dosage for an adult weighing 70 kg is about 5-7 bitter seeds every hour, about 100-250 seeds per day in total. Daily administration of 250-300 apricot seeds in an adult weighing 70 kg gives a quantity of vitamin B17 that is surely toxic. According to these doctors, it is important that seeds are taken on a full stomach, to avoid partial hydrolysis of Amygdalin by gastric juices. This would produce Cyanide ions directly in the stomach. Moreover, in their opinion endovenous administration of Amygdalin can be useful, because it is more tolerated as the maximum dose without reaching the above mentioned toxic quantities.

Finally, it is important to start administrating Amygdalin, if orally, in low doses, not higher than 5 bitter seeds per day, for the first week, and then 7-10 bitter seeds in the following weeks, at different intervals.

The bioavailability of apricot seeds is very high compared to other sources of vitamin B17.

However, I take no responsibility for B17 therapies carried out without a doctor’s supervision.

I especially advise against this therapy on patients who already underwent chemotherapy.

Their liver cannot properly detoxify blood from Cyanide ions and benzaldehyde. As far as this is concerned, doctor Moertel’s work, published on N.Engl.J.Med. in 1982 (Moertel CG: A clinical trial of amygdalin (laetrile) in the treatment of human cancer, N.Engl.J.Med., 306, pp.: 201-206 (1256), shows this therapy’s complete failure (http://fiocco59.altervista.org/nacci/Moertel%201982.pdf   )

Note on the work of New Engl.J.Med., 1982 (Moertel CG: A clinical trial of amygdalin (laetrile) in the treatment of human cancer, N.Engl.J.Med., 306, pp.: 201-206): this work was conduced by the dr. Moertel of the Mayo Clinic;

In this work are:

1) Chemically pure amygdalin was not used. Instead a mixture, which supposedly mimicked what was being used in a Mexican Clinic.

2) 70 per cent of these patients were stable during the first three weeks of the study, during which the patients received intravenous amygdalin.

3) Once the patients were switched to oral amygdalin alone, they did deteriorate fairly quickly.

4) Supporters of amygdalin do not believe that this study was valid proof against amygdalin efficacy.

From : England Journal of Medicine, 307, pp.119, 1982 (on the work of dr. Moertel CG: A clinical trial of amygdalin (laetrile) in the treatment of human cancer, N.Engl.J.Med., 306, pp.: 201-206 ;

http://fiocco59.altervista.org/nacci/Moertel%201982.pdf )

 

To the Editor: In the article on the Laetrile clinical trial, the investigators state, “No substantive benefit was observed in terms of cure, improvement, or stabilization of cancer, improvement of symptoms related to cancer, or extension of life span”. In the accompanying editorial there appears the statement, “Even when combined with the “metabolic” therapy (vitamins and a “natural” diet) so enthusiastically touted by the anti-establishment cancer therapists, Laetrile produced no discernible benefit in a group of 178 patients with a variety of types of advanced cancer”. As one of the touters, I wish to point out that these conclusions are not justified by the evidence. The reason for my contention is that there was no control group with which the group of treated patients could be compared.

The investigators say that the median survival time was 4,8 months (five months for patients with colorectal cancer, five months for those with lung cancer, four months for those with breast cancer, and three months for those with melanoma), and they claim , “These survival times appear to be consistent with the anticipated survivals in comparable patients receiving inactive treatment or no treatment “. No survival curves for these comparable patients are presented, nor are there any references to pertinent reports. The editorial states that “The lack of concurrent controls was partially offset by the fact that all patients were in the advanced stages of a disease known to be almost uniformly and rapidly fatal. Any objective responses in tumor size or apparent prolongation of survival could be identified by comparison with historical controls. But there was not the slightest suggestion of any beneficial effect”.

It is my opinion that there probably was a beneficial effect, including prolongation of survival. Other studies have shown that the median survival time in patients with cancer “for which no standard treatment was known to be curative or to extend life expectancy” was about 1,4 months; an example is the control group in the study by Creagan et al. (Failure of high-dose vitamin C therapy to benefit patients with advanced cancer: a controlled trial. New England Journal Medicine, 1979, No. 301, pp: 687-690).

The observed median of 4,5 months accordingly constitutes a substantial increase. In any case, it is improper to announce a negative result without performing a careful statistical analysis of the treated group and a suitable control group.

The report by Moertel et al is marred by other errors and imperfections. For example, Figure 3 shows that 10 of the  patients in the group survived to the end of the study, whereas in the text it is stated that 26 of the 178 survived; one of these numbers is wrong.

One third of the patients had not received chemotherapy, but despite the well-known contention that vitamins and diet have greater value for these patients than for those who have received chemotherapy, no statistical analysis of the observations on the two sub-groups is presented. Moreover, 14 of the 178 patients received much higher doses of vitamins than the others did, but little information is given about these 14 patients, and no statistical analysis of their responses in comparison to those of the others is reported.

LINUS PAULING Ph.D. Linus Pauling Institute of Science and Medicine Palo Alto, CA 94306

 

To the Editor:

Despite your belief that the National Cancer Institute (NCI) “clinical trial” of Laetrile “closes the books” on the use of amygdalin in cancer therapy, your readers should be well aware of many dissenting views and of our widespread suspicion that the trials were designed to make certain that Laetrile – or whatever the NCI was construing to be Laetrile –failed.

This organisation and the undersigned are parties to ongoing litigation against the NCI in regard to the conducting of the trials.

Officers of this organisation were the only Laetrile proponents who assisted at the early stages in developing the NCI design protocols for the study.

We became involved in litigation only after it became clear to us that the NCI was going to test not pure amygdalin but a degraded or decomposed form of it (the putative “RS-epimer racemic mixture” said by Moertel et al. to be a copy of material provided by a major Mexican manufacturer).

Let me stress that our side does not believe that even with appropriate material the lives of most of the patients with incurable or inoperable cancer could have been saved.

It is our belief that the patients’ responses within the first three weeks of treatment (when most patients were on the 21-day injectable part of the program) indicate at least some fleeting anti-neoplastic action, even from the degraded product.

Indeed, by any of the various semantic renderings of the results of the first three weeks of therapy, either a majority of patients were stable or a sizable minority (46 per cent) had no signs of progressive disease during this part of the program. Unless the English language has substantially changed during the past 24 months, I cannot interpret these renderings as other than suggesting limited efficacy of the injectable material. Would it not have been wise to continue giving injections and to make a real effort at a real metabolic program in these incurable patients ?

Our side also laments the lack of any Laetrile-using physician in the NCI program and the lack of available raw data on the patients.

We insist that the NCI “clinical trial” has asked far more questions than it has answered about Laetrile, but that by no stretch of the imagination can it be said to have “closed the books” on Laetrile.

Michael Culbert

Committee for Freedom of Choise in Cancer Therapy, Inc.

Los Altos, CA 94022

More details about this topic in my book.

Best of health!

Cristian

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Vitamin B 17 (Laetrile)

CLICK AICI pentru  limba ROmana(traducerea „aproximativa” utilizand google translate).

Vitamin B17 was thoroughly studied by Japanese researchers in the early 1970s. Vitamin B17 is found especially in apricot (Prunus armeniaca) kernels.

It is also found in the bitter seeds of wild almonds (Prunus amygdalus), of cherries (Prunus avium), of plums (Prunus domestica), of peaches (Prunus persica), of blackthorns (Prunus spinosa), of acerolas (Malpighia punicifolia), of quinces (Cydonia oblonga), as well as in the seeds and/or pulp of many other fruits like apples, grapes , berries(see table below).

This vitamin is very useful for cancer therapy. Indeed, it takes advantage of cancer cell metabolism, which is different from healthy cell metabolism in human beings.

Neoplastic cells, and especially anaerobiotic neoplastic cells, have a high concentration of beta-

Glucosidase, without Rhodanese. Therefore, they immediately phagocyte vitamin B17, and divide it by hydrolysis into two poisons: benzaldehyde and cyanide ions. On the contrary, healthy cells are normo-oxygenated and rich in Rhodanese, so they quickly convert these two poisons into benzoic acid and thiocyanates respectively.
 Both of them are harmless for healthy cells; actually, they are useful for them.

According to Kanematsu Sugiura, a Japanese researcher, beta-Glucosidase is found in the cells of breast, stomach, womb, mesentery and gullet cancer, in much higher concentrations compared to healthy cells.

On the contrary, the Rhodanese enzyme is not present in cancer cells (514, 515,774-787).

The modern history of vitamin B17 started in 1830, when two French scientists, Roubiquet and

Bontron-Chariand, purified for the first time a vitamin later called Amygdalin or vitamin B17 (1187).

Seven years later two German scientists, Von Liebig and Woehier, discovered that this vitamin

could be found in all fruit seeds (apart from citrus fruits) and could be divided into Cyanide ions,

Benzaldehyde and Glucose by only one specific enzyme.

The use on human beings for medical purposes and cancer therapy followed shortly after.

In 1845, fifteen years after the first French scientific experiences, the French scientific journal “Gazette Medicale de Paris”, (1188) and afterwards the German journal “Journal für die Chirurgie und Augenheil-kunde”(1189), described the first case of metabolic therapy with vitamin B17 to “cure cancer”, created by Russian doctor Inosmetzeff, professor at the Imperial University of Russia in Moscow. Therapy was performed on a twenty-one-year-old boy affected by cancer, and consisted of 46 grams of Amygdalin administered for 3 months. Inosmetzeff had also cured a 48-year-old woman with extended metastases due to womb cancer. In 1845 this woman was still alive, 11 years after metabolic therapy with Amygdalin. In both cases, Inosmetzeff said that he never noticed any side effects with vitamin B17.

This vitamin was only used again for cancer therapy after more than a century, that is in 1950, when US researcher Ernest Krebs started using vitamin B17 again. After boiling it, evaporating it in alcohol, and then settling it in small white crystals, he called the result “Laetrile”.

The term “Laetrile” is the acronym for “LAEvomandeloniTRILE-glucoside”. It is almost the same  as Amygdalin (which is naturally present in fruit bitter seeds). The only difference is in chemical structure: Laetrile has two molecules of glucose, Amygdalin has more.

Indeed, the chemical structure of Laetrile is D-1 mandelonitrile–beta-glucuronide, while for Amygdalin it is Dmandelonitrile- bi-glucoside.

There are at least a dozen other cyanogenetic glucosides (nitrosilides) similar to Amygdalin, that

can be found in vegetables, fruit (including lemons), cassava, legumes and cereals (1190).

Vitamin B 17 is a stable, chemically inert molecule, and it is not noxious if taken in the right quantity under a doctor’s supervision.

The initial recommended dosage in adults is 4-5 bitter seeds per day for apricot bitter seeds (quantity has to be higher or lower if seeds are of a different fruit) for the first week.

In the following week, the doctor can decide whether dosage can be increased or diminished. The values that have to be reached must be carefully calculated according to the following parameters: the biological half-life of vitamin B17, urine analysis (the presence of Sodium Thiocyanate and hippuric acid in certain quantities could mean that the quantity of seeds taken is too high), the patient’s hematic and body mass, the patient’s good or bad liver, kidney (and other organs’) function, the possible massive colliquation of cancer mass with possible death due to irreversible kidney failure, etc…

The pharmaco-cynetics of vitamin B17 are complex and must be taken into account.

In medical and/or phitotherapic literature, episodes of deadly poisoning of children have been reported. Death occurred after they ate food that was particularly rich in vitamin B17, such as peculiar berries, traditionally not eaten and therefore extremely interesting for cancer therapy, or bitter almond seeds, which are notoriously richer in vitamin B17 than apricot bitter seeds. Death in children is easier because the concentration of vitamin B17 is higher in a smaller body. Moreover, their liver mass is smaller: this organ is essential to detoxify blood from vitamin B17. Finally, liver enzymes in children could be less functional.

Treatment has to be interrupted from time to time under a doctor’s supervision. Seeds must be chewed very well or previously ground.

Therapy has to be stopped immediately if sickness arises.

Seeds must never be taken all together, but during the whole day. It is better to eat them on a full stomach, in order to avoid the partial hydrolysis of vitamin B17 by hydrochloric acid.

It is forbidden to take more than six apricot bitter seeds in one hour, even if health conditions are good; as far as peach seeds are concerned, a dosage of no more than half seed per one hour can be taken.

Vitamin B17 poisoning is not the only possible one.

Other natural vitamins, too, can cause death if taken in excess. For instance, medicine books still report an episode that took place at the beginning of the 20th century. A group of arctic explorers died because of vitamin A poisoning: they had eaten huge quantities of polar bear liver, that they had taken for survival.

The only vitamin that seems NOT to cause poisoning is said to be vitamin C. It can be taken in quantities higher than 50 grams per day.

Back to vitamin B17, Krebs discovered that this vitamin reacts to enzyme Beta-glucosidase. The latter is found in many tumors, and is virtually absent in healthy cells. In the reaction, the enzyme splits the innocuous vitamin B17 into two powerful poisons: Cyanide ions and Benzaldehyde. The latter is a strong painkiller. These two substances are produced in small quantities by cancer cells themselves, and combine in cancer cells producing an extremely toxic substance that kills cells in a sort of pseudo-apoptosis.

Small quantities of this poison can still be active even after cancer cells died and can go into circulation, cancer generally having many blood vessels.

On the contrary, healthy cells have another enzyme, called Rhodanese. It is found in cells in quantities that are inversely proportional to those of Beta-glucosidase.

If vitamin B17 comes intocontact with healthy cells, Rhodanese neutralizes Cyanide ions and oxidizes Benzaldehyde. Two products are obtained: Thiocyanate and benzoic acid, which are good nutrition for healthy cells. If these two products are in excess, they are eliminated through the urine.

It is clear then that the enzyme Beta-glucosidase produces Cyanide ions from nitriloside food.

Notice that Cyanide ions have to be freed from vitamin B17 or from Laetrile. Cyanide ions are not found freely in food: they are only produced in cancer cells, because the specific enzyme for this (Beta-glucosidase) can only be found in cancer cells.

In 1947, Fishman and Aniyan wrote in the important medical journal Journal Biol. Chem. (1191):

“…Tissue excised from malignant noeplasms (cancers) of various organs, including breast, uterus, stomach, abdominal wall and esophagus were found to contain 200 to 3600 percent more betaglucosidase activity than uninvolved adjacent tissue. Metastases to lymph nodes from cancers originating in various organs contained beta-glucosidase in higher concentrations than the uninvolved lymph nodes”. http://www.mednat.org/cancro/FISHMAN%201947.pdf

In the same year, they wrote in the notorious journal Science (1192): “…high Beta-glucosidase is probably a characteristic feature of cancer cells”.

In his book “Nitrilosides (Laetriles)”, pages 189-204, Krebs writes:

http://www.mednat.org/cancro/Nitrilosides_Plants_Animals.pdf

In addition to their high levels of Beta-glucosidase, malignant lesions are characterised by a generally profound deficiency of Rhodanese, as was reported by Homberger, Mendel, Rodney and Bowman. Rosenthal reported an 80% decrease in Rhodanese in cancerous liver tissue, and a similar decrease was found in the leukemic invasion of tissues”(1187).

Researcher James South explains the essential biochemistry of what happens when a person eats nitriloside food or takes vitamin B17 in pharmaceutical form, either as Laetrile or as Amygdalin:

“…These two properties of cancel cells – an excess of Laetrile-splitting Beta-glucosidase and a deficiency of cyanide-detoxifiying Rhodanese – are presumed to provide the explanation of both why Laetrile kills cancer cells, and why it is preferentially split by cancer cells into Cyanide ions, Benzaldehyde and sugar. They will then be poisoned, since cancer cells lack the Cyanidedetoxifying enzyme Rhodanese. If some Cyanide “spills out” from the cancer cells, adjacent normal cells will then be able to detoxify it through their Rhodanese enzymes.” (1187).

http://www.mednat.org/cancro/JAMES_SOUTH.pdf

If quantities do not exceed liver (and other organs’) function of purifying blood from this poison, it is the doctor’s task to assess how the metabolic therapy is going from blood and urine tests and rom the patient’s general check-up.

The Rhodanese enzyme destroys hydrocyanic acid and produces a non-toxic substance:

Thiocyanate.

As Oke notes:

“…Rhodanese is widely distributed in all the tissues with the highest concentrations in the liver.

Detoxification can therefore take place in all parts of the body, but with the liver as the chief site.

When hydrocyanic acid (Cyanide) is converted to thiocyanic acid (Thiocyanate) there is a 200-fold reduction in toxicity”(1190). http://www.mednat.org/cancro/OKE.pdf

When Beta-glucosidase destroys Laetrile, Benzaldehyde and Cyanide ions are released in cancer cells.

Several studies on humans used Benzaldehyde itself as a drug against cancer (1193,1194). In 1980-

1985 Kochi wrote: “ …no toxic effects were reported, including hematologic or biochemical disorders, even when Benzaldehyde was repeatedly administered for long periods.”

http://www.mednat.org/cancro/benzaldehyde_derivative.pdf

Tatsumura used an average total dose of 393 grams of a substance similar to Benzaldehyde, that subsequently changed into Benzaldehyde, and obtained a positive reaction rate of about half the patients who were given treatment:

“…Careful monitoring showed no toxic action of the drug at these large doses. Complete necrotic liquefaction of tumour was seen in 2 of 3 cases in which histological examination was feasible” (1195). http://www.mednat.org/cancro/TATSUMURA.pdf

During the Seventh International Congress of Chemotherapy in Prague, in 1971, Dean Burk said:

In vitro tests with Ehrlich ascites carcinoma (a type of cancer cell culture) revealed that, where  cyanide alone killed one percent of the cells and Benzaldehyde alone killed twenty percent, a combination of the two was effective against all the cells. Amygdalin with Beta-glucosidase added also succeeded in killing 100 percent of the ascites tumor cells, due to the same two chemicals” (1187).

But Krebs soon realized that he had clashed with huge economic interests. Chemo-pharmaceutical multinationals could not obtain a registration nor have exclusive rights on vitamin B17. Thus, they began a long defamatory campaign against apricot bitter seeds, and they convinced the whole American population that these are allegedly dangerous.

At the moment, cancer treatment with Laetrile is forbidden by law in the USA, even if under a doctor’s supervision. That is why dozens of thousands of American citizens get treatment in expensive private hospitals just beyond the Mexican border, in Bahamas, and in other places, where they officially go “on holiday”.

For instance, doctor Francisco Contreras, the current managing director of the Oasis of Hope hospital in Tijuana, Mexico, treated more that 60,000 patients with a vegetarian therapy and vitamin B17 in 35 years of activity (1187). http://www.mednat.cancro/Contreras.pdf

Doctor Ernesto Contreras has been using Laetrile since 1963, and thinks that

“…The majority of most frequent cancers, such as lung, breast, colon, ovarian, stomach,esophagus, prostate cancer, and lymphoma, can improve dramatically with Laetrile” (1187).

Clinical Case history

 

Amygdalin taken orally has been known to be a poison since ancient times, though amygdalin-laden black and brown bitter seeds were described as antitumor agents in the pharmacopeia of ancient China (1497)

Egyptian, Greek, Roman and Arabic physicians also used amygdalin to treat tumors (1498).

In a study conducted in 1958, Prof Marco Tasca, head of the radiology department of the Civil Hospital in Sanremo, treated 21 Italian terminally ill patients – 3 suffering from seminomas, 4 from breast cancers, 1 from womb cancer, 2 from laryngitis cancers, 7 from lung cancers, 1 from cancer of the oesophagus, 2 from stomach cancers, 1 from Hodgkin’s disease – with intramuscular injections of Laetrile. He noticed that patients showed good drug tolerance, their clinical conditions improved during the entire treatment period and only one month – on average – after the interruption of the therapy the neoplastic pathology resumed its progression. He pointed out only two complications:

hemorrhage and icterus. The former probably caused by necrotic eschars coming off the tissues, the latter induced by a direct toxic action on hepatic cells, which rarely happens though (5% of his case histories). The article is available in PDF format (1373) at http://www.fiocco59.altervista.org/images/tasca.pdf  or http://www.mednat.org/cancro/tasca.pdf.

In the 1966 report, Proceedings of the Ninth International Cancer Congress, Rossi cites a ten-year trial in Europe involving 150 patients that found „50 percent of all cases in treatment showed objective improvement” and concluded that laetrile was „an extremely useful chemotherapeutic drug.”(1382) http://fiocco59.altervista.org/vitamina_b_17.htm

In 1994, professor Dr .Binzel published the results he obtained treating patients with Laetrile between 1974 and 1991. His case history included 180 patients with primary cancer (with no metastasis and limited to only one organ or tissue). 131 patients were still alive in 1991, when the report was published. At that time, 58 patients had been followed for 2 to 4 years, while 80 of them had had a medical follow-up for 5 to 18 years. Out of the 42 patients that had died by 1991, 23 had died from cancer, 12 from “unrelated causes” and 7 of “unknown causes” (Binzel E.P.: “Alive and Well”). http://www.mednat.org/cancro/ALIVE_AND_WELL.pdf

Among patients with metastasis, 32 out of 108 had died from their disease, 6 from “unrelated causes” and 9 from “unknown causes”. Out of the 61 patients that were still alive in 1991, 30 had had a medical follow-up of 2-4 years, 31 had been followed for 5-18 years.

Doctor John A. Richardson’s case history of 1976 reports over 6,000 cases that show a positive effect of vitamin B17 against cancer. (1187)

There are 4,800 cases reported and carefully studied by doctor Ernesto Contreras. Those were

selected among 10,000 case sheets collected in 14 years of experiences with Laetrile.

Doctor Paul Wedel from Oregon reported about 4,000 cases of metabolic treatment. He survived cancer himself with vitamin B17 and a diet similar to the gersonian one (1187).

1,000 cases were reported by doctor Manuel Navarro of Santo Tomas University in Manila, the Philippines. The Mexican government is even monitoring about 100 patients that are being treated with metabolic therapy and vitamin B17, under the guidance of doctor Mario Soto de Leon, medical director of the Cydel Clinic in Tijuana (1187).

In Germany, doctor Hans Nieper reported about 1,000 cases. (http://www.mwt.net/~drbrewer  )

It is interesting to notice that cases such as that of Mr. Glen Rutherford from Kansas, who healed completely in Tijuana, are recorded in tribunal archives as “cures” (1187).

Clinical Trial of Chemotherapeutic treatment of advanced cancers with Leatrile

Guidetti Ettore

Rossi Benedetto

Deckers Christian

Presented at the 9th International Cancer Congress in Tokyo, October 1966

From 1954 to 1966 we gave 150 patients the above-mentioned therapy, chiefy at San Cottolengo Hospital, Turin; DosioHospital, Milan; and Louvain University Cancer Institute. All patients were in the terminal stage of the disease, the majority of them prey to cachezia, and all other therapies had failed.

The following table summarizes the cases treated, classified according to the site of the tumor, and showing the number of patients for each degree of reaction to therapy. We use the sign ++ to denote patients who reacted in an objectively favourable manner, by which we mean diminution of volume of the tumor or at least all interruption of its evolution, improvement in the roentgenographic picture, and improvement in laboratory findings. The mark + and + indicates patients who showed a more or less distinct subjective improvement, and the mark – those who reacted negatively to the treatment.

Cases corresponding to ++ represent about 20% of those treated.

We again underline the fact that the majority of these cases were simultaneously subjected to an immunotype therapy, which might have some bearing on the number of positive results observed, grouped under the signs ++ and + totalling about half the number of cases treated.

Cancer Site        No. cases            ++    +    +-          

Toruli tactiles                    26                           5             6             6             9

Breast                                  25                           3             8             7             7

Uterus                                 24                           7             7             4             6

Rectum                                               20                           2             9            2             7

Ovary (with infusion)    10                           2             2             2             4

Other types                       30                           9             7             2             12

Totals                                   135                        28           39           23           45

We have separately considered neoplasms of the pleura with effusion (15 cases), where the product was used direct by injection in the pleural cavity. In these cases we observed our best results, as generally we obtained reduction and then on occasion complete disappearance of the effusion, associated with a distinct improvement in the patients’ condition.

Conclusion:

On the basis of our clinical trial, we are able to state that L-mandelonitrile-beta-diglucoside may be considered an

extremely useful chemotherapeutic drug for palliative medical treatment of malign neoplasms, from the standpoint both of its therapeutic effect and its very low toxicity.

Amygadin metabolic liver aspects

Detoxification of cyanide can take place in all tissues of the body, but principally in the liver. The dosage levels and toxicity of amygdalin (Laetrile) in laboratory animals and humans is well established and documented.

No evidence of acute or accumulative toxicity was observed in any animals giving doses in excess of 100 times the maximum intravenous dose usually given in humans.

These findings coincide with that mentioned by Otto Jacobsen in 1887, Davidson in 1944 and Dr. Dean Burk (National Cancer Institute) in 1968: „Amygdalin is impressively nontoxic from the pharmacological point of view„, and „non-hydrolyzed amygdalin is less toxic than glucose„. The oral toxicity of amygdalin was found to be 39 to 44 times greater than the intramuscular route, and more toxic than intravenous route (parentenal route). Amygdalin is less tolerable by oral administration because of the hydrolysis of amygdalin by the gastric juices. On the other hand amygdalin, in dosages of 20-40/mg/kg orally (for a 200 lb human this would translate to 16 -500mg laetrile/B17 tablets, daily), used in humans, is 10 to 20 times less than the minimum toxic dosage in dogs. The biological half life of amygdalin is only 80 minutes.

Over 80% of the amygdalin administered is excreted from the body in 4 hours.

The usual metabolic approach to amygdalin (laetrile) therapy is to provide the patient with adequate nutritional support, with relatively nontoxic high doses of vitamins and minerals, and other active natural substances.

Amygdalin (laetrile) has been administered in dosages of up to 70 grams (70,000 miligrams-mg) per day in adult humans by combined oral and parentenal routes without adverse effects.

Ever since the days of Louis Pasteur (1822-1895) and Paul Ehrlich (1854-1915), cancer victimshave hoped for the „wonder vaccine” or the „magic bullet”.

Amygdalin (laetrile) does NOT come under the heading of either of these dramatic therapies. There are a number of factors that enter into the cancer treatment complex.

The type of cancer involved is an important factor. Some types of cancer tend to be more sensitive to treatment than other.

Amygdalin (laetrile) is NOT equally effective in all types of cancers.

Rubin (1977) found in their clinical investigations in Israel that Amygdalin (laetrile) was most effective against Adeno-carcinoma and Hodgkin’s disease, somewhat less effective in certain other of the Sarcomas and Melanomas, and relatively poor results were achieved with the Leukaemia. Similar results have been obtained by other clinicians in the United States and elsewhere.

The best results with Amygdalin (laetrile) therapy have been achieved with Lung, Prostate, Breast, Lymphomas, Liver and Brain cancer.

The chemical quality of the Amygdalin (Laetrile) also has a bearing on the clinical therapeutic results.

Only the laevo isomer of Amydalin (Laetrile) has been found to be therapeutically active. A high quality Amygdalin is now produced in Mexico and some products are currently under investigation in the United States and Germany . It is therefore of the utmost importance that quality products be utilized. Failure to recognize this point can result in inadequate dosage levels and false negative therapeutic results (Krible, 1912; Levi, et al, 1965; Rubin, 1978).

Other factors relating directly tothe administration of Amygdalin (Laetrile) concern the dosage.

In the past, most physicians have tended toward administering too low a dosage. Therefore the frequency of administration, the route of administration, and the dosage are of the utmost importance if adequate blood levels are to be maintained. In the past, most errors of administration have been made on the side of too little, rather than too much. However, it should be kept in mind that the most effective routes are by parenteral injection (I.M or I.V.) and the physician should not attempt to achieve the necessary dosage levels by the oral route. Rubin (1978) reports administering 70 gr. per day to each patient with no ill effects.

Another aspect that will have a bearing on the recovery of a patient depends upon the  degree of tissue damage caused by excessive radiation and toxicity resulting from Chemo-Therapy.

It is presently estimated in the United States, Mexico, and elsewhere, that about 90% or more of the patients begin using Amygdalin (Laetrile) only after all other types of cancer therapies have failed.

Most metabolic physicians are of the opinion that if the patient were to begin Metabolic Therapy earlier in the course of the disease, it would improve the patient’s chances of Cancer Control.

The adequacy of liver functions is of the utmost importance in cancer therapy. The liver has varied, intricate and extremely complex metabolic functions. Among other things the liver is concerned with fat, carbohydrate and protein metabolism.

The liver has a propensity for storing vitamins, especially A, D and B 12, and Iron in the form of ferritin. The liver forms a large proportion of the blood constituents: Fibrinogen, Prothrombin,

Accelerator Globulin, Factor VII, and other coagulation factors. The liver is involved in vitamin K metabolism. The liver is concerned with the vascular storage and filtration of blood, with about 1,000 ml of blood flowing from the portal vein through the liver sinusoids each minute, and an additional 400 ml flows into the sinusoid from the hepatic artery. Thus when the liver or kidneys are damaged due to a primary or metastatic malignancy, it may adversely affect the entire metabolism of the body.

The studies conducted thus far on Amygdalin (Laetrile) indicate that there is no damage to the liver or kidney function. Much of the effort of metabolic therapy is dedicated toward sustaining adequate liver and kidney functions, and to attempt to minimize the detoxification load placed upon them.

It should be emphasized that Amygdalin (Laetrile) therapy is most effective when used in conjunction with a comprehensive METABOLIC approach. Most physicians using this form of therapy provide adequate nutritional support with the use of proper vitamin and mineral supplements. The patient is placed on a complete vegetarian diet with a reduction of proteins, fats, refined sugars, and processed foods. All tobacco, alcohol, caffeinated drinks, and most toxic medications are eliminated. The patient is placed on a high intake of select fruit juices, fresh fruits and vegetables. A program of Detoxification is required. A minimum of 9 gr of Amygdalin (Laetrile) per day is administered, largely by the parenteral route, but even higher levels may be given if indicated.

Patients that refuse to follow the general Metabolic Program are discouraged from taking Amygdalin (Laetrile)

 

 

 

 Amygdalin poisoning: medical aspects

1) Effect: quick tissue anoxia due to intracellular respiratory failure and toxic lesion of respiratory centres.

2) Amygdalin plasmatic half-life: about 80 minutes.

3) Clinical symptoms: asthenia, torpor, somnolence, headache, vertigo, coma, dyspnea, apnea, polypnea, heart rhythm disorders (bradycardia, atrial fibrillation). Vomit and diarrhea are possible as well. High abdominal pain. Not associated with cyanotic coloration.

Basic therapy

1) Artificial breathing with 100% oxygen.

2) Hypotension needs to be treated with sympathomimetic amines (if it is of cardiogenic origin) or with liquid infusion (if it is of hypovolemic origin).

3) Electrolytes and acid-base balance have to be checked (risk for lactic acidosis).

Antidotal therapy

1) Inhalation of gauze pads soaked with a vial of amile nitrate for 15-30 seconds, to be repeated every 2-3 minutes using another vial.

2) Slow endovenous infusion (3-5 minutes) of 10 millilitres of 3% sodium nitrite solution.

3) Endovenous infusion of 50 millilitres of 25% sodium thiosulfate.

Clinical observation must be intense for at least 24 hours. Medical treatment should be corrected according to methaemoglobin monitoring (it should not be more than 40%).

 

Therapeutic dosage of vitamin B17

The various kinds of seeds or food contain adequate quantities of vitamin B17. But, unfortunately, it is not possible to calculate the bioavailability of these foods for absorption of vitamin B17 by intestinal walls, and this depends on many factors. Empirically, in adult patients weighing about 70 kg, it can be lethal to administrate daily 15 (fifteen) bitter almond seeds, or 30 (thirty) peach bitter seeds, or 300 (three hundred) apricot bitter seeds.

On the contrary, even a quantity as small as 2-3 bitter almond seeds is deadly for a child.

4 Tables showing the quantity of vitamin B17 found in 100 grams of fruit, the quantity of vitamin B17 found in 100 grams of seeds , quantity of vitamin B17 found in 100 grams of various types of leaves & the quantity of vitamin B17 found in 100 grams of various types of tubers are in my book.

Various sources report a very low biological half-life of about 80 minutes. This confirms that it is possible to administrate a maximum dose of about 5-7 apricot bitter seeds every hour for adults.

Some American doctors that have been working in Mexican clinics for the past 30 years claim that a safe dosage for an adult weighing 70 kg is about 5-7 bitter seeds every hour, about 100-250 seeds per day in total. Daily administration of 250-300 apricot seeds in an adult weighing 70 kg gives a quantity of vitamin B17 that is surely toxic. According to these doctors, it is important that seeds are taken on a full stomach, to avoid partial hydrolysis of Amygdalin by gastric juices. This would produce Cyanide ions directly in the stomach. Moreover, in their opinion endovenous administration of Amygdalin can be useful, because it is more tolerated as the maximum dose without reaching the above mentioned toxic quantities.

Finally, it is important to start administrating Amygdalin, if orally, in low doses, not higher than 5 bitter seeds per day, for the first week, and then 7-10 bitter seeds in the following weeks, at different intervals.

The bioavailability of apricot seeds is very high compared to other sources of vitamin B17.

However, I take no responsibility for B17 therapies carried out without a doctor’s supervision.

I especially advise against this therapy on patients who already underwent chemotherapy.

Their liver cannot properly detoxify blood from Cyanide ions and benzaldehyde. As far as this is concerned, doctor Moertel’s work, published on N.Engl.J.Med. in 1982 (Moertel CG: A clinical trial of amygdalin (laetrile) in the treatment of human cancer, N.Engl.J.Med., 306, pp.: 201-206 (1256), shows this therapy’s complete failure (http://fiocco59.altervista.org/nacci/Moertel%201982.pdf   )

Note on the work of New Engl.J.Med., 1982 (Moertel CG: A clinical trial of amygdalin (laetrile) in the treatment of human cancer, N.Engl.J.Med., 306, pp.: 201-206): this work was conduced by the dr. Moertel of the Mayo Clinic;

In this work are:

1) Chemically pure amygdalin was not used. Instead a mixture, which supposedly mimicked what was being used in a Mexican Clinic.

2) 70 per cent of these patients were stable during the first three weeks of the study, during which the patients received intravenous amygdalin.

3) Once the patients were switched to oral amygdalin alone, they did deteriorate fairly quickly.

4) Supporters of amygdalin do not believe that this study was valid proof against amygdalin efficacy.

From : England Journal of Medicine, 307, pp.119, 1982 (on the work of dr. Moertel CG: A clinical trial of amygdalin (laetrile) in the treatment of human cancer, N.Engl.J.Med., 306, pp.: 201-206 ;

http://fiocco59.altervista.org/nacci/Moertel%201982.pdf )

 

To the Editor: In the article on the Laetrile clinical trial, the investigators state, “No substantive benefit was observed in terms of cure, improvement, or stabilization of cancer, improvement of symptoms related to cancer, or extension of life span”. In the accompanying editorial there appears the statement, “Even when combined with the “metabolic” therapy (vitamins and a “natural” diet) so enthusiastically touted by the anti-establishment cancer therapists, Laetrile produced no discernible benefit in a group of 178 patients with a variety of types of advanced cancer”. As one of the touters, I wish to point out that these conclusions are not justified by the evidence. The reason for my contention is that there was no control group with which the group of treated patients could be compared.

The investigators say that the median survival time was 4,8 months (five months for patients with colorectal cancer, five months for those with lung cancer, four months for those with breast cancer, and three months for those with melanoma), and they claim , “These survival times appear to be consistent with the anticipated survivals in comparable patients receiving inactive treatment or no treatment “. No survival curves for these comparable patients are presented, nor are there any references to pertinent reports. The editorial states that “The lack of concurrent controls was partially offset by the fact that all patients were in the advanced stages of a disease known to be almost uniformly and rapidly fatal. Any objective responses in tumor size or apparent prolongation of survival could be identified by comparison with historical controls. But there was not the slightest suggestion of any beneficial effect”.

It is my opinion that there probably was a beneficial effect, including prolongation of survival. Other studies have shown that the median survival time in patients with cancer “for which no standard treatment was known to be curative or to extend life expectancy” was about 1,4 months; an example is the control group in the study by Creagan et al. (Failure of high-dose vitamin C therapy to benefit patients with advanced cancer: a controlled trial. New England Journal Medicine, 1979, No. 301, pp: 687-690).

The observed median of 4,5 months accordingly constitutes a substantial increase. In any case, it is improper to announce a negative result without performing a careful statistical analysis of the treated group and a suitable control group.

The report by Moertel et al is marred by other errors and imperfections. For example, Figure 3 shows that 10 of the  patients in the group survived to the end of the study, whereas in the text it is stated that 26 of the 178 survived; one of these numbers is wrong.

One third of the patients had not received chemotherapy, but despite the well-known contention that vitamins and diet have greater value for these patients than for those who have received chemotherapy, no statistical analysis of the observations on the two sub-groups is presented. Moreover, 14 of the 178 patients received much higher doses of vitamins than the others did, but little information is given about these 14 patients, and no statistical analysis of their responses in comparison to those of the others is reported.

LINUS PAULING Ph.D. Linus Pauling Institute of Science and Medicine Palo Alto, CA 94306

 

To the Editor:

Despite your belief that the National Cancer Institute (NCI) “clinical trial” of Laetrile “closes the books” on the use of amygdalin in cancer therapy, your readers should be well aware of many dissenting views and of our widespread suspicion that the trials were designed to make certain that Laetrile – or whatever the NCI was construing to be Laetrile –failed.

This organisation and the undersigned are parties to ongoing litigation against the NCI in regard to the conducting of the trials.

Officers of this organisation were the only Laetrile proponents who assisted at the early stages in developing the NCI design protocols for the study.

We became involved in litigation only after it became clear to us that the NCI was going to test not pure amygdalin but a degraded or decomposed form of it (the putative “RS-epimer racemic mixture” said by Moertel et al. to be a copy of material provided by a major Mexican manufacturer).

Let me stress that our side does not believe that even with appropriate material the lives of most of the patients with incurable or inoperable cancer could have been saved.

It is our belief that the patients’ responses within the first three weeks of treatment (when most patients were on the 21-day injectable part of the program) indicate at least some fleeting anti-neoplastic action, even from the degraded product.

Indeed, by any of the various semantic renderings of the results of the first three weeks of therapy, either a majority of patients were stable or a sizable minority (46 per cent) had no signs of progressive disease during this part of the program. Unless the English language has substantially changed during the past 24 months, I cannot interpret these renderings as other than suggesting limited efficacy of the injectable material. Would it not have been wise to continue giving injections and to make a real effort at a real metabolic program in these incurable patients ?

Our side also laments the lack of any Laetrile-using physician in the NCI program and the lack of available raw data on the patients.

We insist that the NCI “clinical trial” has asked far more questions than it has answered about Laetrile, but that by no stretch of the imagination can it be said to have “closed the books” on Laetrile.

Michael Culbert

Committee for Freedom of Choise in Cancer Therapy, Inc.

Los Altos, CA 94022

More details about this topic in my book.

Best of health!

Cristian