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Hydroxycinnamic Acids
Dicaffeoyl-tartaric acid
Chicoric acid is a caffeic acid derivative, belonging to the group of polypfenols.
science.naturalnews.com/C/Caffeic_Acid_and_cancer.html
http://science.naturalnews.com/C/Caffeic_Acid_and_Anticarcinogenic.html
http://science.naturalnews.com/C/Caffeic_Acid_and_Chemotherapeutic.html
http://science.naturalnews.com/C/Caffeic_Acid_and_Anti-Angiogenic.html
Chicoric acid is the most active compound in Echinacea pupurea. Chicoric acid is very stable in dry conditions but can be broken down by enzymes, which are found in the Echinacea, in moist conditions.
- DistributionChicoric is only found in Echinacea purpurea.Health Benefits of Chicoric acidChicoric acid makes our immune cells more efficient in attacking intruders. In vivo en vitro studies have shown that chicoric acid promotes phagocytosis. This is the process whereby white blood cells and lymphocytes attack and destroy pathogens. Chicoric acid stimulates T-cell activation, stimulates healing of wounds and reduces the inflammation in arthritis. Chicoric acid increases the production of interferon, immunoglobulin and other chemicals important for the immune system.Studies have indicated that chicoric acid can inhibit the penetration of viruses in cells.Chicoric acid also acts as an antioxidant by preventing the oxidation of collagen and cells.
1,2-Benzopyrone, 2H-1-Benzopyran-2-one
Coumarin is a phytochemical with a vanilla like flavour. Coumarin is a oxygen heterocycle. Coumarin can occur either free or combined with the sugar glucose (coumarin glycoside).
Distribution
Coumarin is found in several plants, including tonka beans, lavender, licorice, strawberries, apricots, cherries, cinnamon, and sweet clover.
Health Benefits of Coumarin
Coumarin has blood-thinning, anti-fungicidal and anti-tumor activities.
science.naturalnews.com/C/Coumarin_and_cancer.html
- A review of Coumarin derivatives in pharmacotherapy of breast cancer.
2008 Current medicinal chemistry
- A synthetic Coumarin (4-methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice.
2009 European journal of pharmacology
- Lack of effect of Coumarin in women with lymphedema after treatment for breast cancer.
1999 The New England journal of medicine
- Comparative study of the clinical efficacy of two different Coumarin dosages in the management of arm lymphedema after treatment for breast cancer.
1999 Lymphology
- Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- and caspase-3 dependent mechanism and NF-kappaB down-regulation.
2007 In vivo (Athens, Greece)
- Impact of short-term hypothyroidism on systemic anticoagulation in patients with thyroid cancer and Coumarin therapy.
2006 Thyroid : official journal of the American Thyroid Association
- Effects of Coumarin and 7OH-coumarin on bcl-2 and Bax expression in two human lung cancer cell lines in vitro.
2005 Cell biology international
- A Coumarin derivative (RKS262) inhibits cell-cycle progression, causes pro-apoptotic signaling and cytotoxicity in ovarian cancer cells.
2011 Investigational new drugs
- 7-Diethylamino-3(2′-benzoxazolyl)-coumarin is a novel microtubule inhibitor with antimitotic activity in multidrug resistant cancer cells.
2009 Biochemical pharmacology
- Low-molecular-weight heparin versus a Coumarin for the prevention of recurrent venous thromboembolism in patients with cancer.
2003 The New England journal of medicine
- An in vitro investigation of the induction of apoptosis and modulation of cell cycle events in human cancer cells by bisphenanthroline-coumarin-6,7-dioxacetatocopper(II) complex.
2007 Chemico-biological interactions
- Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreaticcancer toxicity.
2007 Journal of medicinal chemistry
- Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo.
2009 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
- Synthesis and antiproliferative activity of coumarin-estrogen conjugates against breastcancer cell lines.
2009 Letters in drug design & discovery
- Novel coumarin-3-(N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1.
2005 Bioorganic & medicinal chemistry
- Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer–a prospective,randomized, placebo-controlled, double-blind study.
2001 The British journal of oral & maxillofacial surgery
- Randomized comparison of low molecular weight heparin and Coumarin derivatives on the survival of patients with cancer and venous thromboembolism.
2005 Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Studies on cancer chemoprevention by traditional folk medicines XXIV. Inhibitory effect of a Coumarin derivative, 7-isopentenyloxycoumarin, against tumor-promotion.
2002 Biological & pharmaceutical bulletin
- Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer.
2004 Current pharmaceutical design
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http://science.naturalnews.com/C/Coumarin_and_Antimitotic.html
http://science.naturalnews.com/C/Coumarin_and_Antiproliferative.html
http://science.naturalnews.com/C/Coumarin_and_Apoptotic.html
Coumarin should not be taken while using anticoagulants. Coumarin increases the blood flow in the veins and decreases capillary permeability. Coumarin can be toxic when used at high doses for a long period
Facts about Coumarin
Coumarin seems to work as a pesticide in the plants that produce it. Coumarin is responsible for the sweet smell of new mown hay.
4-hydroxy-3-methoxycinnamic acid
Pure ferulic acid is a yellowish powder. Ferulic acid belong to the family of hydroxycinnamic acid. The chemical structure of ferulic acid is very similar to that of curcumin.
The phytochemical ferulic acid is found in the leaves and seeds of many plants, but especially in cereals such as brown rice, whole wheat and oats. Ferulic acid is also present in coffee, apple, artichoke, peanut, orange and pineapple.
Health Benefits of Ferulic acid
Ferulic acid is an antioxidant which neutralizes free radicals (superoxide, nitric oxide and hydroxyl radical) which could cause oxidative damage of cell membranes and DNA. Ferulic acid helps to prevent damage to our cells caused by ultraviolet light. Exposure to ultraviolet light actually increases the antioxidant potency of ferulic acid.
science.naturalnews.com/…/88169_Protective_effects_of_a_topical_ antioxidant_mixture_containing_vitamin_C.html
… ferulic acid, and phloretin against ultraviolet induced photodamage in human skin. …and chronic reactions, including premature skin aging and skin cancer.
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science.naturalnews.com/…/2559062_Protective_effect_of_ferulic_acid_on_ nicotine_induced_DNA_damage.html
Protective effect of ferulic acid on nicotine induced DNA damage and cellular … smoke and plays an important etiological role in the development of lung cancer.
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science.naturalnews.com/F/Ferulic_acid_and_Inflammatory.html
FA15, a hydrophobic derivative of ferulic acid, suppresses Inflammatory responses and skin tumor promotion: comparison with ferulic acid. 2002 Cancer letters
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science.naturalnews.com/…/875229_Ferulic_acid_augments_angiogenesis_ via_VEGF_PDGF_and_HIF_1.html
Ferulic acid augments angiogenesis via VEGF, PDGF and HIF 1 alpha. … broad range of therapeutic effects on human diseases, including diabetes and cancer.
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science.naturalnews.com/…/1973049_Actions_of_ferulic_acid_and_vitamin_ E_on_prevention_of.html
Actions of ferulic acid and vitamin E on prevention of hypercholesterolemia and atherogenic lesion … Vitamin D is nutritional key for prevention of breast cancer.
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science.naturalnews.com/…/2144597_Protective_effect_of_ferulic_acid_on_ 712_dimethylbenzaanthracene_induced_skin.html
Protective effect of ferulic acid on 7,12 dimethylbenz[a]anthracene induced skin carcinogenesis in Swiss … List of Cancer-Causing Agents Grows (press release).
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Ferulic acid is often added as ingredient of anti-aging supplements. Studies have shown that ferulic acid can decrease blood glucose levels and can be of help to diabetes patients.Ferulic acid seems to protect against cancer, bone degeneration, menopausal symptoms (hot flushes). Like many other antioxidants, ferulic acid reduces the level of cholesterol and triglyceride, thereby reducing the risk of hearth disease. Ferulic acid seems to reduce the risk of many cancers, including cancer of the stomach, colon, breast, prostate, liver, lung and tongue. A study by W Kuenzig et all Caffeic and ferulic acid as blockers of nitrosamine formation published in Carcinogenesis (Vol 5, 1984) showed that dietary caffeic acid and ferulic acid may play a role in the body’s defence against carcinogenesis by inhibiting the formation of N- nitroso compounds.
Ferulic acid can be converted into the flavour vanillin by biochemical reaction.
Isoprenoides :
Abscisic acid, Acorenone, Alloaromadendrene, Aromadendrene, Bergamotene, Bisabolene,Borneol, Bornyl acetate, Isoborneol, Cadinene, Camphene, Caranol, Carene, Carvacrol, Carvone,Pinocarvone, Caryophyllene, Cedrine, Cineole, Cinnamaldehyde, Cinnamate, Citral,Cinnamaldehyde, Cyclocitral, Citronella, Citronellyl acetate or butyrate or propionate, Copaene, Cresol, Cubebene, Cymene, Damascenone,Elemene, Estragol, Eugenol, Farnesene, Fencone, Geraniol, Germacrene, Hotrienol, Humulene, Ionol, Ionone, Isopinocamphone, Isopulegol, Linalool, Longifolene, Mentol, Neomenthol, Menthone, Isomenthone, Murolene, Myrcenol, Myrcene, Myrtenol, Neral, Nerol, Nerolidol, Nootkatone, Ocimene, Ocimenol, Perillaldehyde, Phellandrene, Pinene, Pinocamphone, Piperitol,Piperitone, Pristane, Pulegone, Sabinene, Sabinol, Santalol, Selinadiene, Selinene, Sinensal, Styrene, Terpinene, Terpineol, Terpinolene, Thymol, Tricyclene, Vanillin, Valencene, Verbenone, Vitispirane, etc.
Sources:Cinnamon
science.naturalnews.com/…/188629_Allyl_isothiocyanates_and_ cinnamaldehyde_potentiate_miniature_excitatory_postsynaptic_inp…
… Cancer Pathophysiology Division, National Cancer Center Reseach Institute, … Allyl Isothiocyanates (AITC) and cinnamaldehyde are pungent compounds …
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science.naturalnews.com/…/1769088_Growth_inhibition_of_human_colon_ cancer_cells_by_plant_compounds.html
CONCLUSION : Cinnamaldehyde, piperine, and resveratrol offer significant in vitro anti-proliferative effects on cultured human colon cancer cells. While each …
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science.naturalnews.com/…/1499711_Coumarin_and_cinnamaldehyde_in_ cinnamon_marketed_in_Italy_a_natural.html
Coumarin and cinnamaldehyde in cinnamon marketed in Italy: a natural … The Cure in the Kitchen: Honey and Cinnamon can Cure Cancer and Arthritis.
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Sources: (Curcuma zedoaria and another plants)
A significant effect on the treatment of glioma was reported using Elemene which is found in small
amounts in many essential oils: it prolonged quality survival time of 40 patients with glioma (1574)
(Tan P.: Clinical study on treatment of 40 cases of malignant brain tumor by Elemene emulsion injection, Chin. J.
Integ. Trad. Western Med, 20, pp.: 645-648, 2000) http://www.mednat.org/cancro/cancro_cervello.pdf
OBJECTIVE: To investigate the effect of elemene emulsion injection (EEI) in treating malignant brain tumor.
METHODS: By conducting a retrospective study of 40 patients with brain tumor, 29 of malignant glioma and 11 metastatic tumor, who were treated with EEI from January 1994 to May 1998. EEI 0.4-1.2 g/d was given to each patient by intravenous dripping or/and intravenous infusion by pumps, and directly injected into carotid artery or infused through a carotid artery catheter with pumps. The total dosage of 6-12 g was given in 2-6 therapeutic courses with an interval of 1-1.5 months between courses. The effectiveness of treatment was accessed according to the changes of tumor size, Karnofsky Performance Status (KPS) and survival time of patients. The control group consisted of 29 cases of malignant brain tumor (22 of primary and 7 of metastatic) was treated with chemotherapy 2-3 therapeutic courses with an interval of 1-1.5 months between them.
RESULTS:
(1) In the EEI treated group the mean tumor size was changed from 6.70 cm3 (before treatment) to 2.67 cm3 (after treatment), t = 3.02, P < 0.01, it was reduced by 61%;
(2) In the EEI treated group 4 cases was CR, 26 PR, the total effective rate being 75.0% (95% credibility interval +/- 13.4%), while in the control group, 2 of CR, 10 PR, and the total effective rate 41.4% (95% credibility interval +/- 17.9%), the difference between the two groups was significant, chi 2 = 3.867, P < 0.05;
(3) KPS decreased in the EEI group from 94.7 scores (before treatment) to 88.2 scores (after treatment), the decrement was 6.5 scores (t = 3.5313, P < 0.01); (4) The survival time in the EEI treated group was 25.4 months, and that in the control group was 17.4 months (t = 3.74, P < 0.01).
CONCLUSION: Elemene has significant effect on treatment of malignant brain tumor. It could prolong the high quality survival time of patients and is worthy of further investigation.
Elemene , induced apoptosis in leukaemia (1409).
Dă clic pentru a accesa elemene_zedoaria_provoca_apoptosi_nella_leucemia.pdf
science.naturalnews.com/E/Eugenol_and_cancer.html
science.naturalnews.com/E/Eugenol_and_Apoptotic.html
2007 Molecular cancer. Pro-apoptotic effect of the landrace Bangla Mahoba of Piper betle on Leishmania donovani may be due to the high content of eugenol.
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Lecithins :
science.naturalnews.com/L/Lecithin_and_cancer.html
science.naturalnews.com/…/2237506_Oral_carcinogenesis_induced_by_4_ nitroquinoline_1_oxide_in_lecithinretinol.html
Oral carcinogenesis induced by 4 nitroquinoline 1 oxide in lecithin:retinol … induced a higher incidence of oral cancer in LRAT knockout (LRAT(-/-)) than in …
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Lignans
- How lignans fight cancer? – NutraPro Internationalnutraprointl.com/2009/12/25/how-lignans-fight-cancer/ Lignans are being studied for possible use in cancer prevention, particularly breast cancer. Lignans acts as anticancer compounds by blocking …
- Breast Cancer Survival and Lignan Intake | NutritionFacts.org
One teaspoon of flax seeds may double one’s daily production of lignans, phytonutrients that appear to play a role in both breast cancer prevention and survival.
- Lignans – Linus Pauling Institute at Oregon State Universitylpi.oregonstate.edu/infocenter/phytochemicals/lignans/Lignan-rich foods are part of a healthful dietary pattern, but the role of lignans in the prevention of hormone-associated cancers, osteoporosis …
- PUBMED Dietary lignans: potential role in cancer prevention.http://www.ncbi.nlm.nih.gov/pubmed/15860433Dietary lignans: potential role in cancer prevention. Webb AL, McCullough ML. Graduate Program in Nutrition and Health …
- Dietary intakes of total and specific lignans are associated with …http://www.ncbi.nlm.nih.gov/pubmed/22113872 – Dietary lignans may affect breast cancer by modifying tumor characteristics likely to affect prognosis. We investigated usual dietary intakes of …
- Fighting breast cancer with flaxseeds : Disease Proofhttp://www.diseaseproof.com › Breast Cancer- Anti-cancer effects of lignans. Enterolignans are structurally similar to estrogen and can bind to estrogen receptors – this capability allows …
- Higher lignan levels improve breast cancer survival – Life Extension …http://www.lef.org/…/0920_Higher-Lignan-Levels-Improve-Breast-Cancer-Sur… In an article published online on September 6, 2011 in the Journal of Clinical Oncology, German researchers report that having high serum …
- Dietary Lignan Intake and Postmenopausal Breast Cancer Risk by …
jnci.oxfordjournals.org/content/99/6/475 Studies conducted in Asian populations have suggested that high consumption of soy-based foods that are rich in isoflavone phytoestrogens is …
science.naturalnews.com/…/2632135_Estrogenic_activities_of_sesame_ lignans_and_their_metabolites_on_human.html
Estrogenic activities of sesame lignans and their metabolites on human breast cancercells. Publication: Journal of agricultural and food chemistry. Publication …
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science.naturalnews.com/…/2602942_Cytostatic_inhibition_of_cancer_cell_ growth_by_lignan_secoisolariciresinol_diglucoside.html
Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside.
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science.naturalnews.com/…/1558789_Spirocyclic_Lignans_from_Guaiacum_ Zygophyllaceae_Induce_Apoptosis_in_Human_Breast.html
Spirocyclic Lignans from Guaiacum (Zygophyllaceae) Induce Apoptosis in Human BreastCancer Cell Lines. Publication: Journal of natural products. Publication …
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science.naturalnews.com/…/1311157_Extraction_of_lignans_from_flaxseed_ and_evaluation_of_their_biological.html
Our results show that lignans modulate development of breast cancer cells. The most intense effect was observed for anhydrosecoisolariciresinol, which …
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science.naturalnews.com/…/1478913_Vitexins_nature_derived_lignan_ compounds_induce_apoptosis_and_suppress_tumor.html
Vitexins, nature derived lignan compounds, induce apoptosis and suppress tumor growth. Publication: Clinical cancer research : an official journal of the …
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science.naturalnews.com/…/2157407_Inhibition_of_Akt_signaling_by_the_ lignan_matairesinol_sensitizes_prostate.html
Dietary lignans have shown cancer preventive and antitumorigenic activity, but the mechanisms behind these effects are poorly known. Here we observed that of …
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science.naturalnews.com/…/1938497_The_effects_of_different_lignans_and _isoflavones_tested_as_aglycones.html
PURPOSE: Phytooestrogens are known to cause anti-cancer effects on mamma carcinoma cells. In this study, the effects of the lignan Secoisolariciresinol and …
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science.naturalnews.com/…/2445678_Enterolactone_and_breast_cancer_ methodological_issues_may_contribute_to_conflicting.html
Enterolactone and breast cancer: methodological issues may contribute to conflicting …Lignans found in plant foods are converted by the intestinal microflora to …
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Lignans sources
Flaxseeds |
1 oz |
85.5
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Sesame seeds |
1 oz |
11.2
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Curly kale |
½ cup, chopped |
0.8
|
Broccoli |
½ cup, chopped |
0.6
|
Apricots |
½ cup, sliced |
0.4
|
Cabbage |
½ cup, chopped |
0.3
|
Brussels sprouts |
½ cup, chopped |
0.3
|
Strawberries |
½ cup |
0.2
|
Tofu |
¼ block (4 oz) |
0.2
|
Dark rye bread |
1 slice |
0.1
|
science.naturalnews.com/S/Silymarin_and_cancer.html
- Chemopreventive efficacy of Silymarin in skin and prostate cancer.
2007 Integrative cancer therapies
- Silymarin and epithelial cancer chemoprevention: how close we are to bedside?
2007 Toxicology and applied pharmacology
- Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells.
2001 The Prostate
- Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (Review).
2005 International journal of oncology
- Multitargeted therapy of cancer by silymarin.
2008 Cancer letters
- Identifying the differential effects of Silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
2008 International journal of cancer. Journal international du cancer
- Modulation of mitogen-activated protein kinase activation and cell cycle regulators by the potent skin cancer preventive agent silymarin.
1999 Biochemical and biophysical research communications
- Silymarin in the Prevention and Treatment of Liver Diseases and Primary Liver Cancer.
2011 Current pharmaceutical biotechnology
- Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancerchemoprevention.
1999 Carcinogenesis
- Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP.
2001 Carcinogenesis
- Synergistic anti-cancer effect of baicalein and Silymarin on human hepatoma HepG2 Cells.
2009 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Anti-angiogenic effect of Silymarin on colon cancer LoVo cell line.
2003 The Journal of surgical research
- Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells.
2009 Cell proliferation
- Cell signaling and regulators of cell cycle as molecular targets for prostate cancerprevention by dietary agents.
2000 Biochemical pharmacology
- Prostate cancer prevention by silibinin.
2004 Current cancer drug targets
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science.naturalnews.com/…/1248379_Multitargeted_therapy_of_cancer_by_ silymarin.html
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Publication: Cancer letters. Publication Date: 2008. Study Author(s): Ramasamy, Kumaraguruparan;Agarwal, Rajesh; Institution: Department of Pharmaceutical …
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science.naturalnews.com/…/99288_Synergistic_anti_cancer_effect_of_ baicalein_and_silymarin_on_human.html
Synergistic anti cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells.
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science.naturalnews.com/…/1182795_Identifying_the_differential_effects_of _silymarin_constituents_on_cell_growth.html
Prostate cancer (PCa) is the leading cause of cancer-related deaths in men; urgent measures are warranted to lower this deadly malignancy. Silymarin is a …
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science.naturalnews.com/…/2504182_Silymarin_use_and_liver_disease_ progression_in_the_Hepatitis_C.html
Silymarin from milk thistle protects against liver damage and brain aging · Milk Thistle promotes a healthy liver and fights cancer · Milk thistle is a natural …
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science.naturalnews.com/…/927691_Chemopreventive_effect_of_silymarin_ on_liver_pathology_in_HBV_X.html
Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice. Publication: Cancer research. Publication Date: 2008. Study Author(s): …
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science.naturalnews.com/…/2425788_The_safety_and_efficacy_of_a_ silymarin_and_selenium_combination.html
Silymarin, a milk thistle flavonolignan mixture, has anti-proliferative and anti- angiogenic activities in xenografts of human prostate cancer (PCa). Low dietary …
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science.naturalnews.com/…/1500090_Cytoprotective_effects_of_silymarin_ on_epithelial_cells_against_arsenic_induced.html
SIGNIFICANCE : These results strongly suggest that the use of silymarin increases the possibility of designing better arsenic-based cancer chemotherapies with …
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science.naturalnews.com/…/2729814_Silybin_and_silymarin__new_and_ emerging_applications_in_medicine.html
Silybin and silymarin new and emerging applications in medicine. … that bring silymarinpreparations closer to respective application in the cancer treatment.
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science.naturalnews.com/…/1019113_Silymarin_downregulates_COX_2_ expression_and_attenuates_hyperlipidemia_during_NDEA.html
Silymarin is a naturally available bioflavonoid and is a strong antioxidant with a capacity to inhibit the formation of tumors in several cancer models.
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science.naturalnews.com/…/476485_A_randomized_controlled_trial_to_ assess_the_safety_and_efficacy.html
A randomized controlled trial to assess the safety and efficacy of silymarin on … Medical science continues to remain silent about milk thistle as a cancer remedy.
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science.naturalnews.com/…/773906_Silymarin_efficacy_against_influenza_A _virus_replication.html
Silymarin from milk thistle protects against liver damage and brain aging · Milk Thistle promotes a healthy liver and fights cancer · Milk thistle is a natural …
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science.naturalnews.com/…/1298034_A_comparative_study_on_the_stability _of_silybin_and_that.html
Silymarin from milk thistle protects against liver damage and brain aging · Milk Thistle promotes a healthy liver and fights cancer · Milk thistle is a natural …
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science.naturalnews.com/…/1731440_Modulation_of_early_stress_related_ biomarkers_in_cytoplasm_by_the.html
Since the Flavonoids Silymarin (S) and Quercetin (Q) are Antioxidants and may protect cells, … Green tea extract coupled with quercetin kills cancer tumor cells.
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science.naturalnews.com/…/1967052_Preventive_effect_of_silymarin_in_ cerebral_ischemia_reperfusion_induced_brain.html
Preventive effect of silymarin in cerebral ischemia reperfusion induced brain injury in rats possibly … Milk Thistle promotes a healthy liver and fights cancer.
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science.naturalnews.com/…/67036_Anti_inflammatory_activity_of_silymarin _in_patients_with_knee_osteoarthritis.html
Silymarin from milk thistle protects against liver damage and brain aging · Milk Thistle promotes a healthy liver and fights cancer · Milk thistle is a natural …
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science.naturalnews.com/…/2606626_Effects_of_the_plant_flavonoids_ silymarin_and_quercetin_on_arsenite.html
Effects of the plant flavonoids silymarin and quercetin on arsenite induced oxidative …various cellular processes, causing adverse effects, including cancer.
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science.naturalnews.com/…/1037814_Elicitation_of_silymarin_in_cell_ cultures_of_Silybum_marianum_effect.html
Silymarin from milk thistle protects against liver damage and brain aging · Milk Thistle promotes a healthy liver and fights cancer · Milk thistle is a natural …
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science.naturalnews.com/…/1076119_Impact_of_treatment_with_ praziquantel_silymarin_and_or_beta_glucan.html
Impact of treatment with praziquantel, silymarin and or beta glucan on pathophysiological… Mushrooms That Fight Cancer and Boost the Immune System.
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science.naturalnews.com/milk_thistle.html
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Aug 15, 2013 … European journal of clinical pharmacology. Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum …
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science.naturalnews.com/…/1451860_Reduction_of_oxidative_stress_and_ liver_injury_following_silymarin_and.html
Silymarin from milk thistle protects against liver damage and brain aging · Milk Thistle promotes a healthy liver and fights cancer · Milk thistle is a natural …
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science.naturalnews.com/…/762897_Silymarin_inhibits_melanin_synthesis_ in_melanocyte_cells.html
Silymarin from milk thistle protects against liver damage and brain aging · Milk Thistle promotes a healthy liver and fights cancer · Milk thistle is a natural …
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science.naturalnews.com/…/1572621_Inhibition_of_atopic_dermatitis_by_ topical_application_of_silymarin_in.html
Silymarin from milk thistle protects against liver damage and brain aging · Milk Thistle promotes a healthy liver and fights cancer · Milk thistle is a natural …
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science.naturalnews.com/…
/263545_Positive_effect_of_silymarin_on_cell_ growth_and_differentiation_in.html
Silymarin from milk thistle protects against liver damage and brain aging · Milk Thistle promotes a healthy liver and fights
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science.naturalnews.com/S/Silymarin_and_prostate_cancer.html
Identifying the differential effects of Silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. 2008 International …
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SOURCES :Milk thistle
See this article on milk Thistle click here
Hydroxytyrosol is believed to be the antioxidant with the highest
free radical scavenging capacity: double that of quercetin and more than 3 times that of epicatechin.
Hydroxytyrosol is the main polyphenol found in olives.
Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.European Journal of Cancer Prevention. 2002 August;11(4):351-8Epidemiologic studies and animal studies show that olive oil may reduce the risk of several diseases such as cancer and heart disease. The aim of this study was to determine the effect of the main polyphenol in virgin olive oil, hydroxytyrosol, on tumor growth. The in vitro test were carried out in human colon cancer and leukemia cell lines. They found that hydroxytyrosol inhibited proliferation of both cancer cell lines. human promyelocytic leukaemia cells HL60 and colon adenocarcinoma cells HT29 and HT29 clone 19A. Hydroxytyrosol induced cell apoptosis and reduced cancer cell proliferation was reduced up to 50 percent. Hydroxytyrosol caused no such effects on non-cancer human cells, such as lymphocytes and polymorphonuclear cells. The study concluded that hydroxytyrosol may protect against cancer by arresting cell cycle and inducing apoptosis in cancer cells.
Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. Biochemical and Biophysical Research Communications. 2000 November 30;278(3):733-9Hydroxytyrosol is a natural phenolic antioxidant found in olive oil. It has many claimed biological and pharmacological activities. The aim of this study was to investigate the effect of hydroxytyrosol on the proliferation and survival of a leukemia cell line. The researchers found that hydroxytyrosol caused a complete arrest of leukemia cell proliferation and even induced apoptosis. This apoptotic effect was not observed with tyrosol, suggesting that presence of two ortho-hydroxyl groups is required. The study concluded that hydroxytyrosol reduces the immunological response, resulting in antinflammatory and chemopreventive effects.
science.naturalnews.com/…/2378205_Oleuropein_and_hydroxytyrosol_ inhibit_MCF_7_breast_cancer_cell_proliferation.html
Oleuropein and hydroxytyrosol inhibit MCF 7 breast cancer cell proliferation interfering with ERK1 2 activation.
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science.naturalnews.com/…/606773_Anti_proliferative_and_apoptotic_ effects_of_oleuropein_and_hydroxytyrosol_on.html
In this study, oleuropein and hydroxytyrosol, major phenolic compound of olive oil, was studied for its effects on growth in MCF-7 human breast cancer cells …
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science.naturalnews.com/Hydroxytyrosol.html
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Aug 15, 2013 … The Journal of nutritional biochemistry. Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancerMCF-7 …
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science.naturalnews.com/…/2577390_Hydroxytyrosol_inhibits_growth_and_ cell_proliferation_and_promotes_high_expression.html
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The aim of this study was to investigate, for the first time in an animal model of experimental mammary carcinoma, the anti-cancer ability of Hydroxytyrosoland to …
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science.naturalnews.com/…/2561646_Synthesis_of_a_novel_ester_of_ hydroxytyrosol_and_a_lipoic.html
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Synthesis of a novel ester of hydroxytyrosol and a lipoic acid exhibiting an antiproliferative effect on human colon cancer HT 29 cells.
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science.naturalnews.com/…/945006_Hydroxytyrosol_from_laboratory_ investigations_to_future_clinical_trials.html
Hydroxytyrosol: from laboratory investigations to future clinical trials. … lower rates of mortality from Cardiovascular disease and cancer than Northern European …
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science.naturalnews.com/…/1518292_Hydroxytyrosol_inhibits_the_ proliferation_of_human_colon_adenocarcinoma_cells_through.htm…
Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells … many pathological processes, including the development of colon cancer.
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Aug 15, 2013 … Hydroxytyrosol studies. … Neuroprotective effect ofhydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected …breast cancer (27)
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science.naturalnews.com/…/1150773_A_concise_synthesis_of_glucuronide_ metabolites_of_urolithin_B_resveratrol.html
Finally, three O-beta-D-glucuronides of hydroxytyrosol 6, 7, and 8 have been … Has Anti-aging and Anti-Cancer Properties, Linked to Cardiovascular Health.
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science.naturalnews.com/…/1423703_Protective_effect_of_hydroxytyrosol_ and_tyrosol_against_oxidative_stress_in.html
Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells. …New Study Finds Olive Oil Effective against HER-2 Breast Cancer.
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science.naturalnews.com/…/2501663_Effect_of_the_olive_oil_phenol_ hydroxytyrosol_on_human_hepatoma.html
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Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection … New Study Finds Olive Oil Effective against HER-2 Breast Cancer.
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Influence of Hydroxystyrol on Heart Disease
Monoterpenes
Lemonol, beta-Geraniol, trans-3,7-Dimethyl-2,6-octadien-1-ol
Geraniol is acyclic monoterpene-alcohol. Pure geraniol is a colourless oily liquid, with a sweet rose-like scent. When oxidized, geraniol becomes geranial or citral.
Bergamot, carrot, coriander, lavender, lemon, lime, nutmeg, orange, rose, blueberry and blackberry.
Health Benefits of Geraniol
Geraniol is a natural antioxidant. Geraniol has been suggested to help prevent cancer. Carnesecchi S. et al demonstrated in his study „Geraniol, a component of Plant Essential Oils, Inhibits Grwoth and Polyamine Biosyntehsis in Human Colon Cancer Cells”, (Pharmacology, July 2001) that geraniol caused a 50% increase of ornithine decarboxylase activity, which is enhances during cancer growth. Geraniol inhibits DNA synthesis.
Burk YD concluded in his study „Inhibition of Pancreatic Cancer Growth by the dietary isoprenoids farnesol and geraniol” (Lipids, February 1997) that geraniol, farnesol and perilll alcohol suppress pancreatic tumor growth.
Other animal studies have also demonstrated the anticancer effects of geraniol.
science.naturalnews.com/…/287047_Geraniol_inhibits_prostate_cancer_ growth_by_targeting_cell_cycle_and.html
Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways.
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science.naturalnews.com/G/Geraniol_and_cancer.html
Methyl-4-isopropenyl cyclohexene, Cajaputene, Carvene, Cinene, Dipentene, Efchole
Pure limonene is a clear liquid. Limonene is a monoterpene, made up of two isoprene units. Limonene occurs in two optically active forms, l-limonene and d-limonen. Both isomers have different odours: l-limonene smells piney and turpentine like and d-limonene has a pleasing orange scent.
Limonene is found in the essential oils of citrus fruits and many other plant species.
Limonene, found in lemons (Citrus limonum), oranges (Citrus aurantium), juniper (Juniperus communis) Foeniculum vulgare, Mentha pulegium, Mentha spicata, Verbena officinalis, Hyssopus officinalis, and in sage (Salvia officinalis), induces apatosis in leukaemia cells (693).
Health Benefits of Limonene
Studies have shown that limonene have anti- cancer effects.
Limonen increase the levels of liver enzymes involved in detoxifying carcinogens. The Glutathione S-transferase (GST) is a system which eliminates carcinogens. Limonene seems to promote the GST system in the liver and small bowel, thereby decreasing the damaging effects of carcinogens. Animal studies demonstrated that dietary limonene reduced mammary tumor growth.
Limonene induces the formation of apoptotic bodies on BCG-823 gastric cancer cells in a dose-and time –dependent manner (1565) and induced significant reductions of hepatocellular carcinomas (1566).
Limonene showed anti-angiogenic and pro-apoptotic effects on human gastric cancer implanted in nude mice, thus inhibiting tumor growth and metastasis (1577).
At least 6-7 lemons a day should be taken, possibly fresh, because lemons help eliminate the acid wastes from the body, increasing the reserves of alkaline substances in the blood and helping the urinary apparatus to expel uric acids. One lemon a day should be taken in the first week, to reach 7 lemons a day by the seventh week of the treatment; this should be continued this throughout the illness until the hoped-for cure. The honey from lemon flowers is currently under evaluation.
The essential oil of Citrus limonum is extremely nutritious both for its K-cals and for the phytochemicals found in it. N.B. the pressing of the oil must be done cold and without solvents.
Industrial limonene is produced by by alkali extraction of citrus residues and steam distillation. This distillate contains more than 90% d-limonene.
for studies cited above SEE LAST PAGE of DATABASE
Organosulfides
Allicin is an unstable compound that is strongly antibacterial and mainly responsible for garlic’s characteristic odor.
In vitro studies show that allicin inhibits the invasion and metastasis of human colon carcinoma cells. The phytochemical also exhibits antigenotoxic action. But the anticancer effect of allicin in humans remains uncertain, because of its low stability and poor bioavailability.
A study conducted at the Nanjing Medical University, China, concluded that allicininhibited the invasion and metastasis of human colon carcinoma cells in vitro at non-cytotoxic concentration through down-regulating the expression of vascular endothelial growth factor (VEGF), urokinase receptor (uPAR) and heparanase mRNA [1]. The researchers tested the effect of allicin on invasion and metastasis of human colon cancer cell line LoVo in vitro by using migratory test, adhesion test and Transwell chamber experiment. Allicin showed an inhibitive effects on growth of the cells in a dose and time-dependent manner. The phytochemicals suppressed the movement, adhesion and invasive capability of carcinoma cells.
A study by the Weizmann Institute of Science, Israel, demonstrated the antiproliferative function of allicin on two leukemia cell lines (HL60 and U937) [2]. They found that allicin showed anticancer effect by inducing growth inhibition, apoptotic events such as blebbing, mitochondrial membrane depolarization, cytochrome c release into the cytosol, activation of caspase 9 and caspase 3 and DNA fragmentation. Allicin reduced glutathione in the cytosol and mitochondria and changed the intracellular redox status.
Siddique and Afzal of the Aligarh Muslim University, India, investigated the antigenotoxic potential of allicin in cultured human lymphocytes using chromosomal aberrations and sister chromatid exchanges induced by the genotoxic methyl methanesulphonate [3]. They found that allicin treatment reduced the damage caused by the genotoxin, as illustrated by lower levels of chromosomal aberrations and sister chromatid exchanges.
[1] Effects of allicin on invasion and metastasis of colon cancer LoVo cell line in vitro. Zhonghua Yi Xue Za Zhi. 2009 May 26;89(20):1382-6.
[2] Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells. J Nutr Biochem. 2008 Aug;19(8):524-35.
[3] Antigenotoxic effect of allicin against methyl methanesulphonate induced genotoxic damage. J Environ Biol. 2005 Jul;26(3):547-50.
See this extensive article on garlic click here
Gamma-Glutamylcysteinylglycine
Glutathione is a sulfur-containing amino acid that is composed of three amino acids: cysteine, glutamic acid and glycine.
Although glutathione is produced by our body is can be beneficial to consume extra glutathione through the diet.
Glutathione is mainly in animal products but also in many plants including avocado, asparagus, broccoli, grapefruit, potato, strawberries, orange, tomato, peach and spinach.
Health Benefits of Glutathine
Glutathione is an important antioxidant. Glutathione neutralizes toxic peroxide which could otherwise damage our DNA and cell membranes. As we get older the glutathione level decreases in intracellular fluids. Dietary intake of glutathione can be important for older individuals which have reduced capabilities to detoxify free radicals. Glutathione also reacts with some toxins and helps to break them down, such as the pain reliever acetaminophen.
Glutathione improves the stability of other antioxidants including vitamin C and vitamin E. Glutathione supports our immune system and stimulates the production of lymphocyte immune cells.
Studies on Glutathione and cancer
- Relationship between colorectal cancer Glutathione levels and patient survival: early results.
2000 Diseases of the colon and rectum
- Polymorphisms of N-acetyltransferases, Glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
1998 Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
- A study of Glutathione status in the blood and tissues of patients with breast cancer.
2006 Cell biochemistry and function
- Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus utericancer in the general population.
2010 The pharmacogenomics journal
- Genetic polymorphisms of Glutathione S-transferase genes and susceptibility to colorectal cancer: A case-control study in an Indian population.
2011 Cancer epidemiology
- The redox state of the glutathione/glutathione disulfide couple mediates intracellular arginase activation in HCT-116 colon cancer cells.
2010 Digestive diseases and sciences
- Glutathione S-transferase M1 gene polymorphism in bladder cancer patients. a marker for invasive bladder cancer?
2001 Cancer genetics and cytogenetics
- Serum glutathione-S-transferase and Glutathione reductase activity in head and neckcancer patients.
2002 Neoplasma
- Serum glutathione-S-transferase and Glutathione reductase activity in head and neckcancer patients.
2002 Neoplasma
- Association between Glutathione S-transferase p1 polymorphisms and lung cancerrisk in Caucasians: a case-control study.
2003 Lung cancer (Amsterdam, Netherlands)
- Glutathione level and its relation to radiation therapy in patients with cancer of uterine cervix.
1999 Indian journal of experimental biology
- The Glutathione S-transferase M1 genotype in ovarian cancer.
2000 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Relationship between Glutathione S-transferase M1, P1 and T1 polymorphisms and early onset prostate cancer.
2001 Pharmacogenetics
- The glutathione-related detoxification system is increased in human breast cancer in correlation with clinical and histopathological features.
2001 Journal of cancer research and clinical oncology
- Alcohol consumption, Glutathione S-transferase M1 and T1 genetic polymorphisms and breast cancer risk.
2000 Pharmacogenetics
- Genetic polymorphism at the Glutathione S-transferase (GST) P1 locus is a breastcancer risk modifier.
2001 International journal of cancer. Journal international du cancer
- The Glutathione biotransformation system and colorectal cancer risk in humans.
2001 Scandinavian journal of gastroenterology. Supplement
- Genotypes of Glutathione S-transferase M1 and N-acetyltransferase 2 in Japanese patients with gastric cancer.
1999 Gastric cancer : official journal of the International Gastric cancer Association and the Japanese Gastric cancer Association
- Polymorphisms in the Glutathione S-transferase M1, T1, and P1 genes and prostatecancer prognosis.
2006 The Prostate
- No evidence for Glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk.
2010 Breast cancer research and treatment
- Combined analysis of polymorphisms in Glutathione S-transferase M1 and microsomal epoxide hydrolase in lung cancer patients.
2004 Neoplasma
- Combinations of Glutathione S-transferase genotypes and risk of early-onset lungcancer in Caucasians and African Americans: a population-based study.
2005 Carcinogenesis
- Epigenetic mechanisms for silencing Glutathione S-transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer.
2011 Cancer
- Gallic acid-induced lung cancer cell death is related to Glutathione depletion as well as reactive oxygen species increase.
2010 Toxicology in vitro : an international journal published in association with BIBRA
- Glutathione S-transferase P1 gene polymorphism associated with gastric canceramong Caucasians.
2009 European journal of cancer (Oxford, England : 1990)
- Determination of glutathione, Glutathione reductase, Glutathione peroxidase andGlutathione S-transferase levels in human lung cancer tissues.
1997 Cancer letters
- Isothiocyanates, Glutathione S-transferase M1 and T1 polymorphisms and gastriccancer risk: a prospective study of men in Shanghai, China.
2009 International journal of cancer. Journal international du cancer
- Relation of Glutathione S-transferase T1, M1 and P1 genotypes and breast cancerrisk.
2008 Cell biochemistry and function
- Impaired expression of Glutathione peroxidase-4 gene in peripheral blood mononuclear cells: a biomarker of increased breast cancer risk.
2010 Cancer biomarkers : section A of Disease markers
- CYP17, catechol-o-methyltransferase, and Glutathione transferase M1 genetic polymorphisms, lifestyle factors, and breast cancer risk in women on prince edward island.
2011 The breast journal
- Serum total glutathione-s-transferase levels in oral cancer.
2007 Journal of cancer research and therapeutics
- Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women.
2008 Breast cancer research and treatment
- Glutathione S-transferases M1, T1 genotypes and the risk of gastric cancer: a case-control study.
2001 World journal of gastroenterology : WJG
- The role of Glutathione in cancer.
2004 Cell biochemistry and function
- A meta-analysis of 20 case-control studies of the Glutathione S-transferase M1 (GSTM1) status and colorectal cancer risk.
2003 Medical science monitor : international medical journal of experimental and clinical research
- Polymorphisms of N-acetyltransferase 2, Glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis.
2000 The Journal of urology
- The role of human Glutathione S-transferases M1 and T1 in individual susceptibility to bladder cancer.
1999 Physiological research / Academia Scientiarum Bohemoslovaca
- Impact of genetic polymorphisms in cytochrome P450 2E1 and Glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
2000 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Glutathione in the prevention of cisplatin induced toxicities. A prospectively randomized pilot trial in patients with head and neck cancer and non small cell lung cancer.
2000 Wiener klinische Wochenschrift
- Dietary isothiocyanates, Glutathione S-transferase -M1, -T1 polymorphisms and lungcancer risk among Chinese women in Singapore.
2001 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Glutathione S-transferase T1-null genotype interacts synergistically with heavy smoking on lung cancer risk.
2001 Environmental and molecular mutagenesis
- Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis.
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Glutathione S-transferase M1, T1 and P1 genetic polymorphisms, cigarette smoking and gastric cancer risk.
2005 Cell biochemistry and function
- Glutathione S-transferases M1, T1, and P1 and breast cancer: a pooled analysis.
2004 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Glutathione S-transferase M1, T1 and P1 genetic polymorphisms, cigarette smoking and gastric cancer risk.
2005 Cell biochemistry and function
- Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lungcancer patients.
1998 Experimental & molecular medicine
- Polymorphisms at the Glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype.
2001 Carcinogenesis
- Allelotype influence at Glutathione S-transferase M1 locus on breast cancersusceptibility.
1999 British journal of cancer
- Changes in Glutathione status and the antioxidant system in blood and in cancercells associate with tumour growth in vivo.
1999 Free radical biology & medicine
- Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer.
2004 Cancer detection and prevention
- Glutathione S-transferase (GST) polymorphisms as risk factors for cancer in a highly homogeneous population from southern Italy.
2002 Anticancer research
- Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk.
2003 British journal of cancer
- A population-based study of Glutathione S-transferase M1, T1 and P1 genotypes and risk for lung cancer.
2003 Lung cancer (Amsterdam, Netherlands)
- Glutathione pathway genes and lung cancer risk in young and old populations.
2004 Carcinogenesis
- Marine n-3 fatty acid intake, Glutathione S-transferase polymorphisms and breastcancer risk in post-menopausal Chinese women in Singapore.
2004 Carcinogenesis
- Polymorphisms in glutathione-S-transferase genes (GST-M1, GST-T1 and GST-P1) and susceptibility to prostate cancer among male smokers of the ATBC cancer prevention study.
2003 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
- Interaction of genetic polymorphisms in cytochrome P450 2E1 and Glutathione S-transferase M1 to breast cancer in Taiwanese woman without smoking and drinking habits.
2006 Breast cancer research and treatment
- Glutathione S-transferase M1 gene but not insulin-like growth factor-2 gene or epidermal growth factor gene is associated with prostate cancer.
2005 Urologic oncology
- Glutathione S-transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers.
2004 International journal of cancer. Journal international du cancer
- Glutathione S-transferase M1, T1, and P1 polymorphisms and prostate cancer risk in middle-aged men.
2006 The Prostate
- Lack of influence of Glutathione S-transferase genotype profile on cancersusceptibility in smokers and nonsmokers.
2009 Medical science monitor : international medical journal of experimental and clinical research
- Polymorphism of cytochrome p450, glutathione-s-transferase and N-acetyltransferases: influence on lung cancer susceptibility.
2010 Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
- Genetic polymorphisms of Glutathione S-transferase T1 and bladder cancer risk: a meta-analysis.
2010 Clinical and experimental medicine
- Investigation of Glutathione S-transferase M1 and T1 deletions in lung cancer.
2010 Molecular biology reports
- Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk.
2009 International urology and nephrology
- Polymorphisms of glutathione-S-transferase M1, T1, P1 and the risk of prostate cancer: a case-control study.
2009 Journal of experimental & clinical cancer research : CR
- Glutathione S-transferase M1 (GSTM1) polymorphisms and lung cancer: a literature-based systematic HuGE review and meta-analysis.
2008 American journal of epidemiology
- An 8-gene signature, including methylated and down-regulated Glutathioneperoxidase 3, of gastric cancer.
2010 International journal of oncology
- The influence of polymorphisms of Glutathione S-transferases M1 and M3 on the development of human urothelial cancer.
2008 Journal of toxicology and environmental health. Part A
- Critical role of Glutathione in melatonin enhancement of tumor necrosis factor and ionizing radiation-induced apoptosis in prostate cancer cells in vitro.
2008 Journal of pineal research
- Polymorphisms of Glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women.
2008 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
- Glutathione S-transferase T1 gene deletion polymorphism and lung cancer risk in Chinese population: a meta-analysis.
2010 Cancer epidemiology
- Glutathione S-transferase M1 null genotype associated with gastric cancer among Asians.
2010 Digestive diseases and sciences
- Glutathione S-transferase T1 (GSTT1) gene polymorphism and gastric cancersusceptibility: a meta-analysis of epidemiologic studies.
2010 Digestive diseases and sciences
- The role of Glutathione transferases M1 and T1 in individual susceptibility to bladdercancer in a Tunisian population.
2006 Annals of human biology
- Glutathione S-transferase T1 status and gastric cancer risk: a meta-analysis of the literature.
2006 Mutagenesis
- Role of the Glutathione metabolic pathway in lung cancer treatment and prognosis: a review.
2006 Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- The association between polymorphisms in Glutathione S-transferase (GSTM1 and GSTT1) and lung cancer outcome.
2006 Cancer investigation
- Association between a Glutathione S-transferase A1 promoter polymorphism and survival after breast cancer treatment.
2003 International journal of cancer. Journal international du cancer
- Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovariancancer patients.
2006 Journal of cancer research and clinical oncology
- Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferases.
2007 International journal of cancer. Journal international du cancer
- Augmentation of cisplatin sensitivity in cisplatin-resistant human bladder cancer cells by modulating Glutathione concentrations and glutathione-related enzyme activities.
2005 BJU international
- Effects of Glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk.
2006 Carcinogenesis
- Cytochrome p450 and Glutathione transferase expression in human breast cancer.
2003 Clinical cancer research : an official journal of the American Association forcancer Research
- Enhancement of diethylstilbestrol induced cytotoxicity by bcl-2 antisense oligodeoxynucleotides and a Glutathione depletor for prostate cancer.
2003 The Journal of urology
- Blood Glutathione as a surrogate marker of cancer tissue Glutathione S-transferase activity in non-small cell lung cancer and squamous cell carcinoma of the head and neck.
2003 European journal of cancer (Oxford, England : 1990)
- Glutathione S-transferase M1 status and gastric cancer risk: a meta-analysis.
2005 Cancer letters
- Cruciferous vegetables, genetic polymorphisms in Glutathione S-transferases M1 and T1, and prostate cancer risk.
2004 Nutrition and cancer
- Genetic polymorphism of Glutathione S-transferases M1 and T1 as a risk factor in lung and bladder cancers.
1998 Neoplasma
- Glutathione-S-transferase (GSTM1) genetic polymorphisms do not affect human breast cancer risk, regardless of dietary antioxidants.
1999 The Journal of nutrition
- Nuclear morphometry and Glutathione S-transferase pi expression in breast cancer.
2000 Oncology reports
- Glutathione S-transferase M1, M3, P1, and T1 genetic polymorphisms and susceptibility to breast cancer.
2001 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Glutathione S-transferase (GST) M1, T1, P1, N-acetyltransferase (NAT) 1 and 2 genetic polymorphisms and susceptibility to colorectal cancer.
1999 Journal of UOEH
- The Glutathione S-transferases: influence of polymorphism on cancer susceptibility.
1999 IARC scientific publications
- Significance of genetic polymorphisms in Glutathione S-transferase multigene family and lung cancer risk.
2001 International journal of occupational medicine and environmental health
- [Lung cancer risk and genetic polymorphism at the Glutathione S-transferase P1 locus in male Japanese].
2000 Fukuoka igaku zasshi = Hukuoka acta medica
- -SH groups and Glutathione in cancer patient’s blood.
2000 Anticancer research
- Aldehyde dehydrogenase 2 and Glutathione S-transferase M 1 polymorphisms in relation to the risk for oral cancer in Japanese drinkers.
2000 Oral oncology
- Polymorphisms of glutathione-S-transferase genes (GSTP1, GSTM1 and GSTT1) and prostate-cancer risk.
2001 International journal of cancer. Journal international du cancer
- Association between Glutathione S-transferase pi genetic polymorphisms and oralcancer risk.
1999 Pharmacogenetics
- Cytosine methylation represses Glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells.
2001 Cancer research
- Glutathione S-transferases as risk factors in prostate cancer.
1999 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
- Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk.
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Genetic polymorphism of Glutathione S-transferase P1 and breast cancer risk.
2004 Journal of biochemistry and molecular biology
- Genetic polymorphism of Glutathione S-transferase P1 and breast cancer risk.
2004 Journal of biochemistry and molecular biology
- Glutathione S-transferase M1 status and breast cancer risk: a meta-analysis.
2004 Yonsei medical journal
- Genetic polymorphisms of Glutathione S-transferases as modulators of lung cancersusceptibility.
2002 Carcinogenesis
- Redox regulation of pancreatic cancer cell growth: role of Glutathione peroxidase in the suppression of the malignant phenotype.
2004 Human gene therapy
- Significance of genetic variation at the Glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase 1 detoxification genes in breast cancerdevelopment.
2002 Oncology
- Glutathione S-transferase polymorphisms in thyroid cancer patients.
2003 Cancer letters
- Identification of multidrug resistance-associated protein 1 and Glutathione as multidrug resistance mechanisms in human prostate cancer cells: chemosensitization with leukotriene D4 antagonists and buthionine sulfoximine.
2004 BJU international
- Glutathione S-transferase M1, T1, and P1 polymorphisms and survival among lungcancer patients.
2003 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Lung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kong.
2004 Lung cancer (Amsterdam, Netherlands)
- Glutathione S-transferase pi (GSTP1) hypermethylation in prostate cancer: review 2007.
2007 Pathology
- Genetic alterations in chromosome 10q24.3 and Glutathione S-transferase omega 2 gene polymorphism in ovarian cancer.
2006 Journal of experimental & clinical cancer research : CR
- Glutathione S-transferases activity in patients with colorectal cancer.
2005 Clinical biochemistry
- Genetic polymorphisms of Glutathione S-transferase T1 (GSTT1) and susceptibility to gastric cancer: a meta-analysis.
2006 Cancer science
- Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis.
2007 Cancer research
- Glutathione S-Transferase M1 (GSTM1) and Glutathione S-Transferase T1 (GSTT1) Null Polymorphisms, Smoking, and Their Interaction in Oral Cancer: A HuGE Review and Meta-Analysis.
2011 American journal of epidemiology
- Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancercells through interaction with the Glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex.
2006 Cancer research
- Association of genetic polymorphism of Glutathione S-transferase M1, T1, P1 and susceptibility to bladder cancer.
2005 European urology
- Interactive effect of genetic polymorphism of Glutathione S-transferase M1 and smoking on squamous cell lung cancer risk in Korea.
2006 Oncology reports
- Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular Glutathione and augmentation of reactive oxygen species.
2008 Cancer chemotherapy and pharmacology
- Five Glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies.
2006 PLoS medicine
- Glutathione in cancer biology and therapy.
2006 Critical reviews in clinical laboratory sciences
- Genetic polymorphism of Glutathione S-transferase genes (GSTM1, GSTT1 and GSTP1) and susceptibility to prostate cancer in Northern India.
2005 BJU international
- Nuclear Factor-?B modulates cellular Glutathione and prevents oxidative stress incancer cells.
2010 Cancer letters
- Dietary isothiocyanates, Glutathione S-transferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, California.
2009 Nutrition and cancer
- Combined polymorphism analysis of Glutathione S-transferase M1/G1 and interleukin-1B (IL-1B)/interleukin 1-receptor antagonist (IL-1RN) and gastric cancer risk in an Omani Arab Population.
2009 Journal of clinical gastroenterology
- Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: a meta-analysis involving 34,658 subjects.
2011 Breast cancer research and treatment
- Glutathione S-transferase P1 ILE105Val polymorphism in occupationally exposed bladder cancer cases.
2008 Journal of toxicology and environmental health. Part A
- Glutathione S-transferase M1, T1 and P1 polymorphisms: susceptibility and outcome in lung cancer patients.
2008 Journal of experimental therapeutics & oncology
- Glutathione S-transferase P1 Ile105Val polymorphism and colorectal cancer risk: a meta-analysis and HuGE review.
2009 European journal of cancer (Oxford, England : 1990)
- Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population.
2010 Cancer epidemiology
- In vitro selected RNA aptamer recognizing Glutathione induces ROS mediated apoptosis in the human breast cancer cell line MCF 7.
2011 RNA biology
- Increase in thiol oxidative stress via Glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation.
2009 Free radical biology & medicine
- A comparative study of selenium concentration and Glutathione peroxidase activity in normal and breast cancer patients.
2009 Public health nutrition
- Evaluation of Glutathione metabolic genes on outcomes in advanced non-small cell lung cancer patients after initial treatment with platinum-based chemotherapy: an NCCTG-97-24-51 based study.
2009 Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
- Combined effect of smoking and inherited polymorphisms in arylamine N-acetyltransferase 2, Glutathione S-transferases M1 and T1 on bladder cancer in a Tunisian population.
2009 Cancer genetics and cytogenetics
- Role of oxidative stress and intracellular Glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells.
2009 BMC cancer
- Preferential Glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer.
2009 Chemical research in toxicology
- Isothiocyanate exposure, Glutathione S-transferase polymorphisms, and colorectalcancer risk.
2010 The American journal of clinical nutrition
- Urinary isothiocyanates; Glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study.
2009 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Glutathione S-transferases: an overview in cancer research.
2010 Expert opinion on drug metabolism & toxicology
- Glutathione S-transferase P1 Ile105Val polymorphism is associated with haematological toxicity in elderly rectal cancer patients receiving preoperative chemoradiotherapy.
2008 Drugs & aging
- Glutathione S-transferase (GSTM1 and GSTT1) polymorphisms in cervical cancer in Northeastern Thailand.
2009 Asian Pacific journal of cancer prevention : APJCP
- Glutathione-S-transferase P1, T1 and M1 genetic polymorphisms in neoadjuvant-treated locally advanced gastric cancer: GSTM1-present genotype is associated with better prognosis in completely resected patients.
2008 International journal of colorectal disease
- Glutathione S-transferase Pi mediates proliferation of androgen-independent prostate cancer cells.
2008 Carcinogenesis
- An updating meta-analysis of the Glutathione S-transferase T1 polymorphisms and colorectal cancer risk: a HuGE review.
2010 International journal of colorectal disease
- Glutathione S-transferase M1 polymorphism and breast cancer susceptibility: a meta-analysis involving 46,281 subjects.
2010 Breast cancer research and treatment
- Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer.
2010 Head & neck
- Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population.
2009 World journal of gastroenterology : WJG
- Antioxidant defense markers modulated by Glutathione S-transferase genetic polymorphism: results of lung cancer case-control study.
2007 Genes & nutrition
- Glutathione S-transferase polymorphisms and oral cancer: a case-control study in Rio de Janeiro, Brazil.
2008 Oral oncology
- Glutathione S-transferase pi1 promotes tumorigenicity in HCT116 human coloncancer cells.
2005 Cancer research
- Dietary isothiocyanates, Glutathione S-transferase polymorphisms and colorectalcancer risk in the Singapore Chinese Health Study.
2002 Carcinogenesis
- Evaluating polymorphic status of glutathione-S-transferase genes in blood and tissue samples of prostate cancer patients.
2006 Asian Pacific journal of cancer prevention : APJCP
- The role of glutathione-S-transferase polymorphisms in ovarian cancer survival.
2007 European journal of cancer (Oxford, England : 1990)
- Genetic polymorphisms of glutathione-S-transferase genes (GSTM1, GSTT1 and GSTP1) and upper aerodigestive tract cancer risk among smokers, tobacco chewers and alcoholics in an Indian population.
2007 European journal of cancer (Oxford, England : 1990)
- Glutathione S-transferase genotypes and cancer risk.
2005 Cancer letters
- Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women.
2006 International journal of cancer. Journal international du cancer
- Distribution of Glutathione S-transferase M1, P1 and T1 genotypes in different age-groups of Finns without diagnosed cancer.
2006 Cancer detection and prevention
- Combined effect of Glutathione S-transferase M1 and T1 genotypes on bladdercancer risk.
2002 Cancer letters
- Prognostic potential of Glutathione S-transferase M1 and T1 null genotypes for gastric cancer progression.
2003 Cancer letters
- Increased risk of bladder cancer associated with a Glutathione peroxidase 1 codon 198 variant.
2004 The Journal of urology
- Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide Glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells.
2004 The Journal of biological chemistry
- Glutathione S-transferase genotype GSTM1 as a predictor of elevated angiogenic phenotype in patients with early onset breast cancer.
2004 Angiogenesis
- The role of N-acetyltransferase-2 and Glutathione S-transferase on the risk and aggressiveness of bladder cancer.
2002 Anticancer research
- [Antioxidant barrier in patients with gastric cancer–preliminary study].
2005 Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
- Polymorphisms of Glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population.
2001 Archives of toxicology
- Glutathione S-transferase M1 gene polymorphism is related to COPD in patients with non-small-cell lung cancer.
2004 Wiener klinische Wochenschrift
- Combined effects of Glutathione S-transferase polymorphisms and thyroid cancerrisk.
2004 Cancer genetics and cytogenetics
- Meta- and pooled analyses of the effects of Glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk.
2002 Carcinogenesis
- Glutathione S-transferase M1 and P1 metabolic polymorphism and lung cancerpredisposition.
2003 Neoplasma
- Detailed methylation analysis of the Glutathione S-transferase pi (GSTP1) gene in prostate cancer.
1999 Oncogene
- Human Glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population.
2005 Journal of cancer research and clinical oncology
- Association between Glutathione S-transferase M1 and T1 polymorphisms and increased risk for bladder cancer in Korean smokers.
2003 Cancer letters
- Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes.
2000 Anticancer research
- Glutathione S-transferases M1, T1, and P1 and breast cancer.
2000 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Glutathione and glutathione-dependent enzymes in cancer drug resistance.
1999 Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
- Glutathione S-transferases and iododeoxyuridine labelling index during chemotherapy of gastric cancer.
2000 Anticancer research
- Glutathione S-transferase M1 genotypes and the risk of vulvar cancer: a population-based case-control study.
1999 American journal of epidemiology
- Reduced Glutathione system: role in cancer development, prevention and treatment (review).
2001 International journal of oncology
- Genetic polymorphism of Glutathione S-transferase P1 gene and lung cancer risk.
1999 Cancer causes & control : CCC
- Glutathione S-transferases in wild-type and doxorubicin-resistant MCF-7 human breast cancer cell lines.
1999 Xenobiotica; the fate of foreign compounds in biological systems
- Glutathione-linked enzymes in benign and malignant oesophageal tissue.
1999 British journal of cancer
- Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor.
2001 Carcinogenesis
- Estimation of Glutathione S-transferase and its Pi isoenzyme in tumor tissues and sera of patients with ovarian cancer.
2000 Anticancer research
- Detoxification of 1-chloro-2,4-dinitrobenzene in MCF7 breast cancer cells expressingGlutathione S-transferase P1-1 and/or multidrug resistance protein 1.
1999 Toxicology and applied pharmacology
- Glutathione S-transferase null genotypes in transitional cell bladder cancer: a case-control study.
2000 European urology
- Parameters related to oxygen free radicals in human skin: a study comparing healthy epidermis and skin cancer tissue.
2002 The Journal of investigative dermatology
- The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including Glutathione depletion and oxidative stress.
2004 International journal of oncology
- Glutathione S-transferase (GST) M1, T1 and N-acetyltransferase 2 (NAT2) polymorphisms and urothelial cancer risk with tobacco smoking.
2004 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
- Effect of dietary glutamine on tumor Glutathione levels and apoptosis-related proteins in DMBA-induced breast cancer of rats.
2004 Breast cancer research and treatment
- Role of Glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes in modulating susceptibility to smoking-related lung cancer.
1998 Pharmacogenetics
- Prognostic value of p53, Glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer.
1999 Clinical cancer research : an official journal of the American Association forcancer Research
- Parameters related to oxygen free radicals in human skin: a study comparing healthy epidermis and skin cancer tissue.
2002 The Journal of investigative dermatology
- Glutathione and glutathione-related enzymes in colorectal cancer patients.
2003 Journal of toxicology and environmental health. Part A
- Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes.
2002 Lung cancer (Amsterdam, Netherlands)
- Glutathione and mercapturic acid conjugates of sulofenur and their activity against a human colon cancer cell line.
2002 Drug metabolism and disposition: the biological fate of chemicals
- Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1.
2003 Pharmacogenetics
- Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National cancer Institute’s anticancer drug screen.
2004 Drug metabolism and disposition: the biological fate of chemicals
- Glutathione S-transferase M1 associated with cancer occurrence in Korean HNPCC families carrying the hMLH1/hMSH2 mutation.
2003 Oncology reports
- Reproductive factors, Glutathione S-transferase M1 and T1 genetic polymorphism and breast cancer risk.
2003 Breast cancer research and treatment
- Genistein, a soy isoflavone, induces Glutathione peroxidase in the human prostatecancer cell lines LNCaP and PC-3.
2002 International journal of cancer. Journal international du cancer
- N-acetyltransferase (NAT1, NAT2) and Glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer.
2003 Cancer letters
- Association between Glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer.
2002 Journal of the National cancer Institute
- Pooled analysis and meta-analysis of Glutathione S-transferase M1 and bladder cancer: a HuGE review.
2002 American journal of epidemiology
- Inhibition of cellular enzymes by equine catechol estrogens in human breast cancercells: specificity for Glutathione S-transferase P1-1.
2002 Chemical research in toxicology
- Association of genetic polymorphisms of glutathione-S-transferase genes (GSTM1, GSTT1 and GSTP1) with familial prostate cancer risk in a Japanese population.
2003 Anticancer research
- Role of Se-dependent Glutathione peroxidases in gastrointestinal inflammation and cancer.
2004 Free radical biology & medicine
- Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer.
2003 The Prostate
- Vegetable/fruit, smoking, Glutathione S-transferase polymorphisms and risk for colorectal cancer in Taiwan.
2005 World journal of gastroenterology : WJG
- Hemolysate thioredoxin reductase and Glutathione peroxidase activities correlate with serum selenium in a group of New Zealand men at high prostate cancer risk.
2006 The Journal of nutrition
- The effect of the cyclin D1 (CCND1) A870G polymorphism on colorectal cancer risk is modified by glutathione-S-transferase polymorphisms and isothiocyanate intake in the Singapore Chinese Health Study.
2006 Carcinogenesis
- Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancerrisk in the Central and Eastern European Kidney cancer Study.
2007 Carcinogenesis
- 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial Glutathione to induce apoptosis in pancreatic cancer.
2005 The Journal of biological chemistry
- Ceramide induces early and late apoptosis in human papilloma virus+ cervical cancercells by inhibiting reactive oxygen species decay, diminishing the intracellular concentration of Glutathione and increasing nuclear factor-kappaB translocation.
2007 Anti-cancer drugs
- Glutathione peroxidase 1 gene polymorphism and risk of recurrence in patients with superficial bladder cancer.
2005 Urology
- Effect of glutathione-S-transferase polymorphisms on the cancer preventive potential of isothiocyanates: an epidemiological perspective.
2005 Mutation research
- Phospholipid hydroperoxide Glutathione peroxidase plays a role in protectingcancer cells from docosahexaenoic acid-induced cytotoxicity.
2007 Molecular cancer therapeutics
- Pooled analysis and meta-analysis of the Glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review.
2007 American journal of epidemiology
- Sulfasalazine-induced reduction of Glutathione levels in breast cancer cells: enhancement of growth-inhibitory activity of Doxorubicin.
2007 Chemotherapy
- Expression of glutathione-S-transferases isoenzymes and P53 in exfoliated human bladder cancer cells.
2009 Urologic oncology
- Prognostic value of expression of ERCC1, thymidylate synthase, and Glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer.
2007 Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
- Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer.
2007 Cancer
- Protein carbonyl levels, Glutathione S-transferase polymorphisms and risk of colorectal cancer.
2010 Carcinogenesis
- Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of Glutathione S-transferase pi.
2010 Investigational new drugs
- The GSTT1 polymorphism of the Glutathione S-transferase system in the intratumoral microvessel density of breast cancer patients.
2010 Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Predictive and prognostic significance of Glutathione levels and DNA damage in cervix cancer patients undergoing radiotherapy.
2010 International journal of radiation oncology, biology, physics
- Prognostic value of ERCC1, thymidylate synthase, and Glutathione S-transferase pi for 5-FU/oxaliplatin chemotherapy in advanced colorectal cancer.
2009 American journal of clinical oncology
- Genetic polymorphism of glutathione-S-transferase (GST-M1 and GST-T1) in schistosomiasis -associated bladder cancer in Egyptian patients.
2008 Journal of the Egyptian Society of Parasitology
- Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk.
2010 Journal of cancer research and clinical oncology
- Sensitization by docosahexaenoic acid (DHA) of breast cancer cells to anthracyclines through loss of Glutathione peroxidase (GPx1) response.
2008 Free radical biology & medicine
- Administration of reduced Glutathione in FOLFOX4 adjuvant treatment for colorectal cancer: effect on oxaliplatin pharmacokinetics, Pt-DNA adduct formation, and neurotoxicity.
2009 Anti-cancer drugs
- Role of Glutathione S-transferase omega gene polymorphisms in breast-cancer risk.
2009 Tumori
- Oxidative stress in non-small cell lung cancer: role of nicotinamide adenine dinucleotide phosphate oxidase and glutathione.
2009 Acta oncologica (Stockholm, Sweden)
- A by-product of Glutathione production in cancer cells may cause disruption in bone metabolic processes.
2010 Canadian journal of physiology and pharmacology
- Genetic variation in Glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients.
2010 Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
- 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific Glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer.
2008 Molecular cancer therapeutics
- Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers.
2008 British journal of cancer
- Blood iron, glutathione, and micronutrient levels and the risk of oral cancer.
2008 Nutrition and cancer
- Prolactin confers resistance against cisplatin in breast cancer cells by activating glutathione-S-transferase.
2009 Carcinogenesis
- Polymorphisms in Glutathione S-transferase genes increase risk of prostate cancerbiochemical recurrence differentially by ethnicity and disease severity.
2009 Cancer causes & control : CCC
- Phenotyping breast cancer cell lines EM-G3, HCC1937, MCF7 and MDA-MB-231 using 2-D electrophoresis and affinity chromatography for glutathione-binding proteins.
2010 BMC cancer
- Thermodynamic role of Glutathione oxidation by peroxide and peroxybicarbonate in the prevention of Alzheimer’s disease and cancer.
2009 The journal of physical chemistry. A
- Apoptosis/necrosis switch in two different cancer cell lines: influence of benzoquinone- and hydrogen peroxide-induced oxidative stress intensity, and glutathione.
2008 Toxicology in vitro : an international journal published in association with BIBRA
- Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells.
2008 International journal of cancer. Journal international du cancer
- The association between Glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population.
2009 Mutation research
- Glutathione S-transferase M1, T1, and P1 polymorphisms and ovarian cancer risk: a meta-analysis.
2010 International journal of gynecological cancer : official journal of the International Gynecological cancer Society
- Cigarette smoking and Glutathione S-transferase M1 polymorphism associated with risk for uterine cervical cancer.
2008 The journal of obstetrics and gynaecology research
- Evidence that a polymorphism within the 3’UTR of Glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer.
2007 Genes & nutrition
- Polymorphisms of glutathione-S-transferase genes and the risk of aerodigestive tract cancers in the Northeast Indian population.
2010 Genetic testing and molecular biomarkers
- Germline Glutathione S-transferase variants in breast cancer: relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapy.
2007 International journal of radiation oncology, biology, physics
- Modification of N-acetyltransferases and Glutathione S-transferases by coffee components: possible relevance for cancer risk.
2005 Methods in enzymology
- Polymorphisms in sulfotransferase 1A1 and Glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients’ survival.
2005 World journal of gastroenterology : WJG
- Polymorphisms in manganese superoxide dismutase, myeloperoxidase and glutathione-S-transferase and survival after treatment for metastatic breast cancer.
2008 Breast cancer research and treatment
- Multi-institutional phase 2 study of TLK286 (TELCYTA, a Glutathione S-transferase P1-1 activated Glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer.
2005 International journal of gynecological cancer : official journal of the International Gynecological cancer Society
- Docosahexaenoic acid induces apoptosis in the human PaCa-44 pancreatic cancer cell line by active reduced Glutathione extrusion and lipid peroxidation.
2005 Nutrition and cancer
- Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study.
2007 Journal of translational medicine
- Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.
2008 Bioorganic & medicinal chemistry
- [Transferase S-glutathione class pi gene (GSTP1) polymorphism in thyroid cancerpatients].
2006 Endokrynologia Polska
- High superoxide dismutase and low Glutathione peroxidase activities in red blood cells predict susceptibility of lung cancer patients to radiation pneumonitis.
2007 Free radical biology & medicine
- Polymorphisms in the Glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer.
2006 International journal of oncology
- Glutathione S-transferase M1 gene null genotype and gastric cancer risk in Taiwan.
2005 Hepato-gastroenterology
- Impact of hormonal therapy on the detection of promoter hypermethylation of the detoxifying glutathione-S-transferase P1 gene (GSTP1) in prostate cancer.
2006 BMC urology
- Association analysis of glutathione-S-transferase P1 (GSTP1) polymorphism with urothelial cancer susceptibility and myelosuppression after M-VAC chemotherapy.
2007 International journal of urology : official journal of the Japanese Urological Association
- Glutathione S-transferase polymorphisms associated with risk of breast cancer in southern Taiwan.
2006 Breast (Edinburgh, Scotland)
- Prognostic significance of Glutathione S-transferase-pi in invasive breast cancer.
2003 Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
- Glutathione-S transferase-pi expression in non small cell lung cancer in the assessment of response to chemotherapy.
2003 Saudi medical journal
- Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme.
2003 The Biochemical journal
- High-throughput detection of Glutathione s-transferase polymorphic alleles in a pediatric cancer population.
2004 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostatecancer cells.
2002 Oncogene
- Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer.
2004 International journal of gynecological cancer : official journal of the International Gynecological cancer Society
- Overexpression of Glutathione S-transferase pi enhances the adduct formation of cisplatin with Glutathione in human cancer cells.
1999 Free radical research
- Detection of head and neck cancer with 99Tc(m) glutathione: a correlative study with tissue Glutathione and Glutathione S-transferase levels.
2001 Nuclear medicine communications
- A patient with genetic deletion of glutathione-S-transferase T1 and M1 who developed non-small-cell lung cancer and myelodysplastic syndromes.
1999 The American journal of the medical sciences
- Cyclodextrin-derived diorganyl tellurides as Glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth.
2004 Journal of medicinal chemistry
- Association of p53 genomic instability with the Glutathione S-transferase null genotype in gastric cancer in the Portuguese population.
1999 Molecular pathology : MP
- Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping,Glutathione transferase-Ml and ras.
2004 Mutation research
- Glutathione S-transferase pi expression in nasopharyngeal cancer.
2002 Archives of otolaryngology–head & neck surgery
- Attenuation by Glutathione of hsp72 gene expression induced by cadmium in cisplatin-resistant human ovarian cancer cells.
1999 Biochemical pharmacology
- Glutathione S-transferase GSTM1 and GSTT1 genotypes in ovarian cancer: association with p53 expression and survival.
2001 International journal of gynecological cancer : official journal of the International Gynecological cancer Society
- Polymorphism of Glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt.
1999 Cancer letters
- Polymorphisms in Glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer.
2001 Cancer research
- Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells.
2000 Cancer
- Effect of cisplatin-based chemotherapy on emergence of cisplatin resistance, and its correlation with intracellular Glutathione levels and accumulation of p53 protein in human ovarian cancer.
2000 Cancer biotherapy & radiopharmaceuticals
- Dietary ortho phenols that induce Glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms: the alleviation of oxidative stress and the detoxification of mutagenic xenobiotics.
2000 Cancer letters
- Glutathione S-transferase polymorphisms in children with myeloid leukemia: a Children’s cancer Group study.
2000 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Low levels of colonic Glutathione S-transferase in patients with X-linked agammaglobulinaemia.
2000 European journal of clinical investigation
- Chemoprevention of colon cancer by a Glutathione conjugate of 1,4-phenylenebis(methylene)selenocyanate, a novel organoselenium compound with low toxicity.
2001 Cancer research
- [The expression of Glutathione S-transferase pi in human ovarian cancer as an indicator of resistance to chemotherapy].
1998 Zhonghua fu chan ke za zhi
- Effects of Glutathione S-transferase (GST) M1 and GSTT1 genotypes on urothelialcancer risk.
1998 Cancer letters
- The Glutathione S-transferase-mu and -theta genotypes in the etiology of prostate cancer: genotype-environment interactions with smoking.
2000 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- The effect of hOGG1 and Glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer.
2000 Carcinogenesis
- Whey protein concentrate (WPC) and Glutathione modulation in cancer treatment.
2000 Anticancer research
- Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States).
2002 Cancer causes & control : CCC
- The role of glutathione-S-transferase in anti-cancer drug resistance.
2003 Oncogene
- Aplidin induces apoptosis in human cancer cells via Glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.
2003 The Journal of biological chemistry
- Does Glutathione S-transferase Pi (GST-Pi) a marker protein for cancer?
2003 Molecular and cellular biochemistry
- The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing Glutathione depletion.
2010 Molecular medicine reports
- Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States).
2002 Cancer causes & control : CCC
- The role of glutathione-S-transferase in anti-cancer drug resistance.
2003 Oncogene
- Possible involvement of Glutathione and p53 in trichloroethylene- and perchloroethylene-induced lipid peroxidation and apoptosis in human lung cancercells.
2002 Free radical biology & medicine
- [Killing effect of adenovirus mediated fusion gene cytosine and deaminase uracil phosphoribosyl transferase directed by Glutathione S-transferase P1 promoter on cisplatin-resistant ovarian cancer cells in vitro].
2004 Zhonghua fu chan ke za zhi
- Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione.
2002 Biochimica et biophysica acta
- Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and Glutathione S-transferase micro1 polymorphisms.
2004 Oncology reports
- Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancerassociated with occupational exposure to chemicals.
2003 Occupational and environmental medicine
- Differences in the expression of Glutathione S-transferases in normal pancreas, chronic pancreatitis, secondary chronic pancreatitis, and pancreatic cancer.
2002 Pancreas
- Photoactivation of hypericin down-regulates Glutathione S-transferase activity in nasopharyngeal cancer cells.
2004 Cancer letters
- Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of Glutathione S-transferases GSTM1, GSTM3, and GSTT1 genetic polymorphisms.
2004 The Prostate
- Association of homozygous wild-type Glutathione S-transferase M1 genotype with increased breast cancer risk.
2004 Cancer research
- Dual effects of glutathione-S-transferase pi on As2O3 action in prostate cancer cells: enhancement of growth inhibition and inhibition of apoptosis.
2004 Oncogene
- Nicotinamide adenine dinucleotide phosphate-regenerating system coupled to a glutathione-reductase microtiter method for determination of total Glutathioneconcentrations in adherent growing cancer cell lines.
2003 Analytical biochemistry
- Allele frequencies for Glutathione S-transferase and N-acetyltransferase 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence.
2003 Clinical chemistry and laboratory medicine : CCLM / FESCC
- Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer.
2004 Anticancer research
- Glutathione S-transferase M1 and T1 polymorphism and response to neoadjuvant chemotherapy (CAF) in breast cancer patients.
2011 Surgery today
- Genetic polymorphisms of human cytosol Glutathione S-transferases and prostate cancer.
2008 Pharmacogenomics
- [Allelic variants of cytochrome P4501A1 (CYP1A1), Glutathione S transferase M1 (GSTM1) polymorphisms and their association with smoking and alcohol consumption as gastric cancer susceptibility biomarkers].
2006 Revista médica de Chile
- Glutathione-S-transferase pi (GSTP1) codon 105 polymorphism is not associated with oxaliplatin efficacy or toxicity in advanced colorectal cancer patients.
2009 European journal of cancer (Oxford, England : 1990)
- Cisplatin-induced long-term hearing impairment is associated with specificGlutathione s-transferase genotypes in testicular cancer survivors.
2007 Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Genetic polymorphisms of Glutathione S-transferase P1 and bladder cancersusceptibility in a Chinese population.
2011 Genetic testing and molecular biomarkers
- Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study.
2005 Cancer letters
- A systematic approach to analysing gene-gene interactions: polymorphisms at the microsomal epoxide hydrolase EPHX and Glutathione S-transferase GSTM1, GSTT1, and GSTP1 loci and breast cancer risk.
2007 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Expression of Glutathione S-transferase M2 in stage I/II non-small cell lung cancerand alleviation of DNA damage exposure to benzo[a]pyrene.
2010 Toxicology letters
- Green tea catechins in chemoprevention of cancer: a molecular docking investigation into their interaction with Glutathione S-transferase (GST P1-1).
2009 Journal of enzyme inhibition and medicinal chemistry
- Sulphonamide-based bombesin prodrug analogues for Glutathione transferase, useful in targeted cancer chemotherapy.
2009 European journal of medicinal chemistry
- Inhibition of Glutathione and thioredoxin metabolism enhances sensitivity to perifosine in head and neck cancer cells.
2009 Journal of oncology
- The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzymeGlutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.
2008 Journal of molecular biology
- The effects of MAPK inhibitors on antimycin A-treated Calu-6 lung cancer cells in relation to cell growth, reactive oxygen species, and glutathione.
2010 Molecular and cellular biochemistry
- Glutathione transferases as targets for cancer therapy.
2009 Anti-cancer agents in medicinal chemistry
- Comprehensive analysis of excision repair complementation group 1, Glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer treated with FOLFOX or FOLFIRI.
2009 Oncology reports
- Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran.
2011 Prostate cancer and prostatic diseases
- The effects of N-acetyl cysteine on the MG132 proteasome inhibitor-treated lungcancer cells in relation to cell growth, reactive oxygen species and glutathione.
2010 International journal of molecular medicine
- Glutathione-s-transferase-pi expression in early breast cancer: association with outcome and response to chemotherapy.
2010 Cancer investigation
- Redox Protein Expression Predicts Radiotherapeutic Response in Early-Stage Invasive Breast cancer Patients.
2011 International journal of radiation oncology, biology, physics
- Glutathione S-transferase M1 polymorphism and sporadic colorectal cancer risk: An updating meta-analysis and HuGE review of 36 case-control studies.
2010 Annals of epidemiology
- Genetic polymorphism of Glutathione S-transferases M1 and T1 in Egyptian patients with bilharzial bladder cancer.
2010 Urologic oncology
- Polymorphism in cytochrome P450 2A6 and Glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.
2009 Mutation research
- Glutathione s-transferase polymorphisms in breast cancers of Thai patients.
2009 Asian Pacific journal of cancer prevention : APJCP
- Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer.
2009 Surgery
- Is Glutathione the major cellular target of cisplatin? A study of the interactions of cisplatin with cancer cell extracts.
2009 Journal of medicinal chemistry
- Pre-operative intracellular Glutathione levels of peripheral monocytes as a biomarker to predict survival of colorectal cancer patients.
2010 Cancer immunology, immunotherapy : CII
- Detection and relevance of germline genetic polymorphisms in Glutathione S-transferases (GSTs) in breast cancer patients from northern Indian population.
2009 Breast cancer research and treatment
- Glutamine affects Glutathione recycling enzymes in a DMBA-induced breast cancermodel.
2008 Nutrition and cancer
- Functional Glutathione peroxidase 3 polymorphisms associated with increased risk of Taiwanese patients with gastric cancer.
2010 Clinica chimica acta; international journal of clinical chemistry
- Glutathione S-transferase polymorphisms and survival in African-American and white colorectal cancer patients.
2009 Cancer epidemiology
- Overcoming the drug resistance in breast cancer cells by rational design of efficientGlutathione S-transferase inhibitors.
2010 Organic letters
- Placental isoform Glutathione S-transferase and P-glycoprotein expression in advanced nonsmall cell lung cancer: association with response to treatment and survival.
2008 Cancer
- Examination of polymorphic Glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study.
2009 BMC cancer
- Role of Glutathione in the regulation of Cisplatin resistance in cancer chemotherapy.
2010 Metal-based drugs
- Elevated expression of Glutathione S-transferase pi and p53 confers poor prognosis in head and neck cancer patients treated with chemoradiotherapy but not radiotherapy alone.
2008 Clinical cancer research : an official journal of the American Association forcancer Research
- Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of Glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation.
2006 Cell death and differentiation
- Microsomal Glutathione S-transferase gene polymorphisms and colorectal cancerrisk in a Han Chinese population.
2007 International journal of colorectal disease
- Glutathione-S-transferase P1 isoenzyme polymorphisms, platinum-based chemotherapy, and non-small cell lung cancer.
2006 Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
- Glutathione S-transferase T1 null polymorphism and the risk for head and neck cancer.
2006 Acta oto-laryngologica
- Polymorphisms of cytochrome P450 1A1, Glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese.
2007 Clinical biochemistry
- Glutathione-S-transferase M1 polymorphisms on the susceptibility to esophagealcancer among three Chinese minorities: Kazakh, Tajik and Uygur.
2006 World journal of gastroenterology : WJG
- Glutathione S-transferase M1 gene polymorphism and gastric cancer risk: an updated analysis.
2010 Archives of medical research
- Clinicopathologic significance of ERCC1, thymidylate synthase and Glutathione S-transferase P1 expression for advanced gastric cancer patients receiving adjuvant 5-FU and cisplatin chemotherapy.
2011 Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
- Glutathione S-transferase GSTP1 genotypes are associated with response to androgen ablation therapy in advanced prostate cancer.
2002 Cancer detection and prevention
- [Associations between genetic polymorphisms of Glutathione S-transferase M1 and T1, smoking and susceptibility to colorectal cancer: a case-control study].
2004 Zhonghua zhong liu za zhi [Chinese journal of oncology]
- Glutathione S-transferases as antioxidant enzymes: small cell lung cancer (H69) cells transfected with hGSTA1 resist doxorubicin-induced apoptosis.
2006 Archives of biochemistry and biophysics
- Glutathione S-transferase T1 polymorphisms are associated with outcome in colorectal cancer.
2005 Carcinogenesis
- Methylguanine DNA methyl transferase activities, Glutathione s transferase and nitric oxide in bladder cancer patients.
2006 Cancer investigation
- Enhanced invasive and metastatic potential induced by transforming growth factor-beta1 might be correlated with glutathione-S-transferase-pi, cofilin and heat shock protein 27 in SGC-7901 gastric cancer cells.
2007 Acta biochimica et biophysica Sinica
- Dietary intake of Cruciferous vegetables, Glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population.
2004 Cancer causes & control : CCC
- Evidence for the association of synaptotagmin with Glutathione S-transferases: implications for a novel function in human breast cancer.
2005 Clinical biochemistry
- Measurement of Glutathione S-transferase and its class-pi in plasma and tissue biopsies obtained after laparoscopy and endoscopy from subjects with esophagus and gastric cancer.
2003 Clinical biochemistry
- Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity. Effects on thioredoxin reductase and Glutathione reductase.
2002 Biochemical pharmacology
- Prognostic significance of mutant p53 protein, P-glycoprotein and Glutathione S-transferase-pi in patients with unresectable non-small cell lung cancer.
2003 Anticancer research
- The association between Glutathione S-transferase P1 genotype and plasma level in head and neck cancer.
2002 The Laryngoscope
- Genetic polymorphisms in UDP-glucuronosyltransferases and Glutathione S-transferases and colorectal cancer risk.
2004 Carcinogenesis
- High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report from the Italian Group for the Study of Digestive Tract cancer(GISCAD).
2004 British journal of cancer
- Human Glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form.
2004 Pharmacogenetics
- Characterization of the molecular forms of Glutathione S-transferase P1 in human gastric cancer cells (Kato III) and in normal human erythrocytes.
2005 The Biochemical journal
- Polymorphisms in Glutathione S-transferases and non-melanoma skin cancer risk in Australian renal transplant recipients.
2005 Carcinogenesis
- Characterization of the molecular forms of Glutathione S-transferase P1 in human gastric cancer cells (Kato III) and in normal human erythrocytes.
2005 The Biochemical journal
- [Efficacy of hepatic arterial infusion of adriamycin and mitomycin C mixed with degradable starch microspheres for liver metastasis of colorectal cancer–correlation with the mRNA expression of DNA topoisomerase-IIalpha and glutathione-S transferase-pi in primary lesions].
2004 Gan to kagaku ryoho. cancer & chemotherapy
- Liver cancer is induced by a subnecrogenic dose of DENA when associated with fasting/refeeding: role of glutathione-transferase and lipid peroxidation.
1999 Free radical biology & medicine
- Kinetics of Glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells.
2001 European journal of pharmacology
- Glutathione S-transferase-mu (GSTM1) and -theta (GSTT1) genotypes in the etiology of prostate cancer.
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: association with Glutathione levels and drug resistance in the National cancer Institute tumor cell line panel.
2001 Toxicological sciences : an official journal of the Society of Toxicology
- Is glutathione-S-transferase-pi expression a reliable predictor of chemoradiation response in cancer of the head and neck?
2001 American journal of otolaryngology
- Effect of Glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by melphalan (L-phenylalanine mustard) in human colorectal cancer cells.
1999 Biochemical pharmacology
- Potentiation of the cytostatic effect of melphalan on colorectal cancer hepatic metastases by infusion of buthionine sulfoximine (BSO) in the rat: enhanced tumorGlutathione depletion by infusion of BSO in the hepatic artery.
1999 Cancer chemotherapy and pharmacology
- Polymorphisms in Glutathione S-transferases are associated with altered risk of nonmelanoma skin cancer in renal transplant recipients: a preliminary analysis.
2001 The Journal of investigative dermatology
- The role of human Glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTA1 on colorectal cancer risk.
2001 Mutation research
- Concurrent expressions of metallothionein, Glutathione S-transferase-pi, and P-glycoprotein in colorectal cancers.
2000 Diseases of the colon and rectum
- Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, GlutathioneS-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population.
2001 Cancer letters
- Genetic polymorphisms of alcohol and aldehyde dehydrogenases and Glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma.
2002 Carcinogenesis
- Neuroprotective effect of reduced Glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: a randomized, double-blind, placebo-controlled trial.
2002 Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Structural requirements for the flavonoid-mediated modulation of Glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.
2004 Biochemical pharmacology
- Cytochrome p450 and Glutathione transferase expression in squamous cell cancer.
2004 Clinical cancer research : an official journal of the American Association forcancer Research
- Flavonoid-induced Glutathione depletion: potential implications for cancertreatment.
2006 Free radical biology & medicine
- Association of genetic polymorphisms in Glutathione S-transferases and susceptibility to head and neck cancer.
2008 Mutation research
- Glutathione S-transferase (GSTM1 and GSTT1)-dependent risk for colorectal cancer.
2002 Anticancer research
- Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma. 2006 Acta biochimica Polonica
- Glutathione S-transferase polymorphisms and survival from head and neck cancer.
2005 Head & neck
- Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.
2006 Cancer research
- The effects of MAPK inhibitors on pyrogallol-treated Calu-6 lung cancer cells in relation to cell growth, reactive oxygen species and glutathione.
2010 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer.
2010 Current oncology (Toronto, Ont.)
- Conjugating folic acid to gold nanoparticles through Glutathione for targeting and detecting cancer cells.
2010 Bioorganic & medicinal chemistry
- Effects of Genetic Polymorphisms of Glutathione S-transferase P1 on Helicobacter pylori-associated Gastric Cancer.
2008 Gut and liver
- Glutathione peroxidases in different stages of carcinogenesis.
2009 Biochimica et biophysica acta
- Genetic variants of the cytochrome P450 and Glutathione S-transferase associated with risk of bladder cancer in a south-eastern Chinese population.
2008 International journal of urology : official journal of the Japanese Urological Association
- The relationship between antioxidant enzymes and bladder cancer.
2005 Neoplasma
- Primary breast tumor levels of suspected molecular determinants of cellular sensitivity to cyclophosphamide, ifosfamide, and certain other anticancer agents as predictors of paired metastatic tumor levels of these determinants. Rational individualization ofcancer chemotherapeutic regime 2001 Cancer chemotherapy and pharmacology
- Glutathione S-transferase M1 and T1 null genotypes and the risk of gastric and colorectal cancers.
2001 Cancer letters
- Single nucleotide polymorphism of pi-class Glutathione s-transferase and susceptibility to endometrial carcinoma.
2005 Clinical cancer research : an official journal of the American Association forcancer Research
- The expression of GST isoenzymes and p53 in non-small cell lung cancer.
2010 Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society
- [Relationship between the expression of P-glycoprotein, Glutathione S-transferase-pi and thymidylate synthase proteins and adenosine triphosphate tumor chemosensitivity assay in cervical cancer].
2007 Zhonghua fu chan ke za zhi
- Superoxide dismutase and Glutathione peroxidase enzyme activities in larynx carcinoma.
2005 Acta oto-laryngologica
- Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance.
2005 Cancer research
- An association between Glutathione S-transferase P1 gene polymorphism and younger age at onset of lung carcinoma.
2006 Cancer
- Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma.
1999 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- [Immunohistologic and molecular genetic studies of the effect of glutathione-S-transferases on the development of squamous epithelial carcinomas in the area of the head-neck].
1999 Laryngo- rhino- otologie
- Glutathione S-transferase T1 and M1 genotypes in normal mucosa, transitional mucosa and colorectal adenocarcinoma.
1999 International journal of cancer. Journal international du cancer
- [Expression of pi Glutathione S-transferase in intestinal metaplasia and its relationship with Helicobacter pylori infection].
2002 Zhonghua yi xue za zhi
- Microsomal epoxide hydrolase and Glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.
2002 Cancer letters
- Microsomal epoxide hydrolase and Glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.
2002 Cancer letters
- Human Glutathione S-transferase P1 polymorphism and susceptibility to smoking related epithelial cancer; oral, lung,gastric, colorectal and urothelial cancer.1999 Pharmacogenetics
- [Genetic polymorphisms of cytochrome P450 2E1 and Glutathione S-transferase P1 and susceptibility to esophageal cancer].
1998 Zhonghua zhong liu za zhi [Chinese journal of oncology]
- Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum.
2002 Cancer research
- Oxidative stress and inflammation contribute to lung toxicity after a common breastcancer chemotherapy regimen.
2002 American journal of physiology. Lung cellular and molecular physiology
- Reactive oxygen species, antioxidant mechanisms, and serum cytokine levels in cancerpatients: impact of an antioxidant treatment.
2003 Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
- Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells.
2003 Biochemistry
- Reactive oxygen species, antioxidant mechanisms and serum cytokine levels in cancerpatients: impact of an antioxidant treatment.
2002 Journal of cellular and molecular medicine
- Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.
2009 Carcinogenesis
- Pharmacometabolomics of docetaxel-treated human MCF7 breast cancer cells provides evidence of varying cellular responses at high and low doses.
2010 Breast cancer research and treatment
- Relevance of Glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers.
2008 Clinical chemistry and laboratory medicine : CCLM / FESCC
- Glutathione S-transferase p-isoform is not altered in bladder tissue from smokers.
1998 Urologic oncology
- Glutathione depletion-induced apoptosis of Ha-ras-transformed NIH3T3 cells can be prevented by melatonin.
2003 Oncogene
- JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, Glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin.
2002 Biochemical pharmacology
- Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1.
2007 British journal of cancer
- Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins.
2001 Cancer research
- [Glutathione and cisplatin resistance in head and neck cancer].
1999 Nippon Jibiinkoka Gakkai kaiho
science.naturalnews.com/G/Glutathione_and_prostate_cancer.html
science.naturalnews.com/G/Glutathione_and_colon_cancer.html
I3C, 3-hydroxymethyl indole, 3-indole methanol
The phytochemical indole-3-carbinol is found in cruciferous vegetables such as cabbage, cauliflower, broccoli, kale and brussels sprouts. Indole-3-carbinol is made from indole-3-glucosinolate by the enzyme myrosinase. This enzyme is only activated after maceration of the vegetables.Pure indole-3-Carbinol is an off-white solid belonging to the group of indoles. Indole-3-carbinol is only formed in these vegetable after crushing or during cooking
Health Benefits of Indole-3-Carbinol
Indole-3-carbinol and its main metabolite diindoylmethane modulates several nuclear transcription factors resulting in a variety of biological and biochemical effects. Indole-3-carbinol works as a strong antioxidant, thereby protecting the DNA and other cell structures.Chemopreventive
Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying enzymes. The phytochemical protects against carcinogenic effect of pesticides and other toxins.Anticancer
The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane are the result of specific activities: inducing enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis.
Diets high in vegetables, especially cruciferous vegetables provide protection against cancer. Cruciferous vegetables provide the only source of glucosinolates, which breaks down in indole-3-carbinol and sulforaphane. The anticancer effects of indole-3-carbinol and diindoylmethane are the result of specific activities: inducing phase I and phase II enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis.
Most studies have focused on the effects on endometrial cancer, breast cancer and prostate cancer.Tumor progression relies on the upregulation of signaling pathways relevant to cell proliferation and increased resistance against chemotherapeutic agents. Indole-3-carbinol and its metabolite diindoylmethane target different aspects of carcinogenesis, such as estrogen metabolism, estrogen receptor signaling, Akt-NF kappa B signaling, caspase activation, cyclin-dependent kinase activities, endoplasmic reticulum stress, and expression of tumor suppression genes [1].
Many in-vitro results have demonstrated the anticancer effect of indol-3-carbinol, but these favorable results should be treated with extra care because of its low biological availability in humans. A phase I trial demonstrated that after a oral intake of up to 1200 mg indol-3-carbionol did not result in detectable plasma levels of the phytochemical [2].
The researchers could only detect diindolylmethane , a metabolite of indole-3-carbinol, which reached max plasma level 2 hours after the administration on indole-63-carbinol, but disappeared almost completely after 12 hours. The pharmaceutical industry has already developed and patented anti-cancer chemicals with structure similar to that of diindolyl)methane, a metabolite of indole-3-carbinol.
[1] Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Lett. 2008 Apr 18;262(2):153-63.
[2] Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3′-diindolylmethane. Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2477-81.[3] The natural chemopreventive compound indole-3-carbinol: state of the science. In Vivo. 2006 Mar-Apr;20(2):221-8.
Indole-3-carbinol blocks estrogen receptor sites on the membranes of breast and other cells, thereby reducing the risk of cervical and
breast cancer.
Recent results from epidemiology, in vitro cell culture and in vivo studies have suggested the benefits of indole-3-carbinol for the prevention of many types of cancer, including breast cancer. Oral administration of indole-3-carbinol has been shown to influence our estrogen metabolism in humans in a beneficial manner. It increases the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone.
Experimental and clinical evidence suggests that 16alpha-hydroxylated estrogen metabolites react as strong estrogens, and are associated with breast cancer risk, while 2-hydroxylated metabolites have a lower estrogenic activity and are weakly related to this disease. Indole-3-carbinol is a good candidate for clinical trial in women at increased risk of developing breast cancer. Fan S and co-workers of the Georgetown University (New York) reported that both indole-3-carrbinol and genistein target the breast cancer susceptibility genes in both prostate and breast cancer cells [4].
The breast cancer susceptibility genes are responsible for the suppression of tumor growth, not only of breast cancer cells but also ovarian and prostate cancer cells. This in-vitro study showed that the phytochemicals induced the expression of these genes.An in-vitro study with cultured human breast cancer cells demonstrated that indole-3-carbinol directly inhibited elastase enzymatic activity and concluded that this phytochemicals, or similar compounds, should be further investigated as drug for the treatment of human breast cancers where high elastase levels are correlated with poor prognosis [2].
More specifically they found that indole-3-carbinol shifted the stable accumulation of cyclin E protein from the lower molecular mass form, that is associated with cancer cell proliferation and poor clinical outcomes, to its higher molecular mass form, that is typically produced in normal cells. A Taiwanese study found that indole-3-carbinol reduced the invasion and migration of breast cancer cells [3].
The phytochemical inhibited matrix metalloproteinases expression by blocking the ERK/Sp1-mediated gene transcription.Indole-3-carbinol might improve the effect of tamoxifen according to an experiment with rats carried out by the University of Minnesota [4].
Tamoxifen is a selective estrogen receptor modulator that is used in the treatment of breast cancer. The scientists induced tumors in rats by dosing the carcinogen dimethylbenz-a-anthracene and then treated the rats with tamoxifen, indole-3-carbionol or a combination of both. All three types of treatment resulted in a significant increased latency and decreased mass of malignant mammary tumors, but also treatment with indole-3-carbinol, although the effect of indole-3-carbinol alone was weaker.A study by scientists of the University of California concluded that indole-32-carbinol had an influence on the function and expression of estrogen receptor-alpha (ERA) and estrogen receptor-beta (ERB) [6].
By increasing the ratio of ERA to ERB indole-3-carbinol could reduce the proliferation of human breast cancer cells. The tests were conducted on breast cancer cells that expressed both ERA and ERB. Treatment of these breast cancer cells with indole-3-carbinol strongly inhibited ERB protein production, without that of ERA.Indole-3-carbinol selectively induced apoptosis in breast cancer cells, but not in nontumorigenic breast cells, suggesting the potential therapeutic benefit of I3C against breast cancer [7]. Low levels of indole-3-carbinol inhibited the growth of the tumor cells more than that of normal breast cells. The phytochemical upregulated Bax/Bcl-2 ratio and downregulated Bcl-xL expression only in the breast cancer cells.
[1] Prevention and treatment of cancer with indole-3-carbinol. Altern Med Rev. 2001 Dec;6(6):580-9.
[2] The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing. Proc Natl Acad Sci U S A. 2008 Dec 8.
[3] Indole-3-carbinol Inhibits Sp1-Induced Matrix Metalloproteinase-2 Expression To Attenuate Migration and Invasion of Breast Cancer Cells. J Agric Food Chem. 2008 Dec 5.
[4] BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer. 2006 Feb 13;94(3):407-26.
[5] Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination. Eur J Cancer Prev. 2007 Apr;16(2):130-41.
[6] Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells. Mol Endocrinol. 2006 Dec;20(12):3070-82. Epub 2006 Aug 10.
[7] Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells. Nutr Cancer. 2003;45(1):101-12.
Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol. This is a favourable action of indole-3-carbinol because 16 alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action.
The estrogen metabolite 2-hydroxyestrone has protective against several types of cancer. Studies with animals have demonstrated that indole-3-carbinol reduced the carcinogenic affects of aflatoxins. The influence of indole-3-carbinol on the development of
prostate cancer is less clear. Most studies report protective effects but a few studies indicate that indole-3-carbinol may promote prostate cancer formation.
In the USA prostate cancer is one of the most common cancers in men and the second leading cause of cancer-related deaths. Epidemiological and dietary studies have shown a link between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. A study conducted by Technion Israel Institute of Technology (Haifa) showed that indole-3-carbinol had a significant inhibitory effect on prostate cancer cells in vitro and in vivo and concluded that this phytochemicals is a potential candidate as both preventive and therapeutic agent for humans [1].
The researchers tested the effect of indole-3-carbinol on the growth of prostate cancer cells inoculated subcutaneously in mice. They found that the administration of indole-3-carbinol significantly reduced cells proliferation and promoted the apoptosis of the prostate cancer cells. Fan S and co-workers of the Georgetown University (New York) reported that both indole-3-carrbinol and genistein target the breast cancer susceptibility genes in both prostate and breast cancer cells [2].
The breast cancer susceptibility genes are responsible for the suppression of tumor growth, not only of breast cancer cells but also ovarian and prostate cancer cells. This in-vitro study showed that the phytochemicals induced the expression of these genes.Another study found that injected indole-3-carbinol has anti-prostate cancer activity in rats [3].
Both intraperitoneal (in the body cavity) and intravenous injection of the phytochemical inhibited the growth, incidence and metastases of prostate cancer cells which were injected in rats.A study conducted at the Wayne State University School of Medicine, Detroit, concluded that indole-3-carbinol and its metabolite diindolylmethane are candidates for the prevention and the treatment of prostate cancer [4].
The researchers confirmed that indole-3-carbinol and diindolylmethane upregulate the expression of phase I and phase II enzymes, which are involved in the detoxification and inhibition of carcinogens. Both phytochemicals regulate many genes that are important for the control of cell cycle, cell proliferation, signal transduction, and other cellular processes.A study conducted by the Long Island Jewish Medical Center, New York, suggested that indole-3-carbinol may be an effective sensitizer of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment against TRAIL-resistant prostate cancer cell lines [5].
TRAIL is a ligand molecule which induces the process apoptosis in a variety of transformed cells including prostate cancer cells but has no effect on normal cells. The researchers, led by Jeon KI, tested the potential sensitizing effects of indole-3-carbinol on TRAIL-mediated apoptosis in a prostate cancer cell line. They found that the phytochemical enhanced TRAIL-mediated apoptosis and that the apoptosis was the result of increased levels of two trail death receptors.
[1] Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice. Food Chem Toxicol. 2008 Mar;46(3):863-70.
[2] BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer. 2006 Feb 13;94(3):407-26.
[3] Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer. Oncol Rep. 2005 Jan;13(1):89-93.
[4] Indole-3-carbinol and prostate cancer.J Nutr. 2004 Dec;134(12 Suppl):3493S-3498S.Sarkar FH, Li Y.
Treatment of
skin cancer cells with ultraviolet-B results in the apoptosis of their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol. Some studies also show a beneficial effect on the treatment of skin cancer.Every year more than 1 million new cases of ultraviolet radiation-induced non-melanoma skin cancers occur in the USA. Although exposure to sun and specifically ultraviolet radiation increases the risk of skin cancers, treatment of skin cancer cells with ultraviolet-B also results in their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol.
That is what scientist of the Seoul National University found in an experiment with cultured human melanoma cells [1].
They investigated the effect of indole-3-carbinol on the sensitization to ultraviolet-B-induced apoptosis . They found that a combined treatment with the indole-3-carbinol and ultraviolet-B synergistically reduced melanoma cell viability, whereas the phytochemical or ultraviolet-B alone had little effect. Indole-3-carbinol acted by down-regulating pro-apoptotic protein Bcl-2.
Another study also demonstrated the protective action of indol-3-carbinol on ultraviolet-induced carcinogenic process on skin cells of mice [2]. They conducted tests on groups of 20 mice exposed ultraviolet radiation and to fed with respectively chlorophyllin, indole-3-carbinol or placebo. The scientists found that rats fed with chlorophyllin should a significant increase in tumor multiplicity, whereas those supplemented with indol-3-carbinol has significant lower tumor multiplicity.[
1] Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells. Cell Mol Life Sci. 2006 Nov;63(22):2661-8.
[2] Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol. Photochem Photobiol Sci. 2006 May;5(5):499-507.Indol-3-carbinol, and OTHER (Brassica vegetables); conversion to isothiocyanates.
Indole 3 Carbinol (See also Di-indole methane) I3C, as it is frequently called, has been tested and documented in humans and results are highly promising. Indole-3-carbinol reduced or halted the formation of precancerous lesions (papillomas) in 12 out of 18 people with recurrent respiratory tract papillomas. In addition, in a small double-blind trial, supplementation with 200 or 400 mg of indole-3-carbinol per day for 12 weeks reversed early-stage cervical cancer in 8 of 17 women. Preliminary studies have also shown indole-3-carbinol has significantly increased the conversion of estrogen from cancer-producing forms to nontoxic breakdown products. Indole-3-carbinol is found in highest concentrations in broccoli, but is also found in other cruciferous vegetables, such as cauliflower, cabbage, and kale. This treatment would be indicated for those with hormonal related cancers. Note: Di-indole methane is considered a stronger metabolite of I3C.
science.naturalnews.com/I/Indole-3-Carbinol_and_cancer.html
- Pretreatment of Indole-3-Carbinol augments TRAIL-induced apoptosis in a prostatecancer cell line, LNCaP.
2003 FEBS letters
- Indole-3-Carbinol and prostate cancer.
2004 The Journal of nutrition
- Indole-3-Carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
2001 Oncogene
- Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells.
2004 Nutrition and cancer
- Indole-3-Carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice.
1999 Cancer research
- Therapeutic intervention of experimental breast cancer bone metastasis by Indole-3-Carbinol in SCID-human mouse model.
2006 Molecular cancer therapeutics
- The effect of Indole-3-Carbinol and sulforaphane on a prostate cancer cell line.
2003 ANZ journal of surgery
- A potent Indole-3-Carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells.
2007 Cancer research
- Indole-3-Carbinol as a chemopreventive and anti-cancer agent.
2008 Cancer letters
- 1-Benzyl-indole-3-carbinol is a novel Indole-3-Carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breastcancer cells.
2010 Chemico-biological interactions
- Indole-3-Carbinol prevents PTEN loss in cervical cancer in vivo.
2005 Molecular medicine (Cambridge, Mass.)
- Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol.
2010 Anticancer research
- BRCA1 and BRCA2 as molecular targets for phytochemicals Indole-3-Carbinol and genistein in breast and prostate cancer cells.
2006 British journal of cancer
- Indole-3-Carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.
1999 Cancer research
- Anti-carcinogenic and anti-metastatic properties of Indole-3-Carbinol in prostate cancer.
2005 Oncology reports
- Bax translocation to mitochondria is an important event in inducing apoptotic cell death by Indole-3-Carbinol (I3C) treatment of breast cancer cells.
2003 The Journal of nutrition
- A new Indole-3-Carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines.
2003 Cancer research
- Indole-3-Carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells.
2004 Carcinogenesis
- Anti-estrogenic activities of Indole-3-Carbinol in cervical cells: implication for prevention of cervical cancer.
1999 Anticancer research
- Indole-3-Carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway.
2010 Medical oncology (Northwood, London, England)
- Direct inhibition of elastase activity by Indole-3-Carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breastcancer cells.
2010 Cancer research
- Putative mechanisms of action for Indole-3-Carbinol in the prevention of colorectal cancer.
2008 Expert opinion on therapeutic targets
- Indole-3-Carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity.
2009 International journal of cancer. Journal international du cancer
- Indole-3-Carbinol inhibits Sp1-induced matrix metalloproteinase-2 expression to attenuate migration and invasion of breast cancer cells.
2009 Journal of agricultural and food chemistry
- Indole-3-Carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells.
2006 Molecular endocrinology (Baltimore, Md.)
- Indole-3-Carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.
2006 Biochemical pharmacology
- Modulation of the constitutive activated STAT3 transcription factor in pancreaticcancer prevention: effects of Indole-3-Carbinol (I3C) and genistein.
2004 Anticancer research
- Indole-3-Carbinol and 3,3′-diindolylmethane induce apoptosis in human prostatecancer cells.
2003 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol.
2002 Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
- The Indole-3-Carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor positive and triple negative breast cancer cell lines.
2011 Breast cancer research : BCR
- Indole-3-Carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.
2010 Molecular biology of the cell
- Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs.
2008 Cancer letters
- Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol.
2006 Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
- Indole-3-carbinol-induced modulation of NF-kappaB signalling is breast cancer cell-specific and does not correlate with cell death.
2008 Breast cancer research and treatment
- Indole-3-Carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.
2005 Carcinogenesis
- N-Alkoxy derivatization of Indole-3-Carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.
2008 Biochemical pharmacology
- Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer.
2006 The Prostate
- Indole-3-Carbinol and 3-3′-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions.
2003 The Journal of nutrition
- Indole-3-Carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breastcancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex.
2005 The Journal of biological chemistry
- Indole-3-Carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
2001 The Journal of biological chemistry
- Multiple molecular targets of indole-3-carbinol, a chemopreventive anti-estrogen in breast cancer.
2002 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
- Targets for Indole-3-Carbinol in cancer prevention.
2005 The Journal of nutritional biochemistry
- Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, Indole-3-Carbinol and myo-inositol, alone and in combination.
2010 Carcinogenesis
- Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the Indole-3-Carbinol metabolite 3,3′-diindolylmethane in breastcancer cells.
2009 The Journal of nutrition
- Review. Indole-3-Carbinol as a chemoprotective agent in breast and prostate cancer.
2008 In vivo (Athens, Greece)
- Indole-3-Carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines.
2008 Biochemical pharmacology
- Molecular targets and anticancer potential of Indole-3-Carbinol and its derivatives.
2005 Cell cycle (Georgetown, Tex.)
- Inhibition of MUC1 expression by indole-3-carbinol.
2004 International journal of cancer. Journal international du cancer
- Indole-3-Carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells.
2003 Nutrition and cancer
- A novel mechanism of Indole-3-Carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation.
2010 Cancer prevention research (Philadelphia, Pa.)
- Indole-3-Carbinol is a negative regulator of estrogen.
2003 The Journal of nutrition
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NOTE: Di-Indole Methane
Di-Indole Methane is the direct metabolite of I3C (Indole-3-Carbinol) and twice as strong. This naturally occurring extract of the cabbage (cruciferous) family vegetables has proven effective in studies worldwide against hormonal related cancers. It’s mechanism is to decrease high estrogen levels in both men and women, an issue which usually leads to cancer or other illnesses often associated with aging. Included are prostate disease, breast and uterine cancers, and weight gain. Supplementing the diet with DIM and eating cruciferous vegetables increases the specific aerobic metabolism for estrogen, multiplying the chance for so-called bad estrogen to be broken down into beneficial, or good estrogen metabolites. These good estrogen metabolites are known as the 2-hydroxy estrogens.
DIM (diindolylmethane) DIM is a phytochemical that is found in broccoli, cabbage, turnip and mustard greens, kale, brussel sprouts, collards, etc. „The first development in this research using chemically altered [sic] DIM from broccoli came when the growth of breast cancer cells was inhibited in laboratory studies. Subsequent research showed these compounds also inhibited growth of pancreatic, colon, bladder and ovarian cancer cells in culture, Safe said. Limited trials on lab mice and rats have produced the similar results, he noted.” „Researchers from the University of California at Berkeley looked at the effects of broccoli on human breast cancer cells. According to findings, compounds in broccoli known as indoles are digested and broken down in the stomach to a compound called 3,3′-diindolylmethane (DIM). This compound may be the key to keeping cancer at bay.”
Isothiocyanates are sulphur-containing phytochemicals with the general formula R-NCS. Different molecules belong to this group. Isothiocyanates with the stongest anticancer effects are phenylethylisothiocyanate, benzylisothiocyanate and 3-phenylpropylisothiocyanate. Isothiocyanates occur naturally as glucosinolate conjugates in cruciferous vegetables. Isothiocyanates are also responsible for the typical flavour of these vegetables.
Isothiocyanates can be found in cruciferous vegetables such as broccoli, cauliflower, kale, turnips, collards, Brussels sprouts, cabbage, radish, turnip and watercress. Glucosinolates are precursors of isothiocyanates. When the raw vegetables are chewed the plant cells are broken and an enzyme (myrosinase) hydrolyses the glucosinolates into isothiocyanates.
Health Benefits of Isothiocyanates
Isothiocyanates combat carcinogens by neutralizing them, reducing their poisonous effect and stimulating the secretion of carcinogens of carcinogens. Isothiocyanates act by inhibition of cell proliferation and induction of apoptosis.
The isothiocyanates with the stongest anticancer effects are phenylethylisothiocyanate, benzylisothiocyanate and 3-phenylpropylisothiocyanate. Studies have shown that isothiocyanates help to prevent lung cancer and esophageal cancer. Isothiocyanates can also lower the risk of other cancers, including gastrointestinal cancer.
science.naturalnews.com/…/1947743_Dietary_isothiocyanates_glutathione_S _transferase_M1_GSTM1_and_lung_cancer.html
Dietary isothiocyanates, glutathione S transferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, California.
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science.naturalnews.com/…/132691_Selective_Depletion_of_Mutant_p53_by _Cancer_Chemopreventive_Isothiocyanates_and.html
Isothiocyanates (ITCs) derived from cruciferous vegetables induce apoptosis in cancercells. We demonstrate that certain naturally occurring ITCs selectively …
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science.naturalnews.com/…/568279_Cancer_preventive_isothiocyanates_ induce_selective_degradation_of_cellular_alpha_.html
Cancer preventive isothiocyanates induce selective degradation of cellular alpha and beta tubulins by proteasomes.
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science.naturalnews.com/…/1314059_Isothiocyanates_glutathione_S_ transferase_M1_and_T1_polymorphisms_and_gastric.html
Isothiocyanates, glutathione S transferase M1 and T1 polymorphisms and gastric cancerrisk: a prospective study of men in Shanghai, China.
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science.naturalnews.com/…/786957_Chemoprevention_of_cancer_by_ isothiocyanates_and_anthocyanins_mechanisms_of_action.html
Chemoprevention of cancer by isothiocyanates and anthocyanins: mechanisms of action and structure activity relationship.
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science.naturalnews.com/…/2410_Isothiocyanate_exposure_glutathione_S_ transferase_polymorphisms_and_colorectal_cancer_risk.html
Isothiocyanate exposure, glutathione S transferase polymorphisms, and colorectal cancerrisk. Publication: The American journal of clinical nutrition. Publication …
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science.naturalnews.com/…/27163_Urinary_isothiocyanates_glutathione_S_ transferase_M1_T1_and_P1_polymorphisms.html
The present study examined the associations among urinary isothiocyanates, Glutathione S-transferase (GST) polymorphisms, and colorectal cancer risk in a …
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science.naturalnews.com/…/1265130_Isothiocyanates_induce_oxidative_ stress_and_suppress_the_metastasis_potential_of.html
However, the effect of isothiocyanates on lung cancer cell metastasis has not been studied. In the present study, we investigated the inhibitory effects of BITC …
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science.naturalnews.com/…/3294354_Head_and_neck_cancer_a_case_for_ inhibition_by_isothiocyanates.html
Head and neck cancer: a case for inhibition by isothiocyanates and indoles from cruciferous vegetables.
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science.naturalnews.com/…/1569614_Prostate_cancer_chemopreventive_ activity_of_phenethyl_isothiocyanate_through_epigenetic_regulatio…
Consumption of cruciferous Vegetables has been reported to be associated with reduced incidence of prostate cancer cases. The isothiocyanates, including …
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science.naturalnews.com/…/3381294_Repression_of_androgen_receptor_in_ prostate_cancer_cells_by_phenethyl.html
Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate. Publication: Carcinogenesis Publication Date: 2006. Study Author(s): …
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science.naturalnews.com/…/629276_Isothiocyanates_sensitize_the_effect_of_ chemotherapeutic_drugs_via_modulation_of.html
Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells.
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science.naturalnews.com/…/125542_Anti_NF_kappaB_and_anti_ inflammatory_activities_of_synthetic_isothiocyanates.html
Of the natural compounds, the Isothiocyanates (ITCs) found in cruciferous Vegetables have received particular attention because of their potential anti- cancer …
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science.naturalnews.com/…/1338610_ABC_transporters_and_isothiocyanates _potential_for_pharmacokinetic_diet_drug_interactions.html
Isothiocyanates, a class of anti-cancer agents, are derived from cruciferous Vegetables such as broccoli, cabbage and watercress, and have demonstrated …
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science.naturalnews.com/…/209522_New_biomarkers_for_monitoring_the_ levels_of_isothiocyanates_in_humans.html
Isothiocyanates (ITCs) found in cruciferous vegetables have demonstrated cancerpreventive activity in animals, and increased dietary intake of ITCs has been …
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science.naturalnews.com/…/2587875_Urinary_isothiocyanate_levels_and_ lung_cancer_risk_among_non_smoking.html
Urinary isothiocyanate levels and lung cancer risk among non smoking women: A prospective investigation.
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science.naturalnews.com/…/1538721_Metabolism_of_isothiocyanates_in_ individuals_with_positive_and_null_GSTT1.html
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BACKGROUND & AIMS : Isothiocyanates (ITCs) derived from cruciferous vegetables have been shown to be promising agents against cancer in human cell …
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Researchers at the Johns Hopkins University School of Medicine in Baltimore studied the metabolism of isothiocyanates and found that isothiocyanates were about six times more bioavailable than glucosinolates.
Sulforaphane is a phytochemical belonging to the family of isothiocyanates, which means it contains the typical NCS group.
(R)-1-isothiocyanto-4-methyl-sulfonyl butane
Sulforaphane occurs in plants bound to a sugar molecule: sulforaphane glucosinolate. Only after eating will the sulforaphane by released. Sulforaphane glucosinolate is found in cruciferous vegetables such as broccoli, cauliflower, cabbage and kale. The richest source of sulforaphane are broccoli sprouts.
Health Benefits of Sulforaphane
Sulforaphane is an antioxidant and stimulators of natural detoxifying enzymes. Sulforaphane may reduce the risk of breast, bladder and prostate cancer.
Anti-cancer effect
Epidemiological studies show that people who eat a lot of cruciferous vegetables have reduces incidences of cancer. In-vitro and animals studies have confirmed the anti-cancer effects and have demonstrated that the phytochemical reduces the frequency, size, and number of tumors.
During the fight against cancer cells our body produces special enzymes, called phase 2 enzymes. Sulforaphane is a phase 2 enzyme inducer, thereby neutralizing carcinogens before they can damage DNA. Sulforaphane inhibits benzo[a]pyrene-DNA and 1,6-dinitropyrene-DNA adducts formation. A study by James D. Brooks et al entitled Potent Induction of Phase 2 Enzymes in Human Prostate Cells by Sulforaphane has shown that sulforaphane induces phase 2 enzyme expression and activity in human prostate cells [1]. This study may help to explain the lower prostate cancer risk with men who consume more cruciferous vegetables.A team of scientists lead by B. Abbouit at the Ohio State University investigated the effect of isothiocyanates (sulforaphane and erucin) in primary or secondary bladder cancer prevention. Both phytochemicals showed inhibition of bladder cancer cells, which was associated downregulation of survivin, epidermal growth factor receptor and human epidermal growth factor receptor 2 and apoptosis.
A 2012 study by the Texas Children’s Hospital suggested a potential role of sulforaphane as an adjunctive agent to improve the therapeutic response in acute lymphoblastic leukemia patients [3]. This type of cancer is the most common hematological cancer in children. The scientists found that purified sulforaphane had anticancer properties in a broad range of leukemic cells. More specifically they found that sulforaphane caused dose-dependent apoptosis and cell cycle arrest, mainly by activation of caspases. While sulforaphane killed cancer cells, it did not affect healthy cells. It should be noted that the levels of sulforaphane used in this study were quite high and can not be obtained by eating cruciferous vegetables, such as broccoli.
[1] Potent induction of phase-2-enzymes in human prostate cells by sulforaphane.. Cancer Epidemiology Biomarkers and Prevention, Vol. 10, 949-954, September 2001
[2] Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion. Mol Nutr Food Res. 2012 Nov;56(11):1675-87
[3] Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. PLoS One. 2012;7(12):e51251
science.naturalnews.com/S/Sulforaphane_and_cancer.html
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Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines.
2007 Molecular cancer therapeuticsSulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells.
2008 International journal of cancer. Journal international du cancerAntiproliferative activity of Sulforaphane in Akt-overexpressing ovarian cancer cells.
2007 Molecular cancer therapeuticsSulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.
2009 Proceedings of the National Academy of Sciences of the United States of AmericaSulforaphane enhances the therapeutic potential of TRAIL in prostate cancerorthotopic model through regulation of apoptosis, metastasis, and angiogenesis.
2008 Clinical cancer research : an official journal of the American Association forcancer ResearchAnti-carcinogenic effects of Sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells.
2010 Cancer epidemiologyTemporal changes in gene expression induced by Sulforaphane in human prostatecancer cells.
2009 The ProstateDietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with Sulforaphane in the growth suppression of PANC-1 cancer cells.
2009 Cancer cell internationalp38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells.
2010 Oncology reports
Identification of sensor cysteines in human Keap1 modified by the cancerchemopreventive agent sulforaphane.
2005 Chemical research in toxicology
Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent.
2005 Cancer research
Sulforaphane causes epigenetic repression of hTERT expression in human breastcancer cell lines.
2010 PloS one
Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells.
2000 Cancer research
Targeting cell cycle machinery as a molecular mechanism of Sulforaphane in prostatecancer prevention.
2004 International journal of oncology
Sulforaphane inhibits growth of a colon cancer cell line.
2004 Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
The effect of indole-3-carbinol and Sulforaphane on a prostate cancer cell line.
2003 ANZ journal of surgery
The dietary isothiocyanate Sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
2004 Molecular cancer therapeutics
The dietary isothiocyanate Sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
2004 Molecular cancer therapeutics
Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention.
2009 The Journal of nutrition
Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy.
2010 International journal of pharmaceutics
Comparison of the apoptosis-inducing capability of Sulforaphane analogues in human colon cancer cells.
2010 Anticancer research
Inhibition of activator protein-1 by Sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.
2009 Cancer research
Multi-targeted prevention of cancer by sulforaphane.
2008 Cancer letters
D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells.
2009 Molecular cancer therapeutics
Effect of Sulforaphane on cell growth, G(0)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells.
2006 International journal of oncology
Efficacy of Sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.
2007 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug.
2005 Investigational new drugs
Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells.
2006 Cancer research
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.
2006 Current drug targets
Sulforaphane as a promising molecule for fighting cancer.
2007 Mutation research
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreaticcancer stem cells.
2011 Frontiers in bioscience (Elite edition)
Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promisingcancer chemopreventive agent.
2010 Biochemistry
[Herb honey containing sulforaphane-aglycone with potential use in cancerprophylaxis].
2003 Roczniki Panstwowego Zakladu Higieny
Sulforaphane halts breast cancer cell growth.
2004 Drug discovery today
Sulforaphane halts breast cancer cell growth.
2004 Drug discovery today
Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.
2005 The Journal of biological chemistry
Discovery and development of Sulforaphane as a cancer chemopreventive phytochemical.
2007 Acta pharmacologica Sinica
Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization.
2004 The Journal of nutrition
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostatecancer cells and retards growth of PC-3 xenografts in vivo.
2004 Carcinogenesis
Phytochemicals Resveratrol and Sulforaphane as Potential Agents for Enhancing the Anti-Tumor Activities of Conventional cancer Therapies.
2011 Current pharmaceutical biotechnology
Comparison of the effects of phenethyl isothiocyanate and Sulforaphane on gene expression in breast cancer and normal mammary epithelial cells.
2009 Experimental biology and medicine (Maywood, N.J.)
Synergistic activity of sorafenib and Sulforaphane abolishes pancreatic cancer stem cell characteristics.
2010 Cancer research
Concurrent Sulforaphane and Eugenol Induces Differential Effects on Human Cervical cancer Cells.
2011 Integrative cancer therapies
Activation of several concurrent proapoptic pathways by Sulforaphane in human colon cancer cells SW620.
2009 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human coloncancer cells.
2010 Annals of surgical oncology
Quantitative combination effects between Sulforaphane and 3,3′-diindolylmethane on proliferation of human colon cancer cells in vitro.
2007 Carcinogenesis
Molecular targets of dietary phenethyl isothiocyanate and Sulforaphane for cancerchemoprevention.
2010 The AAPS journal
Autophagy inhibition enhances sulforaphane-induced apoptosis in human breastcancer cells.
2010 Anticancer research
Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.
2011 Molecular therapy : the journal of the American Society of Gene Therapy
Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane.
2009 The Journal of nutritional biochemistry
In vitro antiproliferative effects of Sulforaphane on human colon cancer cell line SW620.
2007 Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breastcancer stem cells.
2010 Clinical cancer research : an official journal of the American Association forcancer Research
Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells.
2010 Cancer prevention research (Philadelphia, Pa.)
Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect.
2011 Age (Dordrecht, Netherlands)
Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells.
2007 Acta obstetricia et gynecologica Scandinavica
D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.
2007 Carcinogenesis
Suppression of NF-kappaB and NF-kappaB-regulated gene expression bySulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostatecancer PC-3 cells.
2005 Oncogene
Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line.
2007 Molecular cancer therapeutics
Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.
2006 Carcinogenesis
The role of protein binding in induction of apoptosis by phenethyl isothiocyanate andSulforaphane in human non-small lung cancer cells.
2007 Cancer research
Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human coloncancer cells.
2004 Nutrition and cancer
Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by Sulforaphane in DU145 prostate cancer cells.
2005 Nutrition and cancer
Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species.
2009 Pharmaceutical research
Isothiocyanate Sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-ß/Smad signaling pathway.
2010 Molecular nutrition & food research
Suppression of microtubule dynamic instability and turnover in MCF7 breast cancercells by sulforaphane.
2008 Carcinogenesis
Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells.
2010 Proteome science
Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells.
2008 Biochemical and biophysical research communications
Biphasic modulation of cell proliferation by Sulforaphane at physiologically relevant exposure times in a human colon cancer cell line.
2007 Molecular nutrition & food research
Pharmacogenomics of cancer chemopreventive isothiocyanate compoundSulforaphane in the intestinal polyps of ApcMin/+ mice.
2006 Biopharmaceutics & drug disposition
Gene expression profiles induced by cancer chemopreventive isothiocyanateSulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.
2006 Cancer letters
Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.
2004 Experimental biology and medicine (Maywood, N.J.)
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.
2006 Carcinogenesis |
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science.naturalnews.com/S/Sulforaphane_and_breast_cancer.html
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Heart health
The antioxidant action of sulforaphane helps to fight high blood pressure. A study by the Tokyo University of Agriculture has shown that persons who eat about 100 g of broccoli sprouts daily during one week had reduces levels of cholesterol.
Research Reviews
Potent induction of phase-2-enzymes in human prostate cells by sulforaphane.
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo-a-pyrene-induced stomach tumors
Phenolic Acids
trans-8-methyl-N-vanillyl-6-nonenamide, N-(4-Hydroxy-3-methoxyphenyl)-8-methyl-non-trans-6-enamide
Capsaicin is the phytochemical in chilli peppers that causes the typical heat. Pure capsaicin is a white crystalline powder. Capsaicin is a capsaicinoid which belongs to the alkaloid family. It is very heat stable and keeps its activity despite cooking. Capsaicin is only slightly soluble in water, but very soluble in ethanol and vegetable oil. Other capsaicinoid are dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin and homodihydrocapsaicin.
Health Benefits of Capsaicin
ANTIcancer
science.naturalnews.com/C/Capsaicin_and_cancer.html
Capsaicin is used in many topical ointments used to relieve the pain of peripheral neuropathy (treatment of pain in the nerve endings near the surface of the skin). Capsaicin is then applied on the skin and removed when the patient starts feeling the burning sensation. The nerves seem to become insensitive to pain. The burning sensations of capsaicin is caused by its interaction with the nerve cells. Capsaicin binds with special receptor cells (vanilloid receptor subtype 1) and produces the same effect as physical heat. Consumption of capsaicin can also create a euphoric sensation caused by the release endorphins.
Studies have shown that capsaicin can relieve arthritic symptoms and improve flexibility of the joints. Capsaicin seems to inhibit the activity of DSP (Decapeptide Substance P), which the painful feeling of arthritis.
Capsaicin might protect against gastric ulcers. Studies have shown that capsaicin protects the stomach membrane by increasing the blood flow.
Capsaicin seems to reduce the symptoms of psoriasis. A study by Ellis CN et al., „A double-blind evaluation of topical capsaicin in pruritic psoriasis” (Journal of the American Academy of Dermatology, Sept 1993) showed that patients with psoriasis who took capsaicin cream had reduced itching, scaling and redness compared with patients who used a placebo.
Why do plants contain capsaicin? By producing the burning capsaicin the pepper plant prevents animals from eating its fruits. Birds don?t feel the burning sensation of capsaicin so they eat the fruits and are responsible for the spreading of seeds. The chilli seeds survive the digestion process. Capsaicin is also a component of pepper spray, used as chemical riot control agent.
Abstracts
Capsaicin and Health
Benzoaric acid, eleagic acid, elagostasine, gallogen
Ellagic acid is a fused four-ring polyphenol.
Ellagic acid is present in many red fruits and berries, including raspberries, strawberries, blackberries, cranberries, pomegranate and some nuts including pecans and walnuts. The highest levels of ellagic acid are found in raspberries. In plants ellagic acid is present in the form of ellagitannin, which is ellagic acid bound to a sugar molecule.
Pure ellagic acid is a cream to light yellow crystalline solid.
Health Benefits of Ellagic Acid
Ellagic acid has antioxidant, anti-mutagen and anti-cancer properties. Studies have shown the anti-cancer activity on cancer cells of the breast, oesophagus, skin, colon, prostate and pancreas. More specifically, ellagic acid prevents the destruction of P53 gene by cancer cells. Ellagic acid can bind with cancer causing molecules, thereby making them inactive. In their studie The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes. Ahn D et al showed that ellagic acid causes a decrease in total hepatic mucosal cytochromes and an increase in some hepatic phase II enzyme activities, thereby enhancing the ability of the target tissues to detoxify the reactive intermediates. Ellagic acid showed also a chemoprotective effect against various chemically induced cancers.
Studies on Ellagic Acid and cancer –
A study by Thresiamma KC and Kuttan R.Indian (Indian Journal Physiology and Pharmacology, 1996 October) indicate that oral administration of ellagic acid by rats can circumvent the carbon tetrachloride toxicity and subsequent fibrosis of the liver.
Ellagic acid has also antiviral and antibacterial activities.
Plants produce ellagic acid to protect themselves from microbiological infection and pests.
Research Reviews
Pomegranate Juice Ellagitannin Metabolites Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours
Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.
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3,4,5-Trihydroxybenzoic acid
Gallic acid occurs as a freemolecule or as part of a tannin molecule.
Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts, grapes, tea, hops and oak bark. Pure gallic acid is a colourless crystalline organic powder.
Health Benefits of Gallic acid
Gallic acid seems to have anti-fungal and anti-viral properties. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells.
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Gallic acid is used a remote astringent in cases of internal haemorrhage. Gallic acid is also used to treat albuminuria and diabetes. Some ointment to treat psoriasis and external haemorrhoids contain gallic acid.
Rosmarinic acid is found in big quantities in oregano, lemon balm, sage, marjoram, rosemary.
Rosmarinic acid has antioxidant, anti-inflammatory and antimicrobial activities.
The antioxidant activity of rosmarinic acid is stronger than that of vitamin E. Rosmarinic acid helps to prevent cell damage caused by free radicals, thereby reducing the risk for cancer and atherosclerosis.
Rosmarinic acid has anti-inflammatory properties. Perilla, rich in rosmarinic acid, is used for its anti-allergic activity. A study by Sanbongi C and colleagues (Clinical and Experimental Allergy, June 2004) have shown that the oral administration of rosmarinic acid is an effective intervention for allergic asthma. Another study by Youn J and colleagues (Journal of Rheumatology, June 2003) demonstrated that rosmarinic acid suppressed synovitis in mice and that it may be beneficial for the treatment of rheumatoid arthritis. Unlike antihistamines, rosmarinic acid prevents the activation of immune responder cells, which cause swelling and fluid formation.
Rosmarinic acid is also used for food preservation. In Japan the perilla extracts, rich in rosmarinic acid, is used the garnish and improve the shelf life of fresh seafood.
Rosmarinic acid is used to treat peptic ulcers, arthritis, cataract, cancer, rheumatoid arthritis and bronchial asthma.
Studies on Rosmarinic acid and cancer
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Rosmarinic acid antagonizes activator protein 1 dependent activation of cyclooxygenase 2 expression in human cancer and nonmalignant cell lines.
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Subsequently, six extracts and the active compounds, carnosic acid, andRosmarinic acid were applied to various human cancer cell lines including NCI- H82 …
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science.naturalnews.com/…/1331077_Rosmarinic_acid_sensitizes_cell_death _through_suppression_of_TNF_alpha.html
Rosmarinic acid sensitizes cell death through suppression of TNF alpha … of RA have not been well elucidated in TNF-alpha-mediated anti-cancer therapy.
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science.naturalnews.com/Rosmarinic_acid.html
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Aug 15, 2013 … Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell …
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Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. 2008 The …
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science.naturalnews.com/…/264528_Inhibition_of_bone_metastasis_from_ breast_carcinoma_by_rosmarinic_acid.html
Our study showed that Rosmarinic acid (RA) could inhibit the migration of MDA- MB-231BO human bone-homing breast cancer cells dose-dependently.
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science.naturalnews.com/…/2450932_Combination_of_active_components_ enhances_the_efficacy_of_Prunella_in.html
… enhances the efficacy of Prunella in prevention and treatment of lung cancer. … caffeic acid, rosmarinic acid, rutin, quercetin, Oleanolic acid and Ursolic Acid.
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Gallotanic acid, digallic acid, allotannin, tannimum.Tannic acid is a polymer of gallic acid molecules and glucose. It the example there are 3 gallic acid molecules, but normally there are about 8. Because there are different molecular structures for tannic acid it would have been better to speak about tannic acids (in plural). Tannic acid will hydrolyze into glucose and gallic or ellagic acid units. Tannic acid is odourless but has a very astringent taste. Pure tannic acid is a light yellowish and amorphous powder.
Tea, nettle, wood, berries, Chinese galls. Oak wood is very rich in tannic acid. When wine is kept in oak kegs some tannic acid will migrate into the wine. High levels of tannic acid are found in some plant galls. These are formed by plants when they are infected by certain insects. These insects pierce the plant leaves and when the egg hatches out into a larva the plant produces a gall which surrounds the larva.
Health Benefits of Tannic Acid
Tannic acid has anti-bacterial, anti-enzymatic and astringent properties. Tannic acid has constringing action upon mucous tissues such as tongue and inside of mouth. The ingestion of tannic acid caused constipation and can be used to treat diarrhoea (in the absence of fever or inflammation). The anti-oxidant and anti-mutagenic properties of tannic acid are beneficial.
Studies on Tannic Acid and cancer
However, tannic acid should not be used continuously or in high quantities ad it slows down the absorption of iron and possibly other trace minerals. A study by Afsana K et al entitled Reducing effect of ingesting tannic acid on the absorption of iron, but not of zinc, copper and manganese by rats. published by Bioscience, Biotechnology, and Biochemistry (March 2004) concluded that the usual intake of polyphenols is relatively safe, but that a high intake by supplementation or by dietary habit of tannin affects only the iron level. Tannic acid can also reduce the effectiveness of digestive enzymes.
Phytosterols
(3beta)-stigmast-5-en-3-ol, 22:23-dihydrostigmasterol, alpha-dihydrofucosterol, cinchol, cupreol, rhamnol, quebrachol and sitosterin.
Beta-sitosterol is a phytosterols or plant sterol. The structure of beta-sitosterol is similar to that of cholesterol. Beta-sitosterol differs from cholesterol by the presence of an extra ethyl group.
There are many plant sources of beta-sitosterol, but the most important are wheat germ, rice bran, flax seeds, peanuts, soybeans, pumpkin seeds and corn oil. Muli and co-workers showed that a plant-based diet, rich in fibre, soy and flax seed, can increase serum levels of beta-sitosterol.
Health Benefits of Beta-Sitosterol
Beta-sitosterol is mainly known and used for its cholesterol lowering property. But studies have shown that the phytochemical may have other health benefits: easing symptoms of benign prostatic enlargement, reducing risk of cancer and prevention of oxidative damage through its antioxidant activity.
Anti-cancer
Epidemiological and experimental studies have suggested a protective role of beta-sitosterol in the development of some types of cancer such as breast, colon and prostate cancer. In-vivo studies have shown that the phytochemical inhibited proliferation and induce apoptosis in human solid tumors such as colon and breast cancers.
Beta-sitosterol is mainly studied for its cholesterol-lowering properties but many studies also find that the phytochemical may help to prevent cancer. Epidemiological and experimental studies have suggested a protective role of beta-sitosterol in the development of some types of cancer such as breast, colon and prostate cancer. In-vivo studies have shown that the phytochemical inhibited proliferation and induce apoptosis in human solid tumors such as colon and breast cancers.
A Japanese study led by Imanaka demonstrated that the oral intake of beta-sitosterol, encapsulated in a liposome, was able to prevent tumour metastasis in rats, although the phytochemical was not absorbed in the serum. The researchers believed that beta-sitosterol works by stimulating the gut immune surveillance systems, as indicated by an increase in natural killer cell activity and production of immune response cytokines [1]. Park and co-workers concluded in their study that „beta-sitosterol potently induces apoptosis in U937 cells (these are leukemia cells) and that beta-sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.” Beta-sitosterol induced apoptosis in the leukemia cells in a dose-dependent manner [2].
Beta-sitosterol seems to induce apoptosis of cancer cells through two pathways: the extrinsic and intrinsic pathways, which are catalyzed by by the initiator caspases 8 and 9 respectively. Both pathways result in the activation of caspase 3, which is an effector caspases that cleaves protein substrates within the cell resulting in the apoptotic process. Korean study lead by Moon also found this effect of beta-sitosterol on caspase activation on cultured fibrosarcoma cells: treatment of the cells with an caspase-3 inhibitor inhibited the beta-sitosterol induced apoptosis. Treatment of the fibrosarcoma cells with beta-sitosterol also induced activation (phosphorylation) of extracellular-signal regulating kinase and blocked protein kinase B, which inhibits apoptotic processes [3]. Nakamura and co-workers found that beta-sitosterol restored the impaired gap junctional intercellular communication of transfected rat liver epithelial cells. The beta-sitosterol used in this experiment was extracted from the husks of psyllium seeds. Beta-sitosterol and also stigmasterol increased the level of gap junction proteins and restored their level of phosphorylation to levels similar to nontransfected cells [4].
Epidemiological evidence has shown that men consuming high amounts of plant products have a lower risk of prostate cancer. Von Holtz and colleagues investigated the possible effect of the plant sterol, beta-sitosterol, on cancer cells. They found that beta-sitosterol decreased the numbers of prostate cancer cells and increased apoptosis. Beta-sitosterol the production of ceramide, which is cellular signaling molecule regulating the differentiation, proliferation, programmed cell death and apoptosis of cells [5]. An in-vitro experiment with bone marrow cells showed that beta-sitosterol reduced the genotoxic damage caused by doxorubicin [6]. Beta-sitosterol significantly reduced the frequency of sister chromatid exchanges, which are exchange of genetic material between two identical sister chromatids. When the frequency of chromatid exchange is too high, cell damage can occur.
[1] Imanaka H, Koide H, Shimizu K, Asai T, Kinouchi Shimizu N, Ishikado A, Makino T, Oku N. ” Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake” Biol Pharm Bull. 2008 Mar;31(3):400-4.
[2] Park C, Moon DO, Rhu CH, Choi BT, Lee WH, Kim GY, Choi YH. ” Beta-sitosterol induces anti-proliferation and apoptosis in human leukemia U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.” Biol Pharm Bull. 2007 Jul;30(7):1317-23.
[3] Moon DO, Lee KJ, Choi YH, Kim GY. „Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells.” Int Immunopharmacol. 2007 Aug;7(8):1044-53.
[4] .Nakamura Y, Yoshikawa N, Hiroki I, Sato K, Ohtsuki K, Chang CC, Upham BL, Trosko JE. „Beta-sitosterol from psyllium seed husk (Plantago ovata Forsk) restores gap junctional intercellular communication in Ha-ras transfected rat liver cells.” Nutr Cancer. 2005;51(2):218-25.
[5]Von Holtz RL, Fink CS, Awad AB. ” beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells.” Nutr Cancer. 1998;32(1):8-12.
[6] Paniagua-Pérez R, Madrigal-Bujaidar E, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J, Hernández N, Flores-Mondragón G, Velasco O. ” Cell protection induced by beta-sitosterol: inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity. ” Arch Toxicol. 2008 Feb 6.
The studies about the protective effect of beta-sitosterol on breast cancer only involved in-vitro experiments using cultured breast cancer cells. These studies clearly show that the phytochemicals kills breast cancer cells and is not toxic to normal cell. Clinical studies linking beta-sitosterol and breast cancer are still missing but some scientists suggest that it may improve the efficiency of tamoxifen, a drug often used to treat breast cancer.
School of Public Health and Health Professions at the University at Buffal investigated the effects of beta-sitosterol and tamoxifen on the cultured breast cancer cells. The study led by Awad concluded that „these results suggest that the combination regimen of dietary beta-sitosterol and tamoxifen chemotherapy may be beneficial in the management of breast cancer patients”[1]. Tamoxifen is drug used for the treatment of breast cancer and works as a selective estrogen receptor modulator. Therefore it only works on estrogen receptor positive breast cancer cells. They tested the effect of beta-sitosterol and tamoxifen, separately and combined, on the growth of estrogen receptor positive breast cancer cells and estrogen receptor negative breast cancer cells. They found that a treatment with beta-sitosterol inhibited the growth of both type of cells whereas tamoxifen only inhibited of estrogen receptor positive breast cancer cells. A combined treatment further inhibited the growth of both cell types. Both beta-sitosterol and tamoxifen modulated the ceramide metabolism. Ceramides act as a signaling molecule, regulating differentiation, proliferation, programmed cell death and apoptosis. Beta-sitosterol increased ceramide levels by stimulating ceramide production whereas tamoxifen tamoxifen increased ceramide levels by inhibting ceramide glycosylation.
A study conducted by the State University of New York concluded that beta-sitosterol is an effective apoptosis-promoting phytochemical and more dietary phytosterols may protect against breast cancer. The scientists studied the effect of beta-sitosterol on cultured breast cancer cells and adenocarcinoma cells. Beta-sitosterol concentrated in the cell membranes and significantly inhibited tumor cell growth. It increased the Fas levels and caspase-8 activity [2]. Beta-sitosterol seems to induce apoptosis of cancer cells through two pathways: the extrinsic and intrinsic pathways, which are catalyzed by by the initiator caspases 8 and 9 respectively. Both pathways result in the activation of caspase 3, which is an effector caspases that cleaves protein substrates within the cell resulting in the apoptotic process. Awad and his team found that beta-sitosterol treatment of cultured breast cancer cells increased the activities of caspases 8 and 9 by 39% and 80% respectively, resulting in a a three-fold increase in the activity of caspase 3 [3].
In another in-vivo experiment conducted by Awad also showed that beta-sitosterol inhibited the growth of breast cancer cells by up to 80%, caused a six-fold increase in apoptosis cells but showed no cytotoxicity. The found no effect of beta-sitosterol on the level of protein phosphatase 2A in the tumor cells [4].
A study by Ju et al investigated the estrogenic effects of the plant sterols beta-sitosterol, beta-sitosterol glucoside and Moducare (mixture of beta-sitosterol, beta-sitosterol glucoside). The test was carried out on estrogen dependent human breast cancer cells in vitro and in vivo. The researchers concluded that beta-sitosterol and Moducare stimulated cancer cells in vitro and that dietary beta-sitosterol and Moducare protected against estrogen stimulated tumor growth. These findings suggest that beta-sitosterol could have potential benefits for women with a risk for estrogen-dependent breast cancer [5].
[1] Awad AB, Barta SL, Fink CS, Bradford PG. ” beta-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism.”Mol Nutr Food Res. 2008 Apr;52(4):419-26.
[2] Awad AB, Chinnam M, Fink CS, Bradford PG. ” beta-Sitosterol activates Fas signaling in human breast cancer cells.” Phytomedicine. 2007 Nov;14(11):747-54.
[3] Awad AB, Roy R, Fink CS. „Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. „Oncol Rep. 2003 Mar-Apr;10(2):497-500
[4] Awad AB, Downie AC, Fink CS. „Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture.” Int J Mol Med. 2000 May;5(5):541-5.
[5] Ju YH, Clausen LM, Allred KF, Almada AL, Helferich WG. „Beta-sitosterol, beta-sitosterol glucoside, and a mixture of beta-sitosterol and beta-sitosterol glucoside modulate the growth of estrogen-responsive breast cancer cells in vitro and in ovariectomized athymic mice.” J. Nutr. 134: 1145-1151.
Antioxidant
Beta-sitosterol is an antioxidant able to reduce DNA damage, reduce the level of freeradical in our cells and to increase the level of typical antioxidant enzymes.
Atherosclerosis
Regular intake of beta-sitosterol may reduce blood cholesterol levels by directly inhibiting the absorption of cholesterol. Beta-sitosterol also prevents the oxidation of LDL cholesterol thereby reducing the risk of atherosclerosis.
Prostate enlargement
Clinical studies have confirmed the beneficial effects of beta-sitosterol in patients withprostate enlargement. The phytochemical decreases post-void residual urinary volume and increases urinary flow rate in these patients.
Saponins are glucosides with foaming characteristics. Saponins consist of a polycyclic aglycones attached to one or more sugar side chains. The aglycone part, which is also called sapogenin, is either steroid (C27) or a triterpene (C30). The foaming ability of saponins is caused by the combination of a hydrophobic (fat-soluble) sapogenin and a hydrophilic (water-soluble) sugar part. Saponins have a bitter taste. Some saponins are toxic and are known as sapotoxin.
Saponins are phytochemicals which can be found in most vegetables, beans and herbs. The best known sources of saponins are peas, soybeans, and some herbs with names indicating foaming properties such as soapwort, saoproot, soapbark and soapberry. Commercial saponins are extracted mainly from Yucca schidigera and Quillaja saponaria.
Health Benefits of Saponins
Saponinshave many health benefits. Studies have illustrated the beneficial effects on blood cholesterol levels, cancer, bone health and stimulation of the immune system. Most scientific studies investigate the effect of saponins from specific plant sources and the results cannot be applied to other saponins.
Cholesterol reduction
Saponins bind with bile salt and cholesterol in the intestinal tract. Bile salts form small micelles with cholesterol facilitating its absorption. Saponins cause a reduction of blood cholesterol by preventing its re-absorption.
Reduce cancer risk
Studies have shown that saponins have antitumor and anti-mutagenic activities and canlower the risk of human cancers, by preventing cancer cells from growing. Saponins seem to react with the cholesterol rich membranes of cancer cells, thereby limiting their growth and viability. Roa and colleagues found that saponins may help to prevent colon cancer and as shown in their article „Saponins as anti-carcinogens” published in The Journal of Nutrition (1995, 125, 717s-724S).
Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship.
Chemical & Pharmaceutical Bulletin. 2005 November;53(11):1451-4
The aim of this study was to determine the antitumor properties of saponins from the root of Korean pasque flower (Pulsatilla koreana). The researchers measured the in-vitro cytotoxic activity against cultured human solid cancer cells and the in-vivo antitumor activity in mice bearing lung carcinoma. The saponins with a free acidic group at C-28 of aglycon showed moderate to considerable in-vitro cytotoxic activity. In the in-vivo test hederagenin saponins showed stronger antitumor effect than the taxol and doxorubicin saponins. The precense of a hederagenin aglycones and a special sugar sequence at C-3 are essential factors for the antitumor activity of saponins.
Protective effect of Astragalus corniculatus saponins against myeloid graffi tumor in hamsters.
Phytother Research. 2004 March;18(3):255-7
This study investigated the antitumor effect of a saponin rich extract from Astragalus corniculatus Bieb, a garden plant originating from Eastern European, against myeloid Graffi tumors in hamsters. The researchers found that an injection of extract in the peritoneal cavity decreased tumor transplantability, inhibited tumor growth in the early stages of tumor progression, increased survival time and reduced mortality. The study concluded that the saponin extract of Astragalus corniculatus should be further investigated as a antitumor treatment of myeloid Graffi tumour.
Protective effect of soybean saponins and major antioxidants against aflatoxin B1-induced mutagenicity and DNA-adduct formation.
Journal of Medicinal Food. 2002 Winter;5(4):235-40.
Previous studies have suggested that saponins have possible anti-cancer effect. The main dietary sources of saponins are legumes, including soybeans. The aim of this study was to determine the effect of soybean saponins mutagenic activity of aflatoxin B1 on Salmonella typhimurium and human liver cells. The anti-mutagenic effect of saponins was compared to those of other typical antioxidants such as vitamin C, vitamin E including L-ascorbic acid, alpha-tocopherol, vitamin A and butylated hydroxytoluene. The researchers found that the anti-mutagenic activity of saponins was between those of butylated hydroxytoluene and vitamin E. Soybean saponins reduced the muitagenic effect of aflatoxin B1 up to 81%. The preincubation of human liver cells with saponins reduced the amount of DNA adducts significantly. The study concluded that soybean saponins possess a significant anti-mutagenic activity. More studies are required to determine the exact mechanism but soybean saponins seems to block the initial stages of carcinogenesis.
Environmental influences on isoflavones and saponins in soybeans and their role in colon cancer.
Journal of Nutrition. 2005 May;135(5):1239-42
Soybeans are not only an important source of high quality proteins but contain also health promoting phytochemicals such as isoflavones and saponins. The aim of this study was to quantify isoflavone and saponin levels in soybean cultivars grown under different conditions and to determine the influence of isoflavones and saponins on carcinogenic process of cultured human colon cancer cells. The researchers found an inhibitive effect of soy isoflavones and saponins on the colon cancer cells. There were no adverse effects of the intake of pure saponins on growth, organ weight or intestinal morphology, even when the diet contained 3% saponins. The study concluded that soy isoflavones and saponins may protect against colon cancer and are well tolerated.
Soy saponins and the anticancer effects of soybeans and soy-based foods.
Current Medicinal Chemistry – Anti-Cancer Agents. 2004 May;4(3):263-72
There are indications that the consumption of soy products help to protect against cancer but the exact constituents, which are responsible for this action, remain elusive. The aim of this review was to summarize epidemiological studies linking saponins to cancer risk. Recents studies have shown that soy saponins have a direct effect on cancer cells but may also influence carcinogenesis in alternative mechanisms. The anti-cancer action of saponins may result in the discovery of new anticancer agents.
Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages.
Cancer Letters. 2005 December 18;230(2):219-27
Pro-inflammatory mediators play also a role in cancer development. Phytochemicals with anti-inflammatory properties may help to reduce the risk of cancer. The aim of this study was to investigate the effects of soybean saponins on the production of proinflammatory mediators peritoneal macrophages stimulated with liposaccharides. The researchers found that soybean saponins reduced the levels of pro-inflammatory indicators such as cyclooxygenase-2, nitric oxide synthases and Nuclear Factor kappa B. The study concluded that soybean saponins may be useful for ameliorating inflammatory diseases and suppressing tumor progression.
Some studies have shown that saponins can cause apoptosis of leukemia cells by inducing mitotic arrest.
Cytotoxic and apoptogenic effect of tea (Camellia sinensis var. assamica) root extract (TRE) and two of its steroidal saponins TS1 and TS2 on human leukemic cell lines K562 and U937 and on cells of CML and ALL patients.
Leukemia Research. 2006 April;30(4):459-68
Not only tea leaves but also tea roots contain phytochemicals with potential health benefits. The aim of this study was to investigate the anti-cancer properties of tea root extract and two specific steroidal saponins found in the tea root on human cancer cells. The study showed that the tea root extract and the two steroidal saponins induced apoptosis of leukemia cells. Consumption of the tea root extract by healthy volunteers caused an insignificant reduction in cell count.
The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines.
Biological and Pharmaceutical Bulletin. 2004 July;27(7):1059-65
Previous studies have shown that diosgenyl saponins could induce cytotoxicity and apoptosis in human leukemia cells. The aim of this study was to investigate mechanisms of action. The researchers found that diosgenyl saponins activated some caspases (caspases are essential in cells for apoptosis, one of the main types of programmed cell death) and down-regulated anti-apoptotic proteins. Dioscin treatment of leukemia cells inhibited cell mitosis. The study concluded that diosgenyl saponins may act by inducing mitotic arrest and apoptosis. Diosgenyl saponins might be used antimitotic agents.
science.naturalnews.com/…/693_Cancer_chemopreventive_and_therapeutic_ effects_of_diosgenin_a_food_saponin.html
Food saponins have been used in complimentary and traditional medicine against a variety of diseases including several cancers. Diosgenin, a naturally …
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science.naturalnews.com/…/2005340_Dimeric_antioxidant_and_cytotoxic_ triterpenoid_saponins_from_Terminalia_ivorensis_A.html
Dimeric antioxidant and cytotoxic triterpenoid saponins from Terminalia ivorensis A. … and further for their Cytotoxic activity against four human cancer cell lines.
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science.naturalnews.com/…/432621_Chemical_and_pharmacological_studies _of_saponins_with_a_focus_on.html
It is believed that the ginseng saponins called ginsenosides are the major … and central Nervous system as well as the antidiabetes and anti-cancer effects.
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science.naturalnews.com/…/270524_Cytotoxic_saponin_against_lung_cancer _cells_from_Dioscorea_birmanica_Prain.html
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Cytotoxic saponin against lung cancer cells from Dioscorea birmanica Prain & Burkill.
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Immunity booster
Plants produce saponins to fight infections by parasites. When ingested by humans, saponins also seem to help our immune system and to protect against viruses and bacteria.
Reduce bone loss
Studies with ovariectomized induced rats have shown that some saponins, such as the steroidal saponins from Anemarrhena asphodeloides, a Chinese herb, have a protective role on bone loss.
Antioxidant
The non-sugar part of saponins have also a direct antioxidant acitivity, which may results in other benefits such as reduced risk of cancer and heart diseases.
Stilbenes:
Biological/chemopreventive activity of stilbenes and their effect on …
http://www.ncbi.nlm.nih.gov/pubmed/18843589
Biological/Chemopreventive Activity of Stilbenes and their Effect on …
ddr.nal.usda.gov/bitstream/10113/21890/1/IND44135589.pdf
Stilbene derivatives as new cancer therapeutic agents
http://www.faqs.org/patents/app/20080261982
antitumour effect of synthetic stilbenes against breast, lung … – Biotek
http://www.biotek.gov.my/…/hc/…/Ibtisam%20Abdul%20Wahab%20UiTM.pd…
ANTITUMOUR EFFECT OF SYNTHETIC STILBENES AGAINST. BREAST, LUNG AND COLON CANCER CELL LINES. K. J. Jalani 1,
Pharmacometrics of Stilbenes: Seguing Towards … – Bentham Science
http://www.benthamscience.com/ccp/samples/ccp1-1/Davies.pdf One stilbene, resveratrol, has been extensively studied and has been shown to possess potent anti-cancer, anti- inflammatory and anti-oxidant activities.
Methoxy Stilbenes as Potent, Specific, Untransported, and …
pubs.acs.org/doi/pdf/10.1021/cb200435yOct 31, 2011 – Methoxy Stilbenes as Potent, Specific, Untransported, and. Noncytotoxic Inhibitors of Breast Cancer Resistance Protein. Glaucio Valdameri,.
Resveratrol – Discussion – Ovarian Cancer National Alliance …
http://www.inspire.com/groups/ovarian-cancer-national…/resveratrol-4/
Anti-Cancer Activity from Natural Plant Pterostilbenes by Jeffrey …
jeffreydachmd.com/…/anti-cancer-activity-from-natural-plant-substances…
Pterostilbene_Metastases-Associated_Protein_1_Tumor_inhibition2 Anti-Cancer Activity from Natural Plant Pterostilbenes by Jeffrey Dach MD.
Stilbenes as Multidrug Resistance Modulators and Apoptosis …
ar.iiarjournals.org/content/30/11/4587.full.pdf
The Inhibitory Effect of Natural Stilbenes and Their … – InTech
http://www.intechopen.com/download/pdf/32960
Found in blueberries and grapes. It’s an antioxidant that has shown promise for the treatment and prevention of cancer and cardiovascular disease,
science.naturalnews.com/P/Pterostilbene_and_cancer.html
- Pterostilbene inhibits lung cancer through induction of apoptosis.
2010 The Journal of surgical research
- Anti-inflammatory action of Pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells.
2009 Cancer prevention research (Philadelphia, Pa.)
- Pterostilbene inhibits breast cancer in vitro through mitochondrial depolarization and induction of caspase-dependent apoptosis.
2010 The Journal of surgical research
- Pterostilbene and tamoxifen show an additive effect against breast cancer in vitro.
2010 American journal of surgery
- Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells.
2010 Molecular nutrition & food research
- Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.
2002 Journal of agricultural and food chemistry
- In vitro evaluation of the cytotoxic, anti-proliferative and anti-oxidant properties ofPterostilbene isolated from Pterocarpus marsupium.
2010 Toxicology in vitro : an international journal published in association with BIBRA
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science.naturalnews.com/…/1422100_Pterostilbene_induces_autophagy_and _apoptosis_in_sensitive_and_chemoresistant_human.html
Pterostilbene (PT), a naturally occurring phytoalexin, possesses a variety of pharmacologic activities, including antioxidant, cancer prevention activity and …
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Pterostilbene, a dimethyl ester derivative of resveratrol, may act as an Cytotoxic and hence as an anti-cancer agent. The present study was conducted to test the …
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science.naturalnews.com/…/878600_Pterostilbene_inhibited_tumor_invasion _via_suppressing_multiple_signal_transduction_pathways.html
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However, the effects of Pterostilbene in preventing invasion of cancer cells have not been studied. Here, we report our finding that Pterostilbene significantly …
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science.naturalnews.com/…/1318411_Suppression_of_Heregulin_beta1_ HER2_Modulated_Invasive_and_Aggressive_Phenotype.html
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Pterostilbene, a natural analog of resveratrol, exerts its cancerChemopreventive activity similar to Resveratrol by inhibiting cancer cell proliferation and inducing …
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science.naturalnews.com/…/1721866_Pterostilbene_suppressed_ lipopolysaccharide_induced_up_expression_of_iNOS_and_COX.ht…
Pterostilbene, an active constituent of blueberries, is known to possess Anti- Inflammatory activity and also to induce apoptosis in various types of cancer cells .
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science.naturalnews.com/…/912354_Pterostilbene_a_natural_dimethylated_ analog_of_resveratrol_inhibits_rat_aortic.html
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Pterostilbene, a natural dimethylated analog of resveratrol, is known to have diverse pharmacological activities including anti-cancer, anti-inflammation and …
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Effects of pterostilbene on melanoma alone and in synergy with inositol hexaphosphate.… IP6 – A Rising Star in the Prevention and Treatment of Cancer.
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onlinelibrary.wiley.com › … › Vol 57 Issue 7
Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and …
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Pterostilbene inhibits lung cancer through induction of apoptosis.
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A number of preliminary studies suggest that pterostilbene may offer anti-cancer benefits. In a 2012 report published in the Journal of Surgical Research, for instance, scientists reviewed the available research on pterostilbene as an anti-cancer agent and found that pterostilbene may hinder cancer growth by altering cancer cell cycles, inducing apoptosis (a type of programmed cell death essential for stopping the proliferation of cancer cells), and inhibiting metastasis (the spread of cancer from one part of the body to another). In addition, the review determined that pterostilbene’s antioxidant effects may play a key role in cancer protection.
Resveratrol is a flavonol belonging to the group of flavonoids.
Resveratrol is present in many plants and fruits, including red grapes, eucalyptus, spruce, blueberries, mulberries, peanuts, giant knotweed. Also red wine contains a lot of it. The longer the grape juice is fermented with the grape skins the higher the resveratrol content will be. It is produced by the plant as a defence against diseases.
Health Benefits of Resveratrol
Resveratrol is an antioxidant but its antioxidant properties are weaker that those of quercetin and epicatechin. It has anticancer properties and inhibits lipid peroxidation of low-density lipoprotein and prevents the cytotoxicity of oxidized LDL. Resveratrol also increases the activity of some antiretroviral drugs in vitro.
Antioxidant
In vitro studies have shown that resveratrol inhibits the oxidative damage caused by the heavy metal cadmium. The antioxidant activity of resveratrol reduces damage to endothelial cells exposed to nitrite radicals and protects skin cells against damage caused by UV radiation.
Anticancer
The antioxidant action of resveratrol helps to prevent damage to DNA but it also influences the transcriptions of genes responsible for redox metabolism and inhibits proliferartion of cancer cells. Resveratrol appears to decrease tumor promotion activity by inhibiting the enzyme cyclooxygenase-1, which converts arachidonic acid to substances that promote tumor growth. In vitro experiments provide support for resveratrol to serve as a candidate preventive agent against prostate cancer, but in vivo effects of resveratrol and the mechanisms of action of resveratrol on prostate cancer prevention remain largely unknown.
Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells.
Journal of Biological Chemistry. 2007 February;388(2):207-19
Previous studies have shown that phytochemical resveratrol has antioxidant properties and influences the cellular redox reactions in eukaryotic cells. The researchers investigated the effects of resveratrol on the transcription of genes and activity of enzymes involved with the redox metabolism and cell cycle regulation in lung cancer cells. They found that resveratrol significantly increased the transcription of glutathione peroxidase resulting in lower glutathione levels. Glutathione also increased the transcription of many genes involved in the cell cycle, differentiation and apoptosis. The researchers concluded that resveratrol increased the expression of genes responsible for cell survival, differentiation, proliferation inhibition and apoptosis. Resveratrol may therefore have a chemopreventive and anticancer effect.
Effect of resveratrol and mixtures of resveratrol and mitomycin C on cancer cells under irradiation.
Anticancer Research. 2006 November-December;26(6B):4403-8
This study investigated the antitumor and radiation protective effects of resveratrol in combination with mitomycin-C, an antibiotic that is also used as chemotherapeutic agent because of its antitumour activity. The in-vitro tests were carried out on human breast cancer cells in aerated and anaerobic media. In the aerated media resveratrol showed anti-tumor and antioxidant activities, which were enhanced by mitomycin-C. Under anaerobic conditions, resveratrol acted as a radiation-protecting agent and at high concentration it stopped cell growth. The study concluded that resveratrol has both radiation protective and anticancer activity. Resveratrol acts by ejection of electrons and by reacting on primary radicals, such as hydroxyl radical.
Resveratrol Inhibits Pancreatic Cancer Cell Proliferation through Transcriptional Induction of Macrophage Inhibitory Cytokine-1.
Journal of Surgical Research. 2007 January 24
Resveratrol is a phytochemical found in many mainly in red grape skins, mulberries and some nuts. Previous studies have shown that resveratrol has potential antitumorigenic and anti-inflammatory activities. It is known that macrophages produce a cytokine (MIC-1) which has antitumorigenic activity. The aim of this in-vitro study was to determine the effect resveratrol on the activity of MIC-1 and the regulation the growth of lines human pancreatic cancer cells. The researchers found that resveratrol upregulated the expression of the MIC-1 gene. When the cells were first treated with a transcriptional inhibitor the effect of resveratrol was reduced, confirming that resveratrol works expression of genes. The study concluded that resveratrol increases MIC-1 gene expression in pancreatic cancer cells.
Resveratrol inhibits proliferation, induces apoptosis and overcomes chemoresistance through downregulation of STAT3 and nuclear factor-{kappa}B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.
Blood, 15 March 2007, Vol. 109, No. 6, pp. 2293-2302
This study investigated the effect of resveratrol, a phytochemical found in red grapes, red berries and peanuts on the growth of human multiple myeloma cells. Multiple myeloma is cancer of immune system cells in bone marrow. Bhardwaj and his colleagues found that resveratrol inhibited the proliferation of human multiple myeloma cell lines. Resveratrol also increased the apoptotic affect of bortezomib and thalidomide. They concluded that resveratrol may have a potential in the treatment of multiple myeloma cancer.
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells.
Molecular Cancer. 2006 October 17;5:45
Endometrial cancers (cancer of the lining of the uterus) are the most common gynecologic cancers in the Western world. Studies have shown that resveratrol, an anti-oxidant found in high quantities in red wine, has anticancer activity and acts by inhibiting the proliferation and inducing apoptosis of cancer cells. The aim of this study was to investigate the antiproliferative and apoptotic activity of resveratrol in six different endometrial cancer cell lines. The researchers found that resveratrol caused apoptosis apoptosis in five out of six uterine cancer cell lines and decreased cell proliferation. They found that resveratrol acts by regulating the cyclooxygenase expression.
Benefits for diabetes
Resveratrol may be benificial for diabetes. Administration of resveratrol may protect against oxidative damage caused by high glucose levels. It also reduces diabetic neuropathic pain.
Heart health
Resveratrol protects our heart and blood vessels by directly scavenging oxidants, which could cause oxidation of lipids, and by preventing apoptosis of endothelial cells. It may also help to prevent heart damage after a cardiac arrest. Reduced platelet aggregation has been attributes to resveratrol, thereby reducing the risk of atherosclerosis.
Increase of lifespan
Tests with animals have shown that that high food intake reduces lifespan. One study showed that resveratrol was able to able to increase the life span of mice on a high calorie diet.
Antitoxic
Many studies on animals have shown antitoxic effects of resveratrol. Resveratrol was able to reverse damages caused by the administration of the chemotherapeutic drug bleomycin. Resveratrol also helped to reduce brain damage and oxidative damage of the liver during ethanol intoxication. It also reduced kidney damage of rats treated with the antibiotic gentamicin.
Facts about Resveratrol
Resveratrol explains partly the French Paradox: the low incidence of heart disease among French people, who eat relatively a lot of unhealthy fat but drink resveratrol containing red wine.
Research Reviews
Resveratrol Promotes Clearance of Alzheimer’s Disease
Resveratrol Inhibits TNF-alpha?Induced Proliferation and Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells
Resveratrol in cancer management
Studies on Resveratrol and cancer
- Resveratrol-induced growth inhibition in MDA-MB-231 breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation.2007 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
- Regulation of p53 and cell proliferation by Resveratrol and its derivatives in breastcancer cells: An in silico and biochemical approach targeting integrin avß3.2011 International journal of cancer. Journal international du cancer
- Resveratrol inhibits pancreatic cancer stem cell characteristics in human and kras transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition.2011 PloS one
- Resveratrol suppresses colitis and colon cancer associated with colitis.2010 Cancer prevention research (Philadelphia, Pa.)
- Resveratrol inhibits migration and invasion of human breast-cancer cells 2008 Molecular nutrition & food researchDifferential effects of Resveratrol on androgen-responsive LNCaP human prostatecancer cells in vitro and in vivo.2008 CarcinogenesisFighting cancer with red wine? Molecular mechanisms of resveratrol.2009 Critical reviews in food science and nutritionResveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats.2006 Journal of carcinogenesisResveratrol suppresses prostate cancer progression in transgenic mice.
2007 Carcinogenesis
Cancer chemopreventive activity of resveratrol.
2002 Annals of the New York Academy of Sciences
Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells.
2003 The Journal of biological chemistry
Role of Resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
2004 Anticancer research
Differential effects on growth, cell cycle arrest, and induction of apoptosis byResveratrol in human prostate cancer cell lines.
1999 Experimental cell research
Chemoprevention of cancer and cardiovascular disease by resveratrol.
1999 Proceedings of the National Science Council, Republic of China. Part B, Life sciences
Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha.
2004 Molecular cancer therapeutics
Genome-scale analysis of resveratrol-induced gene expression profile in human ovarian cancer cells using a cDNA microarray.
2003 International journal of oncology
Pharmacokinetics in mice and growth-inhibitory properties of the putative cancerchemopreventive agent Resveratrol and the synthetic analogue trans 3,4,5,4′-tetramethoxystilbene.
2004 British journal of cancer
Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol.
2009 Molecular pharmacology
Estrogen and Resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells.
2007 Neoplasia (New York, N.Y.)
Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway.
2007 Annals of the New York Academy of Sciences
Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer.
2006 Current drug targets
Resveratrol confers resistance against taxol via induction of cell cycle arrest in humancancer cell lines.
2010 Molecular nutrition & food research
Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines.
2010 Human molecular genetics
Anti-cancer effect of Resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment.
2008 Advances in experimental medicine and biology
Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer.
2010 Pharmaceutical research
Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, Resveratrol and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells.
2008 International journal of oncology
Curcumin synergizes with Resveratrol to inhibit colon cancer.
2009 Nutrition and cancer
Repeat dose study of the cancer chemopreventive agent Resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.
2010 Cancer research
Resveratrol enhances anti-proliferative effect of VACM-1/cul5 in T47D cancer cells.
2010 Cell biology and toxicology
Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4hydrolase.
2010 Cancer research
Resveratrol and derivatives for the prevention and treatment of cancer.
2010 Drug discovery today
Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancercells in vitro and inhibits tumor growth in vivo.
2010 Cancer science
Results of a phase I pilot clinical trial examining the effect of plant-derivedResveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer.
2009 Cancer management and research
Molecular mechanisms of Resveratrol action in lung cancer cells using dual protein and microarray analyses.
2007 Cancer research
Resveratrol and cancer: chemoprevention, apoptosis, and chemo-immunosensitizing activities.
2003 Current medicinal chemistry. Anti-cancer agents
Resveratrol-induced autophagocytosis in ovarian cancer cells.
2004 Cancer research
Enhanced radiation-induced apoptosis of cancer cell lines after treatment with resveratrol.
2004 International journal of molecular medicine
Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line.
2002 The Journal of urology
Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells.
1999 Journal of cellular physiology
Resveratrol induces prostate cancer cell entry into s phase and inhibits DNA synthesis.
2002 Cancer research
Effect of Resveratrol on the expression of autocrine growth modulators in human breast cancer cells.
2001 Antioxidants & redox signaling
Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines.
2007 Journal of andrology
Inhibition of prostate cancer growth by muscadine grape skin extract andResveratrol through distinct mechanisms.
2007 Cancer research
Resveratrol enhances radiosensitivity of human non-small cell lung cancer NCI-H838 cells accompanied by inhibition of nuclear factor-kappa B activation.
2005 Journal of radiation research
Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells.
2005 Investigational new drugs
Resveratrol down-regulates the growth and telomerase activity of breast cancercells in vitro.
2006 International journal of oncology
Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target.
2009 Cancer research
Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives.
2008 Cancer letters
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.
2010 International journal of cancer. Journal international du cancer
Resveratrol in cancer management: where are we and where we go from here?
2011 Annals of the New York Academy of Sciences
Resveratrol and cellular mechanisms of cancer prevention.
2011 Annals of the New York Academy of Sciences
Differential effects of Resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells.
2010 Molecular nutrition & food research
Resveratrol down-regulates the androgen receptor at the post-translational level in prostate cancer cells.
2007 Journal of nutritional science and vitaminology
Liposome encapsulation of curcumin and Resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice.
2009 International journal of cancer. Journal international du cancer
Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials.
2009 Cancer prevention research (Philadelphia, Pa.)
Effects of Resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells.
2009 International journal of cancer. Journal international du cancer
Antitumor activity of Resveratrol and its sulfated metabolites against human breastcancer cells.
2009 Planta medica
[Inhibitory effect of Resveratrol on the growth of human colon cancer ls174t cells and its subcutaneously transplanted tumor in nude mice and the mechanism of action].
2009 Zhonghua zhong liu za zhi [Chinese journal of oncology]
Role of non-canonical Beclin 1-independent autophagy in cell death induced byResveratrol in human breast cancer cells.
2008 Cell death and differentiation
Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of Resveratrol in liver cancer cells.
2011 Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
Metabolomic analysis of resveratrol-induced effects in the human breast cancer cell lines MCF-7 and MDA-MB-231.
2011 Omics : a journal of integrative biology
Spontaneous and 5-fluorouracil-induced centrosome amplification lowers the threshold to resveratrol-evoked apoptosis in colon cancer cells.
2010 Cancer letters
Protein kinase CK2 modulates apoptosis induced by Resveratrol and epigallocatechin-3-gallate in prostate cancer cells.
2007 Molecular cancer therapeutics
The red wine polyphenol Resveratrol displays bilevel inhibition on aromatase in breast cancer cells.
2006 Toxicological sciences : an official journal of the Society of Toxicology
Comparison of the effects of the chemopreventive agent Resveratrol and its synthetic analog trans 3,4,5,4′-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived coloncancer cells.
2005 International journal of cancer. Journal international du cancer
Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling.
2011 Cancer letters
Transport of a cancer chemopreventive polyphenol, resveratrol: interaction with serum albumin and hemoglobin.
2007 Journal of fluorescence
Resveratrol-induced gene expression profiles in human prostate cancer cells.
2005 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells.
2006 Molecular cancer therapeutics
Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition.
2004 Investigational new drugs
Resveratrol structure and ceramide-associated growth inhibition in prostate cancercells.
2003 Drugs under experimental and clinical research
Resveratrol enhances the differentiation induced by butyrate in caco-2 colon cancercells.
2002 The Journal of nutrition
Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.
2011 Oncology reports
Cancer chemopreventive activity of resveratrol.
1999 Drugs under experimental and clinical research
Modulating effect of Resveratrol and quercetin on oral cancer cell growth and proliferation.
1999 Anti-cancer drugs
Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evaluation.
2004 Cancer detection and prevention
Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake.
2004 Biochemical pharmacology
Inhibition of gastric cancer cell proliferation by resveratrol: role of nitric oxide.
2002 American journal of physiology. Gastrointestinal and liver physiology
Identification of a p53-dependent pathway in the induction of apoptosis of human breast cancer cells by the natural product, resveratrol.
2004 Journal of alternative and complementary medicine (New York, N.Y.)
Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat.
2006 Expert review of anticancer therapy
Modulation of androgen receptor-dependent transcription by Resveratrol and genistein in prostate cancer cells.
2004 The Prostate
Involvement of HSP70 in resveratrol-induced apoptosis of human prostate cancer.
2003 Anticancer research
Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells.
2007 Biochemical pharmacology
Metabolism of Resveratrol in breast cancer cell lines: impact of sulfotransferase 1A1 expression on cell growth inhibition.
2008 Cancer letters
Potent inhibitory effects of Resveratrol derivatives on progression of prostatecancer cells.
2006 Archiv der Pharmazie
The novel Resveratrol analog HS-1793-induced polyploid LNCaP prostate cancer cells are vulnerable to downregulation of Bcl-xL.
2011 International journal of oncology
Expression of sulfotransferases and sulfatases in human breast cancer: impact onResveratrol metabolism.
2010 Cancer letters
Low concentrations of Resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention.
2008 Molecular nutrition & food research
Resveratrol imparts photoprotection of normal cells and enhances the efficacy of radiation therapy in cancer cells.
2008 Photochemistry and photobiology
SOCS-3 antagonizes pro-apoptotic effects of TRAIL and Resveratrol in prostatecancer cells.
2011 The Prostate
Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells.
2008 Journal of cellular biochemistry
New enlightenment of French Paradox: resveratrol’s potential for cancerchemoprevention and anti-cancer therapy.
2007 Cancer biology & therapy
Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human coloncancer cells.
2007 Oncology reports
Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breastcancer cells.
2008 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Resveratrol Induces Notch2-Mediated Apoptosis and Suppression of Neuroendocrine Markers in Medullary Thyroid Cancer.
2010 Annals of surgical oncology
Resveratrol does not ameliorate muscle wasting in different types of cancercachexia models.
2007 Clinical nutrition (Edinburgh, Scotland)
Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breastcancer cells are associated with modulation of phosphorylated Akt and caspase-9.
2006 Applied biochemistry and biotechnology
Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase.
2007 Cancer letters
Bifunctional effect of Resveratrol on the expression of ErbB2 in human breast cancercell.
2006 Cancer letters
Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration.
2003 Life sciences
The cancer preventative agent Resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.
2002 British journal of cancer
Estrogenic effects of Resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2.
2004 The Journal of steroid biochemistry and molecular biology
Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells.
2004 British journal of cancer
Effect of Resveratrol and in combination with 5-FU on murine liver cancer.
2004 World journal of gastroenterology : WJG
Wine and resveratrol: mechanisms of cancer prevention?
2003 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
Endocytosis of Resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells.
2011 Cancer prevention research (Philadelphia, Pa.)
Effect of Resveratrol on cell cycle proteins in murine transplantable liver cancer.
2003 World journal of gastroenterology : WJG
Resveratrol induces growth inhibition and apoptosis in metastatic breast cancercells via de novo ceramide signaling.
2003 The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Effect of Resveratrol on cell cycle proteins in murine transplantable liver cancer.
2003 World journal of gastroenterology : WJG
Resveratrol induces growth inhibition and apoptosis in metastatic breast cancercells via de novo ceramide signaling.
2003 The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines.
2001 The Journal of nutrition
Molecular mechanisms of the chemopreventive effects of Resveratrol and its analogs in colorectal cancer: key role of polyamines?
2004 The Journal of nutrition
Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines.
2002 Clinical cancer research : an official journal of the American Association forcancer Research
Phytoestrogen regulation of a Vitamin D3 receptor promoter and 1,25-dihydroxyvitamin D3 actions in human breast cancer cells.
2003 The Journal of steroid biochemistry and molecular biology
Effect of Resveratrol on growth of 4T1 breast cancer cells in vitro and in vivo.
2002 Biochemical and biophysical research communications
Resveratrol regulates insulin-like growth factor-II in breast cancer cells.
2005 Endocrinology
2,3′,4,4′,5′-Pentamethoxy-trans-stilbene, a Resveratrol derivative, is a potent inducer of apoptosis in colon cancer cells via targeting microtubules.
2009 Biochemical pharmacology
[Effects of garlic oil combined with Resveratrol on inducting of apoptosis and expression of Fas, bcl-2 and bax in human gastric cancer cell line].
2008 Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Inhibition of cell proliferation by a Resveratrol analog in human pancreatic and breast cancer cells.
2009 Experimental & molecular medicine
Involvement of breast cancer resistance protein (BCRP1/ABCG2) in the bioavailability and tissue distribution of trans-resveratrol in knockout mice.
2010 Journal of agricultural and food chemistry
Suppression of prostate cancer growth by Resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model.
2008 Asian Pacific journal of cancer prevention : APJCP
Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth.
2008 Nutrition and cancer
Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells.
2009 Autophagy
Resveratrol induces apoptosis in human SK-HEP-1 hepatic cancer cells.
2009 Cancer genomics & proteomics
Inhibition of aryl hydrocarbon receptor-dependent transcription by Resveratrol or kaempferol is independent of estrogen receptor a expression in human breast cancercells.
2010 Cancer letters
The chemopreventive agent Resveratrol stimulates cyclic AMP-dependent chloride secretion in vitro.
2005 Clinical cancer research : an official journal of the American Association forcancer Research
Resveratrol inhibits glucose metabolism in human ovarian cancer cells.
2007 Gynecologic oncology
Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer.
2007 Molecular pharmacology
Resveratrol and breast cancer chemoprevention: molecular mechanisms.
2005 Molecular nutrition & food research
Resveratrol: a review of preclinical studies for human cancer prevention.
2007 Toxicology and applied pharmacology
Insulin-like growth factor II mediates Resveratrol stimulatory effect on cathepsin D in breast cancer cells.
2006 Growth factors (Chur, Switzerland)
Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.
2010 Journal of agricultural and food chemistry
Effect of Resveratrol on proliferation and telomerase activity of human colon cancercells in vitro.
2006 Journal of experimental & clinical cancer research : CR
Resveratrol–a prostate cancer chemopreventive agent?
2002 Urologic oncology
Analysis of Resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene.
2004 British journal of cancer
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.
2002 Journal of agricultural and food chemistry
Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancermodel.
2007 Cancer letters
Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancercells treated with resveratrol.
2006 The Journal of biological chemistry
Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms.
2007 The Prostate
Concentrations of Resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into cancer and Nutrition (EPIC)-Spain cohort.
2008 The British journal of nutrition
Synthesis of a Resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells.
2005 Journal of medicinal chemistry
trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways.
2007 Genes & nutrition
Colorectal cancer: chemopreventive role of curcumin and resveratrol.
2010 Nutrition and cancer
Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats.
2009 The Prostate
Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol.
2009 Journal of medicinal chemistry
Regulation of cell survival by Resveratrol involves inhibition of NF kappa B-regulated gene expression in prostate cancer cells.
2009 The Prostate
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancercells in vitro and in vivo.
2010 European journal of cancer (Oxford, England : 1990)
Finding more active antioxidants and cancer chemoprevention agents by elongating the conjugated links of resveratrol.
2011 Free radical biology & medicine
Dihydroceramide intracellular increase in response to Resveratrol treatment mediates autophagy in gastric cancer cells.
2009 Cancer letters
Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells.
2010 The Journal of nutrition
Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-kappaB pathway and subsequently downregulating expression of matrix metalloproteinases.
2010 Molecular nutrition & food research
Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells.
2011 Free radical biology & medicine
Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?
2008 Mutation research
Use of Resveratrol to improve the effectiveness of cisplatin and doxorubicin: study in human gynecologic cancer cell lines and in rodent heart.
2006 American journal of obstetrics and gynecology
The cancer chemopreventive agent Resveratrol induces tensin, a cell-matrix adhesion protein with signaling and antitumor activities.
2005 Oncogene
Chronic treatment with Resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells.
2007 The Journal of biological chemistry
Treatment of ovarian cancer cells with nutlin-3 and Resveratrol combination leads to apoptosis via caspase activation.
2011 Journal of medicinal food
Role of Na(+)/H (+) exchanger in resveratrol-induced growth inhibition of human breast cancer cells.
2010 Medical oncology (Northwood, London, England)
Antitumor effect of Resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C.
2003 Carcinogenesis
Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism.
2003 Carcinogenesis
Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha.
2003 International journal of cancer. Journal international du cancer
Phytochemicals Resveratrol and Sulforaphane as Potential Agents for Enhancing the Anti-Tumor Activities of Conventional cancer Therapies.
2011 Current pharmaceutical biotechnology
Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism.
2002 The Journal of clinical endocrinology and metabolism
trans-3,4,5′-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells.
2004 Clinical cancer research : an official journal of the American Association forcancer Research
Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
2006 Proteomics
Non-genomic action of Resveratrol on androgen and oestrogen receptors in prostate cancer: modulation of the phosphoinositide 3-kinase pathway.
2007 British journal of cancer
Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D.
2007 Carcinogenesis
Molecular mechanism of apoptosis induction by resveratrol, a natural cancerchemopreventive agent.
2008 International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells.
2010 The Journal of nutritional biochemistry
Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex.
2010 International journal of cancer. Journal international du cancer
Structure-activity relationships of Resveratrol and derivatives in breast cancer cells.
2009 Molecular nutrition & food research
Design, synthesis, and biological evaluation of Resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer.
2010 Bioorganic & medicinal chemistry
E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancercell growth inhibitory beta-E-nitrostyrenes.
2009 Bioorganic & medicinal chemistry
Differential effect of proIGF-II and IGF-II on Resveratrol induced cell death by regulating survivin cellular localization and mitochondrial depolarization in breastcancer cells.
2007 Growth factors (Chur, Switzerland)
Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway.
2008 Archives of medical research
4′-Chloro-3,5-dihydroxystilbene, a Resveratrol derivative, induces lung cancer cell death.
2010 Acta pharmacologica Sinica
Evaluation of radiotherapy effect in resveratrol-treated medulloblastoma cancerstem-like cells.
2009 Child’s nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection.
2009 British journal of pharmacology
Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a Resveratrol structural modification.
2009 Journal of natural products
Novel Resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells: inhibition of ribonucleotide reductase activity.
2008 Oncology reports
Antitumor effects of KITC, a new Resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells.
2009 Investigational new drugs
Novel Resveratrol derivatives induce apoptosis and cause cell cycle arrest in prostatecancer cell lines.
2007 Anticancer research
The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and Resveratrol in in vitro drug transport models.
2007 Molecular pharmacology
Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells.
2007 Pharmacology
Differential expression of genes induced by Resveratrol in human breast cancer cell lines.
2006 Nutrition and cancer
Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB.
2005 International journal of cancer. Journal international du cancer
Effect of Resveratrol and mixtures of Resveratrol and mitomycin C on cancer cells under irradiation.
2006 Anticancer research
Resveratrol and cancer: a review.
2002 Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
Inhibition of cancer growth by Resveratrol is related to its low bioavailability.
2002 Free radical biology & medicine
Flavonoid effects relevant to cancer.
2002 The Journal of nutrition
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
2002 Pharmacological research : the official journal of the Italian Pharmacological Society
Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines.
2002 The Journal of nutrition
[Mechanisms of Resveratrol bovine serum albumin nanoparticle-induced cell death in human ovarian cancer SKOV3 cells].
2010 Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Inducible COX-2-dependent apoptosis in human ovarian cancer cells.
2011 Carcinogenesis
Regulation of the human vitamin D3 receptor promoter in breast cancer cells is mediated through Sp1 sites.
2005 Molecular and cellular endocrinology
Resveratrol induces SIRT1- and energy-stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment.
2011 Cancer chemotherapy and pharmacology
Chemoprevention in experimental animals.
2011 Annals of the New York Academy of Sciences
Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells.
2007 Clinical cancer research : an official journal of the American Association forcancer Research
Studies on Resveratrol and colon cancer (MANY STUDIES) http://science.naturalnews.com/R/Resveratrol_and_colon_cancer.html
Studies on Resveratrol and ovarian cancer ( MANY STUDIES) http://science.naturalnews.com/R/Resveratrol_and_ovarian_cancer.html
Studies on Resveratrol and Anti-Tumor
-
.2008
Cancer chemotherapy and pharmacology
2011 Cancer immunology, immunotherapy : CII\
2010 European journal of pharmacology
2007 The Journal of biological chemistry
2008 Bioorganic & medicinal chemistry
2011 Current pharmaceutical biotechnology
2005 Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Studies on Resveratrol and Apoptotic
- Resveratrol induces Apoptotic cell death in rat H4IIE hepatoma cells but necrosis in C6 glioma cells.
- 2006 Toxicology
- Resveratrol modifies the expression of Apoptotic regulatory proteins and sensitizes non-Hodgkin’s lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis.
- 2004 Molecular cancer therapeutics
- Resveratrol at high doses acts as an Apoptotic inducer in endothelial cells.
- 2006 Cancer research and treatment : official journal of Korean Cancer Association
- Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against Apoptotic insults to cerebrovascular endothelial cells.
- 2011 Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- Resveratrol-induced Apoptotic death in human U251 glioma cells.
- 2005 Molecular cancer therapeutics
- Protective effects of Resveratrol and quercetin against MPP+ -induced oxidative stress act by modulating markers of Apoptotic death in dopaminergic neurons.
- 2009 Cellular and molecular neurobiology
- Resveratrol disrupts peroxynitrite-triggered mitochondrial Apoptotic pathway: a role for Bcl-2.
- 2008 Apoptosis : an international journal on programmed cell death
- Resveratrol induces apoptosis of human nasopharyngeal carcinoma cells via activation of multiple Apoptotic pathways.
- 2011 Journal of cellular physiology
- Mechanisms of Apoptotic effects induced by resveratrol, dibenzoylmethane, and their analogues on human lung carcinoma cells.
- 2009 Journal of agricultural and food chemistry
- Inhibition of citrinin-induced Apoptotic biochemical signaling in human hepatoma G2 cells by resveratrol.
- 2009 International journal of molecular sciences
- Resveratrol prevents antibody-induced Apoptotic death of retinal cells through upregulation of Sirt1 and Ku70.
- 2008 BMC research notesResveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and Apoptotic insults to mouse cerebrovascular endothelial cells.2010 The Journal of nutritionResveratrol and quercetin, two natural polyphenols, reduce Apoptotic neuronal cell death induced by neuroinflammation.2008 Journal of neuroscience researchComparative analysis of the effects of Resveratrol in two Apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons.2007 NeuroscienceResveratrol Metabolites Do Not Elicit Early Pro-apoptotic Mechanisms in Neuroblastoma Cells.2011 Journal of agricultural and food chemistryResveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells.2007 Oncology reportsNanomolar level of Resveratrol (trans-3,5,4′-trihydroxystilbene) is required, but is not sufficient, to inhibit the growth of human monocytoid tumor cells through an apoptotic-like mechanism.2002 Drugs under experimental and clinical researchAnti-apoptotic effect of trans-resveratrol on paclitaxel-induced apoptosis in the human neuroblastoma SH-SY5Y cell line.2001 Neuroscience letters
SOCS-3 antagonizes pro-apoptotic effects of TRAIL and Resveratrol in prostate cancer cells.
2011 The Prostate
Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes.
2008 Rheumatology (Oxford, England)
Dose-dependency of Resveratrol in providing health benefits.
2010 Dose-response : a publication of International Hormesis Society
The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and Apoptotic activities.
2004 Anticancer research
Resveratrol analog, 3,4,5,4′-tetrahydroxystilbene, differentially induces pro-apoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts.
2001 Carcinogenesis
Antiproliferative and pro-apoptotic activity of novel phenolic derivatives of resveratrol.
2007 Life sciences
Cathepsin L mediates resveratrol-induced autophagy and Apoptotic cell death in cervical cancer cells.
2009 Autophagy
Caspase mediated enhanced Apoptotic action of cyclophosphamide- and resveratrol-treated MCF-7 cells.
2009 Journal of pharmacological sciences
A methoxy derivative of Resveratrol analogue selectively induced activation of the mitochondrial Apoptotic pathway in transformed fibroblasts.
2005 British journal of cancer
Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediated.
2008 Carcinogenesis
Resveratrol engages selective Apoptotic signals in gastric adenocarcinoma cells.
2006 World journal of gastroenterology : WJG
Studies on Resveratrol and Chemotherapeutic
http://science.naturalnews.com/R/Resveratrol_and_Chemopreventive.html
http://science.naturalnews.com/R/Resveratrol_and_Antiproliferative.html
http://science.naturalnews.com/R/Resveratrol_and_Anti-Angiogenic.html
http://science.naturalnews.com/R/Resveratrol_and_Apoptotic.html
Oxindole alkaloids:
Pteropodin, Specrofillin, Hystopteropodin, Uncaria F, Uncaria Tomentosa, Isomitrofillin, etc.
- Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline …
http://www.ncbi.nlm.nih.gov/pubmed/19724995
Sep 1, 2009 – In this study, the pentacyclic oxindole alkaloid mitraphylline was isolated … on human Ewing’s sarcoma MHH-ES-1 and breast cancer MT-3 cell …
- Cat’s Claw Oxindole Alkaloid Isomerization Induced by Cell …
http://www.ncbi.nlm.nih.gov/pubmed/23975868
Aug 23, 2013 – Cat’s Claw Oxindole Alkaloid Isomerization Induced by Cell Incubation and Cytotoxic Activity against T24 and RT4 Human Bladder Cancer Cell …
- Mitraphylline – Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Mitraphylline
„Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing’s sarcoma and breast cancer cell lines” …
- Cat’s Claw – American Cancer Society
Sep 12, 2011 – Thanks to American Cancer Society volunteers, cancer patients receive…. Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline …
- Oxindole alkaloids from Uncaria tomentosa induce apoptosis in onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05907.x/pdf Nov 9, 2005 – increasing survival rates amongst cancer patients. However, mutations …purified oxindole alkaloids, namely isopteropodine (A1), pteropodine …
- cancer | Naturopathy by Savvas Ioannides N.D.
naturalhealingcyprus.wordpress.com/tag/cancer/
Jul 10, 2013 – Posts about cancer written by Naturopathy by Savvas Ioannides. …minimal traces of immune-suppressing tetracyclic oxindole alkaloids (TOAs) …
- Cat’s Claw: A Rainforest Herb Quells Inflammation, Supports … www
.lef.org/magazine/mag2007/mar2007_nu_catsclaw_01.htm
He improved remarkably, and one year later was apparently free of cancer. … of cat’s claw to compounds called oxindole alkaloids;1 more recently, however, …
see this article Cat’s Claw click here
Styryl-lactones :
Altholactone, Goniothalamin,etc
Tannins:
A group of polyhenols; tannins are divided into 2 chemically distinct groups:
1) the condensed tannins (Proanthocyanidin)
2) the hydrolysable tannins (as hydrolysable Ellagitannins, such as Woodfordin C (macrocyclic ellagitannin dimmer), Oenotheietc.
NOTE: Anthocyanins: Peonidine-3-glucoside, Cyanidin-3-glucoside , etc.
see Tannic acid above
Terpenes:
Alisol B acetate, Atractylon, Atractylenolides, Betulinic acid, Bisabolol, Boswellic acid, Carnosic acid,
Ferutidin, Ferutinin, Myristicin, Oleanolic acid, Parthenolide, Pomolic acid, Tymoquinone, …etc…
See Myristicin,above
Vanillys-phenols :
a group of polyhenols; share structural similarities possessing both the vanillyl (4-hydroxy
3-methoxyphenyl) moiety and the ketone functional group in their structure; Paradols, Gingerols, Yakuchinone B,
Curcumin (diferuloyl methane), Capsaicin (homo-vanillic acid derivative : 8 methyl-N-Vanillyl-6-nonenamide),etc.
See Capsaicin,above
Turmeric(cucurmin) : http://science.naturalnews.com/c/curcumin_and_cancer.html ,
- Curcumin induces chemo/radio-sensitization in ovarian cancer cells and Curcuminnanoparticles inhibit ovarian cancer cell growth.
2010 Journal of ovarian research
- Polyethylene glycosylated Curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1.
2009 Molecular pharmacology
- Androgen responsive and refractory prostate cancer cells exhibit distinct Curcuminregulated transcriptome.
2008 Cancer biology & therapy
- Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1.
2008 Cancer research
- Time- and dose-dependent effects of Curcumin on gene expression in human coloncancer cells.
2004 Journal of carcinogenesis
- Involvement of Bcl-2 family members, phosphatidylinositol 3′-kinase/AKT and mitochondrial p53 in Curcumin (diferulolylmethane)-induced apoptosis in prostate cancer.
2007 International journal of oncology
- Chemotherapeutic potential of Curcumin for colorectal cancer.
2002 Current pharmaceutical design
- Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells.
2010 Journal of cellular biochemistry
- Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells.
2010 Cancer letters
- Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner.
2008 Experimental and molecular pathology
- Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF).
2009 Cancer letters
- Wilms’ tumour gene 1 (WT1) as a target in Curcumin treatment of pancreatic cancercells.
2009 European journal of cancer (Oxford, England : 1990)
- Curcumin-induced GADD153 gene up-regulation in human colon cancer cells.
2004 Carcinogenesis
- [DLys(6)]-luteinizing hormone releasing hormone-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo.
2011 International journal of cancer. Journal international du cancer
- Therapeutic potential of Curcumin in prostate cancer–V: Interference with the osteomimetic properties of hormone refractory C4-2B prostate cancer cells.
2004 The Prostate
- Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.
2007 Molecular cancer therapeutics
- Consumption of the putative chemopreventive agent Curcumin by cancer patients: assessment of Curcumin levels in the colorectum and their pharmacodynamic consequences.
2005 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for cancer Research, cosponsored by the American Society of Preventive Oncology
- Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo.
2011 Nanoscale
- Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion.
2008 Cancer prevention research (Philadelphia, Pa.)
- Modulation of the BRCA1 protein and induction of apoptosis in triple negative breastcancer cell lines by the polyphenolic compound curcumin.
2009 Breast cancer : basic and clinical research
- Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells.
2009 Annals of the New York Academy of Sciences
- New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin.
2010 Cancer prevention research (Philadelphia, Pa.)
- Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.
2008 Cancer research
- An evaluation of the anti-neoplastic activity of Curcumin in prostate cancer cell lines.
2009 International braz j urol : official journal of the Brazilian Society of Urology
- Potent growth suppressive activity of Curcumin in human breast cancer cells: Modulation of Wnt/beta-catenin signaling.
2009 Chemico-biological interactions
- Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL.
2005 Carcinogenesis
- Notch-1 down-regulation by Curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells.
2006 Cancer
- Induction of apoptosis by Curcumin and its implications for cancer therapy.
2005 Current cancer drug targets
- Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis.
2004 Carcinogenesis
- Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis.
2004 Carcinogenesis
- Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells.
2004 Cell motility and the cytoskeleton
- [The inhibitory effect of Curcumin on the growth of human colon cancer cells (HT-29, WiDr) in vitro].
2005 The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
- Curcumin for chemoprevention of colon cancer.
2007 Cancer letters
- Expression profiles of apoptotic genes induced by Curcumin in human breast cancerand mammary epithelial cell lines.
2005 Anticancer research
- Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breastcancer cells and inhibits lung metastasis of human breast cancer in nude mice.
2005 Clinical cancer research : an official journal of the American Association forcancer Research
- Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription.
2009 Phytomedicine : international journal of phytotherapy and phytopharmacology
- Fabrication and characterization of silk fibroin-derived Curcumin nanoparticles forcancer therapy.
2009 International journal of nanomedicine
- beta-Cyclodextrin-curcumin self-assembly enhances Curcumin delivery in prostatecancer cells.
2010 Colloids and surfaces. B, Biointerfaces
- Injectable sustained release microparticles of curcumin: a new concept for cancerchemoprevention.
2010 Cancer research
- Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells.
2009 Anti-cancer drugs
- Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells.
2010 Free radical biology & medicine
- Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.
2010 Biochemical pharmacology
- Apoptosis of human lung cancer cells by Curcumin mediated through up-regulation of „growth arrest and DNA damage inducible genes 45 and 153”.
2010 Biological & pharmaceutical bulletin
- Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB in breast cancercells and potentiates the growth inhibitory effect of paclitaxel in a breast cancer nude mice model.
2009 The breast journal
- Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression.
2009 Cancer biology & therapy
- Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy.
2010 Nanomedicine (London, England)
- Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.
2008 International journal of cancer. Journal international du cancer
- Induction of apoptosis in human lung cancer cells by curcumin.
2004 Cancer letters
- Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3.
2004 Oncogene
- Liposomal Curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer.
2007 Molecular cancer therapeutics
- Polymeric nanoparticle-encapsulated Curcumin („nanocurcumin”): a novel strategy for human cancer therapy.
2007 Journal of nanobiotechnology
- Chemosensitization of hormone-refractory prostate cancer cells by Curcumin to TRAIL-induced apoptosis.
2005 Journal of experimental therapeutics & oncology
- Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway.
2007 The Journal of pharmacology and experimental therapeutics
- Curcumin decreases acid sphingomyelinase activity in colon cancer Caco-2 cells.
2007 Planta medica
- Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells.
2006 Toxicology
- Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin.
2006 Molecular cancer therapeutics
- Curcuminoids-cellular uptake by human primary colon cancer cells as quantitated by a sensitive HPLC assay and its relation with the inhibition of proliferation and apoptosis.
2007 Journal of agricultural and food chemistry
- Curcumin inhibits telomerase activity in human cancer cell lines.
2006 International journal of molecular medicine
- Dietary Curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer.
2002 Cancer research
- Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin.
2004 Archives of pharmacal research
- Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R.
2010 Anticancer research
- Effects of Curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.
2008 Cancer letters
- Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression.
2010 International journal of cancer. Journal international du cancer
- Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon cancer Cells; Involvement of Reactive Oxygen Species.
2010 The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
- Liposome encapsulation of Curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice.
2009 International journal of cancer. Journal international du cancer
- Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells.
2009 International journal of molecular medicine
- Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways.
2010 Anticancer research
- Curcumin therapeutic promises and bioavailability in colorectal cancer.
2010 Drugs of today (Barcelona, Spain : 1998)
- Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice.
2009 Carcinogenesis
- Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3.
2006 Anticancer research
- A phase I/II study of gemcitabine-based chemotherapy plus Curcumin for patients with gemcitabine-resistant pancreatic cancer.
2010 Cancer chemotherapy and pharmacology
- Curcumin synergizes with resveratrol to inhibit colon cancer.
2009 Nutrition and cancer
- Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells.
2008 Biomacromolecules
- Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.
2009 Cancer research
- Curcumin as an Anti-Cancer Agent: Review of the Gap between Basic and Clinical Applications.
2009 Current medicinal chemistry
- Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by Curcumin in breast cancer cell lines.
2010 Chemico-biological interactions
- Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovariancancer cells by modulating Akt and p38 MAPK.
2007 Cancer biology & therapy
- Age-related differential responses to curcumin-induced apoptosis during the initiation of colon cancer in rats.
2009 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Curcumin and gemcitabine in patients with advanced pancreatic cancer.
2010 Nutrition and cancer
- Anti cancer effects of curcumin: cycle of life and death.
2008 Cell division
- Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials.
2010 Archiv der Pharmazie
- Curcumin decreases specificity protein expression in bladder cancer cells.
2008 Cancer research
- Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications.
2010 Current medicinal chemistry
- Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma.
2011 Molecular cancer
- Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer.
2009 Annals of the New York Academy of Sciences
- Activation of ATM/Chk1 by Curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells.
2009 British journal of cancer
- Molecular evidences for the chemosensitizing efficacy of liposomal Curcumin in paclitaxel chemotherapy in mouse models of cervical cancer.
2011 Oncogene
- Therapeutic efficacy of curcumin/TRAIL combination regimen for hormone-refractory prostate cancer.
2008 Oncology research
- Evaluation of a nanotechnology-based carrier for delivery of Curcumin in prostatecancer cells.
2008 International journal of oncology
- Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancercells.
2008 Menopause (New York, N.Y.)
- New Curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells.
2009 Cancer science
- Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibitcancer cell invasion through the down-regulation of MMPs and uPA.
2009 The Journal of nutritional biochemistry
- Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.
2004 Molecular cancer therapeutics
- Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells.
2004 Carcinogenesis
- Preparation and characterization of lyophilised EGG PC liposomes incorporatingCurcumin and evaluation of its activity against colorectal cancer cell lines.
2011 Journal of nanoscience and nanotechnology
- Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it.
2004 Carcinogenesis
- Mechanisms of cancer chemoprevention by curcumin.
2001 Proceedings of the National Science Council, Republic of China. Part B, Life sciences
- Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.
2006 Carcinogenesis
- Inhibition of cell survival signal protein kinase B/Akt by Curcumin in human prostatecancer cells.
2003 Journal of cellular biochemistry
- Apoptosis-inducing effects of Curcumin derivatives in human bladder cancer cells.
2006 Anti-cancer drugs
- Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
2007 Cancer research
- The effects of Curcumin on the invasiveness of prostate cancer in vitro and in vivo.
2006 Prostate cancer and prostatic diseases
- Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells.
2006 Carcinogenesis
- Anti-carcinogenic properties of Curcumin on colorectal cancer.
2010 World journal of gastrointestinal oncology
- Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa.
2007 Carcinogenesis
- Growth-inhibitory effects of Curcumin on ovary cancer cells and its mechanisms.
2004 Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
- The combination of epigallocatechin gallate and Curcumin suppresses ER alpha-breast cancer cell growth in vitro and in vivo.
2008 International journal of cancer. Journal international du cancer
- Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cells.
2006 Nutrition and cancer
- Growth inhibition and apoptosis inducing mechanisms of Curcumin on human ovarian cancer cell line A2780.
2006 Chinese journal of integrative medicine
- Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in Curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancercells.
2002 Oncogene
- Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin.
2005 International journal of cancer. Journal international du cancer
- Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines.
2002 International journal of oncology
- Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines.
2002 International journal of oncology
- Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells.
2002 Mutation research
- Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary Curcumin in HT-29 human colon cancer cells.
2001 Cancer letters
- Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by Curcumin is dependent on specificity protein down-regulation.
2010 The Journal of biological chemistry
- Murine prostate cancer inhibition by dietary phytochemicals–curcumin and phenyethylisothiocyanate.
2008 Pharmaceutical research
- Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products.
2008 Clinical cancer research : an official journal of the American Association forcancer Research
- New difluoro Knoevenagel condensates of curcumin, their Schiff bases and copper complexes as proteasome inhibitors and apoptosis inducers in cancer cells.
2009 Pharmaceutical research
- Anti-proliferative potential of Curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway.
2011 International journal of oncology
- Encapsulation of Curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells.
2010 Nanomedicine : nanotechnology, biology, and medicine
- Phase I dose escalation trial of docetaxel plus Curcumin in patients with advanced and metastatic breast cancer.
2010 Cancer biology & therapy
- Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells.
2009 Journal of agricultural and food chemistry
- Elimination of Colon cancer Stem-Like Cells by the Combination of Curcumin and FOLFOX.
2009 Translational oncology
- Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator.
2009 Blood
- Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles.
2010 International journal of pharmaceutics
- Modulatory effects of Curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells.
2010 Cancer chemotherapy and pharmacology
- Proteomics-based approach to elucidate the mechanism of antitumor effect ofCurcumin in cervical cancer.
2009 Prostaglandins, leukotrienes, and essential fatty acids
- Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells.
2011 Molecular and cellular biochemistry
- AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells.
2008 Oncology reports
- The anti-cancer efficacy of Curcumin scrutinized through core signaling pathways in glioblastoma.
2010 International journal of molecular medicine
- New mechanisms and therapeutic potential of Curcumin for colorectal cancer.
2008 Molecular nutrition & food research
- Phase II trial of Curcumin in patients with advanced pancreatic cancer.
2008 Clinical cancer research : an official journal of the American Association forcancer Research
- Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention.
2009 Molecular and cellular biochemistry
- Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells.
2010 European journal of pharmacology
- Determination of minimum effective dose and optimal dosing schedule for liposomalCurcumin in a xenograft human pancreatic cancer model.
2009 Anticancer research
- Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells.
2011 International journal of cancer. Journal international du cancer
- Hypomethylation effects of curcumin, demethoxycurcumin and bisdemethoxycurcumin on WIF-1 promoter in non-small cell lung cancer cell lines.
2011 Molecular medicine reports
- Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancercells by targeting beta-catenin-mediated transactivation and cell-cell adhesion pathways.
2004 Journal of molecular histology
- [Analysis of anti-proliferation of Curcumin on human breast cancer cells and its mechanism].
2003 Zhonghua yi xue za zhi
- Biologic evaluation of Curcumin and structural derivatives in cancerchemoprevention model systems.
2004 Phytochemistry
- Biologic evaluation of Curcumin and structural derivatives in cancerchemoprevention model systems.
2004 Phytochemistry
- Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.
1999 Cancer research
- Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancercells.
2001 Anticancer research
- Antiproliferation and apoptosis induced by Curcumin in human ovarian cancer cells.
2006 Cell biology international
- Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP.
2007 Acta pharmacologica Sinica
- Sensitivity of bladder cancer cells to Curcumin and its derivatives depends on the extracellular matrix.
2007 Anticancer research
- Curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa B /p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions.
2006 Anticancer research
- Cancer chemopreventive effects of curcumin.
2007 Advances in experimental medicine and biology
- Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression.
2005 Cancer letters
- Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells.
2006 International journal of cancer. Journal international du cancer
- Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by Curcumin in human bladder cancer T24 cells.
2006 Oncology reports
- Multiple molecular targets in cancer chemoprevention by curcumin.
2006 The AAPS journal
- Therapeutic potential of Curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancercells in vivo.
2001 The Prostate
- Therapeutic potential of Curcumin in human prostate cancer. II. Curcumin inhibits tyrosine kinase activity of epidermal growth factor receptor and depletes the protein.
2000 Molecular urology
- Curcumin and Liver Cancer: A Review.
2011 Current pharmaceutical biotechnology
- Redox modulation and human bile duct cancer inhibition by curcumin.
2010 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells.
2008 Molecular cancer therapeutics
- Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancercell lines and downregulation of survivin/BIRC5 gene expression.
2010 Cancer investigation
- Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model.
2010 Phytotherapy research : PTR
- [The inhibitory effect of Curcumin on the proliferation of HT-29 colonic cancer cell induced by deoxycholic acid].
2009 Zhonghua nei ke za zhi [Chinese journal of internal medicine]
- Suppression of interleukin 6 and 8 production in head and neck cancer cells withCurcumin via inhibition of Ikappa beta kinase.
2009 Archives of otolaryngology–head & neck surgery
- Synergistic role of Curcumin with current therapeutics in colorectal cancer: minireview.
2009 Nutrition and cancer
- Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells.
2008 Cancer chemotherapy and pharmacology
- Curcumin loaded pH-sensitive nanoparticles for the treatment of colon cancer.
2009 Journal of biomedical nanotechnology
- Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity.
2009 International journal of radiation oncology, biology, physics
- Chemopreventive potential of Curcumin in prostate cancer.
2010 Genes & nutrition
- Modulation of anti-apoptotic and survival pathways by Curcumin as a strategy to induce apoptosis in cancer cells.
2008 Biochemical pharmacology
- Mechanisms for the activity of heterocyclic cyclohexanone Curcumin derivatives in estrogen receptor negative human breast cancer cell lines.
2011 Investigational new drugs
- Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.
2010 Cancer letters
- Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
2009 International journal of cancer. Journal international du cancer
- Difluorinated-Curcumin (CDF): A Novel Curcumin Analog is a Potent Inhibitor of Coloncancer Stem-Like Cells.
2010 Pharmaceutical research
- Targeting breast stem cells with the cancer preventive compounds Curcumin and piperine.
2010 Breast cancer research and treatment
- Multifunctional role of VIP in prostate cancer progression in a xenograft model: suppression by Curcumin and COX-2 inhibitor NS-398.
2009 Peptides
- Prevention and treatment of pancreatic cancer by Curcumin in combination with omega-3 fatty acids.
2008 Nutrition and cancer
- Synthesis, oxidant properties, and antitumoral effects of a heteroleptic palladium(II) complex of Curcumin on human prostate cancer cells.
2009 Journal of medicinal chemistry
- Curcumin: a potential radio-enhancer in head and neck cancer.
2009 The Laryngoscope
- PAC, a novel Curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells.
2010 Breast cancer research and treatment
- Curcumin induces apoptosis-independent death in oesophageal cancer cells.
2009 British journal of cancer
- Novel anti-prostate cancer Curcumin analogues that enhance androgen receptor degradation activity.
2009 Anti-cancer agents in medicinal chemistry
- Curcumin synergizes the growth inhibitory properties of Indian toad (Bufo melanostictus Schneider) skin-derived factor (BM-ANF1) in HCT-116 colon cancer cells.
2009 Anticancer research
- Upregulation of p53 Expression in Patients with Colorectal cancer by Administration of Curcumin.
2011 Cancer investigation
- Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: towards targeting of cancer stem cells with phytochemicals.
2010 Cancer letters
- Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by Curcumin or its analogue CDF.
2010 Cancer research
- Curcumin decreases the expression of Pokemon by suppressing the binding activity of the Sp1 protein in human lung cancer cells.
2010 Molecular biology reports
- Curcumin derivatives: molecular basis of their anti-cancer activity.
2009 Biochemical pharmacology
- Synthesis and biological evaluation of novel Curcumin analogs as anti-cancer and anti-angiogenesis agents.
2004 Bioorganic & medicinal chemistry
- Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancercells via NFkappaB.
2008 Carcinogenesis
- The antitumor activities of Curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis.
2007 International journal of molecular medicine
- Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction.
2002 FEBS letters
- The chemopreventive polyphenol Curcumin prevents hematogenous breast cancermetastases in immunodeficient mice.
2007 Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
- Curcumin mediates ceramide generation via the de novo pathway in colon cancercells.
2006 Carcinogenesis
- Combined inhibitory effects of Curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.
2006 Cancer research
- EF24, a novel synthetic Curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism.
2005 Anti-cancer drugs
- Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases.
2003 FEBS letters
- Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells.
2005 Biochemical and biophysical research communications
- Structure of Curcumin in complex with lipoxygenase and its significance in cancer.
2003 International journal of molecular medicine
- Activation of PPAR{gamma} by Curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR.
2005 American journal of physiology. Gastrointestinal and liver physiology
- Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line.
2002 Cancer letters
- Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis.
2000 Carcinogenesis
- Activation of PPAR{gamma} by Curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR.
2005 American journal of physiology. Gastrointestinal and liver physiology
- The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro.
2000 Anticancer research
- Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
2009 The AAPS journal
- Curcumin potentiates the pro-apoptotic effects of sulindac sulfone in colorectal cancer.
2010 Expert opinion on investigational drugs
- Curcumin in cancer management: recent results of analogue design and clinical studies and desirable future research.
2008 Molecular nutrition & food research
- Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and Curcumin against cancer and cardiovascular diseases.
2009 Current medicinal chemistry
- Curcumin sensitizes lung cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation.
2009 Cancer investigation
- Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by Curcumin is independent.
2010 Molecular cancer
- Anti-breast cancer activity of Curcumin on the human oxidation-resistant cells ZR-75-1 with gamma-glutamyltranspeptidase inhibition.
2010 Journal of experimental therapeutics & oncology
- Celecoxib and Curcumin additively inhibit the growth of colorectal cancer in a rat model.
2006 Digestion
- Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells.
2008 Experimental biology and medicine (Maywood, N.J.)
- Evaluation of Curcumin acetates and amino acid conjugates as proteasome inhibitors.
2010 International journal of molecular medicine
- Colorectal cancer: chemopreventive role of Curcumin and resveratrol.
2010 Nutrition and cancer
- Curcumin reduced the side effects of mitomycin C by inhibiting GRP58-mediated DNA cross-linking in MCF-7 breast cancer xenografts.
2009 Cancer science
- Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for Curcumin delivery to cancer cells.
2008 Acta biomaterialia
- New structural analogues of Curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells.
2009 BMC cancer
- Combined xanthorrhizol-curcumin exhibits synergistic growth inhibitory activity via apoptosis induction in human breast cancer cells MDA-MB-231.
2009 Cancer cell international
- Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent.
2008 Molecular nutrition & food research
- Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells.
2006 Clinical cancer research : an official journal of the American Association forcancer Research
- Celecoxib and Curcumin synergistically inhibit the growth of colorectal cancer cells.
2005 Clinical cancer research : an official journal of the American Association forcancer Research
- Anticarcinogenic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione aCurcumin analog on DMH-induced colon cancer model.
2003 Pharmacological research : the official journal of the Italian Pharmacological Society
- Curcumin impairs tumor suppressor p53 function in colon cancer cells.
2004 Carcinogenesis
- Antitumor agents. 250. Design and synthesis of new Curcumin analogues as potential anti-prostate cancer agents.
2006 Journal of medicinal chemistry
- Curcumin suppresses human papillomavirus oncoproteins, restores p53, Rb, and PTPN13 proteins and inhibits benzo[a]pyrene-induced upregulation of HPV E7.
2011 Molecular carcinogenesis
- Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and Curcumin and implications for chemoprevention of colon cancer.
2000 Cancer research
- A new Curcumin derivative, HBC, interferes with the cell cycle progression of coloncancer cells via antagonization of the Ca2+/calmodulin function.
2004 Chemistry & biology
- Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu.
1999 Clinical cancer research : an official journal of the American Association forcancer Research
- A new Curcumin derivative, HBC, interferes with the cell cycle progression of coloncancer cells via antagonization of the Ca2+/calmodulin function.
2004 Chemistry & biology
- Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention.
2010 The Journal of nutritional biochemistry
- Curcumin: from food spice to cancer prevention.
2009 Asian Pacific journal of cancer prevention : APJCP
- Poly(ß-cyclodextrin)/curcumin self-assembly: a novel approach to improve Curcumindelivery and its therapeutic efficacy in prostate cancer cells.
2010 Macromolecular bioscience
- Chemoprevention of colon cancer by a synthetic Curcumin analog involves amelioration of oxidative stress.
2005 Toxicology mechanisms and methods
- Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.2007 Biochemical pharmacology
- RNA Binding Protein CUGBP2/CELF2 Mediates Curcumin-Induced Mitotic Catastrophe of Pancreatic cancer Cells.
2011 PloS one
- 4-Hydroxy-3-methoxybenzoic acid methyl ester: a Curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management.
2003 Neoplasia (New York, N.Y.)
- [Research of anti-proliferation of Curcumin on A549 human lung cancer cells and its mechanism].
2004 Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Antitumor effects of Curcumin and structurally beta-diketone modified analogs on multidrug resistant cancer cells.
2008 Bioorganic & medicinal chemistry letters
- Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism.
2009 Bioorganic & medicinal chemistry letters
- Metabolism of Curcumin and induction of mitotic catastrophe in human cancer cells.
2008 Molecular nutrition & food research
- Curcumin polymers as anticancer conjugates.
2010 Biomaterials
- Activation of the p38 pathway by a novel monoketone Curcumin analog, EF24, suggests a potential combination strategy.
2010 Biochemical pharmacology
- Anti-cancer and anti-angiogenic effects of Curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice.
2008 World journal of gastroenterology : WJG
- [Anti-proliferative and anti-metastatic effects of Curcumin on oral cancer cells].
2011 Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
- Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancercells: molecular mechanisms of apoptosis, migration and angiogenesis.
2007 Journal of molecular signaling
- Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation.
2002 The Prostate
- Synthesis of Curcumin analogues as potential antioxidant, cancer chemopreventive agents.
2004 Archiv der Pharmazie
- [Curcumin-induced the expression of inhibitor kappaBalpha protein in human prostatecancer cells].
2006 Zhonghua wai ke za zhi [Chinese journal of surgery]
- Synthesis, characterization and biological evaluation of succinate prodrugs of curcuminoids for colon cancer treatment.
2011 Molecules (Basel, Switzerland)
- Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.
2010 Molecular cancer research : MCR
- Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas.
2009 International journal of oncology
- Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
2001 Clinical cancer research : an official journal of the American Association forcancer Research
- Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.
2007 Molecular cancer therapeutics
- Consumption of some polyphenols reduces fecal deoxycholic acid and lithocholic acid, the secondary bile acids of risk factors of colon cancer.
2009 Journal of agricultural and food chemistry
- Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells.
2006 Molecular cancer therapeutics
- http://articles.mercola.com/sites/articles/archive/2011/06/13/this-powerful-herb-to-combat-cancer.aspx
http://science.naturalnews.com/C/Curcumin_and_Anti-Angiogenic.html
http://science.naturalnews.com/C/Curcumin_and_Apoptotic.html
http://science.naturalnews.com/C/Curcumin_and_Antineoplastic.html
http://science.naturalnews.com/C/Curcumin_and_Chemopreventive.html
See also:
Ginger: http://science.naturalnews.com/G/Ginger_and_cancer.html
Cinnamon: http://science.naturalnews.com/C/Cinnamon_and_cancer.html
SPICES – more spices and herbs.plants in the book .
Triterpenoids
Malol, micromerol, urson, prunol, (3b)-3-hydroxyurs-12-en-28-oic acid
Ursolic acid is a is a pentacyclic triterpenoid.
Ursolic acid is present in many plants, including apples, bilberries, cranberries, elder flower, peppermint, lavender, oregano, thyme, hawthorn, prunes.
Ursolic acid has medicinally action, both topically and internally. Ursolic acid is used in many cosmetic preparations for its anti-inflammatory, antitumor and antimicrobial properties.Ursolic acid has antibacterial and antifungal activity. Tests have shown that Ursolic acid inhibits the growth of Candida albicans and Microsporium lenosum.Ursolic acid has anti-inflammatory properties and is used in ointments to treat burns.Topical application of ursolic acid inhibited TPA-induced initiation and promotion of tumor growth.
science.naturalnews.com/U/Ursolic_Acid_and_cancer.html
http://science.naturalnews.com/U/Ursolic_Acid_and_Anti-Inflammatory.html important for preventing inflammation (i.e:used in conjunction with CESIUM treatment)
http://science.naturalnews.com/U/Ursolic_Acid_and_Immune_system.html
http://science.naturalnews.com/U/Ursolic_Acid_and_Anti-Proliferative.html
http://science.naturalnews.com/U/Ursolic_Acid_and_Apoptotic.html
http://science.naturalnews.com/U/Ursolic_Acid_and_Chemotherapeutic.html
Other Phytochemicals
Inositol-phosphate
In plants phytic acid is the principal store of phosphate. Phytic acid is a natural plant antioxidant.
Phytic acid can be found in most grains, seeds and beans. Rich sources of phytic acid are wheat bran and flaxseed (3 % phytic acid).
Health Benefits of Phytic acid
Phytic acid has been considered as an anti-nutritional component in cereals, seeds and beans. Research has traditionally focused on its structure that gives it the ability to bind minerals, proteins and starch, and the resulting lower absorption of these elements. However, resent research have shown that phytic acid has many health benefits. Phytic acid has antioxidant, anticancer, hypocholesterolemic and hypolipidemic effects.
Anticancer effect of phytic acid
In animal studies phytic acid showed a protective action in carcinogenesis. This action could be explained by its mineral chelating potential. Some studies suggest that phytic acid acts as anti-cancer agent by reversing the proliferative effects of carcinogens.
Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.
Journal of Nutrition. 2003 November;133:3778S-3784S.
Phytic acid seems only to affect cancer cells and not normal cells. Phytic acid and inositol improves the effectiveness of chemotherapy. More studies are required to determine optimal dosage, effectiveness and safety of phytic acid.
The biochemical changes associated with phytic Acid on induced breast proliferative lesions in rats: preliminary findings.
Cancer Biology and Therapy. 2006 September;5(9):1129-33
Previous studies shown that phytic acid inhibits or prevents the growth of neoplasms. The aim of this study was to investigate if phytic acid has an effect on tumorigenesis by inducing apoptosis and inhibiting of oxidative stress. The in-vivo test was carried out on rats which were treated with the carcinogen dimethylbenz(a)anthracene (DMBA). The researchers found that the administration of phytic removed the benign proliferative breast changes. Phytic acid significantly decreased trichostatin A and nitric oxide levels and increased apoptosis. The study concluded that the administration of phytic acid reversed the proliferative effects of the carcinogen DMBA, and could have a protective effect.
Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea.
Carcinogenesis. 1997 October;18(10):2023-6
Epidemiological studies show a relation between diet and the incidence of colon cancer. Both phytic acid and phytochemicals in green tea seems to act as anticancer agents and have been linked wit reduced risk of cancer. The aim of this in vivo study with rats was to determine the possible synergistic effect of phytic acid and green tea on the inhibition of colonic preneoplastic lesions formations and the enzyme glutathione S-transferase. The rats were treated with the carcinogen azoxymethane and received different combinations of phytic acid and green tea. The researchers found that green tea alone had only marginal effect whereas phytic acid significantly reduced the incidence of aberrant crypt foci. The combination of phytic acid and green tea showed a significant and synergistic anticancer effect.
Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention.
Biochemical and Biophysical Research Communications. 2001 November 2;288(3):552-7
According to K Midorikawa and colleagues, phytic acid is one of the most promising cancer chemopreventive agents. The aim of this study was the determine the anticancer mechanism of phytic acid. They found that phytic acid inhibited the oxidative damage of hydrogen peroxide, but that phytic acid did not directly scavenge hydrogen peroxide. Phytic acid did not cause damage to DNA. They concluded that phytic acid acts as an antioxidant and anticancer agent by chelating metals.
Antitumor activity of phytic acid (inositol hexaphosphate) in murine transplanted and metastatic fibrosarcoma, a pilot study.
Cancer Letters. 1992 July 31;65(1):9-13
In vivo tests have shown that phytic acid exerts a antitumor effect on experimental colon cancer. The purpose of this study was to determine the antitumor activity of phytic acid on other experimental tumor models, such as murine fibrosarcoma. The researchers found that the intraperitoneal injection of mice with phytic acid reduced the growth of subcutaneously transplanted fibrosarcoma and prolonged survival. Phytic acid could have a potential use in the therapy of cancer.
science.naturalnews.com/P/phytic_acid_and_cancer.html
2008 Acta poloniae pharmaceutica
2008 Acta poloniae pharmaceutica
|
Benificial for diabetic patients
Phytic acid may have health benefits for diabetes patients. It lowers blood glucose response by reducing the rate of starch digestion and slowing the gastric emptying.
Other effects
Phytic acid releases inositol that during digestion. Although inositol is not an essential nutrient it might reduce depressions. Studies also show that phytic acid may reduceinflammation.
Other things:
Melatonin( night sleep between 22 pm – 3am) -VERY IMPORTANT
www.naturalnews.com/033511_melatonin_cancer.html – IMPORTANT article ,
http://articles.mercola.com/sites/articles/archive/2013/03/19/melatonin-benefits.aspx
1. „Melatonin is a potent immune-enhancing hormone produced by the human pineal gland and appears to have substantial cancer-repelling power. In addition to boosting the activity of key immune cells called T helper cells, melatonin stimulates the tumor-killing action of natural killer cells (NK) by increasing the white blood cell production of the cytokine Interleukin-2 (IL-2) [Excerpt from the Definitive Guide to Cancer, by John Diamond, M.D. and Lee Cowden, M.D]
2. „Researchers at Brigham and Women’s Hospital (BWH), led by Eva Schernhammer, MD, DrPH, (Assistant Professor of Medicine at Harvard Medical School) were among the first to report that nightshift workers may have an increased risk of developing breast cancer. Decreased levels of melatonin – a hormone closely linked to sleep patterns – is believed to be a possible cause. Now, in the next phase of this research, Schernhammer reports that lower melatonin levels are associated with a higher risk of breast cancer. The findings are published in the July 20, 2005 issue of the Journal of the National Cancer Institute (JNCI). The hormone melatonin is typically released from the brain during the night. It is the reason people get sleepy. Nightshift workers, exposed to bright light during the evenings, produce less melatonin. Laboratory studies have shown that melatonin production can put tumor cells “to sleep” by stunting growth. A recent report indicated that in constant light, tumors grew seven times faster than they did in the dark. In this study, the researchers measured urinary melatonin in 147 women who developed invasive breast cancer and 291 matched women who did not develop breast cancer. They found that women with the lowest levels of the melatonin metabolite in their urine were 70 percent more likely to develop breast cancer.” [Press Release – Brigham and Women’s Hospital Research Unit]
3. On October 17 2001, the Journal of the National Cancer Institute (Vol. 93, No. 20, pp. 1557-1568) published two papers reporting a significant increase in the risk of breast cancer among women who frequently did not sleep during the period of the night, about 1:30am, when melatonin levels are typically at their highest.
4. Research presented recently at the 94th Annual Meeting of the American Association for Cancer Research in Washington, D.C., shows evidence that the night-time production of the hormone melatonin (produced during deep sleep) inhibits the growth of human breast cancer by blocking the tumor’s uptake of dietary linoleic acid. [Bassett Research Institute – Preclinical Study supported by the National Cancer Institute]
5. Studies at the University of Texas Medical Branch showed that „melatonin significantly increased the latency period of the tumor, by delaying the appearance of the tumor”.
6. According to the University of Maryland Medical Center: „Women with breast cancer and men with prostate cancer tend to have lower levels of melatonin than those without the disease. Low levels of melatonin stimulate the growth of certain types of cancer cells and adding melatonin to these cells inhibits their growth. Meditation appears to be a valuable addition to the treatment of cancer due to a rise in levels of melatonin in the body.”
7. According to the University of Massachusetts Medical Center: „Melatonin has been shown by a number of studies to significantly inhibit breast cancer in animals and tissue culture.” In a separate study performed at the University a higher level of melatonin was found in meditators than in non-meditators.
8. According to the American Cancer Society: „A National Institute of Health panel found evidence that regular meditation can also reduce symptoms of post-traumatic stress syndrome, and increase longevity and quality of life. The same study found that those who meditated had a better immune response than those who did not meditate.”
9. „Melatonin can kill directly many different types of tumour cells. It is a naturally produced cytotoxin, which can induce tumor cell death (apoptosis). In instances where the tumour has already established itself in the body, melatonin has been shown to inhibit the tumour’s growth rate. Melatonin exhibits natural oncostatic activity and inhibits cancer cell growth. In patients in whom cancer has become a noticeable physical burden and produces overt symptoms, melatonin has been shown to alleviate numerous cancer symptoms and to inhibit development of new tumour blood vessels (tumour angiogenesis), which in turn inhibits the cancer from spreading further (mestastasis). Radiation therapy usually induces anemia. Melatonin stimulates platelet production and has been shown to effectively treat cancer patients with low platelet counts and anemia. Melatonin reduces chemotherapy-induced cardiotoxicity, neurotoxicity, thrombocytopenia (reduced platelet counts), stomatitis (inflammation of mouth), and asthenia (weakness), and improves the overall response in cancer patients.” [Clinical Study, The Life Extension Foundation]
10. “Results from a new study in laboratory mice show that night-time exposure to artificial light stimulated the growth of human breast tumors by suppressing the levels of a key hormone called melatonin. The study also showed that extended periods of night-time darkness greatly slowed the growth of these tumors.” [US Department of Health and Human Services – National Institute of Health]
11. „Experienced meditators practicing either TM-Sidihi or another internationally well known form of yoga meditation showed significantly higher melatonin levels in the period following meditation.” [School of Psychology, La Trobe University, Australia]
Hyperthermia:
Scientific Publications
- Bicher, James Haim, MD., Wolfstein, Ralf, M.D. Thermoradiotherapy with curative intent – breast, head and neck and prostate tumors. Deutsche Zeitschrift für Onkologie (German Journal of Oncology) 2006, 38: 116-122.
- Bicher HI, McLaren JR, Pigliucci GM, (eds). Consensus on Hyperthermia for the 1990s.Clinical Practice in Cancer Treatment. Plenum Press, New York and London, 1990.
- Bicher HI, Hetzel FW, Sandhu TS. Physiology and Morphology of Tumor Microcirculation on Hyperthermia. Chapter 9. Ed. K Storm, K Hall Publisher, New York, 1982.
- Bicher HI, Hetzel FW, D’Agostino L, Johnson RJ. Changes in tumor tissue oxygenation induced by microwave hyperthermia. Int J. Radiat Oncol Biol Phys 1977, S2:157.
- Bicher HI, Hetzel FW, Mitagvaria N, O’hara M. Reoxygenation induced by localized microwave hyperthermia as an adjuvant to radiation therapy. 6th International Congress of Radiation Research, 1979, 5:171-175.
- Bicher HI, Hetzel FW, Sandhu TS, Frinak S, Vaupel P, O’Hara MD, O’Brien T. Effects of hyperthermia on normal and tumor microenviroment. Radiology 1980, 137:523530.
- James Haim Bicher, M.D. The physiological effects of hyperthermia. Radiology; 1980:511513.
- Sandhu TS, Bicher HI, Hetzel FW. A thermal dosimetry system with blood flow simulation. Journal of National Cancer Institute, 6:361-363.
- Bicher HI, Sandhu TS, Vaupel P, Hetzel FW. The effect of localized microwave hyperthermia on physiological responses. Journal of National Cancer Institute, 6:375-377.
- Bicher HI, Sandhu TS, Hetzel FW. Inhomogenities in oxygen and pH distributions in tumors. Radiat Res 1980, 83376.
- Hetzel FW, Kaufman N, Brown M, Bicher HI. Indirect sensitization by drug induced reoxygenation in spheroids. Radiat Res 1980, 83:375376.
- Bicher HI, Sandhu TS, Vaupel P, Hetzel FW. Physiological mechanisms of action of localized microwave hyperthermia. Presented at the Third International Symposium on Cancer Therapy by Hyperthermia, Drugs and Radiation. Fort Collins, Colorado, June 1920, 1980.
- Bicher HI, Sandhu TS, Hetzel FW, Matvia F. An effective fractionation protocol for the clinical use of hyperthermia with adjuvant radiation. Presented at the Second Meeting of the European Group on Hyperthermia in Radiation. Rome, Italy, September 1920, 1980.
- Bicher HI, Vaupel P, O’Hara MD, O’Brien T, Mitagvaria N. Tissue oxygenation in normal and hyperthermic conditions. In proceedings of the XXVIIIth International Congress of Physiological Sciences. Budapest, Hungary, July 1318, 1980. Akademial Kiado Publishers: Adv. Physiol Sci. 1981, 25:215233.
- Bicher HI, Hetzel FW, Vaupel P, Sandhu TS. Microcirculation modification by localized microwave hyperthermia and hematoporphyrin phototherapy. Bibl Anat 1981, 20:628632.
- James Haim Bicher, M.D., Nodar Mitagvaria Circulatory responses of malignant tumors during hyperthermia. Microvascular Research 1981, 21:1926.
- Bicher HI, Sandhu TS, Vaupel P, Hetzel FW. Effect of localized microwave hyperthermia on physiological responses. Natl Inst Drug Abuse Res Monogr Ser 1982, 61:217219.
- Vaupel P, Frinak S, MuellerKlieser W, Bicher HI. Impact of localized hyperthermia on the cellular microenvironment in solid tumors. Natl Inst Drug Abuse Res Monogr Ser 1982, 61:207209.
- Bicher HI. Impact of microcirculation and physiologic considerations on clinical hyperthermia. Proceedings 13th International Cancer Congress, 235245, Alan R Liss Inc., New York, 1983.
- Bicher HI, Mitagvaria NP. Changes in tumor tissue oxygenation during microwave hyperthermia clinical relevance. Advances in Experimental Medicine and Biology, 180: 190905, 1985.
- Mitagvaria NP, Bicher HI. Effect of microwave radiation on local blood flow and tissue oxygenation in the brain. Bulletin of Experimental Biology and Medicine, 98:895897, 1984.
- Bicher HI, Shani J, Reesman KJ. Use of non perturbing thermocouples (NPT’s) for hyperthermia clinical thermometry. Int. J. Hyperthermia, 3:550551, 1987. (Abst) and J. Microwave power 22: 173, 1987, (Abst).
- Bicher HI, Wolfstein RS. Local Hyperthermia of tumors at moderate depth using POPAS: Results by site (Abstract). 36th Annual Meeting of the Radiation Research Society, 4:1621, 1988.
- Bicher HI, Shani J, Reesman KJ. Use of nonperturbing thermocouple for clinical hyperthermia thermometry (Abstract). 36th Annual Meeting of the Radiation Research Society, 4:1621, 1988.
- Bicher HI, Wolfstein RS. Treatment of intratoracic lesions. Preliminary results (Abstract). 37th Annual Meeting of the Radiation Research Society. 3:1823, 1989.
- Bicher HI, Reesman KJ, Afuwape SA. A target triapplicator system with nonperturbing thermocouples thermometry. Hyperthermic Oncology 1988, Taylor and Francis, 1:778779, 1989.
- Bicher HI, Mitagvaria, N. Oxygen and pH in Human Tumors During Hyperthermia (Abstract). Proceeding of the 1991 International Society on Oxygen Transport to Tissue Meeting (ISSOT). Willemstad, Curaco, Netherlands Antilles, August 24-30, 1991.
- Mitagvaria, N., Bicher HI. Local Blood Flow and PO2 in Rat’s Brain During Maze Behavior (Abstract). Proceeding of the 1991 International Society on Oxygen Transport to Tissue Meeting (ISSOT). Willemstad, Curaco, Netherlands Antilles, August 24-30, 1991.
- Bicher HI, Wolfstein RS. Transcranial Treatment of Brain Tumors with Microwave Hyperthermia (Abstract). Proceeding of the 8th Annual Conference of the American Society for Clinical Hyperthermic Oncology (ASCHO). Chicago, Illinois, October 31-November 2, 1991.
- Bicher HI, Mitagvaria N. Oxygen and pH in Human Tumors During Hyperthermia (Paper presented as a poster). Proceeding of the 6th International Congress on Hyperthermic Oncology. Tucson, Arizona, April 26- May 1, 1992.
- Surowiec, A. Bicher HI, Caridad, C. A Comparison of Heating Characteristics of Two Hyperthermia Systems Used for Deep Seated Malignancies BSD-2000 and Tripas (Abstract). Proceeding of the 16th International Symposium on Clinical Hyperthermia (ISCHO). Kyoto, Japan, June 13-16, 1993.
- Bicher HI, Yarmonenko S, Wainson A, Swrowiec I, Metagvaria N. Specific inhibition of L-Glucose cell proliferation. Potentiation of Hyperthermia, Radiation and Chemotherapy effects (Abstract). Proceeding of the 10th Annual Meeting of the American Society Of Clinical Hyperthermic Oncology (ASCHO). Memphis, Tennessee; November 28-30, 1993.
- Surowiec, A, Bicher HI, Intercomparison of Heating Patterns of the BSD-2000 and the Tripas System (Abstract). Proceeding of the 14th Annual Meeting of the North American Hyperthermia Society (NAHS), Nashville, Tennessee, April 29- May 4, 1994.
- Bicher HI, Yarmonenko, S. Wainson, A. Surowiec, I. Mitagvaria, N. Anticancer Effect of L-Glucose In-Vivo Potentiation of Hyperthermia (Abstract). Proceeding of the 17th International Symposium on Clinical Hyperthermia (ISCH). Pavia, Italy, May 1-5, 1994.
- Bicher HI MD., Eva H. Barker, Patrick J. Bolan, Lance delabarre, Hellmuth Merkle, Lenore I. Everson, Michael Garwood. In VIVO Monitoring to Treatment for Breast Cancer Using 4T H MRS. Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth street SE, Minneapolis, MN. USA;
- H. Bicher, Mitagvaria, I. Kvachadze , T. Khetsuriani, A. Shukakidze, I. Lazrishvili, M. Arabuli, TS.T. Khomeriki, Main factors in development of local hyperthermia-induced morphological changes in cerebral tissue of the rat In Press, Proceedings of Tbilisi State Medical University.
Resources
Here are part of the extended bibliography and enormous amount of studies that exist about natural substances and their effective effect against cancer( I say part as most of them are cited from NaturalNews website, website I also write for; fpr example, see my article on scientific studies on chemo/radiation: http://blogs.naturalnews.com/should-one-use-conventional-cancer-treatments-chemotheraphy-or-radiation/)
NOTEs:
1.Take your nutrients from ORGANIC WHOLE FOODS rather than supplements
2.The impoverishment of vitamin and pro-vitamin complexes no longer present in food, with the consequent increase in degenerative and deficient diseases such as cancer. The deliberate attempt to deactivate the natural substances contained in the plants is very serious: in this way fresh fruit and vegetables – greatly impoverished of many vitamins – can be carried over long distances and long periods of time because their oxidation does not take place.This vitamin impoverishment will ensure commercial
profits and represents a serious act of deliberate damage inflicted on the Ecosystem by means of GMOs.
It’s heavy the possible disappearance of anti-cancer vitamins, that induce apoptosis (suicide) of the
tumors (Anthocyanin, Flavonoids (1122), Polyphenols (1123), sesquiterpene lactone Parthenolide (701), penta-acetyl
Geniposide (1061), Camelliin B (698), beta-Cryptoxantin (1063), Hesperidin (1063), Emodin (247,333,715), ursolic acid (700),
allyl Sulfur (694,696), Eriodictoyol (693), hibiscus protocatechin acid (692), Indoles (809), Isothiocyanates (809), Resverarol
(695), Elemene (690), Acutiaporberine (711), Capsaicin (719), Wagonin (713), Fisetin (713), carnosic acid (1062), Germanium
sesquioxide (269), epigallocatechin Gallate (173,1124), Axerophthol palmitate, alpha and beta Carotene, trans-Retinoic acid,
Tocopherols, Limonene (693), Cynaropicrin, Lycopene (633,1359), Proanthocyanidin, Damnacanthal (1043), Baicalin (718),
Baicalein (718), hydrocinnamic acid (693), sesquiterpenoids as Atractylon (704), as Atractylenolides I, II, III (704),
gelsemium alkaloids (699), tartary buckwheat flavonoid (1064), Sinigrin, ferulic acid, ellagic acid, cumarinic acid, …)
SEE: http://www.erbeofficinali/dati/nacci/allpdf.php
The disappearance of these natural anti-cancer vitamins is a grave threat.
See also a FREE EBOOK detailing Thousand Plants against Cancer without Chemo-Therapy ,May 2010 ,650 pages
EVIDENCE BASED MEDICINE: 2,050 official scientific publications ,2,100 various bibliographical references BONUS in my book, next to other 4 free ebooks(Dr. W .Kelley Dr. Binzel, Dr. Matias Rath , Johanna Brandt. )
In this book the plants are identified by their Latin names – according to the modern scientific classification (see Chapter 20)
– and 2,050 official scientific publications are quoted (out of 2,100 various bibliographical references (see Chapter 21), useful to in depth studies, which confirm the various arguments indicated there.
SPUNE SI ALTORA (click pe butoane):