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oct.2

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Hydroxycinnamic Acids

Dicaffeoyl-tartaric acid

Chicoric acid is a caffeic acid derivative, belonging to the group of polypfenols.
science.naturalnews.com/C/Caffeic_Acid_and_cancer.html

http://science.naturalnews.com/C/Caffeic_Acid_and_Anticarcinogenic.html

http://science.naturalnews.com/C/Caffeic_Acid_and_Chemotherapeutic.html

http://science.naturalnews.com/C/Caffeic_Acid_and_Anti-Angiogenic.html

Chicoric acid is the most active compound in Echinacea pupurea. Chicoric acid is very stable in dry conditions but can be broken down by enzymes, which are found in the Echinacea, in moist conditions.

  • DistributionChicoric is only found in Echinacea purpurea.Health Benefits of Chicoric acidChicoric acid makes our immune cells more efficient in attacking intruders. In vivo en vitro studies have shown that chicoric acid promotes phagocytosis. This is the process whereby white blood cells and lymphocytes attack and destroy pathogens. Chicoric acid stimulates T-cell activation, stimulates healing of wounds and reduces the inflammation in arthritis. Chicoric acid increases the production of interferon, immunoglobulin and other chemicals important for the immune system.Studies have indicated that chicoric acid can inhibit the penetration of viruses in cells.Chicoric acid also acts as an antioxidant by preventing the oxidation of collagen and cells.

1,2-Benzopyrone, 2H-1-Benzopyran-2-one

Coumarin is a phytochemical with a vanilla like flavour. Coumarin is a oxygen heterocycle. Coumarin can occur either free or combined with the sugar glucose (coumarin glycoside).

Distribution

Coumarin is found in several plants, including tonka beans, lavender, licorice, strawberries, apricots, cherries, cinnamon, and sweet clover. 

Health Benefits of Coumarin

Coumarin has blood-thinning, anti-fungicidal and anti-tumor activities.

science.naturalnews.com/C/Coumarin_and_cancer.html

http://science.naturalnews.com/C/Coumarin_and_Antimitotic.html

http://science.naturalnews.com/C/Coumarin_and_Antiproliferative.html

http://science.naturalnews.com/C/Coumarin_and_Apoptotic.html

Coumarin should not be taken while using anticoagulants. Coumarin increases the blood flow in the veins and decreases capillary permeability. Coumarin can be toxic when used at high doses for a long period

Facts about Coumarin

Coumarin seems to work as a pesticide in the plants that produce it. Coumarin is responsible for the sweet smell of new mown hay.

 

4-hydroxy-3-methoxycinnamic acid

Pure ferulic acid is a yellowish powder. Ferulic acid belong to the family of hydroxycinnamic acid. The chemical structure of ferulic acid is very similar to that of curcumin.

The phytochemical ferulic acid is found in the leaves and seeds of many plants, but especially in cereals such as brown rice, whole wheat and oats. Ferulic acid is also present in coffee, apple, artichoke, peanut, orange and pineapple.

Health Benefits of Ferulic acid

Ferulic acid is an antioxidant which neutralizes free radicals (superoxide, nitric oxide and hydroxyl radical) which could cause oxidative damage of cell membranes and DNA. Ferulic acid helps to prevent damage to our cells caused by ultraviolet light. Exposure to ultraviolet light actually increases the antioxidant potency of ferulic acid.

science.naturalnews.com/…/88169_Protective_effects_of_a_topical_ antioxidant_mixture_containing_vitamin_C.html
… ferulic acid, and phloretin against ultraviolet induced photodamage in human skin. …and chronic reactions, including premature skin aging and skin cancer.
science.naturalnews.com/…/2559062_Protective_effect_of_ferulic_acid_on_ nicotine_induced_DNA_damage.html
Protective effect of ferulic acid on nicotine induced DNA damage and cellular … smoke and plays an important etiological role in the development of lung cancer.
science.naturalnews.com/F/Ferulic_acid_and_Inflammatory.html
FA15, a hydrophobic derivative of ferulic acid, suppresses Inflammatory responses and skin tumor promotion: comparison with ferulic acid. 2002 Cancer letters
science.naturalnews.com/…/875229_Ferulic_acid_augments_angiogenesis_ via_VEGF_PDGF_and_HIF_1.html
Ferulic acid augments angiogenesis via VEGF, PDGF and HIF 1 alpha. … broad range of therapeutic effects on human diseases, including diabetes and cancer.
science.naturalnews.com/…/1973049_Actions_of_ferulic_acid_and_vitamin_ E_on_prevention_of.html
Actions of ferulic acid and vitamin E on prevention of hypercholesterolemia and atherogenic lesion … Vitamin D is nutritional key for prevention of breast cancer.
science.naturalnews.com/…/2144597_Protective_effect_of_ferulic_acid_on_ 712_dimethylbenzaanthracene_induced_skin.html
Protective effect of ferulic acid on 7,12 dimethylbenz[a]anthracene induced skin carcinogenesis in Swiss … List of Cancer-Causing Agents Grows (press release).

Ferulic acid is often added as ingredient of anti-aging supplements. Studies have shown that ferulic acid can decrease blood glucose levels and can be of help to diabetes patients.Ferulic acid seems to protect against cancer, bone degeneration, menopausal symptoms (hot flushes). Like many other antioxidants, ferulic acid reduces the level of cholesterol and triglyceride, thereby reducing the risk of hearth disease. Ferulic acid seems to reduce the risk of many cancers, including cancer of the stomach, colon, breast, prostate, liver, lung and tongue. A study by W Kuenzig et all Caffeic and ferulic acid as blockers of nitrosamine formation published in Carcinogenesis (Vol 5, 1984) showed that dietary caffeic acid and ferulic acid may play a role in the body’s defence against carcinogenesis by inhibiting the formation of N- nitroso compounds.

Ferulic acid can be converted into the flavour vanillin by biochemical reaction.

Isoprenoides :

Abscisic acid, Acorenone, Alloaromadendrene, Aromadendrene, Bergamotene, Bisabolene,Borneol, Bornyl acetate, Isoborneol, Cadinene, Camphene, Caranol, Carene, Carvacrol, Carvone,Pinocarvone, Caryophyllene, Cedrine, Cineole, Cinnamaldehyde, Cinnamate, Citral,Cinnamaldehyde, Cyclocitral, Citronella, Citronellyl acetate or butyrate or propionate, Copaene, Cresol, Cubebene, Cymene, Damascenone,Elemene, Estragol, Eugenol, Farnesene, Fencone, Geraniol, Germacrene, Hotrienol, Humulene, Ionol, Ionone, Isopinocamphone, Isopulegol, Linalool, Longifolene, Mentol, Neomenthol, Menthone, Isomenthone, Murolene, Myrcenol, Myrcene, Myrtenol, Neral, Nerol, Nerolidol, Nootkatone, Ocimene, Ocimenol, Perillaldehyde, Phellandrene, Pinene, Pinocamphone, Piperitol,Piperitone, Pristane, Pulegone, Sabinene, Sabinol, Santalol, Selinadiene, Selinene, Sinensal, Styrene, Terpinene, Terpineol, Terpinolene, Thymol, Tricyclene, Vanillin, Valencene, Verbenone, Vitispirane, etc.

  • Cinnamaldehyde

Sources:Cinnamon

science.naturalnews.com/…/188629_Allyl_isothiocyanates_and_ cinnamaldehyde_potentiate_miniature_excitatory_postsynaptic_inp…
… Cancer Pathophysiology Division, National Cancer Center Reseach Institute, … Allyl Isothiocyanates (AITC) and cinnamaldehyde are pungent compounds …
science.naturalnews.com/…/1769088_Growth_inhibition_of_human_colon_ cancer_cells_by_plant_compounds.html
CONCLUSION : Cinnamaldehyde, piperine, and resveratrol offer significant in vitro anti-proliferative effects on cultured human colon cancer cells. While each …
science.naturalnews.com/…/1499711_Coumarin_and_cinnamaldehyde_in_ cinnamon_marketed_in_Italy_a_natural.html
Coumarin and cinnamaldehyde in cinnamon marketed in Italy: a natural … The Cure in the Kitchen: Honey and Cinnamon can Cure Cancer and Arthritis.

  • Elemene

Sources: (Curcuma zedoaria and another plants)

A significant effect on the treatment of glioma was reported using Elemene which is found in small

amounts in many essential oils: it prolonged quality survival time of 40 patients with glioma (1574)

(Tan P.: Clinical study on treatment of 40 cases of malignant brain tumor by Elemene emulsion injection, Chin. J.

Integ. Trad. Western Med, 20, pp.: 645-648, 2000) http://www.mednat.org/cancro/cancro_cervello.pdf

OBJECTIVE: To investigate the effect of elemene emulsion injection (EEI) in treating malignant brain tumor.

METHODS: By conducting a retrospective study of 40 patients with brain tumor, 29 of malignant glioma and 11 metastatic tumor, who were treated with EEI from January 1994 to May 1998. EEI 0.4-1.2 g/d was given to each patient by intravenous dripping or/and intravenous infusion by pumps, and directly injected into carotid artery or infused through a carotid artery catheter with pumps. The total dosage of 6-12 g was given in 2-6 therapeutic courses with an interval of 1-1.5 months between courses. The effectiveness of treatment was accessed according to the changes of tumor size, Karnofsky Performance Status (KPS) and survival time of patients. The control group consisted of 29 cases of malignant brain tumor (22 of primary and 7 of metastatic) was treated with chemotherapy 2-3 therapeutic courses with an interval of 1-1.5 months between them.

RESULTS:

(1) In the EEI treated group the mean tumor size was changed from 6.70 cm3 (before treatment) to 2.67 cm3 (after treatment), t = 3.02, P < 0.01, it was reduced by 61%;

(2) In the EEI treated group 4 cases was CR, 26 PR, the total effective rate being 75.0% (95% credibility interval +/- 13.4%), while in the control group, 2 of CR, 10 PR, and the total effective rate 41.4% (95% credibility interval +/- 17.9%), the difference between the two groups was significant, chi 2 = 3.867, P < 0.05;

(3) KPS decreased in the EEI group from 94.7 scores (before treatment) to 88.2 scores (after treatment), the decrement was 6.5 scores (t = 3.5313, P < 0.01); (4) The survival time in the EEI treated group was 25.4 months, and that in the control group was 17.4 months (t = 3.74, P < 0.01).

CONCLUSION: Elemene has significant effect on treatment of malignant brain tumor. It could prolong the high quality survival time of patients and is worthy of further investigation.

Elemene , induced apoptosis in leukaemia (1409).

Dă clic pentru a accesa elemene_zedoaria_provoca_apoptosi_nella_leucemia.pdf

  • Eugenol
science.naturalnews.com/E/Eugenol_and_cancer.html
science.naturalnews.com/E/Eugenol_and_Apoptotic.html
2007 Molecular cancer. Pro-apoptotic effect of the landrace Bangla Mahoba of Piper betle on Leishmania donovani may be due to the high content of eugenol.

  • Limonene(see below)

Lecithins :

science.naturalnews.com/L/Lecithin_and_cancer.html
science.naturalnews.com/…/2237506_Oral_carcinogenesis_induced_by_4_ nitroquinoline_1_oxide_in_lecithinretinol.html
Oral carcinogenesis induced by 4 nitroquinoline 1 oxide in lecithin:retinol … induced a higher incidence of oral cancer in LRAT knockout (LRAT(-/-)) than in …

Lignans

  1. How lignans fight cancer? – NutraPro Internationalnutraprointl.com/2009/12/25/how-lignans-fight-cancer/‎ Lignans are being studied for possible use in cancer prevention, particularly breast cancer. Lignans acts as anticancer compounds by blocking …
  2. Breast Cancer Survival and Lignan Intake | NutritionFacts.org

    nutritionfacts.org › Videos‎

    One teaspoon of flax seeds may double one’s daily production of lignans, phytonutrients that appear to play a role in both breast cancer prevention and survival.

  3. Lignans – Linus Pauling Institute at Oregon State Universitylpi.oregonstate.edu/infocenter/phytochemicals/lignans/‎Lignan-rich foods are part of a healthful dietary pattern, but the role of lignans in the prevention of hormone-associated cancers, osteoporosis …
  4. PUBMED Dietary lignans: potential role in cancer prevention.http://www.ncbi.nlm.nih.gov/pubmed/15860433‎Dietary lignans: potential role in cancer prevention. Webb AL, McCullough ML. Graduate Program in Nutrition and Health …
  5. Dietary intakes of total and specific lignans are associated with …http://www.ncbi.nlm.nih.gov/pubmed/22113872‎ – Dietary lignans may affect breast cancer by modifying tumor characteristics likely to affect prognosis. We investigated usual dietary intakes of …
  6. Fighting breast cancer with flaxseeds : Disease Proofhttp://www.diseaseproof.com › Breast Cancer‎- Anti-cancer effects of lignans. Enterolignans are structurally similar to estrogen and can bind to estrogen receptors – this capability allows …
  7. Higher lignan levels improve breast cancer survival – Life Extension …http://www.lef.org/…/0920_Higher-Lignan-Levels-Improve-Breast-Cancer-Sur…‎ In an article published online on September 6, 2011 in the Journal of Clinical Oncology, German researchers report that having high serum …
  8. Dietary Lignan Intake and Postmenopausal Breast Cancer Risk by …

    jnci.oxfordjournals.org/content/99/6/475‎ Studies conducted in Asian populations have suggested that high consumption of soy-based foods that are rich in isoflavone phytoestrogens is …

science.naturalnews.com/…/2632135_Estrogenic_activities_of_sesame_ lignans_and_their_metabolites_on_human.html
Estrogenic activities of sesame lignans and their metabolites on human breast cancercells. Publication: Journal of agricultural and food chemistry. Publication …
science.naturalnews.com/…/2602942_Cytostatic_inhibition_of_cancer_cell_ growth_by_lignan_secoisolariciresinol_diglucoside.html
Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside.
science.naturalnews.com/…/1558789_Spirocyclic_Lignans_from_Guaiacum_ Zygophyllaceae_Induce_Apoptosis_in_Human_Breast.html
Spirocyclic Lignans from Guaiacum (Zygophyllaceae) Induce Apoptosis in Human BreastCancer Cell Lines. Publication: Journal of natural products. Publication …
science.naturalnews.com/…/1311157_Extraction_of_lignans_from_flaxseed_ and_evaluation_of_their_biological.html
Our results show that lignans modulate development of breast cancer cells. The most intense effect was observed for anhydrosecoisolariciresinol, which …
science.naturalnews.com/…/1478913_Vitexins_nature_derived_lignan_ compounds_induce_apoptosis_and_suppress_tumor.html
Vitexins, nature derived lignan compounds, induce apoptosis and suppress tumor growth. Publication: Clinical cancer research : an official journal of the …
science.naturalnews.com/…/2157407_Inhibition_of_Akt_signaling_by_the_ lignan_matairesinol_sensitizes_prostate.html
Dietary lignans have shown cancer preventive and antitumorigenic activity, but the mechanisms behind these effects are poorly known. Here we observed that of  …
science.naturalnews.com/…/1938497_The_effects_of_different_lignans_and _isoflavones_tested_as_aglycones.html
PURPOSE: Phytooestrogens are known to cause anti-cancer effects on mamma carcinoma cells. In this study, the effects of the lignan Secoisolariciresinol and …
science.naturalnews.com/…/2445678_Enterolactone_and_breast_cancer_ methodological_issues_may_contribute_to_conflicting.html
Enterolactone and breast cancer: methodological issues may contribute to conflicting …Lignans found in plant foods are converted by the intestinal microflora to …

Lignans sources

Flaxseeds 1 oz
85.5
Sesame seeds 1 oz
11.2
Curly kale ½ cup, chopped
0.8
Broccoli ½ cup, chopped
0.6
Apricots ½ cup, sliced
0.4
Cabbage ½ cup, chopped
0.3
Brussels sprouts ½ cup, chopped
0.3
Strawberries ½ cup
0.2
Tofu ¼ block (4 oz)
0.2
Dark rye bread 1 slice
0.1

  • Silymarin

science.naturalnews.com/S/Silymarin_and_cancer.html
science.naturalnews.com/S/Silymarin_and_prostate_cancer.html
Identifying the differential effects of Silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. 2008 International …

SOURCES :Milk thistle

See this article on milk Thistle click here

Monophenols

Hydroxytyrosol is believed to be the antioxidant with the highest free radical scavenging capacity: double that of quercetin and more than 3 times that of epicatechin.
Hydroxytyrosol is the main polyphenol found in olives.

The wastewaters generated during olive processing contain a high levels hydroxytyrosol, most of which can be recovered to produce hidroxytyrosol extracts. Studies by Visioli et al (2000) showed that a low dose of hydroxytyrosol reduces the consequences of sidestream smoke-induced oxidative stress in rats.

Health Benefits of Hydroxytyrosol

Hydroxytyrosol has the same health promoting properties than other polyphenols: prevention of atherosclerosis, promotion of intestinal and respiratory health and prevention of cancer. Hydroxytyrosol also reduces the oxidative stress caused by smoking.

Abstracts

Benefits of Hydroxytyrosol

In Vivo Studies about Antioxidant Properties of Hydroxytyrosol

In Vitro Studies about Antioxidant Properties of Hydroxytyrosol

Cancer and Hydroxystyrosol

Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.European Journal of Cancer Prevention. 2002 August;11(4):351-8Epidemiologic studies and animal studies show that olive oil may reduce the risk of several diseases such as cancer and heart disease. The aim of this study was to determine the effect of the main polyphenol in virgin olive oil, hydroxytyrosol, on tumor growth. The in vitro test were carried out in human colon cancer and leukemia cell lines. They found that hydroxytyrosol inhibited proliferation of both cancer cell lines. human promyelocytic leukaemia cells HL60 and colon adenocarcinoma cells HT29 and HT29 clone 19A. Hydroxytyrosol induced cell apoptosis and reduced cancer cell proliferation was reduced up to 50 percent. Hydroxytyrosol caused no such effects on non-cancer human cells, such as lymphocytes and polymorphonuclear cells. The study concluded that hydroxytyrosol may protect against cancer by arresting cell cycle and inducing apoptosis in cancer cells.
Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. Biochemical and Biophysical Research Communications. 2000 November 30;278(3):733-9Hydroxytyrosol is a natural phenolic antioxidant found in olive oil. It has many claimed biological and pharmacological activities. The aim of this study was to investigate the effect of hydroxytyrosol on the proliferation and survival of a leukemia cell line. The researchers found that hydroxytyrosol caused a complete arrest of leukemia cell proliferation and even induced apoptosis. This apoptotic effect was not observed with tyrosol, suggesting that presence of two ortho-hydroxyl groups is required. The study concluded that hydroxytyrosol reduces the immunological response, resulting in antinflammatory and chemopreventive effects.
science.naturalnews.com/…/2378205_Oleuropein_and_hydroxytyrosol_ inhibit_MCF_7_breast_cancer_cell_proliferation.html
Oleuropein and hydroxytyrosol inhibit MCF 7 breast cancer cell proliferation interfering with ERK1 2 activation.
science.naturalnews.com/…/606773_Anti_proliferative_and_apoptotic_ effects_of_oleuropein_and_hydroxytyrosol_on.html
In this study, oleuropein and hydroxytyrosol, major phenolic compound of olive oil, was studied for its effects on growth in MCF-7 human breast cancer cells …
science.naturalnews.com/Hydroxytyrosol.html
Aug 15, 2013 … The Journal of nutritional biochemistry. Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancerMCF-7 …
science.naturalnews.com/…/2577390_Hydroxytyrosol_inhibits_growth_and_ cell_proliferation_and_promotes_high_expression.html
The aim of this study was to investigate, for the first time in an animal model of experimental mammary carcinoma, the anti-cancer ability of Hydroxytyrosoland to …
science.naturalnews.com/…/2561646_Synthesis_of_a_novel_ester_of_ hydroxytyrosol_and_a_lipoic.html
Synthesis of a novel ester of hydroxytyrosol and a lipoic acid exhibiting an antiproliferative effect on human colon cancer HT 29 cells.
science.naturalnews.com/…/945006_Hydroxytyrosol_from_laboratory_ investigations_to_future_clinical_trials.html
Hydroxytyrosol: from laboratory investigations to future clinical trials. … lower rates of mortality from Cardiovascular disease and cancer than Northern European …
science.naturalnews.com/…/1518292_Hydroxytyrosol_inhibits_the_ proliferation_of_human_colon_adenocarcinoma_cells_through.htm…
Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells … many pathological processes, including the development of colon cancer.
science.naturalnews.com/Hydroxytyrosol_2.html
Aug 15, 2013 … Hydroxytyrosol studies. … Neuroprotective effect ofhydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected …breast cancer (27)
science.naturalnews.com/…/1150773_A_concise_synthesis_of_glucuronide_ metabolites_of_urolithin_B_resveratrol.html
Finally, three O-beta-D-glucuronides of hydroxytyrosol 6, 7, and 8 have been … Has Anti-aging and Anti-Cancer Properties, Linked to Cardiovascular Health.
science.naturalnews.com/…/1423703_Protective_effect_of_hydroxytyrosol_ and_tyrosol_against_oxidative_stress_in.html
Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells. …New Study Finds Olive Oil Effective against HER-2 Breast Cancer.
science.naturalnews.com/…/2501663_Effect_of_the_olive_oil_phenol_ hydroxytyrosol_on_human_hepatoma.html
Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection … New Study Finds Olive Oil Effective against HER-2 Breast Cancer.

Influence of Hydroxystyrol on Heart Disease

Monoterpenes

Lemonol, beta-Geraniol, trans-3,7-Dimethyl-2,6-octadien-1-ol

Geraniol is acyclic monoterpene-alcohol. Pure geraniol is a colourless oily liquid, with a sweet rose-like scent. When oxidized, geraniol becomes geranial or citral.

Bergamot, carrot, coriander, lavender, lemon, lime, nutmeg, orange, rose, blueberry and blackberry.

Health Benefits of Geraniol

Geraniol is a natural antioxidant. Geraniol has been suggested to help prevent cancer. Carnesecchi S. et al demonstrated in his study „Geraniol, a component of Plant Essential Oils, Inhibits Grwoth and Polyamine Biosyntehsis in Human Colon Cancer Cells”, (Pharmacology, July 2001) that geraniol caused a 50% increase of ornithine decarboxylase activity, which is enhances during cancer growth. Geraniol inhibits DNA synthesis.

Burk YD concluded in his study „Inhibition of Pancreatic Cancer Growth by the dietary isoprenoids farnesol and geraniol” (Lipids, February 1997) that geraniol, farnesol and perilll alcohol suppress pancreatic tumor growth.

Other animal studies have also demonstrated the anticancer effects of geraniol.

science.naturalnews.com/…/287047_Geraniol_inhibits_prostate_cancer_ growth_by_targeting_cell_cycle_and.html
Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways.
science.naturalnews.com/G/Geraniol_and_cancer.html

Methyl-4-isopropenyl cyclohexene, Cajaputene, Carvene, Cinene, Dipentene, Efchole

Pure limonene is a clear liquid. Limonene is a monoterpene, made up of two isoprene units. Limonene occurs in two optically active forms, l-limonene and d-limonen. Both isomers have different odours: l-limonene smells piney and turpentine like and d-limonene has a pleasing orange scent.

Limonene is found in the essential oils of citrus fruits and many other plant species.

Limonene, found in lemons (Citrus limonum), oranges (Citrus aurantium), juniper (Juniperus communis) Foeniculum vulgare, Mentha pulegium, Mentha spicata, Verbena officinalis, Hyssopus officinalis, and in sage (Salvia officinalis), induces  apatosis in leukaemia cells (693).

Health Benefits of Limonene

Studies have shown that limonene have anti- cancer effects.

Limonen increase the levels of liver enzymes involved in detoxifying carcinogens. The Glutathione S-transferase (GST) is a system which eliminates carcinogens. Limonene seems to promote the GST system in the liver and small bowel, thereby decreasing the damaging effects of carcinogens. Animal studies demonstrated that dietary limonene reduced mammary tumor growth.

Limonene induces the formation of apoptotic bodies on BCG-823 gastric cancer cells in a dose-and time –dependent manner (1565) and induced significant reductions of hepatocellular carcinomas (1566).

Limonene showed anti-angiogenic and pro-apoptotic effects on human gastric cancer implanted in nude mice, thus inhibiting tumor growth and metastasis (1577).

At least 6-7 lemons a day should be taken, possibly fresh, because lemons help eliminate the acid wastes from the body, increasing the reserves of alkaline substances in the blood and helping the urinary apparatus to expel uric acids. One lemon a day should be taken in the first week, to reach 7 lemons a day by the seventh week of the treatment; this should be continued this throughout the illness until the hoped-for cure. The honey from lemon flowers is currently under evaluation.

The essential oil of Citrus limonum is extremely nutritious both for its K-cals and for the phytochemicals found in it. N.B. the pressing of the oil must be done cold and without solvents.

Industrial limonene is produced by by alkali extraction of citrus residues and steam distillation. This distillate contains more than 90% d-limonene.

for studies cited above SEE LAST PAGE of DATABASE

Organosulfides

Allicin is an unstable compound that is strongly antibacterial and mainly responsible for garlic’s characteristic odor.

In vitro studies show that allicin inhibits the invasion and metastasis of human colon carcinoma cells. The phytochemical also exhibits antigenotoxic action. But the anticancer effect of allicin in humans remains uncertain, because of its low stability and poor bioavailability.

A study conducted at the Nanjing Medical University, China, concluded that allicininhibited the invasion and metastasis of human colon carcinoma cells in vitro at non-cytotoxic concentration through down-regulating the expression of vascular endothelial growth factor (VEGF), urokinase receptor (uPAR) and heparanase mRNA [1]. The researchers tested the effect of allicin on invasion and metastasis of human colon cancer cell line LoVo in vitro by using migratory test, adhesion test and Transwell chamber experiment. Allicin showed an inhibitive effects on growth of the cells in a dose and time-dependent manner. The phytochemicals suppressed the movement, adhesion and invasive capability of carcinoma cells.

A study by the Weizmann Institute of Science, Israel, demonstrated the antiproliferative function of allicin on two leukemia cell lines (HL60 and U937) [2]. They found that allicin showed anticancer effect by inducing growth inhibition, apoptotic events such as blebbing, mitochondrial membrane depolarization, cytochrome c release into the cytosol, activation of caspase 9 and caspase 3 and DNA fragmentation. Allicin reduced glutathione in the cytosol and mitochondria and changed the intracellular redox status.

Siddique and Afzal of the Aligarh Muslim University, India, investigated the antigenotoxic potential of allicin in cultured human lymphocytes using chromosomal aberrations and sister chromatid exchanges induced by the genotoxic methyl methanesulphonate [3]. They found that allicin treatment reduced the damage caused by the genotoxin, as illustrated by lower levels of chromosomal aberrations and sister chromatid exchanges.

[1] Effects of allicin on invasion and metastasis of colon cancer LoVo cell line in vitro. Zhonghua Yi Xue Za Zhi. 2009 May 26;89(20):1382-6.

[2] Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells. J Nutr Biochem. 2008 Aug;19(8):524-35.

[3] Antigenotoxic effect of allicin against methyl methanesulphonate induced genotoxic damage. J Environ Biol. 2005 Jul;26(3):547-50.

See this extensive article on garlic  click here

Gamma-Glutamylcysteinylglycine

Glutathione is a sulfur-containing amino acid that is composed of three amino acids: cysteine, glutamic acid and glycine.

Although glutathione is produced by our body is can be beneficial to consume extra glutathione through the diet.

Glutathione is mainly in animal products but also in many plants including avocado, asparagus, broccoli, grapefruit, potato, strawberries, orange, tomato, peach and spinach.

Health Benefits of Glutathine

Glutathione is an important antioxidant. Glutathione neutralizes toxic peroxide which could otherwise damage our DNA and cell membranes. As we get older the glutathione level decreases in intracellular fluids. Dietary intake of glutathione can be important for older individuals which have reduced capabilities to detoxify free radicals. Glutathione also reacts with some toxins and helps to break them down, such as the pain reliever acetaminophen.

Glutathione improves the stability of other antioxidants including vitamin C and vitamin E. Glutathione supports our immune system and stimulates the production of lymphocyte immune cells.

Studies on Glutathione and cancer

science.naturalnews.com/G/Glutathione_and_prostate_cancer.html

I3C, 3-hydroxymethyl indole, 3-indole methanol

The phytochemical indole-3-carbinol is found in cruciferous vegetables such as cabbage, cauliflower, broccoli, kale and brussels sprouts. Indole-3-carbinol is made from indole-3-glucosinolate by the enzyme myrosinase. This enzyme is only activated after maceration of the vegetables.Pure indole-3-Carbinol is an off-white solid belonging to the group of indoles. Indole-3-carbinol is only formed in these vegetable after crushing or during cooking

Health Benefits of Indole-3-Carbinol

Indole-3-carbinol and its main metabolite diindoylmethane modulates several nuclear transcription factors resulting in a variety of biological and biochemical effects. Indole-3-carbinol works as a strong antioxidant, thereby protecting the DNA and other cell structures.Chemopreventive

Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying enzymes. The phytochemical protects against carcinogenic effect of pesticides and other toxins.Anticancer

The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane are the result of specific activities: inducing enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis.

Diets high in vegetables, especially cruciferous vegetables provide protection against cancer. Cruciferous vegetables provide the only source of glucosinolates, which breaks down in indole-3-carbinol and sulforaphane. The anticancer effects of indole-3-carbinol and diindoylmethane are the result of specific activities: inducing phase I and phase II enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis.

Most studies have focused on the effects on endometrial cancer, breast cancer and prostate cancer.Tumor progression relies on the upregulation of signaling pathways relevant to cell proliferation and increased resistance against chemotherapeutic agents. Indole-3-carbinol and its metabolite diindoylmethane target different aspects of carcinogenesis, such as estrogen metabolism, estrogen receptor signaling, Akt-NF kappa B signaling, caspase activation, cyclin-dependent kinase activities, endoplasmic reticulum stress, and expression of tumor suppression genes [1].

Many in-vitro results have demonstrated the anticancer effect of indol-3-carbinol, but these favorable results should be treated with extra care because of its low biological availability in humans. A phase I trial demonstrated that after a oral intake of up to 1200 mg indol-3-carbionol did not result in detectable plasma levels of the phytochemical [2].

The researchers could only detect diindolylmethane , a metabolite of indole-3-carbinol, which reached max plasma level 2 hours after the administration on indole-63-carbinol, but disappeared almost completely after 12 hours. The pharmaceutical industry has already developed and patented anti-cancer chemicals with structure similar to that of diindolyl)methane, a metabolite of indole-3-carbinol.

[1] Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Lett. 2008 Apr 18;262(2):153-63.

[2] Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3′-diindolylmethane. Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2477-81.[3] The natural chemopreventive compound indole-3-carbinol: state of the science. In Vivo. 2006 Mar-Apr;20(2):221-8.
Indole-3-carbinol blocks estrogen receptor sites on the membranes of breast and other cells, thereby reducing the risk of cervical and breast cancer.
Recent results from epidemiology, in vitro cell culture and in vivo studies have suggested the benefits of indole-3-carbinol for the prevention of many types of cancer, including breast cancer. Oral administration of indole-3-carbinol has been shown to influence our estrogen metabolism in humans in a beneficial manner. It increases the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone.
Experimental and clinical evidence suggests that 16alpha-hydroxylated estrogen metabolites react as strong estrogens, and are associated with breast cancer risk, while 2-hydroxylated metabolites have a lower estrogenic activity and are weakly related to this disease. Indole-3-carbinol is a good candidate for clinical trial in women at increased risk of developing breast cancer. Fan S and co-workers of the Georgetown University (New York) reported that both indole-3-carrbinol and genistein target the breast cancer susceptibility genes in both prostate and breast cancer cells [4].
The breast cancer susceptibility genes are responsible for the suppression of tumor growth, not only of breast cancer cells but also ovarian and prostate cancer cells. This in-vitro study showed that the phytochemicals induced the expression of these genes.An in-vitro study with cultured human breast cancer cells demonstrated that indole-3-carbinol directly inhibited elastase enzymatic activity and concluded that this phytochemicals, or similar compounds, should be further investigated as drug for the treatment of human breast cancers where high elastase levels are correlated with poor prognosis [2].
More specifically they found that indole-3-carbinol shifted the stable accumulation of cyclin E protein from the lower molecular mass form, that is associated with cancer cell proliferation and poor clinical outcomes, to its higher molecular mass form, that is typically produced in normal cells. A Taiwanese study found that indole-3-carbinol reduced the invasion and migration of breast cancer cells [3].
The phytochemical inhibited matrix metalloproteinases expression by blocking the ERK/Sp1-mediated gene transcription.Indole-3-carbinol might improve the effect of tamoxifen according to an experiment with rats carried out by the University of Minnesota [4].
Tamoxifen is a selective estrogen receptor modulator that is used in the treatment of breast cancer. The scientists induced tumors in rats by dosing the carcinogen dimethylbenz-a-anthracene and then treated the rats with tamoxifen, indole-3-carbionol or a combination of both. All three types of treatment resulted in a significant increased latency and decreased mass of malignant mammary tumors, but also treatment with indole-3-carbinol, although the effect of indole-3-carbinol alone was weaker.A study by scientists of the University of California concluded that indole-32-carbinol had an influence on the function and expression of estrogen receptor-alpha (ERA) and estrogen receptor-beta (ERB) [6].
By increasing the ratio of ERA to ERB indole-3-carbinol could reduce the proliferation of human breast cancer cells. The tests were conducted on breast cancer cells that expressed both ERA and ERB. Treatment of these breast cancer cells with indole-3-carbinol strongly inhibited ERB protein production, without that of ERA.Indole-3-carbinol selectively induced apoptosis in breast cancer cells, but not in nontumorigenic breast cells, suggesting the potential therapeutic benefit of I3C against breast cancer [7]. Low levels of indole-3-carbinol inhibited the growth of the tumor cells more than that of normal breast cells. The phytochemical upregulated Bax/Bcl-2 ratio and downregulated Bcl-xL expression only in the breast cancer cells.
[1] Prevention and treatment of cancer with indole-3-carbinol. Altern Med Rev. 2001 Dec;6(6):580-9.
[2] The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing. Proc Natl Acad Sci U S A. 2008 Dec 8.
[3] Indole-3-carbinol Inhibits Sp1-Induced Matrix Metalloproteinase-2 Expression To Attenuate Migration and Invasion of Breast Cancer Cells. J Agric Food Chem. 2008 Dec 5.
[4] BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer. 2006 Feb 13;94(3):407-26.
[5] Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination. Eur J Cancer Prev. 2007 Apr;16(2):130-41.
[6] Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells. Mol Endocrinol. 2006 Dec;20(12):3070-82. Epub 2006 Aug 10.
[7] Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells. Nutr Cancer. 2003;45(1):101-12.
Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol. This is a favourable action of indole-3-carbinol because 16 alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action.
The estrogen metabolite 2-hydroxyestrone has protective against several types of cancer. Studies with animals have demonstrated that indole-3-carbinol reduced the carcinogenic affects of aflatoxins. The influence of indole-3-carbinol on the development of prostate cancer is less clear. Most studies report protective effects but a few studies indicate that indole-3-carbinol may promote prostate cancer formation.
In the USA prostate cancer is one of the most common cancers in men and the second leading cause of cancer-related deaths. Epidemiological and dietary studies have shown a link between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. A study conducted by Technion Israel Institute of Technology (Haifa) showed that indole-3-carbinol had a significant inhibitory effect on prostate cancer cells in vitro and in vivo and concluded that this phytochemicals is a potential candidate as both preventive and therapeutic agent for humans [1].
The researchers tested the effect of indole-3-carbinol on the growth of prostate cancer cells inoculated subcutaneously in mice. They found that the administration of indole-3-carbinol significantly reduced cells proliferation and promoted the apoptosis of the prostate cancer cells. Fan S and co-workers of the Georgetown University (New York) reported that both indole-3-carrbinol and genistein target the breast cancer susceptibility genes in both prostate and breast cancer cells [2].
The breast cancer susceptibility genes are responsible for the suppression of tumor growth, not only of breast cancer cells but also ovarian and prostate cancer cells. This in-vitro study showed that the phytochemicals induced the expression of these genes.Another study found that injected indole-3-carbinol has anti-prostate cancer activity in rats [3].
Both intraperitoneal (in the body cavity) and intravenous injection of the phytochemical inhibited the growth, incidence and metastases of prostate cancer cells which were injected in rats.A study conducted at the Wayne State University School of Medicine, Detroit, concluded that indole-3-carbinol and its metabolite diindolylmethane are candidates for the prevention and the treatment of prostate cancer [4].
The researchers confirmed that indole-3-carbinol and diindolylmethane upregulate the expression of phase I and phase II enzymes, which are involved in the detoxification and inhibition of carcinogens. Both phytochemicals regulate many genes that are important for the control of cell cycle, cell proliferation, signal transduction, and other cellular processes.A study conducted by the Long Island Jewish Medical Center, New York, suggested that indole-3-carbinol may be an effective sensitizer of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment against TRAIL-resistant prostate cancer cell lines [5].
TRAIL is a ligand molecule which induces the process apoptosis in a variety of transformed cells including prostate cancer cells but has no effect on normal cells. The researchers, led by Jeon KI, tested the potential sensitizing effects of indole-3-carbinol on TRAIL-mediated apoptosis in a prostate cancer cell line. They found that the phytochemical enhanced TRAIL-mediated apoptosis and that the apoptosis was the result of increased levels of two trail death receptors.
[1] Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice. Food Chem Toxicol. 2008 Mar;46(3):863-70.
[2] BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer. 2006 Feb 13;94(3):407-26.
[3] Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer. Oncol Rep. 2005 Jan;13(1):89-93.
[4] Indole-3-carbinol and prostate cancer.J Nutr. 2004 Dec;134(12 Suppl):3493S-3498S.Sarkar FH, Li Y.
Treatment of skin cancer cells with ultraviolet-B results in the apoptosis of their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol. Some studies also show a beneficial effect on the treatment of skin cancer.Every year more than 1 million new cases of ultraviolet radiation-induced non-melanoma skin cancers occur in the USA. Although exposure to sun and specifically ultraviolet radiation increases the risk of skin cancers, treatment of skin cancer cells with ultraviolet-B also results in their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol.
That is what scientist of the Seoul National University found in an experiment with cultured human melanoma cells [1].
They investigated the effect of indole-3-carbinol on the sensitization to ultraviolet-B-induced apoptosis . They found that a combined treatment with the indole-3-carbinol and ultraviolet-B synergistically reduced melanoma cell viability, whereas the phytochemical or ultraviolet-B alone had little effect. Indole-3-carbinol acted by down-regulating pro-apoptotic protein Bcl-2.
Another study also demonstrated the protective action of indol-3-carbinol on ultraviolet-induced carcinogenic process on skin cells of mice [2]. They conducted tests on groups of 20 mice exposed ultraviolet radiation and to fed with respectively chlorophyllin, indole-3-carbinol or placebo. The scientists found that rats fed with chlorophyllin should a significant increase in tumor multiplicity, whereas those supplemented with indol-3-carbinol has significant lower tumor multiplicity.[
1] Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells. Cell Mol Life Sci. 2006 Nov;63(22):2661-8.
[2] Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol. Photochem Photobiol Sci. 2006 May;5(5):499-507.Indol-3-carbinol, and OTHER (Brassica vegetables); conversion to isothiocyanates.

Indole 3 Carbinol (See also Di-indole methane) I3C, as it is frequently called, has been tested and documented in humans and results are highly promising. Indole-3-carbinol reduced or halted the formation of precancerous lesions (papillomas) in 12 out of 18 people with recurrent respiratory tract papillomas. In addition, in a small double-blind trial, supplementation with 200 or 400 mg of indole-3-carbinol per day for 12 weeks reversed early-stage cervical cancer in 8 of 17 women. Preliminary studies have also shown indole-3-carbinol has significantly increased the conversion of estrogen from cancer-producing forms to nontoxic breakdown products. Indole-3-carbinol is found in highest concentrations in broccoli, but is also found in other cruciferous vegetables, such as cauliflower, cabbage, and kale. This treatment would be indicated for those with hormonal related cancers. Note: Di-indole methane is considered a stronger metabolite of I3C.

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  1. Pretreatment of Indole-3-Carbinol augments TRAIL-induced apoptosis in a prostatecancer cell line, LNCaP.
    2003 FEBS letters
  2. Indole-3-Carbinol and prostate cancer.
    2004 The Journal of nutrition
  3. Indole-3-Carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
    2001 Oncogene
  4. Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells.
    2004 Nutrition and cancer
  5. Indole-3-Carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice.
    1999 Cancer research
  6. Therapeutic intervention of experimental breast cancer bone metastasis by Indole-3-Carbinol in SCID-human mouse model.
    2006 Molecular cancer therapeutics
  7. The effect of Indole-3-Carbinol and sulforaphane on a prostate cancer cell line.
    2003 ANZ journal of surgery
  8. A potent Indole-3-Carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells.
    2007 Cancer research
  9. Indole-3-Carbinol as a chemopreventive and anti-cancer agent.
    2008 Cancer letters
  10. 1-Benzyl-indole-3-carbinol is a novel Indole-3-Carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breastcancer cells.
    2010 Chemico-biological interactions
  11. Indole-3-Carbinol prevents PTEN loss in cervical cancer in vivo.
    2005 Molecular medicine (Cambridge, Mass.)
  12. Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol.
    2010 Anticancer research
  13. BRCA1 and BRCA2 as molecular targets for phytochemicals Indole-3-Carbinol and genistein in breast and prostate cancer cells.
    2006 British journal of cancer
  14. Indole-3-Carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.
    1999 Cancer research
  15. Anti-carcinogenic and anti-metastatic properties of Indole-3-Carbinol in prostate cancer.
    2005 Oncology reports
  16. Bax translocation to mitochondria is an important event in inducing apoptotic cell death by Indole-3-Carbinol (I3C) treatment of breast cancer cells.
    2003 The Journal of nutrition
  17. A new Indole-3-Carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines.
    2003 Cancer research
  18. Indole-3-Carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells.
    2004 Carcinogenesis
  19. Anti-estrogenic activities of Indole-3-Carbinol in cervical cells: implication for prevention of cervical cancer.
    1999 Anticancer research
  20. Indole-3-Carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway.
    2010 Medical oncology (Northwood, London, England)
  21. Direct inhibition of elastase activity by Indole-3-Carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breastcancer cells.
    2010 Cancer research
  22. Putative mechanisms of action for Indole-3-Carbinol in the prevention of colorectal cancer.
    2008 Expert opinion on therapeutic targets
  23. Indole-3-Carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity.
    2009 International journal of cancer. Journal international du cancer
  24. Indole-3-Carbinol inhibits Sp1-induced matrix metalloproteinase-2 expression to attenuate migration and invasion of breast cancer cells.
    2009 Journal of agricultural and food chemistry
  25. Indole-3-Carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells.
    2006 Molecular endocrinology (Baltimore, Md.)
  26. Indole-3-Carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.
    2006 Biochemical pharmacology
  27. Modulation of the constitutive activated STAT3 transcription factor in pancreaticcancer prevention: effects of Indole-3-Carbinol (I3C) and genistein.
    2004 Anticancer research
  28. Indole-3-Carbinol and 3,3′-diindolylmethane induce apoptosis in human prostatecancer cells.
    2003 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  29. Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol.
    2002 Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  30. The Indole-3-Carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor positive and triple negative breast cancer cell lines.
    2011 Breast cancer research : BCR
  31. Indole-3-Carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.
    2010 Molecular biology of the cell
  32. Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs.
    2008 Cancer letters
  33. Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol.
    2006 Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  34. Indole-3-carbinol-induced modulation of NF-kappaB signalling is breast cancer cell-specific and does not correlate with cell death.
    2008 Breast cancer research and treatment
  35. Indole-3-Carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.
    2005 Carcinogenesis
  36. N-Alkoxy derivatization of Indole-3-Carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.
    2008 Biochemical pharmacology
  37. Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer.
    2006 The Prostate
  38. Indole-3-Carbinol and 3-3′-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions.
    2003 The Journal of nutrition
  39. Indole-3-Carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breastcancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex.
    2005 The Journal of biological chemistry
  40. Indole-3-Carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
    2001 The Journal of biological chemistry
  41. Multiple molecular targets of indole-3-carbinol, a chemopreventive anti-estrogen in breast cancer.
    2002 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
  42. Targets for Indole-3-Carbinol in cancer prevention.
    2005 The Journal of nutritional biochemistry
  43. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, Indole-3-Carbinol and myo-inositol, alone and in combination.
    2010 Carcinogenesis
  44. Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the Indole-3-Carbinol metabolite 3,3′-diindolylmethane in breastcancer cells.
    2009 The Journal of nutrition
  45. Review. Indole-3-Carbinol as a chemoprotective agent in breast and prostate cancer.
    2008 In vivo (Athens, Greece)
  46. Indole-3-Carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines.
    2008 Biochemical pharmacology
  47. Molecular targets and anticancer potential of Indole-3-Carbinol and its derivatives.
    2005 Cell cycle (Georgetown, Tex.)
  48. Inhibition of MUC1 expression by indole-3-carbinol.
    2004 International journal of cancer. Journal international du cancer
  49. Indole-3-Carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells.
    2003 Nutrition and cancer
  50. A novel mechanism of Indole-3-Carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation.
    2010 Cancer prevention research (Philadelphia, Pa.)
  51. Indole-3-Carbinol is a negative regulator of estrogen.
    2003 The Journal of nutrition

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NOTE: Di-Indole Methane

Di-Indole Methane is the direct metabolite of I3C (Indole-3-Carbinol) and twice as strong. This naturally occurring extract of the cabbage (cruciferous) family vegetables has proven effective in studies worldwide against hormonal related cancers. It’s mechanism is to decrease high estrogen levels in both men and women, an issue which usually leads to cancer or other illnesses often associated with aging. Included are prostate disease, breast and uterine cancers, and weight gain. Supplementing the diet with DIM and eating cruciferous vegetables increases the specific aerobic metabolism for estrogen, multiplying the chance for so-called bad estrogen to be broken down into beneficial, or good estrogen metabolites. These good estrogen metabolites are known as the 2-hydroxy estrogens.

DIM (diindolylmethane) DIM is a phytochemical that is found in broccoli, cabbage, turnip and mustard greens, kale, brussel sprouts, collards, etc. „The first development in this research using chemically altered [sic] DIM from broccoli came when the growth of breast cancer cells was inhibited in laboratory studies. Subsequent research showed these compounds also inhibited growth of pancreatic, colon, bladder and ovarian cancer cells in culture, Safe said. Limited trials on lab mice and rats have produced the similar results, he noted.”  „Researchers from the University of California at Berkeley looked at the effects of broccoli on human breast cancer cells. According to findings, compounds in broccoli known as indoles are digested and broken down in the stomach to a compound called 3,3′-diindolylmethane (DIM). This compound may be the key to keeping cancer at bay.” 

Isothiocyanates are sulphur-containing phytochemicals with the general formula R-NCS. Different molecules belong to this group. Isothiocyanates with the stongest anticancer effects are phenylethylisothiocyanate, benzylisothiocyanate and 3-phenylpropylisothiocyanate. Isothiocyanates occur naturally as glucosinolate conjugates in cruciferous vegetables. Isothiocyanates are also responsible for the typical flavour of these vegetables.

Isothiocyanates can be found in cruciferous vegetables such as broccoli, cauliflower, kale, turnips, collards, Brussels sprouts, cabbage, radish, turnip and watercress. Glucosinolates are precursors of isothiocyanates. When the raw vegetables are chewed the plant cells are broken and an enzyme (myrosinase) hydrolyses the glucosinolates into isothiocyanates.

Health Benefits of Isothiocyanates

Isothiocyanates combat carcinogens by neutralizing them, reducing their poisonous effect and stimulating the secretion of carcinogens of carcinogens. Isothiocyanates act by inhibition of cell proliferation and induction of apoptosis.

The isothiocyanates with the stongest anticancer effects are phenylethylisothiocyanate, benzylisothiocyanate and 3-phenylpropylisothiocyanate. Studies have shown that isothiocyanates help to prevent lung cancer and esophageal cancer. Isothiocyanates can also lower the risk of other cancers, including gastrointestinal cancer.

science.naturalnews.com/…/1947743_Dietary_isothiocyanates_glutathione_S _transferase_M1_GSTM1_and_lung_cancer.html
Dietary isothiocyanates, glutathione S transferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, California.
science.naturalnews.com/…/132691_Selective_Depletion_of_Mutant_p53_by _Cancer_Chemopreventive_Isothiocyanates_and.html
Isothiocyanates (ITCs) derived from cruciferous vegetables induce apoptosis in cancercells. We demonstrate that certain naturally occurring ITCs selectively …
science.naturalnews.com/…/568279_Cancer_preventive_isothiocyanates_ induce_selective_degradation_of_cellular_alpha_.html
Cancer preventive isothiocyanates induce selective degradation of cellular alpha and beta tubulins by proteasomes.
science.naturalnews.com/…/1314059_Isothiocyanates_glutathione_S_ transferase_M1_and_T1_polymorphisms_and_gastric.html
Isothiocyanates, glutathione S transferase M1 and T1 polymorphisms and gastric cancerrisk: a prospective study of men in Shanghai, China.
science.naturalnews.com/…/786957_Chemoprevention_of_cancer_by_ isothiocyanates_and_anthocyanins_mechanisms_of_action.html
Chemoprevention of cancer by isothiocyanates and anthocyanins: mechanisms of action and structure activity relationship.
science.naturalnews.com/…/2410_Isothiocyanate_exposure_glutathione_S_ transferase_polymorphisms_and_colorectal_cancer_risk.html
Isothiocyanate exposure, glutathione S transferase polymorphisms, and colorectal cancerrisk. Publication: The American journal of clinical nutrition. Publication …
science.naturalnews.com/…/27163_Urinary_isothiocyanates_glutathione_S_ transferase_M1_T1_and_P1_polymorphisms.html
The present study examined the associations among urinary isothiocyanates, Glutathione S-transferase (GST) polymorphisms, and colorectal cancer risk in a …
science.naturalnews.com/…/1265130_Isothiocyanates_induce_oxidative_ stress_and_suppress_the_metastasis_potential_of.html
However, the effect of isothiocyanates on lung cancer cell metastasis has not been studied. In the present study, we investigated the inhibitory effects of BITC …
science.naturalnews.com/…/3294354_Head_and_neck_cancer_a_case_for_ inhibition_by_isothiocyanates.html
Head and neck cancer: a case for inhibition by isothiocyanates and indoles from cruciferous vegetables.
science.naturalnews.com/…/1569614_Prostate_cancer_chemopreventive_ activity_of_phenethyl_isothiocyanate_through_epigenetic_regulatio…
Consumption of cruciferous Vegetables has been reported to be associated with reduced incidence of prostate cancer cases. The isothiocyanates, including …
science.naturalnews.com/…/3381294_Repression_of_androgen_receptor_in_ prostate_cancer_cells_by_phenethyl.html
Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate. Publication: Carcinogenesis Publication Date: 2006. Study Author(s): …
science.naturalnews.com/…/629276_Isothiocyanates_sensitize_the_effect_of_ chemotherapeutic_drugs_via_modulation_of.html
Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells.
science.naturalnews.com/…/125542_Anti_NF_kappaB_and_anti_ inflammatory_activities_of_synthetic_isothiocyanates.html
Of the natural compounds, the Isothiocyanates (ITCs) found in cruciferous Vegetables have received particular attention because of their potential anti- cancer …
science.naturalnews.com/…/1338610_ABC_transporters_and_isothiocyanates _potential_for_pharmacokinetic_diet_drug_interactions.html
Isothiocyanates, a class of anti-cancer agents, are derived from cruciferous Vegetables such as broccoli, cabbage and watercress, and have demonstrated …
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Isothiocyanates (ITCs) found in cruciferous vegetables have demonstrated cancerpreventive activity in animals, and increased dietary intake of ITCs has been …
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Urinary isothiocyanate levels and lung cancer risk among non smoking women: A prospective investigation.
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BACKGROUND & AIMS : Isothiocyanates (ITCs) derived from cruciferous vegetables have been shown to be promising agents against cancer in human cell …

Researchers at the Johns Hopkins University School of Medicine in Baltimore studied the metabolism of isothiocyanates and found that isothiocyanates were about six times more bioavailable than glucosinolates.

Sulforaphane is a phytochemical belonging to the family of isothiocyanates, which means it contains the typical NCS group.

(R)-1-isothiocyanto-4-methyl-sulfonyl butane

Sulforaphane occurs in plants bound to a sugar molecule: sulforaphane glucosinolate. Only after eating will the sulforaphane by released. Sulforaphane glucosinolate is found in cruciferous vegetables such as broccoli, cauliflower, cabbage and kale. The richest source of sulforaphane are broccoli sprouts.

Health Benefits of Sulforaphane

Sulforaphane is an antioxidant and stimulators of natural detoxifying enzymes. Sulforaphane may reduce the risk of breast, bladder and prostate cancer.

Anti-cancer effect

Epidemiological studies show that people who eat a lot of cruciferous vegetables have reduces incidences of cancer. In-vitro and animals studies have confirmed the anti-cancer effects and have demonstrated that the phytochemical reduces the frequency, size, and number of tumors.

During the fight against cancer cells our body produces special enzymes, called phase 2 enzymes. Sulforaphane is a phase 2 enzyme inducer, thereby neutralizing carcinogens before they can damage DNA. Sulforaphane inhibits benzo[a]pyrene-DNA and 1,6-dinitropyrene-DNA adducts formation. A study by James D. Brooks et al entitled Potent Induction of Phase 2 Enzymes in Human Prostate Cells by Sulforaphane has shown that sulforaphane induces phase 2 enzyme expression and activity in human prostate cells [1]. This study may help to explain the lower prostate cancer risk with men who consume more cruciferous vegetables.A team of scientists lead by B. Abbouit at the Ohio State University investigated the effect of isothiocyanates (sulforaphane and erucin) in primary or secondary bladder cancer prevention. Both phytochemicals showed inhibition of bladder cancer cells, which was associated downregulation of survivin, epidermal growth factor receptor and human epidermal growth factor receptor 2 and apoptosis.

A 2012 study by the Texas Children’s Hospital suggested a potential role of sulforaphane as an adjunctive agent to improve the therapeutic response in acute lymphoblastic leukemia patients [3]. This type of cancer is the most common hematological cancer in children. The scientists found that purified sulforaphane had anticancer properties in a broad range of leukemic cells. More specifically they found that sulforaphane caused dose-dependent apoptosis and cell cycle arrest, mainly by activation of caspases. While sulforaphane killed cancer cells, it did not affect healthy cells. It should be noted that the levels of sulforaphane used in this study were quite high and can not be obtained by eating cruciferous vegetables, such as broccoli.

[1] Potent induction of phase-2-enzymes in human prostate cells by sulforaphane.. Cancer Epidemiology Biomarkers and Prevention, Vol. 10, 949-954, September 2001

[2] Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion. Mol Nutr Food Res. 2012 Nov;56(11):1675-87

[3] Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. PLoS One. 2012;7(12):e51251

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Heart health

The antioxidant action of sulforaphane helps to fight high blood pressure. A study by the Tokyo University of Agriculture has shown that persons who eat about 100 g of broccoli sprouts daily during one week had reduces levels of cholesterol.

Research Reviews

Potent induction of phase-2-enzymes in human prostate cells by sulforaphane.

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo-a-pyrene-induced stomach tumors

Phenolic Acids

trans-8-methyl-N-vanillyl-6-nonenamide, N-(4-Hydroxy-3-methoxyphenyl)-8-methyl-non-trans-6-enamide

Capsaicin is the phytochemical in chilli peppers that causes the typical heat. Pure capsaicin is a white crystalline powder. Capsaicin is a capsaicinoid which belongs to the alkaloid family. It is very heat stable and keeps its activity despite cooking. Capsaicin is only slightly soluble in water, but very soluble in ethanol and vegetable oil. Other capsaicinoid are dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin and homodihydrocapsaicin.

Health Benefits of Capsaicin

ANTIcancer

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Capsaicin is used in many topical ointments used to relieve the pain of peripheral neuropathy (treatment of pain in the nerve endings near the surface of the skin). Capsaicin is then applied on the skin and removed when the patient starts feeling the burning sensation. The nerves seem to become insensitive to pain. The burning sensations of capsaicin is caused by its interaction with the nerve cells. Capsaicin binds with special receptor cells (vanilloid receptor subtype 1) and produces the same effect as physical heat. Consumption of capsaicin can also create a euphoric sensation caused by the release endorphins.

Studies have shown that capsaicin can relieve arthritic symptoms and improve flexibility of the joints. Capsaicin seems to inhibit the activity of DSP (Decapeptide Substance P), which the painful feeling of arthritis.

Capsaicin might protect against gastric ulcers. Studies have shown that capsaicin protects the stomach membrane by increasing the blood flow.

Capsaicin seems to reduce the symptoms of psoriasis. A study by Ellis CN et al., „A double-blind evaluation of topical capsaicin in pruritic psoriasis” (Journal of the American Academy of Dermatology, Sept 1993) showed that patients with psoriasis who took capsaicin cream had reduced itching, scaling and redness compared with patients who used a placebo.

Why do plants contain capsaicin? By producing the burning capsaicin the pepper plant prevents animals from eating its fruits. Birds don?t feel the burning sensation of capsaicin so they eat the fruits and are responsible for the spreading of seeds. The chilli seeds survive the digestion process. Capsaicin is also a component of pepper spray, used as chemical riot control agent.

Abstracts

Capsaicin and Health

Benzoaric acid, eleagic acid, elagostasine, gallogen

Ellagic acid is a fused four-ring polyphenol.

Ellagic acid is present in many red fruits and berries, including raspberries, strawberries, blackberries, cranberries, pomegranate and some nuts including pecans and walnuts. The highest levels of ellagic acid are found in raspberries. In plants ellagic acid is present in the form of ellagitannin, which is ellagic acid bound to a sugar molecule.

Pure ellagic acid is a cream to light yellow crystalline solid.

Health Benefits of Ellagic Acid

Ellagic acid has antioxidant, anti-mutagen and anti-cancer properties. Studies have shown the anti-cancer activity on cancer cells of the breast, oesophagus, skin, colon, prostate and pancreas. More specifically, ellagic acid prevents the destruction of P53 gene by cancer cells. Ellagic acid can bind with cancer causing molecules, thereby making them inactive. In their studie The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes. Ahn D et al showed that ellagic acid causes a decrease in total hepatic mucosal cytochromes and an increase in some hepatic phase II enzyme activities, thereby enhancing the ability of the target tissues to detoxify the reactive intermediates. Ellagic acid showed also a chemoprotective effect against various chemically induced cancers.

Studies on Ellagic Acid and cancer –

science.naturalnews.com/E/Ellagic_Acid_and_cancer.html

http://science.naturalnews.com/E/Ellagic_acid_and_Antiproliferative.html

http://science.naturalnews.com/E/Ellagic_acid_and_Anti-Angiogenic.html

http://science.naturalnews.com/E/Ellagic_acid_and_Apoptotic.html

A study by Thresiamma KC and Kuttan R.Indian (Indian Journal Physiology and Pharmacology, 1996 October) indicate that oral administration of ellagic acid by rats can circumvent the carbon tetrachloride toxicity and subsequent fibrosis of the liver.

Ellagic acid has also antiviral and antibacterial activities.

Plants produce ellagic acid to protect themselves from microbiological infection and pests.

Research Reviews

Pomegranate Juice Ellagitannin Metabolites Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours

Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.

.

3,4,5-Trihydroxybenzoic acid

Gallic acid occurs as a freemolecule or as part of a tannin molecule.

Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts, grapes, tea, hops and oak bark. Pure gallic acid is a colourless crystalline organic powder.

Health Benefits of Gallic acid

Gallic acid seems to have anti-fungal and anti-viral properties. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells.

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Gallic acid is used a remote astringent in cases of internal haemorrhage. Gallic acid is also used to treat albuminuria and diabetes. Some ointment to treat psoriasis and external haemorrhoids contain gallic acid.

Rosmarinic acid is found in big quantities in oregano, lemon balm, sage, marjoram, rosemary.

Rosmarinic acid has antioxidant, anti-inflammatory and antimicrobial activities.

The antioxidant activity of rosmarinic acid is stronger than that of vitamin E. Rosmarinic acid helps to prevent cell damage caused by free radicals, thereby reducing the risk for cancer and atherosclerosis.

Rosmarinic acid has anti-inflammatory properties. Perilla, rich in rosmarinic acid, is used for its anti-allergic activity. A study by Sanbongi C and colleagues (Clinical and Experimental Allergy, June 2004) have shown that the oral administration of rosmarinic acid is an effective intervention for allergic asthma. Another study by Youn J and colleagues (Journal of Rheumatology, June 2003) demonstrated that rosmarinic acid suppressed synovitis in mice and that it may be beneficial for the treatment of rheumatoid arthritis. Unlike antihistamines, rosmarinic acid prevents the activation of immune responder cells, which cause swelling and fluid formation.

Rosmarinic acid is also used for food preservation. In Japan the perilla extracts, rich in rosmarinic acid, is used the garnish and improve the shelf life of fresh seafood.

Rosmarinic acid is used to treat peptic ulcers, arthritis, cataract, cancer, rheumatoid arthritis and bronchial asthma.

Studies on Rosmarinic acid and cancer

science.naturalnews.com/…/2186820_Rosmarinic_acid_antagonizes_activator _protein_1_dependent_activation_of_cyclooxygenase.html
Rosmarinic acid antagonizes activator protein 1 dependent activation of cyclooxygenase 2 expression in human cancer and nonmalignant cell lines.
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Subsequently, six extracts and the active compounds, carnosic acid, andRosmarinic acid were applied to various human cancer cell lines including NCI- H82 …
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Rosmarinic acid sensitizes cell death through suppression of TNF alpha … of RA have not been well elucidated in TNF-alpha-mediated anti-cancer therapy.
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Aug 15, 2013 … Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell …
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Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. 2008 The …
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Our study showed that Rosmarinic acid (RA) could inhibit the migration of MDA- MB-231BO human bone-homing breast cancer cells dose-dependently.
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… enhances the efficacy of Prunella in prevention and treatment of lung cancer. … caffeic acid, rosmarinic acid, rutin, quercetin, Oleanolic acid and Ursolic Acid.

Gallotanic acid, digallic acid, allotannin, tannimum.Tannic acid is a polymer of gallic acid molecules and glucose. It the example there are 3 gallic acid molecules, but normally there are about 8. Because there are different molecular structures for tannic acid it would have been better to speak about tannic acids (in plural). Tannic acid will hydrolyze into glucose and gallic or ellagic acid units. Tannic acid is odourless but has a very astringent taste. Pure tannic acid is a light yellowish and amorphous powder.

Tea, nettle, wood, berries, Chinese galls. Oak wood is very rich in tannic acid. When wine is kept in oak kegs some tannic acid will migrate into the wine. High levels of tannic acid are found in some plant galls. These are formed by plants when they are infected by certain insects. These insects pierce the plant leaves and when the egg hatches out into a larva the plant produces a gall which surrounds the larva.

Health Benefits of Tannic Acid

Tannic acid has anti-bacterial, anti-enzymatic and astringent properties. Tannic acid has constringing action upon mucous tissues such as tongue and inside of mouth. The ingestion of tannic acid caused constipation and can be used to treat diarrhoea (in the absence of fever or inflammation). The anti-oxidant and anti-mutagenic properties of tannic acid are beneficial.

Studies on Tannic Acid and cancer

However, tannic acid should not be used continuously or in high quantities ad it slows down the absorption of iron and possibly other trace minerals. A study by Afsana K et al entitled Reducing effect of ingesting tannic acid on the absorption of iron, but not of zinc, copper and manganese by rats. published by Bioscience, Biotechnology, and Biochemistry (March 2004) concluded that the usual intake of polyphenols is relatively safe, but that a high intake by supplementation or by dietary habit of tannin affects only the iron level. Tannic acid can also reduce the effectiveness of digestive enzymes.

Phytosterols

(3beta)-stigmast-5-en-3-ol, 22:23-dihydrostigmasterol, alpha-dihydrofucosterol, cinchol, cupreol, rhamnol, quebrachol and sitosterin.

Beta-sitosterol is a phytosterols or plant sterol. The structure of beta-sitosterol is similar to that of cholesterol. Beta-sitosterol differs from cholesterol by the presence of an extra ethyl group.

There are many plant sources of beta-sitosterol, but the most important are wheat germ, rice bran, flax seeds, peanuts, soybeans, pumpkin seeds and corn oil. Muli and co-workers showed that a plant-based diet, rich in fibre, soy and flax seed, can increase serum levels of beta-sitosterol.

Health Benefits of Beta-Sitosterol

Beta-sitosterol is mainly known and used for its cholesterol lowering property. But studies have shown that the phytochemical may have other health benefits: easing symptoms of benign prostatic enlargement, reducing risk of cancer and prevention of oxidative damage through its antioxidant activity.

Anti-cancer

Epidemiological and experimental studies have suggested a protective role of beta-sitosterol in the development of some types of cancer such as breast, colon and prostate cancer. In-vivo studies have shown that the phytochemical inhibited proliferation and induce apoptosis in human solid tumors such as colon and breast cancers.

Beta-sitosterol is mainly studied for its cholesterol-lowering properties but many studies also find that the phytochemical may help to prevent cancer. Epidemiological and experimental studies have suggested a protective role of beta-sitosterol in the development of some types of cancer such as breast, colon and prostate cancer. In-vivo studies have shown that the phytochemical inhibited proliferation and induce apoptosis in human solid tumors such as colon and breast cancers.

A Japanese study led by Imanaka demonstrated that the oral intake of beta-sitosterol, encapsulated in a liposome, was able to prevent tumour metastasis in rats, although the phytochemical was not absorbed in the serum. The researchers believed that beta-sitosterol works by stimulating the gut immune surveillance systems, as indicated by an increase in natural killer cell activity and production of immune response cytokines [1]. Park and co-workers concluded in their study that „beta-sitosterol potently induces apoptosis in U937 cells (these are leukemia cells) and that beta-sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.” Beta-sitosterol induced apoptosis in the leukemia cells in a dose-dependent manner [2].

Beta-sitosterol seems to induce apoptosis of cancer cells through two pathways: the extrinsic and intrinsic pathways, which are catalyzed by by the initiator caspases 8 and 9 respectively. Both pathways result in the activation of caspase 3, which is an effector caspases that cleaves protein substrates within the cell resulting in the apoptotic process. Korean study lead by Moon also found this effect of beta-sitosterol on caspase activation on cultured fibrosarcoma cells: treatment of the cells with an caspase-3 inhibitor inhibited the beta-sitosterol induced apoptosis. Treatment of the fibrosarcoma cells with beta-sitosterol also induced activation (phosphorylation) of extracellular-signal regulating kinase and blocked protein kinase B, which inhibits apoptotic processes [3]. Nakamura and co-workers found that beta-sitosterol restored the impaired gap junctional intercellular communication of transfected rat liver epithelial cells. The beta-sitosterol used in this experiment was extracted from the husks of psyllium seeds. Beta-sitosterol and also stigmasterol increased the level of gap junction proteins and restored their level of phosphorylation to levels similar to nontransfected cells [4].

Epidemiological evidence has shown that men consuming high amounts of plant products have a lower risk of prostate cancer. Von Holtz and colleagues investigated the possible effect of the plant sterol, beta-sitosterol, on cancer cells. They found that beta-sitosterol decreased the numbers of prostate cancer cells and increased apoptosis. Beta-sitosterol the production of ceramide, which is cellular signaling molecule regulating the differentiation, proliferation, programmed cell death and apoptosis of cells [5]. An in-vitro experiment with bone marrow cells showed that beta-sitosterol reduced the genotoxic damage caused by doxorubicin [6]. Beta-sitosterol significantly reduced the frequency of sister chromatid exchanges, which are exchange of genetic material between two identical sister chromatids. When the frequency of chromatid exchange is too high, cell damage can occur.

[1] Imanaka H, Koide H, Shimizu K, Asai T, Kinouchi Shimizu N, Ishikado A, Makino T, Oku N. ” Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake” Biol Pharm Bull. 2008 Mar;31(3):400-4.

[2] Park C, Moon DO, Rhu CH, Choi BT, Lee WH, Kim GY, Choi YH. ” Beta-sitosterol induces anti-proliferation and apoptosis in human leukemia U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.” Biol Pharm Bull. 2007 Jul;30(7):1317-23.

[3] Moon DO, Lee KJ, Choi YH, Kim GY. „Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells.” Int Immunopharmacol. 2007 Aug;7(8):1044-53.

[4] .Nakamura Y, Yoshikawa N, Hiroki I, Sato K, Ohtsuki K, Chang CC, Upham BL, Trosko JE. „Beta-sitosterol from psyllium seed husk (Plantago ovata Forsk) restores gap junctional intercellular communication in Ha-ras transfected rat liver cells.” Nutr Cancer. 2005;51(2):218-25.

[5]Von Holtz RL, Fink CS, Awad AB. ” beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells.” Nutr Cancer. 1998;32(1):8-12.

[6] Paniagua-Pérez R, Madrigal-Bujaidar E, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J, Hernández N, Flores-Mondragón G, Velasco O. ” Cell protection induced by beta-sitosterol: inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity. ” Arch Toxicol. 2008 Feb 6.

The studies about the protective effect of beta-sitosterol on breast cancer only involved in-vitro experiments using cultured breast cancer cells. These studies clearly show that the phytochemicals kills breast cancer cells and is not toxic to normal cell. Clinical studies linking beta-sitosterol and breast cancer are still missing but some scientists suggest that it may improve the efficiency of tamoxifen, a drug often used to treat breast cancer.

School of Public Health and Health Professions at the University at Buffal investigated the effects of beta-sitosterol and tamoxifen on the cultured breast cancer cells. The study led by Awad concluded that „these results suggest that the combination regimen of dietary beta-sitosterol and tamoxifen chemotherapy may be beneficial in the management of breast cancer patients”[1]. Tamoxifen is drug used for the treatment of breast cancer and works as a selective estrogen receptor modulator. Therefore it only works on estrogen receptor positive breast cancer cells. They tested the effect of beta-sitosterol and tamoxifen, separately and combined, on the growth of estrogen receptor positive breast cancer cells and estrogen receptor negative breast cancer cells. They found that a treatment with beta-sitosterol inhibited the growth of both type of cells whereas tamoxifen only inhibited of estrogen receptor positive breast cancer cells. A combined treatment further inhibited the growth of both cell types. Both beta-sitosterol and tamoxifen modulated the ceramide metabolism. Ceramides act as a signaling molecule, regulating differentiation, proliferation, programmed cell death and apoptosis. Beta-sitosterol increased ceramide levels by stimulating ceramide production whereas tamoxifen tamoxifen increased ceramide levels by inhibting ceramide glycosylation.

A study conducted by the State University of New York concluded that beta-sitosterol is an effective apoptosis-promoting phytochemical and more dietary phytosterols may protect against breast cancer. The scientists studied the effect of beta-sitosterol on cultured breast cancer cells and adenocarcinoma cells. Beta-sitosterol concentrated in the cell membranes and significantly inhibited tumor cell growth. It increased the Fas levels and caspase-8 activity [2]. Beta-sitosterol seems to induce apoptosis of cancer cells through two pathways: the extrinsic and intrinsic pathways, which are catalyzed by by the initiator caspases 8 and 9 respectively. Both pathways result in the activation of caspase 3, which is an effector caspases that cleaves protein substrates within the cell resulting in the apoptotic process. Awad and his team found that beta-sitosterol treatment of cultured breast cancer cells increased the activities of caspases 8 and 9 by 39% and 80% respectively, resulting in a a three-fold increase in the activity of caspase 3 [3].

In another in-vivo experiment conducted by Awad also showed that beta-sitosterol inhibited the growth of breast cancer cells by up to 80%, caused a six-fold increase in apoptosis cells but showed no cytotoxicity. The found no effect of beta-sitosterol on the level of protein phosphatase 2A in the tumor cells [4].

A study by Ju et al investigated the estrogenic effects of the plant sterols beta-sitosterol, beta-sitosterol glucoside and Moducare (mixture of beta-sitosterol, beta-sitosterol glucoside). The test was carried out on estrogen dependent human breast cancer cells in vitro and in vivo. The researchers concluded that beta-sitosterol and Moducare stimulated cancer cells in vitro and that dietary beta-sitosterol and Moducare protected against estrogen stimulated tumor growth. These findings suggest that beta-sitosterol could have potential benefits for women with a risk for estrogen-dependent breast cancer [5].

[1] Awad AB, Barta SL, Fink CS, Bradford PG. ” beta-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism.”Mol Nutr Food Res. 2008 Apr;52(4):419-26.

[2] Awad AB, Chinnam M, Fink CS, Bradford PG. ” beta-Sitosterol activates Fas signaling in human breast cancer cells.” Phytomedicine. 2007 Nov;14(11):747-54.

[3] Awad AB, Roy R, Fink CS. „Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. „Oncol Rep. 2003 Mar-Apr;10(2):497-500

[4] Awad AB, Downie AC, Fink CS. „Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture.” Int J Mol Med. 2000 May;5(5):541-5.

[5] Ju YH, Clausen LM, Allred KF, Almada AL, Helferich WG. „Beta-sitosterol, beta-sitosterol glucoside, and a mixture of beta-sitosterol and beta-sitosterol glucoside modulate the growth of estrogen-responsive breast cancer cells in vitro and in ovariectomized athymic mice.” J. Nutr. 134: 1145-1151.

Antioxidant

Beta-sitosterol is an antioxidant able to reduce DNA damage, reduce the level of freeradical in our cells and to increase the level of typical antioxidant enzymes.

Atherosclerosis

Regular intake of beta-sitosterol may reduce blood cholesterol levels by directly inhibiting the absorption of cholesterol. Beta-sitosterol also prevents the oxidation of LDL cholesterol thereby reducing the risk of atherosclerosis.

Prostate enlargement

Clinical studies have confirmed the beneficial effects of beta-sitosterol in patients withprostate enlargement. The phytochemical decreases post-void residual urinary volume and increases urinary flow rate in these patients.

Saponins

Saponins are glucosides with foaming characteristics. Saponins consist of a polycyclic aglycones attached to one or more sugar side chains. The aglycone part, which is also called sapogenin, is either steroid (C27) or a triterpene (C30). The foaming ability of saponins is caused by the combination of a hydrophobic (fat-soluble) sapogenin and a hydrophilic (water-soluble) sugar part. Saponins have a bitter taste. Some saponins are toxic and are known as sapotoxin.

Saponins are phytochemicals which can be found in most vegetables, beans and herbs. The best known sources of saponins are peas, soybeans, and some herbs with names indicating foaming properties such as soapwort, saoproot, soapbark and soapberry. Commercial saponins are extracted mainly from Yucca schidigera and Quillaja saponaria.

Health Benefits of Saponins

Saponinshave many health benefits. Studies have illustrated the beneficial effects on blood cholesterol levels, cancer, bone health and stimulation of the immune system. Most scientific studies investigate the effect of saponins from specific plant sources and the results cannot be applied to other saponins.

Cholesterol reduction

Saponins bind with bile salt and cholesterol in the intestinal tract. Bile salts form small micelles with cholesterol facilitating its absorption. Saponins cause a reduction of blood cholesterol by preventing its re-absorption.

Reduce cancer risk

Studies have shown that saponins have antitumor and anti-mutagenic activities and canlower the risk of human cancers, by preventing cancer cells from growing. Saponins seem to react with the cholesterol rich membranes of cancer cells, thereby limiting their growth and viability. Roa and colleagues found that saponins may help to prevent colon cancer and as shown in their article „Saponins as anti-carcinogens” published in The Journal of Nutrition (1995, 125, 717s-724S).

Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. 

Chemical & Pharmaceutical Bulletin. 2005 November;53(11):1451-4

The aim of this study was to determine the antitumor properties of saponins from the root of Korean pasque flower (Pulsatilla koreana). The researchers measured the in-vitro cytotoxic activity against cultured human solid cancer cells and the in-vivo antitumor activity in mice bearing lung carcinoma. The saponins with a free acidic group at C-28 of aglycon showed moderate to considerable in-vitro cytotoxic activity. In the in-vivo test hederagenin saponins showed stronger antitumor effect than the taxol and doxorubicin saponins. The precense of a hederagenin aglycones and a special sugar sequence at C-3 are essential factors for the antitumor activity of saponins.

Protective effect of Astragalus corniculatus saponins against myeloid graffi tumor in hamsters.

Phytother Research. 2004 March;18(3):255-7

This study investigated the antitumor effect of a saponin rich extract from Astragalus corniculatus Bieb, a garden plant originating from Eastern European, against myeloid Graffi tumors in hamsters. The researchers found that an injection of extract in the peritoneal cavity decreased tumor transplantability, inhibited tumor growth in the early stages of tumor progression, increased survival time and reduced mortality. The study concluded that the saponin extract of Astragalus corniculatus should be further investigated as a antitumor treatment of myeloid Graffi tumour.

Protective effect of soybean saponins and major antioxidants against aflatoxin B1-induced mutagenicity and DNA-adduct formation. 

Journal of Medicinal Food. 2002 Winter;5(4):235-40.

Previous studies have suggested that saponins have possible anti-cancer effect. The main dietary sources of saponins are legumes, including soybeans. The aim of this study was to determine the effect of soybean saponins mutagenic activity of aflatoxin B1 on Salmonella typhimurium and human liver cells. The anti-mutagenic effect of saponins was compared to those of other typical antioxidants such as vitamin C, vitamin E including L-ascorbic acid, alpha-tocopherol, vitamin A and butylated hydroxytoluene. The researchers found that the anti-mutagenic activity of saponins was between those of butylated hydroxytoluene and vitamin E. Soybean saponins reduced the muitagenic effect of aflatoxin B1 up to 81%. The preincubation of human liver cells with saponins reduced the amount of DNA adducts significantly. The study concluded that soybean saponins possess a significant anti-mutagenic activity. More studies are required to determine the exact mechanism but soybean saponins seems to block the initial stages of carcinogenesis.

Environmental influences on isoflavones and saponins in soybeans and their role in colon cancer.

Journal of Nutrition. 2005 May;135(5):1239-42

Soybeans are not only an important source of high quality proteins but contain also health promoting phytochemicals such as isoflavones and saponins. The aim of this study was to quantify isoflavone and saponin levels in soybean cultivars grown under different conditions and to determine the influence of isoflavones and saponins on carcinogenic process of cultured human colon cancer cells. The researchers found an inhibitive effect of soy isoflavones and saponins on the colon cancer cells. There were no adverse effects of the intake of pure saponins on growth, organ weight or intestinal morphology, even when the diet contained 3% saponins. The study concluded that soy isoflavones and saponins may protect against colon cancer and are well tolerated.

Soy saponins and the anticancer effects of soybeans and soy-based foods. 

Current Medicinal Chemistry – Anti-Cancer Agents. 2004 May;4(3):263-72

There are indications that the consumption of soy products help to protect against cancer but the exact constituents, which are responsible for this action, remain elusive. The aim of this review was to summarize epidemiological studies linking saponins to cancer risk. Recents studies have shown that soy saponins have a direct effect on cancer cells but may also influence carcinogenesis in alternative mechanisms. The anti-cancer action of saponins may result in the discovery of new anticancer agents.

Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages.

Cancer Letters. 2005 December 18;230(2):219-27

Pro-inflammatory mediators play also a role in cancer development. Phytochemicals with anti-inflammatory properties may help to reduce the risk of cancer. The aim of this study was to investigate the effects of soybean saponins on the production of proinflammatory mediators peritoneal macrophages stimulated with liposaccharides. The researchers found that soybean saponins reduced the levels of pro-inflammatory indicators such as cyclooxygenase-2, nitric oxide synthases and Nuclear Factor kappa B. The study concluded that soybean saponins may be useful for ameliorating inflammatory diseases and suppressing tumor progression.

Some studies have shown that saponins can cause apoptosis of leukemia cells by inducing mitotic arrest.

Cytotoxic and apoptogenic effect of tea (Camellia sinensis var. assamica) root extract (TRE) and two of its steroidal saponins TS1 and TS2 on human leukemic cell lines K562 and U937 and on cells of CML and ALL patients.

Leukemia Research. 2006 April;30(4):459-68

Not only tea leaves but also tea roots contain phytochemicals with potential health benefits. The aim of this study was to investigate the anti-cancer properties of tea root extract and two specific steroidal saponins found in the tea root on human cancer cells. The study showed that the tea root extract and the two steroidal saponins induced apoptosis of leukemia cells. Consumption of the tea root extract by healthy volunteers caused an insignificant reduction in cell count.

The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines.

Biological and Pharmaceutical Bulletin. 2004 July;27(7):1059-65

Previous studies have shown that diosgenyl saponins could induce cytotoxicity and apoptosis in human leukemia cells. The aim of this study was to investigate mechanisms of action. The researchers found that diosgenyl saponins activated some caspases (caspases are essential in cells for apoptosis, one of the main types of programmed cell death) and down-regulated anti-apoptotic proteins. Dioscin treatment of leukemia cells inhibited cell mitosis. The study concluded that diosgenyl saponins may act by inducing mitotic arrest and apoptosis. Diosgenyl saponins might be used antimitotic agents.

science.naturalnews.com/…/693_Cancer_chemopreventive_and_therapeutic_ effects_of_diosgenin_a_food_saponin.html
Food saponins have been used in complimentary and traditional medicine against a variety of diseases including several cancers. Diosgenin, a naturally …
science.naturalnews.com/…/2005340_Dimeric_antioxidant_and_cytotoxic_ triterpenoid_saponins_from_Terminalia_ivorensis_A.html
Dimeric antioxidant and cytotoxic triterpenoid saponins from Terminalia ivorensis A. … and further for their Cytotoxic activity against four human cancer cell lines.
science.naturalnews.com/…/432621_Chemical_and_pharmacological_studies _of_saponins_with_a_focus_on.html
It is believed that the ginseng saponins called ginsenosides are the major … and central Nervous system as well as the antidiabetes and anti-cancer effects.
science.naturalnews.com/…/270524_Cytotoxic_saponin_against_lung_cancer _cells_from_Dioscorea_birmanica_Prain.html
Cytotoxic saponin against lung cancer cells from Dioscorea birmanica Prain & Burkill.

Immunity booster

Plants produce saponins to fight infections by parasites. When ingested by humans, saponins also seem to help our immune system and to protect against viruses and bacteria.

Reduce bone loss

Studies with ovariectomized induced rats have shown that some saponins, such as the steroidal saponins from Anemarrhena asphodeloides, a Chinese herb, have a protective role on bone loss.

Antioxidant

The non-sugar part of saponins have also a direct antioxidant acitivity, which may results in other benefits such as reduced risk of cancer and heart diseases.

Stilbenes:

What’s more, several recent animal-based studies and studies on human cells have found that pterostilbene may be effective for protection against breast cancer, prostate cancer, andcolon cancer.

  • 2. RESVERATROL

Resveratrol is a flavonol belonging to the group of flavonoids.

Resveratrol is present in many plants and fruits, including red grapes, eucalyptus, spruce, blueberries, mulberries, peanuts, giant knotweed. Also red wine contains a lot of it. The longer the grape juice is fermented with the grape skins the higher the resveratrol content will be. It is produced by the plant as a defence against diseases.

Health Benefits of Resveratrol

Resveratrol is an antioxidant but its antioxidant properties are weaker that those of quercetin and epicatechin. It has anticancer properties and inhibits lipid peroxidation of low-density lipoprotein and prevents the cytotoxicity of oxidized LDL. Resveratrol also increases the activity of some antiretroviral drugs in vitro.

Antioxidant

In vitro studies have shown that resveratrol inhibits the oxidative damage caused by the heavy metal cadmium. The antioxidant activity of resveratrol reduces damage to endothelial cells exposed to nitrite radicals and protects skin cells against damage caused by UV radiation.

Anticancer

The antioxidant action of resveratrol helps to prevent damage to DNA but it also influences the transcriptions of genes responsible for redox metabolism and inhibits proliferartion of cancer cells. Resveratrol appears to decrease tumor promotion activity by inhibiting the enzyme cyclooxygenase-1, which converts arachidonic acid to substances that promote tumor growth. In vitro experiments provide support for resveratrol to serve as a candidate preventive agent against prostate cancer, but in vivo effects of resveratrol and the mechanisms of action of resveratrol on prostate cancer prevention remain largely unknown.

Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells.

Journal of Biological Chemistry. 2007 February;388(2):207-19

Previous studies have shown that phytochemical resveratrol has antioxidant properties and influences the cellular redox reactions in eukaryotic cells. The researchers investigated the effects of resveratrol on the transcription of genes and activity of enzymes involved with the redox metabolism and cell cycle regulation in lung cancer cells. They found that resveratrol significantly increased the transcription of glutathione peroxidase resulting in lower glutathione levels. Glutathione also increased the transcription of many genes involved in the cell cycle, differentiation and apoptosis. The researchers concluded that resveratrol increased the expression of genes responsible for cell survival, differentiation, proliferation inhibition and apoptosis. Resveratrol may therefore have a chemopreventive and anticancer effect.

Effect of resveratrol and mixtures of resveratrol and mitomycin C on cancer cells under irradiation.

Anticancer Research. 2006 November-December;26(6B):4403-8

This study investigated the antitumor and radiation protective effects of resveratrol in combination with mitomycin-C, an antibiotic that is also used as chemotherapeutic agent because of its antitumour activity. The in-vitro tests were carried out on human breast cancer cells in aerated and anaerobic media. In the aerated media resveratrol showed anti-tumor and antioxidant activities, which were enhanced by mitomycin-C. Under anaerobic conditions, resveratrol acted as a radiation-protecting agent and at high concentration it stopped cell growth. The study concluded that resveratrol has both radiation protective and anticancer activity. Resveratrol acts by ejection of electrons and by reacting on primary radicals, such as hydroxyl radical.

Resveratrol Inhibits Pancreatic Cancer Cell Proliferation through Transcriptional Induction of Macrophage Inhibitory Cytokine-1.

Journal of Surgical Research. 2007 January 24

Resveratrol is a phytochemical found in many mainly in red grape skins, mulberries and some nuts. Previous studies have shown that resveratrol has potential antitumorigenic and anti-inflammatory activities. It is known that macrophages produce a cytokine (MIC-1) which has antitumorigenic activity. The aim of this in-vitro study was to determine the effect resveratrol on the activity of MIC-1 and the regulation the growth of lines human pancreatic cancer cells. The researchers found that resveratrol upregulated the expression of the MIC-1 gene. When the cells were first treated with a transcriptional inhibitor the effect of resveratrol was reduced, confirming that resveratrol works expression of genes. The study concluded that resveratrol increases MIC-1 gene expression in pancreatic cancer cells.

Resveratrol inhibits proliferation, induces apoptosis and overcomes chemoresistance through downregulation of STAT3 and nuclear factor-{kappa}B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

Blood, 15 March 2007, Vol. 109, No. 6, pp. 2293-2302

This study investigated the effect of resveratrol, a phytochemical found in red grapes, red berries and peanuts on the growth of human multiple myeloma cells. Multiple myeloma is cancer of immune system cells in bone marrow. Bhardwaj and his colleagues found that resveratrol inhibited the proliferation of human multiple myeloma cell lines. Resveratrol also increased the apoptotic affect of bortezomib and thalidomide. They concluded that resveratrol may have a potential in the treatment of multiple myeloma cancer.

Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells.

Molecular Cancer. 2006 October 17;5:45

Endometrial cancers (cancer of the lining of the uterus) are the most common gynecologic cancers in the Western world. Studies have shown that resveratrol, an anti-oxidant found in high quantities in red wine, has anticancer activity and acts by inhibiting the proliferation and inducing apoptosis of cancer cells. The aim of this study was to investigate the antiproliferative and apoptotic activity of resveratrol in six different endometrial cancer cell lines. The researchers found that resveratrol caused apoptosis apoptosis in five out of six uterine cancer cell lines and decreased cell proliferation. They found that resveratrol acts by regulating the cyclooxygenase expression.

Benefits for diabetes

Resveratrol may be benificial for diabetes. Administration of resveratrol may protect against oxidative damage caused by high glucose levels. It also reduces diabetic neuropathic pain.

Heart health

Resveratrol protects our heart and blood vessels by directly scavenging oxidants, which could cause oxidation of lipids, and by preventing apoptosis of endothelial cells. It may also help to prevent heart damage after a cardiac arrest. Reduced platelet aggregation has been attributes to resveratrol, thereby reducing the risk of atherosclerosis.

Increase of lifespan

Tests with animals have shown that that high food intake reduces lifespan. One study showed that resveratrol was able to able to increase the life span of mice on a high calorie diet.

Antitoxic

Many studies on animals have shown antitoxic effects of resveratrol. Resveratrol was able to reverse damages caused by the administration of the chemotherapeutic drug bleomycin. Resveratrol also helped to reduce brain damage and oxidative damage of the liver during ethanol intoxication. It also reduced kidney damage of rats treated with the antibiotic gentamicin.

Facts about Resveratrol

Resveratrol explains partly the French Paradox: the low incidence of heart disease among French people, who eat relatively a lot of unhealthy fat but drink resveratrol containing red wine.

Research Reviews

Resveratrol Promotes Clearance of Alzheimer’s Disease 

Resveratrol Inhibits TNF-alpha?Induced Proliferation and Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells

Resveratrol in cancer management

Studies on Resveratrol and cancer

Studies on Resveratrol and colon cancer  (MANY STUDIES) http://science.naturalnews.com/R/Resveratrol_and_colon_cancer.html

Studies on Resveratrol and ovarian cancer ( MANY STUDIES) http://science.naturalnews.com/R/Resveratrol_and_ovarian_cancer.html

Studies on Resveratrol and Anti-Tumor

Studies on Resveratrol and Apoptotic

Studies on Resveratrol and Chemotherapeutic

http://science.naturalnews.com/R/Resveratrol_and_Chemopreventive.html

http://science.naturalnews.com/R/Resveratrol_and_Antiproliferative.html

http://science.naturalnews.com/R/Resveratrol_and_Anti-Angiogenic.html

http://science.naturalnews.com/R/Resveratrol_and_Apoptotic.html

Oxindole alkaloids:

Pteropodin, Specrofillin, Hystopteropodin, Uncaria F, Uncaria Tomentosa, Isomitrofillin, etc.

  1. Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline …

    http://www.ncbi.nlm.nih.gov/pubmed/19724995‎

    Sep 1, 2009 – In this study, the pentacyclic oxindole alkaloid mitraphylline was isolated … on human Ewing’s sarcoma MHH-ES-1 and breast cancer MT-3 cell …

  2. Cat’s Claw Oxindole Alkaloid Isomerization Induced by Cell …

    http://www.ncbi.nlm.nih.gov/pubmed/23975868‎

    Aug 23, 2013 – Cat’s Claw Oxindole Alkaloid Isomerization Induced by Cell Incubation and Cytotoxic Activity against T24 and RT4 Human Bladder Cancer Cell …

  3. Mitraphylline – Wikipedia, the free encyclopedia

    en.wikipedia.org/wiki/Mitraphylline‎

    „Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing’s sarcoma and breast cancer cell lines” …

  4. Cat’s Claw – American Cancer Society

    Sep 12, 2011 – Thanks to American Cancer Society volunteers, cancer patients receive…. Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline …

  5. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05907.x/pdf  Nov 9, 2005 – increasing survival rates amongst cancer patients. However, mutations …purified oxindole alkaloids, namely isopteropodine (A1), pteropodine …
  6. cancer | Naturopathy by Savvas Ioannides N.D.

    naturalhealingcyprus.wordpress.com/tag/cancer/‎

    Jul 10, 2013 – Posts about cancer written by Naturopathy by Savvas Ioannides. …minimal traces of immune-suppressing tetracyclic oxindole alkaloids (TOAs) …

  7. Cat’s Claw: A Rainforest Herb Quells Inflammation, Supports … www

    .lef.org/magazine/mag2007/mar2007_nu_catsclaw_01.htm‎

    He improved remarkably, and one year later was apparently free of cancer. … of cat’s claw to compounds called oxindole alkaloids;1 more recently, however, …

    see this article Cat’s Claw click here

Styryl-lactones :

Altholactone, Goniothalamin,etc

Tannins:

A group of polyhenols; tannins are divided into 2 chemically distinct groups:

1) the condensed tannins (Proanthocyanidin)

2) the hydrolysable tannins (as hydrolysable Ellagitannins, such as Woodfordin C (macrocyclic ellagitannin dimmer), Oenotheietc.

NOTE: Anthocyanins: Peonidine-3-glucoside, Cyanidin-3-glucoside , etc.

see Tannic acid above

Terpenes:

Alisol B acetate, Atractylon, Atractylenolides, Betulinic acid, Bisabolol, Boswellic acid, Carnosic acid,

Ferutidin, Ferutinin, Myristicin, Oleanolic acid, Parthenolide, Pomolic acid, Tymoquinone, …etc…

See Myristicin,above

Vanillys-phenols :

a group of polyhenols; share structural similarities possessing both the vanillyl (4-hydroxy

3-methoxyphenyl) moiety and the ketone functional group in their structure; Paradols, Gingerols, Yakuchinone B,

Curcumin (diferuloyl methane), Capsaicin (homo-vanillic acid derivative : 8 methyl-N-Vanillyl-6-nonenamide),etc.

See  Capsaicin,above

  • Curcumin

Turmeric(cucurmin) : http://science.naturalnews.com/c/curcumin_and_cancer.html ,

http://science.naturalnews.com/C/Curcumin_and_Anti-Angiogenic.html

http://science.naturalnews.com/C/Curcumin_and_Apoptotic.html

http://science.naturalnews.com/C/Curcumin_and_Antineoplastic.html

http://science.naturalnews.com/C/Curcumin_and_Chemopreventive.html

See also:

Ginger: http://science.naturalnews.com/G/Ginger_and_cancer.html

Cinnamon: http://science.naturalnews.com/C/Cinnamon_and_cancer.html

SPICES – more spices and herbs.plants in the book .

Triterpenoids

Malol, micromerol, urson, prunol, (3b)-3-hydroxyurs-12-en-28-oic acid

Ursolic acid is a is a pentacyclic triterpenoid.

Ursolic acid is present in many plants, including apples, bilberries, cranberries, elder flower, peppermint, lavender, oregano, thyme, hawthorn, prunes.

Ursolic acid has medicinally action, both topically and internally. Ursolic acid is used in many cosmetic preparations for its anti-inflammatory, antitumor and antimicrobial properties.Ursolic acid has antibacterial and antifungal activity. Tests have shown that Ursolic acid inhibits the growth of Candida albicans and Microsporium lenosum.Ursolic acid has anti-inflammatory properties and is used in ointments to treat burns.Topical application of ursolic acid inhibited TPA-induced initiation and promotion of tumor growth.
science.naturalnews.com/U/Ursolic_Acid_and_cancer.html

http://science.naturalnews.com/U/Ursolic_Acid_and_Anti-Inflammatory.html important for preventing inflammation (i.e:used  in conjunction with CESIUM treatment)

http://science.naturalnews.com/U/Ursolic_Acid_and_Immune_system.html

http://science.naturalnews.com/U/Ursolic_Acid_and_Anti-Proliferative.html

http://science.naturalnews.com/U/Ursolic_Acid_and_Apoptotic.html

http://science.naturalnews.com/U/Ursolic_Acid_and_Chemotherapeutic.html

Other Phytochemicals

Inositol-phosphate

In plants phytic acid is the principal store of phosphate. Phytic acid is a natural plant antioxidant.

Phytic acid can be found in most grains, seeds and beans. Rich sources of phytic acid are wheat bran and flaxseed (3 % phytic acid).

Health Benefits of Phytic acid

Phytic acid has been considered as an anti-nutritional component in cereals, seeds and beans. Research has traditionally focused on its structure that gives it the ability to bind minerals, proteins and starch, and the resulting lower absorption of these elements. However, resent research have shown that phytic acid has many health benefits. Phytic acid has antioxidant, anticancer, hypocholesterolemic and hypolipidemic effects.

Anticancer effect of phytic acid

In animal studies phytic acid showed a protective action in carcinogenesis. This action could be explained by its mineral chelating potential. Some studies suggest that phytic acid acts as anti-cancer agent by reversing the proliferative effects of carcinogens.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

Journal of Nutrition. 2003 November;133:3778S-3784S.

Phytic acid seems only to affect cancer cells and not normal cells. Phytic acid and inositol improves the effectiveness of chemotherapy. More studies are required to determine optimal dosage, effectiveness and safety of phytic acid.

The biochemical changes associated with phytic Acid on induced breast proliferative lesions in rats: preliminary findings. 

Cancer Biology and Therapy. 2006 September;5(9):1129-33

Previous studies shown that phytic acid inhibits or prevents the growth of neoplasms. The aim of this study was to investigate if phytic acid has an effect on tumorigenesis by inducing apoptosis and inhibiting of oxidative stress. The in-vivo test was carried out on rats which were treated with the carcinogen dimethylbenz(a)anthracene (DMBA). The researchers found that the administration of phytic removed the benign proliferative breast changes. Phytic acid significantly decreased trichostatin A and nitric oxide levels and increased apoptosis. The study concluded that the administration of phytic acid reversed the proliferative effects of the carcinogen DMBA, and could have a protective effect.

Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea. 

Carcinogenesis. 1997 October;18(10):2023-6

Epidemiological studies show a relation between diet and the incidence of colon cancer. Both phytic acid and phytochemicals in green tea seems to act as anticancer agents and have been linked wit reduced risk of cancer. The aim of this in vivo study with rats was to determine the possible synergistic effect of phytic acid and green tea on the inhibition of colonic preneoplastic lesions formations and the enzyme glutathione S-transferase. The rats were treated with the carcinogen azoxymethane and received different combinations of phytic acid and green tea. The researchers found that green tea alone had only marginal effect whereas phytic acid significantly reduced the incidence of aberrant crypt foci. The combination of phytic acid and green tea showed a significant and synergistic anticancer effect.

Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention. 

Biochemical and Biophysical Research Communications. 2001 November 2;288(3):552-7

According to K Midorikawa and colleagues, phytic acid is one of the most promising cancer chemopreventive agents. The aim of this study was the determine the anticancer mechanism of phytic acid. They found that phytic acid inhibited the oxidative damage of hydrogen peroxide, but that phytic acid did not directly scavenge hydrogen peroxide. Phytic acid did not cause damage to DNA. They concluded that phytic acid acts as an antioxidant and anticancer agent by chelating metals.

Antitumor activity of phytic acid (inositol hexaphosphate) in murine transplanted and metastatic fibrosarcoma, a pilot study.

Cancer Letters. 1992 July 31;65(1):9-13

In vivo tests have shown that phytic acid exerts a antitumor effect on experimental colon cancer. The purpose of this study was to determine the antitumor activity of phytic acid on other experimental tumor models, such as murine fibrosarcoma. The researchers found that the intraperitoneal injection of mice with phytic acid reduced the growth of subcutaneously transplanted fibrosarcoma and prolonged survival. Phytic acid could have a potential use in the therapy of cancer.

science.naturalnews.com/P/phytic_acid_and_cancer.html
2008 Acta poloniae pharmaceutica
2008 Acta poloniae pharmaceutica
Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats.2010 Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie

Benificial for diabetic patients

Phytic acid may have health benefits for diabetes patients. It lowers blood glucose response by reducing the rate of starch digestion and slowing the gastric emptying.

Other effects

Phytic acid releases inositol that during digestion. Although inositol is not an essential nutrient it might reduce depressions. Studies also show that phytic acid may reduceinflammation.

Other things:

Melatonin( night sleep between 22 pm – 3am) -VERY IMPORTANT

www.naturalnews.com/033511_melatonin_cancer.html  – IMPORTANT article  ,

http://articles.mercola.com/sites/articles/archive/2013/03/19/melatonin-benefits.aspx

 

1.  „Melatonin is a potent immune-enhancing hormone produced by the human pineal gland and appears to have substantial cancer-repelling power. In addition to boosting the activity of key immune cells called T helper cells, melatonin stimulates the tumor-killing action of natural killer cells (NK) by increasing the white blood cell production of the cytokine Interleukin-2 (IL-2) [Excerpt from the Definitive Guide to Cancer, by John Diamond, M.D. and Lee Cowden, M.D]

2.  „Researchers at Brigham and Women’s Hospital (BWH), led by Eva Schernhammer, MD, DrPH, (Assistant Professor of Medicine at Harvard Medical School) were among the first to report that nightshift workers may have an increased risk of developing breast cancer. Decreased levels of melatonin – a hormone closely linked to sleep patterns – is believed to be a possible cause. Now, in the next phase of this research, Schernhammer reports that lower melatonin levels are associated with a higher risk of breast cancer. The findings are published in the July 20, 2005 issue of the Journal of the National Cancer Institute (JNCI). The hormone melatonin is typically released from the brain during the night. It is the reason people get sleepy. Nightshift workers, exposed to bright light during the evenings, produce less melatonin. Laboratory studies have shown that melatonin production can put tumor cells “to sleep” by stunting growth. A recent report indicated that in constant light, tumors grew seven times faster than they did in the dark. In this study, the researchers measured urinary melatonin in 147 women who developed invasive breast cancer and 291 matched women who did not develop breast cancer. They found that women with the lowest levels of the melatonin metabolite in their urine were 70 percent more likely to develop breast cancer.” [Press Release – Brigham and Women’s Hospital Research Unit]

3.  On October 17 2001, the Journal of the National Cancer Institute (Vol. 93, No. 20, pp. 1557-1568) published two papers reporting a significant increase in the risk of breast cancer among women who frequently did not sleep during the period of the night, about 1:30am, when melatonin levels are typically at their highest.

4.  Research presented recently at the 94th Annual Meeting of the American Association for Cancer Research in Washington, D.C., shows evidence that the night-time production of the hormone melatonin (produced during deep sleep) inhibits the growth of human breast cancer by blocking the tumor’s uptake of dietary linoleic acid. [Bassett Research Institute – Preclinical Study supported by the National Cancer Institute]

5.  Studies at the University of Texas Medical Branch showed that „melatonin significantly increased the latency period of the tumor, by delaying the appearance of the tumor”.

6.  According to the University of Maryland Medical Center: „Women with breast cancer and men with prostate cancer tend to have lower levels of melatonin than those without the disease. Low levels of melatonin stimulate the growth of certain types of cancer cells and adding melatonin to these cells inhibits their growth. Meditation appears to be a valuable addition to the treatment of cancer due to a rise in levels of melatonin in the body.”

7.  According to the University of Massachusetts Medical Center: „Melatonin has been shown by a number of studies to significantly inhibit breast cancer in animals and tissue culture.” In a separate study performed at the University a higher level of melatonin was found in meditators than in non-meditators.

8.  According to the American Cancer Society: „A National Institute of Health panel found evidence that regular meditation can also reduce symptoms of post-traumatic stress syndrome, and increase longevity and quality of life. The same study found that those who meditated had a better immune response than those who did not meditate.”

9.  „Melatonin can kill directly many different types of tumour cells. It is a naturally produced cytotoxin, which can induce tumor cell death (apoptosis). In instances where the tumour has already established itself in the body, melatonin has been shown to inhibit the tumour’s growth rate. Melatonin exhibits natural oncostatic activity and inhibits cancer cell growth. In patients in whom cancer has become a noticeable physical burden and produces overt symptoms, melatonin has been shown to alleviate numerous cancer symptoms and to inhibit development of new tumour blood vessels (tumour angiogenesis), which in turn inhibits the cancer from spreading further (mestastasis). Radiation therapy usually induces anemia. Melatonin stimulates platelet production and has been shown to effectively treat cancer patients with low platelet counts and anemia. Melatonin reduces chemotherapy-induced cardiotoxicity, neurotoxicity, thrombocytopenia (reduced platelet counts), stomatitis (inflammation of mouth), and asthenia (weakness), and improves the overall response in cancer patients.” [Clinical Study, The Life Extension Foundation]

10.  “Results from a new study in laboratory mice show that night-time exposure to artificial light stimulated the growth of human breast tumors by suppressing the levels of a key hormone called melatonin. The study also showed that extended periods of night-time darkness greatly slowed the growth of these tumors.” [US Department of Health and Human Services – National Institute of Health]

11.  „Experienced meditators practicing either TM-Sidihi or another internationally well known form of yoga meditation showed significantly higher melatonin levels in the period following meditation.” [School of Psychology, La Trobe University, Australia]

 

 

Hyperthermia:

Scientific Publications

  • Bicher, James Haim, MD., Wolfstein, Ralf, M.D. Thermoradiotherapy with curative intent – breast, head and neck and prostate tumors. Deutsche Zeitschrift für Onkologie (German Journal of Oncology) 2006, 38: 116-122.
  • Bicher HI, McLaren JR, Pigliucci GM, (eds). Consensus on Hyperthermia for the 1990s.Clinical Practice in Cancer Treatment. Plenum Press, New York and London, 1990.
  • Bicher HI, Hetzel FW, Sandhu TS. Physiology and Morphology of Tumor Microcirculation on Hyperthermia. Chapter 9. Ed. K Storm, K Hall Publisher, New York, 1982.
  • Bicher HI, Hetzel FW, D’Agostino L, Johnson RJ. Changes in tumor tissue oxygenation induced by microwave hyperthermia. Int J. Radiat Oncol Biol Phys 1977, S2:157.
  • Bicher HI, Hetzel FW, Mitagvaria N, O’hara M. Reoxygenation induced by localized microwave hyperthermia as an adjuvant to radiation therapy. 6th International Congress of Radiation Research, 1979, 5:171-175.
  • Bicher HI, Hetzel FW, Sandhu TS, Frinak S, Vaupel P, O’Hara MD, O’Brien T. Effects of hyperthermia on normal and tumor microenviroment. Radiology 1980, 137:523530.
  • James Haim Bicher, M.D. The physiological effects of hyperthermia. Radiology; 1980:511513.
  • Sandhu TS, Bicher HI, Hetzel FW. A thermal dosimetry system with blood flow simulation. Journal of National Cancer Institute, 6:361-363.
  • Bicher HI, Sandhu TS, Vaupel P, Hetzel FW. The effect of localized microwave hyperthermia on physiological responses. Journal of National Cancer Institute, 6:375-377.
  • Bicher HI, Sandhu TS, Hetzel FW. Inhomogenities in oxygen and pH distributions in tumors. Radiat Res 1980, 83376.
  • Hetzel FW, Kaufman N, Brown M, Bicher HI. Indirect sensitization by drug induced reoxygenation in spheroids. Radiat Res 1980, 83:375376.
  • Bicher HI, Sandhu TS, Vaupel P, Hetzel FW. Physiological mechanisms of action of localized microwave hyperthermia. Presented at the Third International Symposium on Cancer Therapy by Hyperthermia, Drugs and Radiation. Fort Collins, Colorado, June 1920, 1980.
  • Bicher HI, Sandhu TS, Hetzel FW, Matvia F. An effective fractionation protocol for the clinical use of hyperthermia with adjuvant radiation. Presented at the Second Meeting of the European Group on Hyperthermia in Radiation. Rome, Italy, September 1920, 1980.
  • Bicher HI, Vaupel P, O’Hara MD, O’Brien T, Mitagvaria N. Tissue oxygenation in normal and hyperthermic conditions. In proceedings of the XXVIIIth International Congress of Physiological Sciences. Budapest, Hungary, July 1318, 1980. Akademial Kiado Publishers: Adv. Physiol Sci. 1981, 25:215233.
  • Bicher HI, Hetzel FW, Vaupel P, Sandhu TS. Microcirculation modification by localized microwave hyperthermia and hematoporphyrin phototherapy. Bibl Anat 1981, 20:628632.
  • James Haim Bicher, M.D., Nodar Mitagvaria Circulatory responses of malignant tumors during hyperthermia. Microvascular Research 1981, 21:1926.
  • Bicher HI, Sandhu TS, Vaupel P, Hetzel FW. Effect of localized microwave hyperthermia on physiological responses. Natl Inst Drug Abuse Res Monogr Ser 1982, 61:217219.
  • Vaupel P, Frinak S, MuellerKlieser W, Bicher HI. Impact of localized hyperthermia on the cellular microenvironment in solid tumors. Natl Inst Drug Abuse Res Monogr Ser 1982, 61:207209.
  • Bicher HI. Impact of microcirculation and physiologic considerations on clinical hyperthermia. Proceedings 13th International Cancer Congress, 235245, Alan R Liss Inc., New York, 1983.
  • Bicher HI, Mitagvaria NP. Changes in tumor tissue oxygenation during microwave hyperthermia clinical relevance. Advances in Experimental Medicine and Biology, 180: 190905, 1985.
  • Mitagvaria NP, Bicher HI. Effect of microwave radiation on local blood flow and tissue oxygenation in the brain. Bulletin of Experimental Biology and Medicine, 98:895897, 1984.
  • Bicher HI, Shani J, Reesman KJ. Use of non perturbing thermocouples (NPT’s) for hyperthermia clinical thermometry. Int. J. Hyperthermia, 3:550551, 1987. (Abst) and J. Microwave power 22: 173, 1987, (Abst).
  • Bicher HI, Wolfstein RS. Local Hyperthermia of tumors at moderate depth using POPAS: Results by site (Abstract). 36th Annual Meeting of the Radiation Research Society, 4:1621, 1988.
  • Bicher HI, Shani J, Reesman KJ. Use of nonperturbing thermocouple for clinical hyperthermia thermometry (Abstract). 36th Annual Meeting of the Radiation Research Society, 4:1621, 1988.
  • Bicher HI, Wolfstein RS. Treatment of intratoracic lesions. Preliminary results (Abstract). 37th Annual Meeting of the Radiation Research Society. 3:1823, 1989.
  • Bicher HI, Reesman KJ, Afuwape SA. A target triapplicator system with nonperturbing thermocouples thermometry. Hyperthermic Oncology 1988, Taylor and Francis, 1:778779, 1989.
  • Bicher HI, Mitagvaria, N. Oxygen and pH in Human Tumors During Hyperthermia (Abstract). Proceeding of the 1991 International Society on Oxygen Transport to Tissue Meeting (ISSOT). Willemstad, Curaco, Netherlands Antilles, August 24-30, 1991.
  • Mitagvaria, N., Bicher HI. Local Blood Flow and PO2 in Rat’s Brain During Maze Behavior (Abstract). Proceeding of the 1991 International Society on Oxygen Transport to Tissue Meeting (ISSOT). Willemstad, Curaco, Netherlands Antilles, August 24-30, 1991.
  • Bicher HI, Wolfstein RS. Transcranial Treatment of Brain Tumors with Microwave Hyperthermia (Abstract). Proceeding of the 8th Annual Conference of the American Society for Clinical Hyperthermic Oncology (ASCHO). Chicago, Illinois, October 31-November 2, 1991.
  • Bicher HI, Mitagvaria N. Oxygen and pH in Human Tumors During Hyperthermia (Paper presented as a poster). Proceeding of the 6th International Congress on Hyperthermic Oncology. Tucson, Arizona, April 26- May 1, 1992.
  • Surowiec, A. Bicher HI, Caridad, C. A Comparison of Heating Characteristics of Two Hyperthermia Systems Used for Deep Seated Malignancies BSD-2000 and Tripas (Abstract). Proceeding of the 16th International Symposium on Clinical Hyperthermia (ISCHO). Kyoto, Japan, June 13-16, 1993.
  • Bicher HI, Yarmonenko S, Wainson A, Swrowiec I, Metagvaria N. Specific inhibition of L-Glucose cell proliferation. Potentiation of Hyperthermia, Radiation and Chemotherapy effects (Abstract). Proceeding of the 10th Annual Meeting of the American Society Of Clinical Hyperthermic Oncology (ASCHO). Memphis, Tennessee; November 28-30, 1993.
  • Surowiec, A, Bicher HI, Intercomparison of Heating Patterns of the BSD-2000 and the Tripas System (Abstract). Proceeding of the 14th Annual Meeting of the North American Hyperthermia Society (NAHS), Nashville, Tennessee, April 29- May 4, 1994.
  • Bicher HI, Yarmonenko, S. Wainson, A. Surowiec, I. Mitagvaria, N. Anticancer Effect of L-Glucose In-Vivo Potentiation of Hyperthermia (Abstract). Proceeding of the 17th International Symposium on Clinical Hyperthermia (ISCH). Pavia, Italy, May 1-5, 1994.
  • Bicher HI MD., Eva H. Barker, Patrick J. Bolan, Lance delabarre, Hellmuth Merkle, Lenore I. Everson, Michael Garwood. In VIVO Monitoring to Treatment for Breast Cancer Using 4T H MRS. Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth street SE, Minneapolis, MN. USA;
  • H. Bicher, Mitagvaria, I. Kvachadze , T. Khetsuriani, A. Shukakidze, I. Lazrishvili, M. Arabuli, TS.T. Khomeriki, Main factors in development of local hyperthermia-induced morphological changes in cerebral tissue of the rat In Press, Proceedings of Tbilisi State Medical University.

Resources

Here are part of the extended bibliography and enormous amount of studies that exist about natural substances and their effective effect against cancer( I say part as most of them are cited from NaturalNews website, website I also write for; fpr example, see my article on scientific studies on chemo/radiation: http://blogs.naturalnews.com/should-one-use-conventional-cancer-treatments-chemotheraphy-or-radiation/)

NOTEs:

1.Take your nutrients from ORGANIC WHOLE FOODS rather than supplements

2.The impoverishment of vitamin and pro-vitamin complexes no longer present in food, with the consequent increase in degenerative and deficient diseases such as cancer. The deliberate attempt to deactivate the natural substances contained in the plants is very serious: in this way fresh fruit and vegetables – greatly impoverished of many vitamins – can be carried over long distances and long periods of time because their oxidation does not take place.This vitamin impoverishment will ensure commercial

profits and represents a serious act of deliberate damage inflicted on the Ecosystem by means of GMOs.

It’s heavy the possible disappearance of anti-cancer vitamins, that induce apoptosis (suicide) of the

tumors (Anthocyanin, Flavonoids (1122), Polyphenols (1123), sesquiterpene lactone Parthenolide (701), penta-acetyl

Geniposide (1061), Camelliin B (698), beta-Cryptoxantin (1063), Hesperidin (1063), Emodin (247,333,715), ursolic acid (700),

allyl Sulfur (694,696), Eriodictoyol (693), hibiscus protocatechin acid (692), Indoles (809), Isothiocyanates (809), Resverarol

(695), Elemene (690), Acutiaporberine (711), Capsaicin (719), Wagonin (713), Fisetin (713), carnosic acid (1062), Germanium

sesquioxide (269), epigallocatechin Gallate (173,1124), Axerophthol palmitate, alpha and beta Carotene, trans-Retinoic acid,

Tocopherols, Limonene (693), Cynaropicrin, Lycopene (633,1359), Proanthocyanidin, Damnacanthal (1043), Baicalin (718),

Baicalein (718), hydrocinnamic acid (693), sesquiterpenoids as Atractylon (704), as Atractylenolides I, II, III (704),

gelsemium alkaloids (699), tartary buckwheat flavonoid (1064), Sinigrin, ferulic acid, ellagic acid, cumarinic acid, …)

SEE: http://www.erbeofficinali/dati/nacci/allpdf.php

The disappearance of these natural anti-cancer vitamins is a grave threat.

See also a FREE EBOOK detailing Thousand Plants against Cancer without Chemo-Therapy ,May 2010 ,650 pages

EVIDENCE BASED MEDICINE:  2,050 official scientific publications ,2,100 various bibliographical references BONUS in my book, next to other 4 free ebooks(Dr. W .Kelley Dr. Binzel, Dr. Matias Rath , Johanna Brandt. )

In this book the plants are identified by their Latin names – according to the modern scientific classification (see Chapter 20)

– and 2,050 official scientific publications are quoted (out of 2,100 various bibliographical references (see Chapter 21), useful to in depth studies, which confirm the various arguments indicated there.

<<PREVIOUS PAGE                          NEXT PAGE>>

Scientific Studies DATABASE PAGE 6

oct.2

CLICK AICI pentru  limba ROmana (DACA nu e deja tradusa)

 

PAGE 6 CONTENTS:

  • Hydroxycinnamic Acids
    • Chicoric acid
    • Coumarin
    • Ferulic acid

  • Isoprenoides :Abscisic acid, Acorenone, Alloaromadendrene, Aromadendrene, Bergamotene, Bisabolene,Borneol, Bornyl acetate, Isoborneol, Cadinene, Camphene, Caranol, Carene, Carvacrol, Carvone,Pinocarvone, Caryophyllene, Cedrine, Cineole, Cinnamaldehyde, Cinnamate, Citral,Cinnamaldehyde, Cyclocitral, Citronella, Citronellyl acetate or butyrate or propionate, Copaene, Cresol, Cubebene, Cymene, Damascenone,Elemene, Estragol, Eugenol, Farnesene, Fencone, Geraniol, Germacrene, Hotrienol, Humulene, Ionol, Ionone, Isopinocamphone, Isopulegol, Linalool, Longifolene, Mentol, Neomenthol, Menthone, Isomenthone, Murolene, Myrcenol, Myrcene, Myrtenol, Neral, Nerol, Nerolidol, Nootkatone, Ocimene, Ocimenol, Perillaldehyde, Phellandrene, Pinene, Pinocamphone, Piperitol,Piperitone, Pristane, Pulegone, Sabinene, Sabinol, Santalol, Selinadiene, Selinene, Sinensal, Styrene, Terpinene, Terpineol, Terpinolene, Thymol, Tricyclene, Vanillin, Valencene,
  • Lecithins 
  • Lignans (Silymarin)
  • Monophenols 
  •              Hydroxytyrosol
  • Monoterpenes
    • Geraniol
    • Limonene
  • Organosulfides
    • Allicin
    • Glutathione
    • Indole-3-Carbinol & Di-Indole Methane
    • Isothiocyanates
    • Sulforaphane
  • Phenolic Acids
    • Capsaicin
    • Ellagic acid
    • Galic Acid
    • Rosmarinic acid
    • Tannic Acid
  • Phytosterols
    • Beta-Sitosterol
  • Saponins
  • Stilbenes: 1. Pterostilbene 2. RESVERATROL
  • Oxindole alkaloids
  • Styryl-lactones : Altholactone, Goniothalamin,etc
  • Tannins:
  • 1) the condensed tannins (Proanthocyanidin)
  • 2) the hydrolysable tannins (as hydrolysable Ellagitannins, such as Woodfordin C (macrocyclic ellagitannin dimmer), Oenotheietc.Anthocyanins: Peonidine-3-glucoside, Cyanidin-3-glucoside , etc.
  • Terpenes:  Alisol B acetate, Atractylon, Atractylenolides, Betulinic acid, Bisabolol, Boswellic acid, Carnosic acid,Ferutidin, Ferutinin, Myristicin, Oleanolic acid, Parthenolide, Pomolic acid, Tymoquinone, …etc…
  • Vanillys-phenols : Paradols, Gingerols, Yakuchinone B, Curcumin (diferuloyl methane), Capsaicin (homo-vanillic acid derivative : 8 methyl-N-Vanillyl-6-nonenamide),etc. Curcumin
  • Triterpenoids :
  • Ursolic acid
  • Other Phytochemicals
    • Damnacanthal
    • Digoxin
    • Phytic acid
  • Other things: melatonin

Hydroxycinnamic Acids

Dicaffeoyl-tartaric acid

Chicoric acid is a caffeic acid derivative, belonging to the group of polypfenols.
science.naturalnews.com/C/Caffeic_Acid_and_cancer.html

http://science.naturalnews.com/C/Caffeic_Acid_and_Anticarcinogenic.html

http://science.naturalnews.com/C/Caffeic_Acid_and_Chemotherapeutic.html

http://science.naturalnews.com/C/Caffeic_Acid_and_Anti-Angiogenic.html

Chicoric acid is the most active compound in Echinacea pupurea. Chicoric acid is very stable in dry conditions but can be broken down by enzymes, which are found in the Echinacea, in moist conditions.

  • DistributionChicoric is only found in Echinacea purpurea.Health Benefits of Chicoric acidChicoric acid makes our immune cells more efficient in attacking intruders. In vivo en vitro studies have shown that chicoric acid promotes phagocytosis. This is the process whereby white blood cells and lymphocytes attack and destroy pathogens. Chicoric acid stimulates T-cell activation, stimulates healing of wounds and reduces the inflammation in arthritis. Chicoric acid increases the production of interferon, immunoglobulin and other chemicals important for the immune system.Studies have indicated that chicoric acid can inhibit the penetration of viruses in cells.Chicoric acid also acts as an antioxidant by preventing the oxidation of collagen and cells.

1,2-Benzopyrone, 2H-1-Benzopyran-2-one

Coumarin is a phytochemical with a vanilla like flavour. Coumarin is a oxygen heterocycle. Coumarin can occur either free or combined with the sugar glucose (coumarin glycoside).

Distribution

Coumarin is found in several plants, including tonka beans, lavender, licorice, strawberries, apricots, cherries, cinnamon, and sweet clover. 

Health Benefits of Coumarin

Coumarin has blood-thinning, anti-fungicidal and anti-tumor activities.

science.naturalnews.com/C/Coumarin_and_cancer.html

http://science.naturalnews.com/C/Coumarin_and_Antimitotic.html

http://science.naturalnews.com/C/Coumarin_and_Antiproliferative.html

http://science.naturalnews.com/C/Coumarin_and_Apoptotic.html

Coumarin should not be taken while using anticoagulants. Coumarin increases the blood flow in the veins and decreases capillary permeability. Coumarin can be toxic when used at high doses for a long period

Facts about Coumarin

Coumarin seems to work as a pesticide in the plants that produce it. Coumarin is responsible for the sweet smell of new mown hay.

 

4-hydroxy-3-methoxycinnamic acid

Pure ferulic acid is a yellowish powder. Ferulic acid belong to the family of hydroxycinnamic acid. The chemical structure of ferulic acid is very similar to that of curcumin.

The phytochemical ferulic acid is found in the leaves and seeds of many plants, but especially in cereals such as brown rice, whole wheat and oats. Ferulic acid is also present in coffee, apple, artichoke, peanut, orange and pineapple.

Health Benefits of Ferulic acid

Ferulic acid is an antioxidant which neutralizes free radicals (superoxide, nitric oxide and hydroxyl radical) which could cause oxidative damage of cell membranes and DNA. Ferulic acid helps to prevent damage to our cells caused by ultraviolet light. Exposure to ultraviolet light actually increases the antioxidant potency of ferulic acid.

science.naturalnews.com/…/88169_Protective_effects_of_a_topical_ antioxidant_mixture_containing_vitamin_C.html
… ferulic acid, and phloretin against ultraviolet induced photodamage in human skin. …and chronic reactions, including premature skin aging and skin cancer.
science.naturalnews.com/…/2559062_Protective_effect_of_ferulic_acid_on_ nicotine_induced_DNA_damage.html
Protective effect of ferulic acid on nicotine induced DNA damage and cellular … smoke and plays an important etiological role in the development of lung cancer.
science.naturalnews.com/F/Ferulic_acid_and_Inflammatory.html
FA15, a hydrophobic derivative of ferulic acid, suppresses Inflammatory responses and skin tumor promotion: comparison with ferulic acid. 2002 Cancer letters
science.naturalnews.com/…/875229_Ferulic_acid_augments_angiogenesis_ via_VEGF_PDGF_and_HIF_1.html
Ferulic acid augments angiogenesis via VEGF, PDGF and HIF 1 alpha. … broad range of therapeutic effects on human diseases, including diabetes and cancer.
science.naturalnews.com/…/1973049_Actions_of_ferulic_acid_and_vitamin_ E_on_prevention_of.html
Actions of ferulic acid and vitamin E on prevention of hypercholesterolemia and atherogenic lesion … Vitamin D is nutritional key for prevention of breast cancer.
science.naturalnews.com/…/2144597_Protective_effect_of_ferulic_acid_on_ 712_dimethylbenzaanthracene_induced_skin.html
Protective effect of ferulic acid on 7,12 dimethylbenz[a]anthracene induced skin carcinogenesis in Swiss … List of Cancer-Causing Agents Grows (press release).

Ferulic acid is often added as ingredient of anti-aging supplements. Studies have shown that ferulic acid can decrease blood glucose levels and can be of help to diabetes patients.Ferulic acid seems to protect against cancer, bone degeneration, menopausal symptoms (hot flushes). Like many other antioxidants, ferulic acid reduces the level of cholesterol and triglyceride, thereby reducing the risk of hearth disease. Ferulic acid seems to reduce the risk of many cancers, including cancer of the stomach, colon, breast, prostate, liver, lung and tongue. A study by W Kuenzig et all Caffeic and ferulic acid as blockers of nitrosamine formation published in Carcinogenesis (Vol 5, 1984) showed that dietary caffeic acid and ferulic acid may play a role in the body’s defence against carcinogenesis by inhibiting the formation of N- nitroso compounds.

Ferulic acid can be converted into the flavour vanillin by biochemical reaction.

Isoprenoides :

Abscisic acid, Acorenone, Alloaromadendrene, Aromadendrene, Bergamotene, Bisabolene,Borneol, Bornyl acetate, Isoborneol, Cadinene, Camphene, Caranol, Carene, Carvacrol, Carvone,Pinocarvone, Caryophyllene, Cedrine, Cineole, Cinnamaldehyde, Cinnamate, Citral,Cinnamaldehyde, Cyclocitral, Citronella, Citronellyl acetate or butyrate or propionate, Copaene, Cresol, Cubebene, Cymene, Damascenone,Elemene, Estragol, Eugenol, Farnesene, Fencone, Geraniol, Germacrene, Hotrienol, Humulene, Ionol, Ionone, Isopinocamphone, Isopulegol, Linalool, Longifolene, Mentol, Neomenthol, Menthone, Isomenthone, Murolene, Myrcenol, Myrcene, Myrtenol, Neral, Nerol, Nerolidol, Nootkatone, Ocimene, Ocimenol, Perillaldehyde, Phellandrene, Pinene, Pinocamphone, Piperitol,Piperitone, Pristane, Pulegone, Sabinene, Sabinol, Santalol, Selinadiene, Selinene, Sinensal, Styrene, Terpinene, Terpineol, Terpinolene, Thymol, Tricyclene, Vanillin, Valencene, Verbenone, Vitispirane, etc.

  • Cinnamaldehyde

Sources:Cinnamon

science.naturalnews.com/…/188629_Allyl_isothiocyanates_and_ cinnamaldehyde_potentiate_miniature_excitatory_postsynaptic_inp…
… Cancer Pathophysiology Division, National Cancer Center Reseach Institute, … Allyl Isothiocyanates (AITC) and cinnamaldehyde are pungent compounds …
science.naturalnews.com/…/1769088_Growth_inhibition_of_human_colon_ cancer_cells_by_plant_compounds.html
CONCLUSION : Cinnamaldehyde, piperine, and resveratrol offer significant in vitro anti-proliferative effects on cultured human colon cancer cells. While each …
science.naturalnews.com/…/1499711_Coumarin_and_cinnamaldehyde_in_ cinnamon_marketed_in_Italy_a_natural.html
Coumarin and cinnamaldehyde in cinnamon marketed in Italy: a natural … The Cure in the Kitchen: Honey and Cinnamon can Cure Cancer and Arthritis.

  • Elemene

Sources: (Curcuma zedoaria and another plants)

A significant effect on the treatment of glioma was reported using Elemene which is found in small

amounts in many essential oils: it prolonged quality survival time of 40 patients with glioma (1574)

(Tan P.: Clinical study on treatment of 40 cases of malignant brain tumor by Elemene emulsion injection, Chin. J.

Integ. Trad. Western Med, 20, pp.: 645-648, 2000) http://www.mednat.org/cancro/cancro_cervello.pdf

OBJECTIVE: To investigate the effect of elemene emulsion injection (EEI) in treating malignant brain tumor.

METHODS: By conducting a retrospective study of 40 patients with brain tumor, 29 of malignant glioma and 11 metastatic tumor, who were treated with EEI from January 1994 to May 1998. EEI 0.4-1.2 g/d was given to each patient by intravenous dripping or/and intravenous infusion by pumps, and directly injected into carotid artery or infused through a carotid artery catheter with pumps. The total dosage of 6-12 g was given in 2-6 therapeutic courses with an interval of 1-1.5 months between courses. The effectiveness of treatment was accessed according to the changes of tumor size, Karnofsky Performance Status (KPS) and survival time of patients. The control group consisted of 29 cases of malignant brain tumor (22 of primary and 7 of metastatic) was treated with chemotherapy 2-3 therapeutic courses with an interval of 1-1.5 months between them.

RESULTS:

(1) In the EEI treated group the mean tumor size was changed from 6.70 cm3 (before treatment) to 2.67 cm3 (after treatment), t = 3.02, P < 0.01, it was reduced by 61%;

(2) In the EEI treated group 4 cases was CR, 26 PR, the total effective rate being 75.0% (95% credibility interval +/- 13.4%), while in the control group, 2 of CR, 10 PR, and the total effective rate 41.4% (95% credibility interval +/- 17.9%), the difference between the two groups was significant, chi 2 = 3.867, P < 0.05;

(3) KPS decreased in the EEI group from 94.7 scores (before treatment) to 88.2 scores (after treatment), the decrement was 6.5 scores (t = 3.5313, P < 0.01); (4) The survival time in the EEI treated group was 25.4 months, and that in the control group was 17.4 months (t = 3.74, P < 0.01).

CONCLUSION: Elemene has significant effect on treatment of malignant brain tumor. It could prolong the high quality survival time of patients and is worthy of further investigation.

Elemene , induced apoptosis in leukaemia (1409).

Dă clic pentru a accesa elemene_zedoaria_provoca_apoptosi_nella_leucemia.pdf

  • Eugenol
science.naturalnews.com/E/Eugenol_and_cancer.html
science.naturalnews.com/E/Eugenol_and_Apoptotic.html
2007 Molecular cancer. Pro-apoptotic effect of the landrace Bangla Mahoba of Piper betle on Leishmania donovani may be due to the high content of eugenol.

  • Limonene(see below)

Lecithins :

science.naturalnews.com/L/Lecithin_and_cancer.html
science.naturalnews.com/…/2237506_Oral_carcinogenesis_induced_by_4_ nitroquinoline_1_oxide_in_lecithinretinol.html
Oral carcinogenesis induced by 4 nitroquinoline 1 oxide in lecithin:retinol … induced a higher incidence of oral cancer in LRAT knockout (LRAT(-/-)) than in …

Lignans

  1. How lignans fight cancer? – NutraPro Internationalnutraprointl.com/2009/12/25/how-lignans-fight-cancer/‎ Lignans are being studied for possible use in cancer prevention, particularly breast cancer. Lignans acts as anticancer compounds by blocking …
  2. Breast Cancer Survival and Lignan Intake | NutritionFacts.org

    nutritionfacts.org › Videos‎

    One teaspoon of flax seeds may double one’s daily production of lignans, phytonutrients that appear to play a role in both breast cancer prevention and survival.

  3. Lignans – Linus Pauling Institute at Oregon State Universitylpi.oregonstate.edu/infocenter/phytochemicals/lignans/‎Lignan-rich foods are part of a healthful dietary pattern, but the role of lignans in the prevention of hormone-associated cancers, osteoporosis …
  4. PUBMED Dietary lignans: potential role in cancer prevention.http://www.ncbi.nlm.nih.gov/pubmed/15860433‎Dietary lignans: potential role in cancer prevention. Webb AL, McCullough ML. Graduate Program in Nutrition and Health …
  5. Dietary intakes of total and specific lignans are associated with …http://www.ncbi.nlm.nih.gov/pubmed/22113872‎ – Dietary lignans may affect breast cancer by modifying tumor characteristics likely to affect prognosis. We investigated usual dietary intakes of …
  6. Fighting breast cancer with flaxseeds : Disease Proofhttp://www.diseaseproof.com › Breast Cancer‎- Anti-cancer effects of lignans. Enterolignans are structurally similar to estrogen and can bind to estrogen receptors – this capability allows …
  7. Higher lignan levels improve breast cancer survival – Life Extension …http://www.lef.org/…/0920_Higher-Lignan-Levels-Improve-Breast-Cancer-Sur…‎ In an article published online on September 6, 2011 in the Journal of Clinical Oncology, German researchers report that having high serum …
  8. Dietary Lignan Intake and Postmenopausal Breast Cancer Risk by …

    jnci.oxfordjournals.org/content/99/6/475‎ Studies conducted in Asian populations have suggested that high consumption of soy-based foods that are rich in isoflavone phytoestrogens is …

science.naturalnews.com/…/2632135_Estrogenic_activities_of_sesame_ lignans_and_their_metabolites_on_human.html
Estrogenic activities of sesame lignans and their metabolites on human breast cancercells. Publication: Journal of agricultural and food chemistry. Publication …
science.naturalnews.com/…/2602942_Cytostatic_inhibition_of_cancer_cell_ growth_by_lignan_secoisolariciresinol_diglucoside.html
Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside.
science.naturalnews.com/…/1558789_Spirocyclic_Lignans_from_Guaiacum_ Zygophyllaceae_Induce_Apoptosis_in_Human_Breast.html
Spirocyclic Lignans from Guaiacum (Zygophyllaceae) Induce Apoptosis in Human BreastCancer Cell Lines. Publication: Journal of natural products. Publication …
science.naturalnews.com/…/1311157_Extraction_of_lignans_from_flaxseed_ and_evaluation_of_their_biological.html
Our results show that lignans modulate development of breast cancer cells. The most intense effect was observed for anhydrosecoisolariciresinol, which …
science.naturalnews.com/…/1478913_Vitexins_nature_derived_lignan_ compounds_induce_apoptosis_and_suppress_tumor.html
Vitexins, nature derived lignan compounds, induce apoptosis and suppress tumor growth. Publication: Clinical cancer research : an official journal of the …
science.naturalnews.com/…/2157407_Inhibition_of_Akt_signaling_by_the_ lignan_matairesinol_sensitizes_prostate.html
Dietary lignans have shown cancer preventive and antitumorigenic activity, but the mechanisms behind these effects are poorly known. Here we observed that of  …
science.naturalnews.com/…/1938497_The_effects_of_different_lignans_and _isoflavones_tested_as_aglycones.html
PURPOSE: Phytooestrogens are known to cause anti-cancer effects on mamma carcinoma cells. In this study, the effects of the lignan Secoisolariciresinol and …
science.naturalnews.com/…/2445678_Enterolactone_and_breast_cancer_ methodological_issues_may_contribute_to_conflicting.html
Enterolactone and breast cancer: methodological issues may contribute to conflicting …Lignans found in plant foods are converted by the intestinal microflora to …

Lignans sources

Flaxseeds 1 oz
85.5
Sesame seeds 1 oz
11.2
Curly kale ½ cup, chopped
0.8
Broccoli ½ cup, chopped
0.6
Apricots ½ cup, sliced
0.4
Cabbage ½ cup, chopped
0.3
Brussels sprouts ½ cup, chopped
0.3
Strawberries ½ cup
0.2
Tofu ¼ block (4 oz)
0.2
Dark rye bread 1 slice
0.1

  • Silymarin

science.naturalnews.com/S/Silymarin_and_cancer.html
science.naturalnews.com/S/Silymarin_and_prostate_cancer.html
Identifying the differential effects of Silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. 2008 International …

SOURCES :Milk thistle

See this article on milk Thistle click here

Monophenols

Hydroxytyrosol is believed to be the antioxidant with the highest free radical scavenging capacity: double that of quercetin and more than 3 times that of epicatechin.
Hydroxytyrosol is the main polyphenol found in olives.

The wastewaters generated during olive processing contain a high levels hydroxytyrosol, most of which can be recovered to produce hidroxytyrosol extracts. Studies by Visioli et al (2000) showed that a low dose of hydroxytyrosol reduces the consequences of sidestream smoke-induced oxidative stress in rats.

Health Benefits of Hydroxytyrosol

Hydroxytyrosol has the same health promoting properties than other polyphenols: prevention of atherosclerosis, promotion of intestinal and respiratory health and prevention of cancer. Hydroxytyrosol also reduces the oxidative stress caused by smoking.

Abstracts

Benefits of Hydroxytyrosol

In Vivo Studies about Antioxidant Properties of Hydroxytyrosol

In Vitro Studies about Antioxidant Properties of Hydroxytyrosol

Cancer and Hydroxystyrosol

Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.European Journal of Cancer Prevention. 2002 August;11(4):351-8Epidemiologic studies and animal studies show that olive oil may reduce the risk of several diseases such as cancer and heart disease. The aim of this study was to determine the effect of the main polyphenol in virgin olive oil, hydroxytyrosol, on tumor growth. The in vitro test were carried out in human colon cancer and leukemia cell lines. They found that hydroxytyrosol inhibited proliferation of both cancer cell lines. human promyelocytic leukaemia cells HL60 and colon adenocarcinoma cells HT29 and HT29 clone 19A. Hydroxytyrosol induced cell apoptosis and reduced cancer cell proliferation was reduced up to 50 percent. Hydroxytyrosol caused no such effects on non-cancer human cells, such as lymphocytes and polymorphonuclear cells. The study concluded that hydroxytyrosol may protect against cancer by arresting cell cycle and inducing apoptosis in cancer cells.
Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. Biochemical and Biophysical Research Communications. 2000 November 30;278(3):733-9Hydroxytyrosol is a natural phenolic antioxidant found in olive oil. It has many claimed biological and pharmacological activities. The aim of this study was to investigate the effect of hydroxytyrosol on the proliferation and survival of a leukemia cell line. The researchers found that hydroxytyrosol caused a complete arrest of leukemia cell proliferation and even induced apoptosis. This apoptotic effect was not observed with tyrosol, suggesting that presence of two ortho-hydroxyl groups is required. The study concluded that hydroxytyrosol reduces the immunological response, resulting in antinflammatory and chemopreventive effects.
science.naturalnews.com/…/2378205_Oleuropein_and_hydroxytyrosol_ inhibit_MCF_7_breast_cancer_cell_proliferation.html
Oleuropein and hydroxytyrosol inhibit MCF 7 breast cancer cell proliferation interfering with ERK1 2 activation.
science.naturalnews.com/…/606773_Anti_proliferative_and_apoptotic_ effects_of_oleuropein_and_hydroxytyrosol_on.html
In this study, oleuropein and hydroxytyrosol, major phenolic compound of olive oil, was studied for its effects on growth in MCF-7 human breast cancer cells …
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Aug 15, 2013 … The Journal of nutritional biochemistry. Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancerMCF-7 …
science.naturalnews.com/…/2577390_Hydroxytyrosol_inhibits_growth_and_ cell_proliferation_and_promotes_high_expression.html
The aim of this study was to investigate, for the first time in an animal model of experimental mammary carcinoma, the anti-cancer ability of Hydroxytyrosoland to …
science.naturalnews.com/…/2561646_Synthesis_of_a_novel_ester_of_ hydroxytyrosol_and_a_lipoic.html
Synthesis of a novel ester of hydroxytyrosol and a lipoic acid exhibiting an antiproliferative effect on human colon cancer HT 29 cells.
science.naturalnews.com/…/945006_Hydroxytyrosol_from_laboratory_ investigations_to_future_clinical_trials.html
Hydroxytyrosol: from laboratory investigations to future clinical trials. … lower rates of mortality from Cardiovascular disease and cancer than Northern European …
science.naturalnews.com/…/1518292_Hydroxytyrosol_inhibits_the_ proliferation_of_human_colon_adenocarcinoma_cells_through.htm…
Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells … many pathological processes, including the development of colon cancer.
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Aug 15, 2013 … Hydroxytyrosol studies. … Neuroprotective effect ofhydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected …breast cancer (27)
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Finally, three O-beta-D-glucuronides of hydroxytyrosol 6, 7, and 8 have been … Has Anti-aging and Anti-Cancer Properties, Linked to Cardiovascular Health.
science.naturalnews.com/…/1423703_Protective_effect_of_hydroxytyrosol_ and_tyrosol_against_oxidative_stress_in.html
Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells. …New Study Finds Olive Oil Effective against HER-2 Breast Cancer.
science.naturalnews.com/…/2501663_Effect_of_the_olive_oil_phenol_ hydroxytyrosol_on_human_hepatoma.html
Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection … New Study Finds Olive Oil Effective against HER-2 Breast Cancer.

Influence of Hydroxystyrol on Heart Disease

Monoterpenes

Lemonol, beta-Geraniol, trans-3,7-Dimethyl-2,6-octadien-1-ol

Geraniol is acyclic monoterpene-alcohol. Pure geraniol is a colourless oily liquid, with a sweet rose-like scent. When oxidized, geraniol becomes geranial or citral.

Bergamot, carrot, coriander, lavender, lemon, lime, nutmeg, orange, rose, blueberry and blackberry.

Health Benefits of Geraniol

Geraniol is a natural antioxidant. Geraniol has been suggested to help prevent cancer. Carnesecchi S. et al demonstrated in his study „Geraniol, a component of Plant Essential Oils, Inhibits Grwoth and Polyamine Biosyntehsis in Human Colon Cancer Cells”, (Pharmacology, July 2001) that geraniol caused a 50% increase of ornithine decarboxylase activity, which is enhances during cancer growth. Geraniol inhibits DNA synthesis.

Burk YD concluded in his study „Inhibition of Pancreatic Cancer Growth by the dietary isoprenoids farnesol and geraniol” (Lipids, February 1997) that geraniol, farnesol and perilll alcohol suppress pancreatic tumor growth.

Other animal studies have also demonstrated the anticancer effects of geraniol.

science.naturalnews.com/…/287047_Geraniol_inhibits_prostate_cancer_ growth_by_targeting_cell_cycle_and.html
Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways.
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Methyl-4-isopropenyl cyclohexene, Cajaputene, Carvene, Cinene, Dipentene, Efchole

Pure limonene is a clear liquid. Limonene is a monoterpene, made up of two isoprene units. Limonene occurs in two optically active forms, l-limonene and d-limonen. Both isomers have different odours: l-limonene smells piney and turpentine like and d-limonene has a pleasing orange scent.

Limonene is found in the essential oils of citrus fruits and many other plant species.

Limonene, found in lemons (Citrus limonum), oranges (Citrus aurantium), juniper (Juniperus communis) Foeniculum vulgare, Mentha pulegium, Mentha spicata, Verbena officinalis, Hyssopus officinalis, and in sage (Salvia officinalis), induces  apatosis in leukaemia cells (693).

Health Benefits of Limonene

Studies have shown that limonene have anti- cancer effects.

Limonen increase the levels of liver enzymes involved in detoxifying carcinogens. The Glutathione S-transferase (GST) is a system which eliminates carcinogens. Limonene seems to promote the GST system in the liver and small bowel, thereby decreasing the damaging effects of carcinogens. Animal studies demonstrated that dietary limonene reduced mammary tumor growth.

Limonene induces the formation of apoptotic bodies on BCG-823 gastric cancer cells in a dose-and time –dependent manner (1565) and induced significant reductions of hepatocellular carcinomas (1566).

Limonene showed anti-angiogenic and pro-apoptotic effects on human gastric cancer implanted in nude mice, thus inhibiting tumor growth and metastasis (1577).

At least 6-7 lemons a day should be taken, possibly fresh, because lemons help eliminate the acid wastes from the body, increasing the reserves of alkaline substances in the blood and helping the urinary apparatus to expel uric acids. One lemon a day should be taken in the first week, to reach 7 lemons a day by the seventh week of the treatment; this should be continued this throughout the illness until the hoped-for cure. The honey from lemon flowers is currently under evaluation.

The essential oil of Citrus limonum is extremely nutritious both for its K-cals and for the phytochemicals found in it. N.B. the pressing of the oil must be done cold and without solvents.

Industrial limonene is produced by by alkali extraction of citrus residues and steam distillation. This distillate contains more than 90% d-limonene.

for studies cited above SEE LAST PAGE of DATABASE

Organosulfides

Allicin is an unstable compound that is strongly antibacterial and mainly responsible for garlic’s characteristic odor.

In vitro studies show that allicin inhibits the invasion and metastasis of human colon carcinoma cells. The phytochemical also exhibits antigenotoxic action. But the anticancer effect of allicin in humans remains uncertain, because of its low stability and poor bioavailability.

A study conducted at the Nanjing Medical University, China, concluded that allicininhibited the invasion and metastasis of human colon carcinoma cells in vitro at non-cytotoxic concentration through down-regulating the expression of vascular endothelial growth factor (VEGF), urokinase receptor (uPAR) and heparanase mRNA [1]. The researchers tested the effect of allicin on invasion and metastasis of human colon cancer cell line LoVo in vitro by using migratory test, adhesion test and Transwell chamber experiment. Allicin showed an inhibitive effects on growth of the cells in a dose and time-dependent manner. The phytochemicals suppressed the movement, adhesion and invasive capability of carcinoma cells.

A study by the Weizmann Institute of Science, Israel, demonstrated the antiproliferative function of allicin on two leukemia cell lines (HL60 and U937) [2]. They found that allicin showed anticancer effect by inducing growth inhibition, apoptotic events such as blebbing, mitochondrial membrane depolarization, cytochrome c release into the cytosol, activation of caspase 9 and caspase 3 and DNA fragmentation. Allicin reduced glutathione in the cytosol and mitochondria and changed the intracellular redox status.

Siddique and Afzal of the Aligarh Muslim University, India, investigated the antigenotoxic potential of allicin in cultured human lymphocytes using chromosomal aberrations and sister chromatid exchanges induced by the genotoxic methyl methanesulphonate [3]. They found that allicin treatment reduced the damage caused by the genotoxin, as illustrated by lower levels of chromosomal aberrations and sister chromatid exchanges.

[1] Effects of allicin on invasion and metastasis of colon cancer LoVo cell line in vitro. Zhonghua Yi Xue Za Zhi. 2009 May 26;89(20):1382-6.

[2] Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells. J Nutr Biochem. 2008 Aug;19(8):524-35.

[3] Antigenotoxic effect of allicin against methyl methanesulphonate induced genotoxic damage. J Environ Biol. 2005 Jul;26(3):547-50.

See this extensive article on garlic  click here

Gamma-Glutamylcysteinylglycine

Glutathione is a sulfur-containing amino acid that is composed of three amino acids: cysteine, glutamic acid and glycine.

Although glutathione is produced by our body is can be beneficial to consume extra glutathione through the diet.

Glutathione is mainly in animal products but also in many plants including avocado, asparagus, broccoli, grapefruit, potato, strawberries, orange, tomato, peach and spinach.

Health Benefits of Glutathine

Glutathione is an important antioxidant. Glutathione neutralizes toxic peroxide which could otherwise damage our DNA and cell membranes. As we get older the glutathione level decreases in intracellular fluids. Dietary intake of glutathione can be important for older individuals which have reduced capabilities to detoxify free radicals. Glutathione also reacts with some toxins and helps to break them down, such as the pain reliever acetaminophen.

Glutathione improves the stability of other antioxidants including vitamin C and vitamin E. Glutathione supports our immune system and stimulates the production of lymphocyte immune cells.

Studies on Glutathione and cancer

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I3C, 3-hydroxymethyl indole, 3-indole methanol

The phytochemical indole-3-carbinol is found in cruciferous vegetables such as cabbage, cauliflower, broccoli, kale and brussels sprouts. Indole-3-carbinol is made from indole-3-glucosinolate by the enzyme myrosinase. This enzyme is only activated after maceration of the vegetables.Pure indole-3-Carbinol is an off-white solid belonging to the group of indoles. Indole-3-carbinol is only formed in these vegetable after crushing or during cooking

Health Benefits of Indole-3-Carbinol

Indole-3-carbinol and its main metabolite diindoylmethane modulates several nuclear transcription factors resulting in a variety of biological and biochemical effects. Indole-3-carbinol works as a strong antioxidant, thereby protecting the DNA and other cell structures.Chemopreventive

Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying enzymes. The phytochemical protects against carcinogenic effect of pesticides and other toxins.Anticancer

The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane are the result of specific activities: inducing enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis.

Diets high in vegetables, especially cruciferous vegetables provide protection against cancer. Cruciferous vegetables provide the only source of glucosinolates, which breaks down in indole-3-carbinol and sulforaphane. The anticancer effects of indole-3-carbinol and diindoylmethane are the result of specific activities: inducing phase I and phase II enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis.

Most studies have focused on the effects on endometrial cancer, breast cancer and prostate cancer.Tumor progression relies on the upregulation of signaling pathways relevant to cell proliferation and increased resistance against chemotherapeutic agents. Indole-3-carbinol and its metabolite diindoylmethane target different aspects of carcinogenesis, such as estrogen metabolism, estrogen receptor signaling, Akt-NF kappa B signaling, caspase activation, cyclin-dependent kinase activities, endoplasmic reticulum stress, and expression of tumor suppression genes [1].

Many in-vitro results have demonstrated the anticancer effect of indol-3-carbinol, but these favorable results should be treated with extra care because of its low biological availability in humans. A phase I trial demonstrated that after a oral intake of up to 1200 mg indol-3-carbionol did not result in detectable plasma levels of the phytochemical [2].

The researchers could only detect diindolylmethane , a metabolite of indole-3-carbinol, which reached max plasma level 2 hours after the administration on indole-63-carbinol, but disappeared almost completely after 12 hours. The pharmaceutical industry has already developed and patented anti-cancer chemicals with structure similar to that of diindolyl)methane, a metabolite of indole-3-carbinol.

[1] Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Lett. 2008 Apr 18;262(2):153-63.

[2] Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3′-diindolylmethane. Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2477-81.[3] The natural chemopreventive compound indole-3-carbinol: state of the science. In Vivo. 2006 Mar-Apr;20(2):221-8.
Indole-3-carbinol blocks estrogen receptor sites on the membranes of breast and other cells, thereby reducing the risk of cervical and breast cancer.
Recent results from epidemiology, in vitro cell culture and in vivo studies have suggested the benefits of indole-3-carbinol for the prevention of many types of cancer, including breast cancer. Oral administration of indole-3-carbinol has been shown to influence our estrogen metabolism in humans in a beneficial manner. It increases the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone.
Experimental and clinical evidence suggests that 16alpha-hydroxylated estrogen metabolites react as strong estrogens, and are associated with breast cancer risk, while 2-hydroxylated metabolites have a lower estrogenic activity and are weakly related to this disease. Indole-3-carbinol is a good candidate for clinical trial in women at increased risk of developing breast cancer. Fan S and co-workers of the Georgetown University (New York) reported that both indole-3-carrbinol and genistein target the breast cancer susceptibility genes in both prostate and breast cancer cells [4].
The breast cancer susceptibility genes are responsible for the suppression of tumor growth, not only of breast cancer cells but also ovarian and prostate cancer cells. This in-vitro study showed that the phytochemicals induced the expression of these genes.An in-vitro study with cultured human breast cancer cells demonstrated that indole-3-carbinol directly inhibited elastase enzymatic activity and concluded that this phytochemicals, or similar compounds, should be further investigated as drug for the treatment of human breast cancers where high elastase levels are correlated with poor prognosis [2].
More specifically they found that indole-3-carbinol shifted the stable accumulation of cyclin E protein from the lower molecular mass form, that is associated with cancer cell proliferation and poor clinical outcomes, to its higher molecular mass form, that is typically produced in normal cells. A Taiwanese study found that indole-3-carbinol reduced the invasion and migration of breast cancer cells [3].
The phytochemical inhibited matrix metalloproteinases expression by blocking the ERK/Sp1-mediated gene transcription.Indole-3-carbinol might improve the effect of tamoxifen according to an experiment with rats carried out by the University of Minnesota [4].
Tamoxifen is a selective estrogen receptor modulator that is used in the treatment of breast cancer. The scientists induced tumors in rats by dosing the carcinogen dimethylbenz-a-anthracene and then treated the rats with tamoxifen, indole-3-carbionol or a combination of both. All three types of treatment resulted in a significant increased latency and decreased mass of malignant mammary tumors, but also treatment with indole-3-carbinol, although the effect of indole-3-carbinol alone was weaker.A study by scientists of the University of California concluded that indole-32-carbinol had an influence on the function and expression of estrogen receptor-alpha (ERA) and estrogen receptor-beta (ERB) [6].
By increasing the ratio of ERA to ERB indole-3-carbinol could reduce the proliferation of human breast cancer cells. The tests were conducted on breast cancer cells that expressed both ERA and ERB. Treatment of these breast cancer cells with indole-3-carbinol strongly inhibited ERB protein production, without that of ERA.Indole-3-carbinol selectively induced apoptosis in breast cancer cells, but not in nontumorigenic breast cells, suggesting the potential therapeutic benefit of I3C against breast cancer [7]. Low levels of indole-3-carbinol inhibited the growth of the tumor cells more than that of normal breast cells. The phytochemical upregulated Bax/Bcl-2 ratio and downregulated Bcl-xL expression only in the breast cancer cells.
[1] Prevention and treatment of cancer with indole-3-carbinol. Altern Med Rev. 2001 Dec;6(6):580-9.
[2] The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing. Proc Natl Acad Sci U S A. 2008 Dec 8.
[3] Indole-3-carbinol Inhibits Sp1-Induced Matrix Metalloproteinase-2 Expression To Attenuate Migration and Invasion of Breast Cancer Cells. J Agric Food Chem. 2008 Dec 5.
[4] BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer. 2006 Feb 13;94(3):407-26.
[5] Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination. Eur J Cancer Prev. 2007 Apr;16(2):130-41.
[6] Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells. Mol Endocrinol. 2006 Dec;20(12):3070-82. Epub 2006 Aug 10.
[7] Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells. Nutr Cancer. 2003;45(1):101-12.
Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol. This is a favourable action of indole-3-carbinol because 16 alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action.
The estrogen metabolite 2-hydroxyestrone has protective against several types of cancer. Studies with animals have demonstrated that indole-3-carbinol reduced the carcinogenic affects of aflatoxins. The influence of indole-3-carbinol on the development of prostate cancer is less clear. Most studies report protective effects but a few studies indicate that indole-3-carbinol may promote prostate cancer formation.
In the USA prostate cancer is one of the most common cancers in men and the second leading cause of cancer-related deaths. Epidemiological and dietary studies have shown a link between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. A study conducted by Technion Israel Institute of Technology (Haifa) showed that indole-3-carbinol had a significant inhibitory effect on prostate cancer cells in vitro and in vivo and concluded that this phytochemicals is a potential candidate as both preventive and therapeutic agent for humans [1].
The researchers tested the effect of indole-3-carbinol on the growth of prostate cancer cells inoculated subcutaneously in mice. They found that the administration of indole-3-carbinol significantly reduced cells proliferation and promoted the apoptosis of the prostate cancer cells. Fan S and co-workers of the Georgetown University (New York) reported that both indole-3-carrbinol and genistein target the breast cancer susceptibility genes in both prostate and breast cancer cells [2].
The breast cancer susceptibility genes are responsible for the suppression of tumor growth, not only of breast cancer cells but also ovarian and prostate cancer cells. This in-vitro study showed that the phytochemicals induced the expression of these genes.Another study found that injected indole-3-carbinol has anti-prostate cancer activity in rats [3].
Both intraperitoneal (in the body cavity) and intravenous injection of the phytochemical inhibited the growth, incidence and metastases of prostate cancer cells which were injected in rats.A study conducted at the Wayne State University School of Medicine, Detroit, concluded that indole-3-carbinol and its metabolite diindolylmethane are candidates for the prevention and the treatment of prostate cancer [4].
The researchers confirmed that indole-3-carbinol and diindolylmethane upregulate the expression of phase I and phase II enzymes, which are involved in the detoxification and inhibition of carcinogens. Both phytochemicals regulate many genes that are important for the control of cell cycle, cell proliferation, signal transduction, and other cellular processes.A study conducted by the Long Island Jewish Medical Center, New York, suggested that indole-3-carbinol may be an effective sensitizer of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment against TRAIL-resistant prostate cancer cell lines [5].
TRAIL is a ligand molecule which induces the process apoptosis in a variety of transformed cells including prostate cancer cells but has no effect on normal cells. The researchers, led by Jeon KI, tested the potential sensitizing effects of indole-3-carbinol on TRAIL-mediated apoptosis in a prostate cancer cell line. They found that the phytochemical enhanced TRAIL-mediated apoptosis and that the apoptosis was the result of increased levels of two trail death receptors.
[1] Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice. Food Chem Toxicol. 2008 Mar;46(3):863-70.
[2] BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer. 2006 Feb 13;94(3):407-26.
[3] Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer. Oncol Rep. 2005 Jan;13(1):89-93.
[4] Indole-3-carbinol and prostate cancer.J Nutr. 2004 Dec;134(12 Suppl):3493S-3498S.Sarkar FH, Li Y.
Treatment of skin cancer cells with ultraviolet-B results in the apoptosis of their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol. Some studies also show a beneficial effect on the treatment of skin cancer.Every year more than 1 million new cases of ultraviolet radiation-induced non-melanoma skin cancers occur in the USA. Although exposure to sun and specifically ultraviolet radiation increases the risk of skin cancers, treatment of skin cancer cells with ultraviolet-B also results in their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol.
That is what scientist of the Seoul National University found in an experiment with cultured human melanoma cells [1].
They investigated the effect of indole-3-carbinol on the sensitization to ultraviolet-B-induced apoptosis . They found that a combined treatment with the indole-3-carbinol and ultraviolet-B synergistically reduced melanoma cell viability, whereas the phytochemical or ultraviolet-B alone had little effect. Indole-3-carbinol acted by down-regulating pro-apoptotic protein Bcl-2.
Another study also demonstrated the protective action of indol-3-carbinol on ultraviolet-induced carcinogenic process on skin cells of mice [2]. They conducted tests on groups of 20 mice exposed ultraviolet radiation and to fed with respectively chlorophyllin, indole-3-carbinol or placebo. The scientists found that rats fed with chlorophyllin should a significant increase in tumor multiplicity, whereas those supplemented with indol-3-carbinol has significant lower tumor multiplicity.[
1] Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells. Cell Mol Life Sci. 2006 Nov;63(22):2661-8.
[2] Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol. Photochem Photobiol Sci. 2006 May;5(5):499-507.Indol-3-carbinol, and OTHER (Brassica vegetables); conversion to isothiocyanates.

Indole 3 Carbinol (See also Di-indole methane) I3C, as it is frequently called, has been tested and documented in humans and results are highly promising. Indole-3-carbinol reduced or halted the formation of precancerous lesions (papillomas) in 12 out of 18 people with recurrent respiratory tract papillomas. In addition, in a small double-blind trial, supplementation with 200 or 400 mg of indole-3-carbinol per day for 12 weeks reversed early-stage cervical cancer in 8 of 17 women. Preliminary studies have also shown indole-3-carbinol has significantly increased the conversion of estrogen from cancer-producing forms to nontoxic breakdown products. Indole-3-carbinol is found in highest concentrations in broccoli, but is also found in other cruciferous vegetables, such as cauliflower, cabbage, and kale. This treatment would be indicated for those with hormonal related cancers. Note: Di-indole methane is considered a stronger metabolite of I3C.

science.naturalnews.com/I/Indole-3-Carbinol_and_cancer.html
  1. Pretreatment of Indole-3-Carbinol augments TRAIL-induced apoptosis in a prostatecancer cell line, LNCaP.
    2003 FEBS letters
  2. Indole-3-Carbinol and prostate cancer.
    2004 The Journal of nutrition
  3. Indole-3-Carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
    2001 Oncogene
  4. Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells.
    2004 Nutrition and cancer
  5. Indole-3-Carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice.
    1999 Cancer research
  6. Therapeutic intervention of experimental breast cancer bone metastasis by Indole-3-Carbinol in SCID-human mouse model.
    2006 Molecular cancer therapeutics
  7. The effect of Indole-3-Carbinol and sulforaphane on a prostate cancer cell line.
    2003 ANZ journal of surgery
  8. A potent Indole-3-Carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells.
    2007 Cancer research
  9. Indole-3-Carbinol as a chemopreventive and anti-cancer agent.
    2008 Cancer letters
  10. 1-Benzyl-indole-3-carbinol is a novel Indole-3-Carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breastcancer cells.
    2010 Chemico-biological interactions
  11. Indole-3-Carbinol prevents PTEN loss in cervical cancer in vivo.
    2005 Molecular medicine (Cambridge, Mass.)
  12. Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol.
    2010 Anticancer research
  13. BRCA1 and BRCA2 as molecular targets for phytochemicals Indole-3-Carbinol and genistein in breast and prostate cancer cells.
    2006 British journal of cancer
  14. Indole-3-Carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.
    1999 Cancer research
  15. Anti-carcinogenic and anti-metastatic properties of Indole-3-Carbinol in prostate cancer.
    2005 Oncology reports
  16. Bax translocation to mitochondria is an important event in inducing apoptotic cell death by Indole-3-Carbinol (I3C) treatment of breast cancer cells.
    2003 The Journal of nutrition
  17. A new Indole-3-Carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines.
    2003 Cancer research
  18. Indole-3-Carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells.
    2004 Carcinogenesis
  19. Anti-estrogenic activities of Indole-3-Carbinol in cervical cells: implication for prevention of cervical cancer.
    1999 Anticancer research
  20. Indole-3-Carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway.
    2010 Medical oncology (Northwood, London, England)
  21. Direct inhibition of elastase activity by Indole-3-Carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breastcancer cells.
    2010 Cancer research
  22. Putative mechanisms of action for Indole-3-Carbinol in the prevention of colorectal cancer.
    2008 Expert opinion on therapeutic targets
  23. Indole-3-Carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity.
    2009 International journal of cancer. Journal international du cancer
  24. Indole-3-Carbinol inhibits Sp1-induced matrix metalloproteinase-2 expression to attenuate migration and invasion of breast cancer cells.
    2009 Journal of agricultural and food chemistry
  25. Indole-3-Carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells.
    2006 Molecular endocrinology (Baltimore, Md.)
  26. Indole-3-Carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.
    2006 Biochemical pharmacology
  27. Modulation of the constitutive activated STAT3 transcription factor in pancreaticcancer prevention: effects of Indole-3-Carbinol (I3C) and genistein.
    2004 Anticancer research
  28. Indole-3-Carbinol and 3,3′-diindolylmethane induce apoptosis in human prostatecancer cells.
    2003 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  29. Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol.
    2002 Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  30. The Indole-3-Carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor positive and triple negative breast cancer cell lines.
    2011 Breast cancer research : BCR
  31. Indole-3-Carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.
    2010 Molecular biology of the cell
  32. Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs.
    2008 Cancer letters
  33. Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol.
    2006 Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  34. Indole-3-carbinol-induced modulation of NF-kappaB signalling is breast cancer cell-specific and does not correlate with cell death.
    2008 Breast cancer research and treatment
  35. Indole-3-Carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.
    2005 Carcinogenesis
  36. N-Alkoxy derivatization of Indole-3-Carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.
    2008 Biochemical pharmacology
  37. Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer.
    2006 The Prostate
  38. Indole-3-Carbinol and 3-3′-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions.
    2003 The Journal of nutrition
  39. Indole-3-Carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breastcancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex.
    2005 The Journal of biological chemistry
  40. Indole-3-Carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
    2001 The Journal of biological chemistry
  41. Multiple molecular targets of indole-3-carbinol, a chemopreventive anti-estrogen in breast cancer.
    2002 European journal of cancer prevention : the official journal of the Europeancancer Prevention Organisation (ECP)
  42. Targets for Indole-3-Carbinol in cancer prevention.
    2005 The Journal of nutritional biochemistry
  43. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, Indole-3-Carbinol and myo-inositol, alone and in combination.
    2010 Carcinogenesis
  44. Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the Indole-3-Carbinol metabolite 3,3′-diindolylmethane in breastcancer cells.
    2009 The Journal of nutrition
  45. Review. Indole-3-Carbinol as a chemoprotective agent in breast and prostate cancer.
    2008 In vivo (Athens, Greece)
  46. Indole-3-Carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines.
    2008 Biochemical pharmacology
  47. Molecular targets and anticancer potential of Indole-3-Carbinol and its derivatives.
    2005 Cell cycle (Georgetown, Tex.)
  48. Inhibition of MUC1 expression by indole-3-carbinol.
    2004 International journal of cancer. Journal international du cancer
  49. Indole-3-Carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells.
    2003 Nutrition and cancer
  50. A novel mechanism of Indole-3-Carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation.
    2010 Cancer prevention research (Philadelphia, Pa.)
  51. Indole-3-Carbinol is a negative regulator of estrogen.
    2003 The Journal of nutrition

http://science.naturalnews.com/I/Indole-3-Carbinol_and_Chemopreventive.html

http://science.naturalnews.com/I/Indole-3-Carbinol_and_Anti-Estrogenic.html

http://science.naturalnews.com/I/Indole-3-Carbinol_and_Anti-Proliferative.html

NOTE: Di-Indole Methane

Di-Indole Methane is the direct metabolite of I3C (Indole-3-Carbinol) and twice as strong. This naturally occurring extract of the cabbage (cruciferous) family vegetables has proven effective in studies worldwide against hormonal related cancers. It’s mechanism is to decrease high estrogen levels in both men and women, an issue which usually leads to cancer or other illnesses often associated with aging. Included are prostate disease, breast and uterine cancers, and weight gain. Supplementing the diet with DIM and eating cruciferous vegetables increases the specific aerobic metabolism for estrogen, multiplying the chance for so-called bad estrogen to be broken down into beneficial, or good estrogen metabolites. These good estrogen metabolites are known as the 2-hydroxy estrogens.

DIM (diindolylmethane) DIM is a phytochemical that is found in broccoli, cabbage, turnip and mustard greens, kale, brussel sprouts, collards, etc. „The first development in this research using chemically altered [sic] DIM from broccoli came when the growth of breast cancer cells was inhibited in laboratory studies. Subsequent research showed these compounds also inhibited growth of pancreatic, colon, bladder and ovarian cancer cells in culture, Safe said. Limited trials on lab mice and rats have produced the similar results, he noted.”  „Researchers from the University of California at Berkeley looked at the effects of broccoli on human breast cancer cells. According to findings, compounds in broccoli known as indoles are digested and broken down in the stomach to a compound called 3,3′-diindolylmethane (DIM). This compound may be the key to keeping cancer at bay.” 

Isothiocyanates are sulphur-containing phytochemicals with the general formula R-NCS. Different molecules belong to this group. Isothiocyanates with the stongest anticancer effects are phenylethylisothiocyanate, benzylisothiocyanate and 3-phenylpropylisothiocyanate. Isothiocyanates occur naturally as glucosinolate conjugates in cruciferous vegetables. Isothiocyanates are also responsible for the typical flavour of these vegetables.

Isothiocyanates can be found in cruciferous vegetables such as broccoli, cauliflower, kale, turnips, collards, Brussels sprouts, cabbage, radish, turnip and watercress. Glucosinolates are precursors of isothiocyanates. When the raw vegetables are chewed the plant cells are broken and an enzyme (myrosinase) hydrolyses the glucosinolates into isothiocyanates.

Health Benefits of Isothiocyanates

Isothiocyanates combat carcinogens by neutralizing them, reducing their poisonous effect and stimulating the secretion of carcinogens of carcinogens. Isothiocyanates act by inhibition of cell proliferation and induction of apoptosis.

The isothiocyanates with the stongest anticancer effects are phenylethylisothiocyanate, benzylisothiocyanate and 3-phenylpropylisothiocyanate. Studies have shown that isothiocyanates help to prevent lung cancer and esophageal cancer. Isothiocyanates can also lower the risk of other cancers, including gastrointestinal cancer.

science.naturalnews.com/…/1947743_Dietary_isothiocyanates_glutathione_S _transferase_M1_GSTM1_and_lung_cancer.html
Dietary isothiocyanates, glutathione S transferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, California.
science.naturalnews.com/…/132691_Selective_Depletion_of_Mutant_p53_by _Cancer_Chemopreventive_Isothiocyanates_and.html
Isothiocyanates (ITCs) derived from cruciferous vegetables induce apoptosis in cancercells. We demonstrate that certain naturally occurring ITCs selectively …
science.naturalnews.com/…/568279_Cancer_preventive_isothiocyanates_ induce_selective_degradation_of_cellular_alpha_.html
Cancer preventive isothiocyanates induce selective degradation of cellular alpha and beta tubulins by proteasomes.
science.naturalnews.com/…/1314059_Isothiocyanates_glutathione_S_ transferase_M1_and_T1_polymorphisms_and_gastric.html
Isothiocyanates, glutathione S transferase M1 and T1 polymorphisms and gastric cancerrisk: a prospective study of men in Shanghai, China.
science.naturalnews.com/…/786957_Chemoprevention_of_cancer_by_ isothiocyanates_and_anthocyanins_mechanisms_of_action.html
Chemoprevention of cancer by isothiocyanates and anthocyanins: mechanisms of action and structure activity relationship.
science.naturalnews.com/…/2410_Isothiocyanate_exposure_glutathione_S_ transferase_polymorphisms_and_colorectal_cancer_risk.html
Isothiocyanate exposure, glutathione S transferase polymorphisms, and colorectal cancerrisk. Publication: The American journal of clinical nutrition. Publication …
science.naturalnews.com/…/27163_Urinary_isothiocyanates_glutathione_S_ transferase_M1_T1_and_P1_polymorphisms.html
The present study examined the associations among urinary isothiocyanates, Glutathione S-transferase (GST) polymorphisms, and colorectal cancer risk in a …
science.naturalnews.com/…/1265130_Isothiocyanates_induce_oxidative_ stress_and_suppress_the_metastasis_potential_of.html
However, the effect of isothiocyanates on lung cancer cell metastasis has not been studied. In the present study, we investigated the inhibitory effects of BITC …
science.naturalnews.com/…/3294354_Head_and_neck_cancer_a_case_for_ inhibition_by_isothiocyanates.html
Head and neck cancer: a case for inhibition by isothiocyanates and indoles from cruciferous vegetables.
science.naturalnews.com/…/1569614_Prostate_cancer_chemopreventive_ activity_of_phenethyl_isothiocyanate_through_epigenetic_regulatio…
Consumption of cruciferous Vegetables has been reported to be associated with reduced incidence of prostate cancer cases. The isothiocyanates, including …
science.naturalnews.com/…/3381294_Repression_of_androgen_receptor_in_ prostate_cancer_cells_by_phenethyl.html
Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate. Publication: Carcinogenesis Publication Date: 2006. Study Author(s): …
science.naturalnews.com/…/629276_Isothiocyanates_sensitize_the_effect_of_ chemotherapeutic_drugs_via_modulation_of.html
Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells.
science.naturalnews.com/…/125542_Anti_NF_kappaB_and_anti_ inflammatory_activities_of_synthetic_isothiocyanates.html
Of the natural compounds, the Isothiocyanates (ITCs) found in cruciferous Vegetables have received particular attention because of their potential anti- cancer …
science.naturalnews.com/…/1338610_ABC_transporters_and_isothiocyanates _potential_for_pharmacokinetic_diet_drug_interactions.html
Isothiocyanates, a class of anti-cancer agents, are derived from cruciferous Vegetables such as broccoli, cabbage and watercress, and have demonstrated …
science.naturalnews.com/…/209522_New_biomarkers_for_monitoring_the_ levels_of_isothiocyanates_in_humans.html
Isothiocyanates (ITCs) found in cruciferous vegetables have demonstrated cancerpreventive activity in animals, and increased dietary intake of ITCs has been …
science.naturalnews.com/…/2587875_Urinary_isothiocyanate_levels_and_ lung_cancer_risk_among_non_smoking.html
Urinary isothiocyanate levels and lung cancer risk among non smoking women: A prospective investigation.
science.naturalnews.com/…/1538721_Metabolism_of_isothiocyanates_in_ individuals_with_positive_and_null_GSTT1.html
BACKGROUND & AIMS : Isothiocyanates (ITCs) derived from cruciferous vegetables have been shown to be promising agents against cancer in human cell …

Researchers at the Johns Hopkins University School of Medicine in Baltimore studied the metabolism of isothiocyanates and found that isothiocyanates were about six times more bioavailable than glucosinolates.

Sulforaphane is a phytochemical belonging to the family of isothiocyanates, which means it contains the typical NCS group.

(R)-1-isothiocyanto-4-methyl-sulfonyl butane

Sulforaphane occurs in plants bound to a sugar molecule: sulforaphane glucosinolate. Only after eating will the sulforaphane by released. Sulforaphane glucosinolate is found in cruciferous vegetables such as broccoli, cauliflower, cabbage and kale. The richest source of sulforaphane are broccoli sprouts.

Health Benefits of Sulforaphane

Sulforaphane is an antioxidant and stimulators of natural detoxifying enzymes. Sulforaphane may reduce the risk of breast, bladder and prostate cancer.

Anti-cancer effect

Epidemiological studies show that people who eat a lot of cruciferous vegetables have reduces incidences of cancer. In-vitro and animals studies have confirmed the anti-cancer effects and have demonstrated that the phytochemical reduces the frequency, size, and number of tumors.

During the fight against cancer cells our body produces special enzymes, called phase 2 enzymes. Sulforaphane is a phase 2 enzyme inducer, thereby neutralizing carcinogens before they can damage DNA. Sulforaphane inhibits benzo[a]pyrene-DNA and 1,6-dinitropyrene-DNA adducts formation. A study by James D. Brooks et al entitled Potent Induction of Phase 2 Enzymes in Human Prostate Cells by Sulforaphane has shown that sulforaphane induces phase 2 enzyme expression and activity in human prostate cells [1]. This study may help to explain the lower prostate cancer risk with men who consume more cruciferous vegetables.A team of scientists lead by B. Abbouit at the Ohio State University investigated the effect of isothiocyanates (sulforaphane and erucin) in primary or secondary bladder cancer prevention. Both phytochemicals showed inhibition of bladder cancer cells, which was associated downregulation of survivin, epidermal growth factor receptor and human epidermal growth factor receptor 2 and apoptosis.

A 2012 study by the Texas Children’s Hospital suggested a potential role of sulforaphane as an adjunctive agent to improve the therapeutic response in acute lymphoblastic leukemia patients [3]. This type of cancer is the most common hematological cancer in children. The scientists found that purified sulforaphane had anticancer properties in a broad range of leukemic cells. More specifically they found that sulforaphane caused dose-dependent apoptosis and cell cycle arrest, mainly by activation of caspases. While sulforaphane killed cancer cells, it did not affect healthy cells. It should be noted that the levels of sulforaphane used in this study were quite high and can not be obtained by eating cruciferous vegetables, such as broccoli.

[1] Potent induction of phase-2-enzymes in human prostate cells by sulforaphane.. Cancer Epidemiology Biomarkers and Prevention, Vol. 10, 949-954, September 2001

[2] Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion. Mol Nutr Food Res. 2012 Nov;56(11):1675-87

[3] Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. PLoS One. 2012;7(12):e51251

science.naturalnews.com/S/Sulforaphane_and_cancer.html
science.naturalnews.com/S/Sulforaphane_and_prostate_cancer.html
science.naturalnews.com/S/Sulforaphane_and_breast_cancer.html

Heart health

The antioxidant action of sulforaphane helps to fight high blood pressure. A study by the Tokyo University of Agriculture has shown that persons who eat about 100 g of broccoli sprouts daily during one week had reduces levels of cholesterol.

Research Reviews

Potent induction of phase-2-enzymes in human prostate cells by sulforaphane.

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo-a-pyrene-induced stomach tumors

Phenolic Acids

trans-8-methyl-N-vanillyl-6-nonenamide, N-(4-Hydroxy-3-methoxyphenyl)-8-methyl-non-trans-6-enamide

Capsaicin is the phytochemical in chilli peppers that causes the typical heat. Pure capsaicin is a white crystalline powder. Capsaicin is a capsaicinoid which belongs to the alkaloid family. It is very heat stable and keeps its activity despite cooking. Capsaicin is only slightly soluble in water, but very soluble in ethanol and vegetable oil. Other capsaicinoid are dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin and homodihydrocapsaicin.

Health Benefits of Capsaicin

ANTIcancer

science.naturalnews.com/C/Capsaicin_and_cancer.html

Capsaicin is used in many topical ointments used to relieve the pain of peripheral neuropathy (treatment of pain in the nerve endings near the surface of the skin). Capsaicin is then applied on the skin and removed when the patient starts feeling the burning sensation. The nerves seem to become insensitive to pain. The burning sensations of capsaicin is caused by its interaction with the nerve cells. Capsaicin binds with special receptor cells (vanilloid receptor subtype 1) and produces the same effect as physical heat. Consumption of capsaicin can also create a euphoric sensation caused by the release endorphins.

Studies have shown that capsaicin can relieve arthritic symptoms and improve flexibility of the joints. Capsaicin seems to inhibit the activity of DSP (Decapeptide Substance P), which the painful feeling of arthritis.

Capsaicin might protect against gastric ulcers. Studies have shown that capsaicin protects the stomach membrane by increasing the blood flow.

Capsaicin seems to reduce the symptoms of psoriasis. A study by Ellis CN et al., „A double-blind evaluation of topical capsaicin in pruritic psoriasis” (Journal of the American Academy of Dermatology, Sept 1993) showed that patients with psoriasis who took capsaicin cream had reduced itching, scaling and redness compared with patients who used a placebo.

Why do plants contain capsaicin? By producing the burning capsaicin the pepper plant prevents animals from eating its fruits. Birds don?t feel the burning sensation of capsaicin so they eat the fruits and are responsible for the spreading of seeds. The chilli seeds survive the digestion process. Capsaicin is also a component of pepper spray, used as chemical riot control agent.

Abstracts

Capsaicin and Health

Benzoaric acid, eleagic acid, elagostasine, gallogen

Ellagic acid is a fused four-ring polyphenol.

Ellagic acid is present in many red fruits and berries, including raspberries, strawberries, blackberries, cranberries, pomegranate and some nuts including pecans and walnuts. The highest levels of ellagic acid are found in raspberries. In plants ellagic acid is present in the form of ellagitannin, which is ellagic acid bound to a sugar molecule.

Pure ellagic acid is a cream to light yellow crystalline solid.

Health Benefits of Ellagic Acid

Ellagic acid has antioxidant, anti-mutagen and anti-cancer properties. Studies have shown the anti-cancer activity on cancer cells of the breast, oesophagus, skin, colon, prostate and pancreas. More specifically, ellagic acid prevents the destruction of P53 gene by cancer cells. Ellagic acid can bind with cancer causing molecules, thereby making them inactive. In their studie The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes. Ahn D et al showed that ellagic acid causes a decrease in total hepatic mucosal cytochromes and an increase in some hepatic phase II enzyme activities, thereby enhancing the ability of the target tissues to detoxify the reactive intermediates. Ellagic acid showed also a chemoprotective effect against various chemically induced cancers.

Studies on Ellagic Acid and cancer –

science.naturalnews.com/E/Ellagic_Acid_and_cancer.html

http://science.naturalnews.com/E/Ellagic_acid_and_Antiproliferative.html

http://science.naturalnews.com/E/Ellagic_acid_and_Anti-Angiogenic.html

http://science.naturalnews.com/E/Ellagic_acid_and_Apoptotic.html

A study by Thresiamma KC and Kuttan R.Indian (Indian Journal Physiology and Pharmacology, 1996 October) indicate that oral administration of ellagic acid by rats can circumvent the carbon tetrachloride toxicity and subsequent fibrosis of the liver.

Ellagic acid has also antiviral and antibacterial activities.

Plants produce ellagic acid to protect themselves from microbiological infection and pests.

Research Reviews

Pomegranate Juice Ellagitannin Metabolites Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours

Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.

.

3,4,5-Trihydroxybenzoic acid

Gallic acid occurs as a freemolecule or as part of a tannin molecule.

Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts, grapes, tea, hops and oak bark. Pure gallic acid is a colourless crystalline organic powder.

Health Benefits of Gallic acid

Gallic acid seems to have anti-fungal and anti-viral properties. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells.

science.naturalnews.com/G/Gallic_acid_and_cancer.html

Gallic acid is used a remote astringent in cases of internal haemorrhage. Gallic acid is also used to treat albuminuria and diabetes. Some ointment to treat psoriasis and external haemorrhoids contain gallic acid.

Rosmarinic acid is found in big quantities in oregano, lemon balm, sage, marjoram, rosemary.

Rosmarinic acid has antioxidant, anti-inflammatory and antimicrobial activities.

The antioxidant activity of rosmarinic acid is stronger than that of vitamin E. Rosmarinic acid helps to prevent cell damage caused by free radicals, thereby reducing the risk for cancer and atherosclerosis.

Rosmarinic acid has anti-inflammatory properties. Perilla, rich in rosmarinic acid, is used for its anti-allergic activity. A study by Sanbongi C and colleagues (Clinical and Experimental Allergy, June 2004) have shown that the oral administration of rosmarinic acid is an effective intervention for allergic asthma. Another study by Youn J and colleagues (Journal of Rheumatology, June 2003) demonstrated that rosmarinic acid suppressed synovitis in mice and that it may be beneficial for the treatment of rheumatoid arthritis. Unlike antihistamines, rosmarinic acid prevents the activation of immune responder cells, which cause swelling and fluid formation.

Rosmarinic acid is also used for food preservation. In Japan the perilla extracts, rich in rosmarinic acid, is used the garnish and improve the shelf life of fresh seafood.

Rosmarinic acid is used to treat peptic ulcers, arthritis, cataract, cancer, rheumatoid arthritis and bronchial asthma.

Studies on Rosmarinic acid and cancer

science.naturalnews.com/…/2186820_Rosmarinic_acid_antagonizes_activator _protein_1_dependent_activation_of_cyclooxygenase.html
Rosmarinic acid antagonizes activator protein 1 dependent activation of cyclooxygenase 2 expression in human cancer and nonmalignant cell lines.
science.naturalnews.com/…/1022843_Inhibitory_effects_of_rosemary_ extracts_carnosic_acid_and_rosmarinic_acid.html
Subsequently, six extracts and the active compounds, carnosic acid, andRosmarinic acid were applied to various human cancer cell lines including NCI- H82 …
science.naturalnews.com/…/1331077_Rosmarinic_acid_sensitizes_cell_death _through_suppression_of_TNF_alpha.html
Rosmarinic acid sensitizes cell death through suppression of TNF alpha … of RA have not been well elucidated in TNF-alpha-mediated anti-cancer therapy.
science.naturalnews.com/Rosmarinic_acid.html
Aug 15, 2013 … Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell …
science.naturalnews.com/R/Rosmarinic_acid_and_cancer.html
Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. 2008 The …
science.naturalnews.com/…/264528_Inhibition_of_bone_metastasis_from_ breast_carcinoma_by_rosmarinic_acid.html
Our study showed that Rosmarinic acid (RA) could inhibit the migration of MDA- MB-231BO human bone-homing breast cancer cells dose-dependently.
science.naturalnews.com/…/2450932_Combination_of_active_components_ enhances_the_efficacy_of_Prunella_in.html
… enhances the efficacy of Prunella in prevention and treatment of lung cancer. … caffeic acid, rosmarinic acid, rutin, quercetin, Oleanolic acid and Ursolic Acid.

Gallotanic acid, digallic acid, allotannin, tannimum.Tannic acid is a polymer of gallic acid molecules and glucose. It the example there are 3 gallic acid molecules, but normally there are about 8. Because there are different molecular structures for tannic acid it would have been better to speak about tannic acids (in plural). Tannic acid will hydrolyze into glucose and gallic or ellagic acid units. Tannic acid is odourless but has a very astringent taste. Pure tannic acid is a light yellowish and amorphous powder.

Tea, nettle, wood, berries, Chinese galls. Oak wood is very rich in tannic acid. When wine is kept in oak kegs some tannic acid will migrate into the wine. High levels of tannic acid are found in some plant galls. These are formed by plants when they are infected by certain insects. These insects pierce the plant leaves and when the egg hatches out into a larva the plant produces a gall which surrounds the larva.

Health Benefits of Tannic Acid

Tannic acid has anti-bacterial, anti-enzymatic and astringent properties. Tannic acid has constringing action upon mucous tissues such as tongue and inside of mouth. The ingestion of tannic acid caused constipation and can be used to treat diarrhoea (in the absence of fever or inflammation). The anti-oxidant and anti-mutagenic properties of tannic acid are beneficial.

Studies on Tannic Acid and cancer

However, tannic acid should not be used continuously or in high quantities ad it slows down the absorption of iron and possibly other trace minerals. A study by Afsana K et al entitled Reducing effect of ingesting tannic acid on the absorption of iron, but not of zinc, copper and manganese by rats. published by Bioscience, Biotechnology, and Biochemistry (March 2004) concluded that the usual intake of polyphenols is relatively safe, but that a high intake by supplementation or by dietary habit of tannin affects only the iron level. Tannic acid can also reduce the effectiveness of digestive enzymes.

Phytosterols

(3beta)-stigmast-5-en-3-ol, 22:23-dihydrostigmasterol, alpha-dihydrofucosterol, cinchol, cupreol, rhamnol, quebrachol and sitosterin.

Beta-sitosterol is a phytosterols or plant sterol. The structure of beta-sitosterol is similar to that of cholesterol. Beta-sitosterol differs from cholesterol by the presence of an extra ethyl group.

There are many plant sources of beta-sitosterol, but the most important are wheat germ, rice bran, flax seeds, peanuts, soybeans, pumpkin seeds and corn oil. Muli and co-workers showed that a plant-based diet, rich in fibre, soy and flax seed, can increase serum levels of beta-sitosterol.

Health Benefits of Beta-Sitosterol

Beta-sitosterol is mainly known and used for its cholesterol lowering property. But studies have shown that the phytochemical may have other health benefits: easing symptoms of benign prostatic enlargement, reducing risk of cancer and prevention of oxidative damage through its antioxidant activity.

Anti-cancer

Epidemiological and experimental studies have suggested a protective role of beta-sitosterol in the development of some types of cancer such as breast, colon and prostate cancer. In-vivo studies have shown that the phytochemical inhibited proliferation and induce apoptosis in human solid tumors such as colon and breast cancers.

Beta-sitosterol is mainly studied for its cholesterol-lowering properties but many studies also find that the phytochemical may help to prevent cancer. Epidemiological and experimental studies have suggested a protective role of beta-sitosterol in the development of some types of cancer such as breast, colon and prostate cancer. In-vivo studies have shown that the phytochemical inhibited proliferation and induce apoptosis in human solid tumors such as colon and breast cancers.

A Japanese study led by Imanaka demonstrated that the oral intake of beta-sitosterol, encapsulated in a liposome, was able to prevent tumour metastasis in rats, although the phytochemical was not absorbed in the serum. The researchers believed that beta-sitosterol works by stimulating the gut immune surveillance systems, as indicated by an increase in natural killer cell activity and production of immune response cytokines [1]. Park and co-workers concluded in their study that „beta-sitosterol potently induces apoptosis in U937 cells (these are leukemia cells) and that beta-sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.” Beta-sitosterol induced apoptosis in the leukemia cells in a dose-dependent manner [2].

Beta-sitosterol seems to induce apoptosis of cancer cells through two pathways: the extrinsic and intrinsic pathways, which are catalyzed by by the initiator caspases 8 and 9 respectively. Both pathways result in the activation of caspase 3, which is an effector caspases that cleaves protein substrates within the cell resulting in the apoptotic process. Korean study lead by Moon also found this effect of beta-sitosterol on caspase activation on cultured fibrosarcoma cells: treatment of the cells with an caspase-3 inhibitor inhibited the beta-sitosterol induced apoptosis. Treatment of the fibrosarcoma cells with beta-sitosterol also induced activation (phosphorylation) of extracellular-signal regulating kinase and blocked protein kinase B, which inhibits apoptotic processes [3]. Nakamura and co-workers found that beta-sitosterol restored the impaired gap junctional intercellular communication of transfected rat liver epithelial cells. The beta-sitosterol used in this experiment was extracted from the husks of psyllium seeds. Beta-sitosterol and also stigmasterol increased the level of gap junction proteins and restored their level of phosphorylation to levels similar to nontransfected cells [4].

Epidemiological evidence has shown that men consuming high amounts of plant products have a lower risk of prostate cancer. Von Holtz and colleagues investigated the possible effect of the plant sterol, beta-sitosterol, on cancer cells. They found that beta-sitosterol decreased the numbers of prostate cancer cells and increased apoptosis. Beta-sitosterol the production of ceramide, which is cellular signaling molecule regulating the differentiation, proliferation, programmed cell death and apoptosis of cells [5]. An in-vitro experiment with bone marrow cells showed that beta-sitosterol reduced the genotoxic damage caused by doxorubicin [6]. Beta-sitosterol significantly reduced the frequency of sister chromatid exchanges, which are exchange of genetic material between two identical sister chromatids. When the frequency of chromatid exchange is too high, cell damage can occur.

[1] Imanaka H, Koide H, Shimizu K, Asai T, Kinouchi Shimizu N, Ishikado A, Makino T, Oku N. ” Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake” Biol Pharm Bull. 2008 Mar;31(3):400-4.

[2] Park C, Moon DO, Rhu CH, Choi BT, Lee WH, Kim GY, Choi YH. ” Beta-sitosterol induces anti-proliferation and apoptosis in human leukemia U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.” Biol Pharm Bull. 2007 Jul;30(7):1317-23.

[3] Moon DO, Lee KJ, Choi YH, Kim GY. „Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells.” Int Immunopharmacol. 2007 Aug;7(8):1044-53.

[4] .Nakamura Y, Yoshikawa N, Hiroki I, Sato K, Ohtsuki K, Chang CC, Upham BL, Trosko JE. „Beta-sitosterol from psyllium seed husk (Plantago ovata Forsk) restores gap junctional intercellular communication in Ha-ras transfected rat liver cells.” Nutr Cancer. 2005;51(2):218-25.

[5]Von Holtz RL, Fink CS, Awad AB. ” beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells.” Nutr Cancer. 1998;32(1):8-12.

[6] Paniagua-Pérez R, Madrigal-Bujaidar E, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J, Hernández N, Flores-Mondragón G, Velasco O. ” Cell protection induced by beta-sitosterol: inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity. ” Arch Toxicol. 2008 Feb 6.

The studies about the protective effect of beta-sitosterol on breast cancer only involved in-vitro experiments using cultured breast cancer cells. These studies clearly show that the phytochemicals kills breast cancer cells and is not toxic to normal cell. Clinical studies linking beta-sitosterol and breast cancer are still missing but some scientists suggest that it may improve the efficiency of tamoxifen, a drug often used to treat breast cancer.

School of Public Health and Health Professions at the University at Buffal investigated the effects of beta-sitosterol and tamoxifen on the cultured breast cancer cells. The study led by Awad concluded that „these results suggest that the combination regimen of dietary beta-sitosterol and tamoxifen chemotherapy may be beneficial in the management of breast cancer patients”[1]. Tamoxifen is drug used for the treatment of breast cancer and works as a selective estrogen receptor modulator. Therefore it only works on estrogen receptor positive breast cancer cells. They tested the effect of beta-sitosterol and tamoxifen, separately and combined, on the growth of estrogen receptor positive breast cancer cells and estrogen receptor negative breast cancer cells. They found that a treatment with beta-sitosterol inhibited the growth of both type of cells whereas tamoxifen only inhibited of estrogen receptor positive breast cancer cells. A combined treatment further inhibited the growth of both cell types. Both beta-sitosterol and tamoxifen modulated the ceramide metabolism. Ceramides act as a signaling molecule, regulating differentiation, proliferation, programmed cell death and apoptosis. Beta-sitosterol increased ceramide levels by stimulating ceramide production whereas tamoxifen tamoxifen increased ceramide levels by inhibting ceramide glycosylation.

A study conducted by the State University of New York concluded that beta-sitosterol is an effective apoptosis-promoting phytochemical and more dietary phytosterols may protect against breast cancer. The scientists studied the effect of beta-sitosterol on cultured breast cancer cells and adenocarcinoma cells. Beta-sitosterol concentrated in the cell membranes and significantly inhibited tumor cell growth. It increased the Fas levels and caspase-8 activity [2]. Beta-sitosterol seems to induce apoptosis of cancer cells through two pathways: the extrinsic and intrinsic pathways, which are catalyzed by by the initiator caspases 8 and 9 respectively. Both pathways result in the activation of caspase 3, which is an effector caspases that cleaves protein substrates within the cell resulting in the apoptotic process. Awad and his team found that beta-sitosterol treatment of cultured breast cancer cells increased the activities of caspases 8 and 9 by 39% and 80% respectively, resulting in a a three-fold increase in the activity of caspase 3 [3].

In another in-vivo experiment conducted by Awad also showed that beta-sitosterol inhibited the growth of breast cancer cells by up to 80%, caused a six-fold increase in apoptosis cells but showed no cytotoxicity. The found no effect of beta-sitosterol on the level of protein phosphatase 2A in the tumor cells [4].

A study by Ju et al investigated the estrogenic effects of the plant sterols beta-sitosterol, beta-sitosterol glucoside and Moducare (mixture of beta-sitosterol, beta-sitosterol glucoside). The test was carried out on estrogen dependent human breast cancer cells in vitro and in vivo. The researchers concluded that beta-sitosterol and Moducare stimulated cancer cells in vitro and that dietary beta-sitosterol and Moducare protected against estrogen stimulated tumor growth. These findings suggest that beta-sitosterol could have potential benefits for women with a risk for estrogen-dependent breast cancer [5].

[1] Awad AB, Barta SL, Fink CS, Bradford PG. ” beta-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism.”Mol Nutr Food Res. 2008 Apr;52(4):419-26.

[2] Awad AB, Chinnam M, Fink CS, Bradford PG. ” beta-Sitosterol activates Fas signaling in human breast cancer cells.” Phytomedicine. 2007 Nov;14(11):747-54.

[3] Awad AB, Roy R, Fink CS. „Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. „Oncol Rep. 2003 Mar-Apr;10(2):497-500

[4] Awad AB, Downie AC, Fink CS. „Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture.” Int J Mol Med. 2000 May;5(5):541-5.

[5] Ju YH, Clausen LM, Allred KF, Almada AL, Helferich WG. „Beta-sitosterol, beta-sitosterol glucoside, and a mixture of beta-sitosterol and beta-sitosterol glucoside modulate the growth of estrogen-responsive breast cancer cells in vitro and in ovariectomized athymic mice.” J. Nutr. 134: 1145-1151.

Antioxidant

Beta-sitosterol is an antioxidant able to reduce DNA damage, reduce the level of freeradical in our cells and to increase the level of typical antioxidant enzymes.

Atherosclerosis

Regular intake of beta-sitosterol may reduce blood cholesterol levels by directly inhibiting the absorption of cholesterol. Beta-sitosterol also prevents the oxidation of LDL cholesterol thereby reducing the risk of atherosclerosis.

Prostate enlargement

Clinical studies have confirmed the beneficial effects of beta-sitosterol in patients withprostate enlargement. The phytochemical decreases post-void residual urinary volume and increases urinary flow rate in these patients.

Saponins

Saponins are glucosides with foaming characteristics. Saponins consist of a polycyclic aglycones attached to one or more sugar side chains. The aglycone part, which is also called sapogenin, is either steroid (C27) or a triterpene (C30). The foaming ability of saponins is caused by the combination of a hydrophobic (fat-soluble) sapogenin and a hydrophilic (water-soluble) sugar part. Saponins have a bitter taste. Some saponins are toxic and are known as sapotoxin.

Saponins are phytochemicals which can be found in most vegetables, beans and herbs. The best known sources of saponins are peas, soybeans, and some herbs with names indicating foaming properties such as soapwort, saoproot, soapbark and soapberry. Commercial saponins are extracted mainly from Yucca schidigera and Quillaja saponaria.

Health Benefits of Saponins

Saponinshave many health benefits. Studies have illustrated the beneficial effects on blood cholesterol levels, cancer, bone health and stimulation of the immune system. Most scientific studies investigate the effect of saponins from specific plant sources and the results cannot be applied to other saponins.

Cholesterol reduction

Saponins bind with bile salt and cholesterol in the intestinal tract. Bile salts form small micelles with cholesterol facilitating its absorption. Saponins cause a reduction of blood cholesterol by preventing its re-absorption.

Reduce cancer risk

Studies have shown that saponins have antitumor and anti-mutagenic activities and canlower the risk of human cancers, by preventing cancer cells from growing. Saponins seem to react with the cholesterol rich membranes of cancer cells, thereby limiting their growth and viability. Roa and colleagues found that saponins may help to prevent colon cancer and as shown in their article „Saponins as anti-carcinogens” published in The Journal of Nutrition (1995, 125, 717s-724S).

Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. 

Chemical & Pharmaceutical Bulletin. 2005 November;53(11):1451-4

The aim of this study was to determine the antitumor properties of saponins from the root of Korean pasque flower (Pulsatilla koreana). The researchers measured the in-vitro cytotoxic activity against cultured human solid cancer cells and the in-vivo antitumor activity in mice bearing lung carcinoma. The saponins with a free acidic group at C-28 of aglycon showed moderate to considerable in-vitro cytotoxic activity. In the in-vivo test hederagenin saponins showed stronger antitumor effect than the taxol and doxorubicin saponins. The precense of a hederagenin aglycones and a special sugar sequence at C-3 are essential factors for the antitumor activity of saponins.

Protective effect of Astragalus corniculatus saponins against myeloid graffi tumor in hamsters.

Phytother Research. 2004 March;18(3):255-7

This study investigated the antitumor effect of a saponin rich extract from Astragalus corniculatus Bieb, a garden plant originating from Eastern European, against myeloid Graffi tumors in hamsters. The researchers found that an injection of extract in the peritoneal cavity decreased tumor transplantability, inhibited tumor growth in the early stages of tumor progression, increased survival time and reduced mortality. The study concluded that the saponin extract of Astragalus corniculatus should be further investigated as a antitumor treatment of myeloid Graffi tumour.

Protective effect of soybean saponins and major antioxidants against aflatoxin B1-induced mutagenicity and DNA-adduct formation. 

Journal of Medicinal Food. 2002 Winter;5(4):235-40.

Previous studies have suggested that saponins have possible anti-cancer effect. The main dietary sources of saponins are legumes, including soybeans. The aim of this study was to determine the effect of soybean saponins mutagenic activity of aflatoxin B1 on Salmonella typhimurium and human liver cells. The anti-mutagenic effect of saponins was compared to those of other typical antioxidants such as vitamin C, vitamin E including L-ascorbic acid, alpha-tocopherol, vitamin A and butylated hydroxytoluene. The researchers found that the anti-mutagenic activity of saponins was between those of butylated hydroxytoluene and vitamin E. Soybean saponins reduced the muitagenic effect of aflatoxin B1 up to 81%. The preincubation of human liver cells with saponins reduced the amount of DNA adducts significantly. The study concluded that soybean saponins possess a significant anti-mutagenic activity. More studies are required to determine the exact mechanism but soybean saponins seems to block the initial stages of carcinogenesis.

Environmental influences on isoflavones and saponins in soybeans and their role in colon cancer.

Journal of Nutrition. 2005 May;135(5):1239-42

Soybeans are not only an important source of high quality proteins but contain also health promoting phytochemicals such as isoflavones and saponins. The aim of this study was to quantify isoflavone and saponin levels in soybean cultivars grown under different conditions and to determine the influence of isoflavones and saponins on carcinogenic process of cultured human colon cancer cells. The researchers found an inhibitive effect of soy isoflavones and saponins on the colon cancer cells. There were no adverse effects of the intake of pure saponins on growth, organ weight or intestinal morphology, even when the diet contained 3% saponins. The study concluded that soy isoflavones and saponins may protect against colon cancer and are well tolerated.

Soy saponins and the anticancer effects of soybeans and soy-based foods. 

Current Medicinal Chemistry – Anti-Cancer Agents. 2004 May;4(3):263-72

There are indications that the consumption of soy products help to protect against cancer but the exact constituents, which are responsible for this action, remain elusive. The aim of this review was to summarize epidemiological studies linking saponins to cancer risk. Recents studies have shown that soy saponins have a direct effect on cancer cells but may also influence carcinogenesis in alternative mechanisms. The anti-cancer action of saponins may result in the discovery of new anticancer agents.

Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages.

Cancer Letters. 2005 December 18;230(2):219-27

Pro-inflammatory mediators play also a role in cancer development. Phytochemicals with anti-inflammatory properties may help to reduce the risk of cancer. The aim of this study was to investigate the effects of soybean saponins on the production of proinflammatory mediators peritoneal macrophages stimulated with liposaccharides. The researchers found that soybean saponins reduced the levels of pro-inflammatory indicators such as cyclooxygenase-2, nitric oxide synthases and Nuclear Factor kappa B. The study concluded that soybean saponins may be useful for ameliorating inflammatory diseases and suppressing tumor progression.

Some studies have shown that saponins can cause apoptosis of leukemia cells by inducing mitotic arrest.

Cytotoxic and apoptogenic effect of tea (Camellia sinensis var. assamica) root extract (TRE) and two of its steroidal saponins TS1 and TS2 on human leukemic cell lines K562 and U937 and on cells of CML and ALL patients.

Leukemia Research. 2006 April;30(4):459-68

Not only tea leaves but also tea roots contain phytochemicals with potential health benefits. The aim of this study was to investigate the anti-cancer properties of tea root extract and two specific steroidal saponins found in the tea root on human cancer cells. The study showed that the tea root extract and the two steroidal saponins induced apoptosis of leukemia cells. Consumption of the tea root extract by healthy volunteers caused an insignificant reduction in cell count.

The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines.

Biological and Pharmaceutical Bulletin. 2004 July;27(7):1059-65

Previous studies have shown that diosgenyl saponins could induce cytotoxicity and apoptosis in human leukemia cells. The aim of this study was to investigate mechanisms of action. The researchers found that diosgenyl saponins activated some caspases (caspases are essential in cells for apoptosis, one of the main types of programmed cell death) and down-regulated anti-apoptotic proteins. Dioscin treatment of leukemia cells inhibited cell mitosis. The study concluded that diosgenyl saponins may act by inducing mitotic arrest and apoptosis. Diosgenyl saponins might be used antimitotic agents.

science.naturalnews.com/…/693_Cancer_chemopreventive_and_therapeutic_ effects_of_diosgenin_a_food_saponin.html
Food saponins have been used in complimentary and traditional medicine against a variety of diseases including several cancers. Diosgenin, a naturally …
science.naturalnews.com/…/2005340_Dimeric_antioxidant_and_cytotoxic_ triterpenoid_saponins_from_Terminalia_ivorensis_A.html
Dimeric antioxidant and cytotoxic triterpenoid saponins from Terminalia ivorensis A. … and further for their Cytotoxic activity against four human cancer cell lines.
science.naturalnews.com/…/432621_Chemical_and_pharmacological_studies _of_saponins_with_a_focus_on.html
It is believed that the ginseng saponins called ginsenosides are the major … and central Nervous system as well as the antidiabetes and anti-cancer effects.
science.naturalnews.com/…/270524_Cytotoxic_saponin_against_lung_cancer _cells_from_Dioscorea_birmanica_Prain.html
Cytotoxic saponin against lung cancer cells from Dioscorea birmanica Prain & Burkill.

Immunity booster

Plants produce saponins to fight infections by parasites. When ingested by humans, saponins also seem to help our immune system and to protect against viruses and bacteria.

Reduce bone loss

Studies with ovariectomized induced rats have shown that some saponins, such as the steroidal saponins from Anemarrhena asphodeloides, a Chinese herb, have a protective role on bone loss.

Antioxidant

The non-sugar part of saponins have also a direct antioxidant acitivity, which may results in other benefits such as reduced risk of cancer and heart diseases.

Stilbenes:

What’s more, several recent animal-based studies and studies on human cells have found that pterostilbene may be effective for protection against breast cancer, prostate cancer, andcolon cancer.

  • 2. RESVERATROL

Resveratrol is a flavonol belonging to the group of flavonoids.

Resveratrol is present in many plants and fruits, including red grapes, eucalyptus, spruce, blueberries, mulberries, peanuts, giant knotweed. Also red wine contains a lot of it. The longer the grape juice is fermented with the grape skins the higher the resveratrol content will be. It is produced by the plant as a defence against diseases.

Health Benefits of Resveratrol

Resveratrol is an antioxidant but its antioxidant properties are weaker that those of quercetin and epicatechin. It has anticancer properties and inhibits lipid peroxidation of low-density lipoprotein and prevents the cytotoxicity of oxidized LDL. Resveratrol also increases the activity of some antiretroviral drugs in vitro.

Antioxidant

In vitro studies have shown that resveratrol inhibits the oxidative damage caused by the heavy metal cadmium. The antioxidant activity of resveratrol reduces damage to endothelial cells exposed to nitrite radicals and protects skin cells against damage caused by UV radiation.

Anticancer

The antioxidant action of resveratrol helps to prevent damage to DNA but it also influences the transcriptions of genes responsible for redox metabolism and inhibits proliferartion of cancer cells. Resveratrol appears to decrease tumor promotion activity by inhibiting the enzyme cyclooxygenase-1, which converts arachidonic acid to substances that promote tumor growth. In vitro experiments provide support for resveratrol to serve as a candidate preventive agent against prostate cancer, but in vivo effects of resveratrol and the mechanisms of action of resveratrol on prostate cancer prevention remain largely unknown.

Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells.

Journal of Biological Chemistry. 2007 February;388(2):207-19

Previous studies have shown that phytochemical resveratrol has antioxidant properties and influences the cellular redox reactions in eukaryotic cells. The researchers investigated the effects of resveratrol on the transcription of genes and activity of enzymes involved with the redox metabolism and cell cycle regulation in lung cancer cells. They found that resveratrol significantly increased the transcription of glutathione peroxidase resulting in lower glutathione levels. Glutathione also increased the transcription of many genes involved in the cell cycle, differentiation and apoptosis. The researchers concluded that resveratrol increased the expression of genes responsible for cell survival, differentiation, proliferation inhibition and apoptosis. Resveratrol may therefore have a chemopreventive and anticancer effect.

Effect of resveratrol and mixtures of resveratrol and mitomycin C on cancer cells under irradiation.

Anticancer Research. 2006 November-December;26(6B):4403-8

This study investigated the antitumor and radiation protective effects of resveratrol in combination with mitomycin-C, an antibiotic that is also used as chemotherapeutic agent because of its antitumour activity. The in-vitro tests were carried out on human breast cancer cells in aerated and anaerobic media. In the aerated media resveratrol showed anti-tumor and antioxidant activities, which were enhanced by mitomycin-C. Under anaerobic conditions, resveratrol acted as a radiation-protecting agent and at high concentration it stopped cell growth. The study concluded that resveratrol has both radiation protective and anticancer activity. Resveratrol acts by ejection of electrons and by reacting on primary radicals, such as hydroxyl radical.

Resveratrol Inhibits Pancreatic Cancer Cell Proliferation through Transcriptional Induction of Macrophage Inhibitory Cytokine-1.

Journal of Surgical Research. 2007 January 24

Resveratrol is a phytochemical found in many mainly in red grape skins, mulberries and some nuts. Previous studies have shown that resveratrol has potential antitumorigenic and anti-inflammatory activities. It is known that macrophages produce a cytokine (MIC-1) which has antitumorigenic activity. The aim of this in-vitro study was to determine the effect resveratrol on the activity of MIC-1 and the regulation the growth of lines human pancreatic cancer cells. The researchers found that resveratrol upregulated the expression of the MIC-1 gene. When the cells were first treated with a transcriptional inhibitor the effect of resveratrol was reduced, confirming that resveratrol works expression of genes. The study concluded that resveratrol increases MIC-1 gene expression in pancreatic cancer cells.

Resveratrol inhibits proliferation, induces apoptosis and overcomes chemoresistance through downregulation of STAT3 and nuclear factor-{kappa}B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

Blood, 15 March 2007, Vol. 109, No. 6, pp. 2293-2302

This study investigated the effect of resveratrol, a phytochemical found in red grapes, red berries and peanuts on the growth of human multiple myeloma cells. Multiple myeloma is cancer of immune system cells in bone marrow. Bhardwaj and his colleagues found that resveratrol inhibited the proliferation of human multiple myeloma cell lines. Resveratrol also increased the apoptotic affect of bortezomib and thalidomide. They concluded that resveratrol may have a potential in the treatment of multiple myeloma cancer.

Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells.

Molecular Cancer. 2006 October 17;5:45

Endometrial cancers (cancer of the lining of the uterus) are the most common gynecologic cancers in the Western world. Studies have shown that resveratrol, an anti-oxidant found in high quantities in red wine, has anticancer activity and acts by inhibiting the proliferation and inducing apoptosis of cancer cells. The aim of this study was to investigate the antiproliferative and apoptotic activity of resveratrol in six different endometrial cancer cell lines. The researchers found that resveratrol caused apoptosis apoptosis in five out of six uterine cancer cell lines and decreased cell proliferation. They found that resveratrol acts by regulating the cyclooxygenase expression.

Benefits for diabetes

Resveratrol may be benificial for diabetes. Administration of resveratrol may protect against oxidative damage caused by high glucose levels. It also reduces diabetic neuropathic pain.

Heart health

Resveratrol protects our heart and blood vessels by directly scavenging oxidants, which could cause oxidation of lipids, and by preventing apoptosis of endothelial cells. It may also help to prevent heart damage after a cardiac arrest. Reduced platelet aggregation has been attributes to resveratrol, thereby reducing the risk of atherosclerosis.

Increase of lifespan

Tests with animals have shown that that high food intake reduces lifespan. One study showed that resveratrol was able to able to increase the life span of mice on a high calorie diet.

Antitoxic

Many studies on animals have shown antitoxic effects of resveratrol. Resveratrol was able to reverse damages caused by the administration of the chemotherapeutic drug bleomycin. Resveratrol also helped to reduce brain damage and oxidative damage of the liver during ethanol intoxication. It also reduced kidney damage of rats treated with the antibiotic gentamicin.

Facts about Resveratrol

Resveratrol explains partly the French Paradox: the low incidence of heart disease among French people, who eat relatively a lot of unhealthy fat but drink resveratrol containing red wine.

Research Reviews

Resveratrol Promotes Clearance of Alzheimer’s Disease 

Resveratrol Inhibits TNF-alpha?Induced Proliferation and Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells

Resveratrol in cancer management

Studies on Resveratrol and cancer

Studies on Resveratrol and colon cancer  (MANY STUDIES) http://science.naturalnews.com/R/Resveratrol_and_colon_cancer.html

Studies on Resveratrol and ovarian cancer ( MANY STUDIES) http://science.naturalnews.com/R/Resveratrol_and_ovarian_cancer.html

Studies on Resveratrol and Anti-Tumor

Studies on Resveratrol and Apoptotic

Studies on Resveratrol and Chemotherapeutic

http://science.naturalnews.com/R/Resveratrol_and_Chemopreventive.html

http://science.naturalnews.com/R/Resveratrol_and_Antiproliferative.html

http://science.naturalnews.com/R/Resveratrol_and_Anti-Angiogenic.html

http://science.naturalnews.com/R/Resveratrol_and_Apoptotic.html

Oxindole alkaloids:

Pteropodin, Specrofillin, Hystopteropodin, Uncaria F, Uncaria Tomentosa, Isomitrofillin, etc.

  1. Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline …

    http://www.ncbi.nlm.nih.gov/pubmed/19724995‎

    Sep 1, 2009 – In this study, the pentacyclic oxindole alkaloid mitraphylline was isolated … on human Ewing’s sarcoma MHH-ES-1 and breast cancer MT-3 cell …

  2. Cat’s Claw Oxindole Alkaloid Isomerization Induced by Cell …

    http://www.ncbi.nlm.nih.gov/pubmed/23975868‎

    Aug 23, 2013 – Cat’s Claw Oxindole Alkaloid Isomerization Induced by Cell Incubation and Cytotoxic Activity against T24 and RT4 Human Bladder Cancer Cell …

  3. Mitraphylline – Wikipedia, the free encyclopedia

    en.wikipedia.org/wiki/Mitraphylline‎

    „Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing’s sarcoma and breast cancer cell lines” …

  4. Cat’s Claw – American Cancer Society

    Sep 12, 2011 – Thanks to American Cancer Society volunteers, cancer patients receive…. Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline …

  5. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05907.x/pdf  Nov 9, 2005 – increasing survival rates amongst cancer patients. However, mutations …purified oxindole alkaloids, namely isopteropodine (A1), pteropodine …
  6. cancer | Naturopathy by Savvas Ioannides N.D.

    naturalhealingcyprus.wordpress.com/tag/cancer/‎

    Jul 10, 2013 – Posts about cancer written by Naturopathy by Savvas Ioannides. …minimal traces of immune-suppressing tetracyclic oxindole alkaloids (TOAs) …

  7. Cat’s Claw: A Rainforest Herb Quells Inflammation, Supports … www

    .lef.org/magazine/mag2007/mar2007_nu_catsclaw_01.htm‎

    He improved remarkably, and one year later was apparently free of cancer. … of cat’s claw to compounds called oxindole alkaloids;1 more recently, however, …

    see this article Cat’s Claw click here

Styryl-lactones :

Altholactone, Goniothalamin,etc

Tannins:

A group of polyhenols; tannins are divided into 2 chemically distinct groups:

1) the condensed tannins (Proanthocyanidin)

2) the hydrolysable tannins (as hydrolysable Ellagitannins, such as Woodfordin C (macrocyclic ellagitannin dimmer), Oenotheietc.

NOTE: Anthocyanins: Peonidine-3-glucoside, Cyanidin-3-glucoside , etc.

see Tannic acid above

Terpenes:

Alisol B acetate, Atractylon, Atractylenolides, Betulinic acid, Bisabolol, Boswellic acid, Carnosic acid,

Ferutidin, Ferutinin, Myristicin, Oleanolic acid, Parthenolide, Pomolic acid, Tymoquinone, …etc…

See Myristicin,above

Vanillys-phenols :

a group of polyhenols; share structural similarities possessing both the vanillyl (4-hydroxy

3-methoxyphenyl) moiety and the ketone functional group in their structure; Paradols, Gingerols, Yakuchinone B,

Curcumin (diferuloyl methane), Capsaicin (homo-vanillic acid derivative : 8 methyl-N-Vanillyl-6-nonenamide),etc.

See  Capsaicin,above

  • Curcumin

Turmeric(cucurmin) : http://science.naturalnews.com/c/curcumin_and_cancer.html ,

http://science.naturalnews.com/C/Curcumin_and_Anti-Angiogenic.html

http://science.naturalnews.com/C/Curcumin_and_Apoptotic.html

http://science.naturalnews.com/C/Curcumin_and_Antineoplastic.html

http://science.naturalnews.com/C/Curcumin_and_Chemopreventive.html

See also:

Ginger: http://science.naturalnews.com/G/Ginger_and_cancer.html

Cinnamon: http://science.naturalnews.com/C/Cinnamon_and_cancer.html

SPICES – more spices and herbs.plants in the book .

Triterpenoids

Malol, micromerol, urson, prunol, (3b)-3-hydroxyurs-12-en-28-oic acid

Ursolic acid is a is a pentacyclic triterpenoid.

Ursolic acid is present in many plants, including apples, bilberries, cranberries, elder flower, peppermint, lavender, oregano, thyme, hawthorn, prunes.

Ursolic acid has medicinally action, both topically and internally. Ursolic acid is used in many cosmetic preparations for its anti-inflammatory, antitumor and antimicrobial properties.Ursolic acid has antibacterial and antifungal activity. Tests have shown that Ursolic acid inhibits the growth of Candida albicans and Microsporium lenosum.Ursolic acid has anti-inflammatory properties and is used in ointments to treat burns.Topical application of ursolic acid inhibited TPA-induced initiation and promotion of tumor growth.
science.naturalnews.com/U/Ursolic_Acid_and_cancer.html

http://science.naturalnews.com/U/Ursolic_Acid_and_Anti-Inflammatory.html important for preventing inflammation (i.e:used  in conjunction with CESIUM treatment)

http://science.naturalnews.com/U/Ursolic_Acid_and_Immune_system.html

http://science.naturalnews.com/U/Ursolic_Acid_and_Anti-Proliferative.html

http://science.naturalnews.com/U/Ursolic_Acid_and_Apoptotic.html

http://science.naturalnews.com/U/Ursolic_Acid_and_Chemotherapeutic.html

Other Phytochemicals

Inositol-phosphate

In plants phytic acid is the principal store of phosphate. Phytic acid is a natural plant antioxidant.

Phytic acid can be found in most grains, seeds and beans. Rich sources of phytic acid are wheat bran and flaxseed (3 % phytic acid).

Health Benefits of Phytic acid

Phytic acid has been considered as an anti-nutritional component in cereals, seeds and beans. Research has traditionally focused on its structure that gives it the ability to bind minerals, proteins and starch, and the resulting lower absorption of these elements. However, resent research have shown that phytic acid has many health benefits. Phytic acid has antioxidant, anticancer, hypocholesterolemic and hypolipidemic effects.

Anticancer effect of phytic acid

In animal studies phytic acid showed a protective action in carcinogenesis. This action could be explained by its mineral chelating potential. Some studies suggest that phytic acid acts as anti-cancer agent by reversing the proliferative effects of carcinogens.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

Journal of Nutrition. 2003 November;133:3778S-3784S.

Phytic acid seems only to affect cancer cells and not normal cells. Phytic acid and inositol improves the effectiveness of chemotherapy. More studies are required to determine optimal dosage, effectiveness and safety of phytic acid.

The biochemical changes associated with phytic Acid on induced breast proliferative lesions in rats: preliminary findings. 

Cancer Biology and Therapy. 2006 September;5(9):1129-33

Previous studies shown that phytic acid inhibits or prevents the growth of neoplasms. The aim of this study was to investigate if phytic acid has an effect on tumorigenesis by inducing apoptosis and inhibiting of oxidative stress. The in-vivo test was carried out on rats which were treated with the carcinogen dimethylbenz(a)anthracene (DMBA). The researchers found that the administration of phytic removed the benign proliferative breast changes. Phytic acid significantly decreased trichostatin A and nitric oxide levels and increased apoptosis. The study concluded that the administration of phytic acid reversed the proliferative effects of the carcinogen DMBA, and could have a protective effect.

Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea. 

Carcinogenesis. 1997 October;18(10):2023-6

Epidemiological studies show a relation between diet and the incidence of colon cancer. Both phytic acid and phytochemicals in green tea seems to act as anticancer agents and have been linked wit reduced risk of cancer. The aim of this in vivo study with rats was to determine the possible synergistic effect of phytic acid and green tea on the inhibition of colonic preneoplastic lesions formations and the enzyme glutathione S-transferase. The rats were treated with the carcinogen azoxymethane and received different combinations of phytic acid and green tea. The researchers found that green tea alone had only marginal effect whereas phytic acid significantly reduced the incidence of aberrant crypt foci. The combination of phytic acid and green tea showed a significant and synergistic anticancer effect.

Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention. 

Biochemical and Biophysical Research Communications. 2001 November 2;288(3):552-7

According to K Midorikawa and colleagues, phytic acid is one of the most promising cancer chemopreventive agents. The aim of this study was the determine the anticancer mechanism of phytic acid. They found that phytic acid inhibited the oxidative damage of hydrogen peroxide, but that phytic acid did not directly scavenge hydrogen peroxide. Phytic acid did not cause damage to DNA. They concluded that phytic acid acts as an antioxidant and anticancer agent by chelating metals.

Antitumor activity of phytic acid (inositol hexaphosphate) in murine transplanted and metastatic fibrosarcoma, a pilot study.

Cancer Letters. 1992 July 31;65(1):9-13

In vivo tests have shown that phytic acid exerts a antitumor effect on experimental colon cancer. The purpose of this study was to determine the antitumor activity of phytic acid on other experimental tumor models, such as murine fibrosarcoma. The researchers found that the intraperitoneal injection of mice with phytic acid reduced the growth of subcutaneously transplanted fibrosarcoma and prolonged survival. Phytic acid could have a potential use in the therapy of cancer.

science.naturalnews.com/P/phytic_acid_and_cancer.html
2008 Acta poloniae pharmaceutica
2008 Acta poloniae pharmaceutica
Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats.2010 Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie

Benificial for diabetic patients

Phytic acid may have health benefits for diabetes patients. It lowers blood glucose response by reducing the rate of starch digestion and slowing the gastric emptying.

Other effects

Phytic acid releases inositol that during digestion. Although inositol is not an essential nutrient it might reduce depressions. Studies also show that phytic acid may reduceinflammation.

Other things:

Melatonin( night sleep between 22 pm – 3am) -VERY IMPORTANT

www.naturalnews.com/033511_melatonin_cancer.html  – IMPORTANT article  ,

http://articles.mercola.com/sites/articles/archive/2013/03/19/melatonin-benefits.aspx

Here are part of the extended bibliography and enormous amount of studies that exist about natural substances and their effective effect against cancer( I say part as most of them are cited from NaturalNews website, website I also write for; fpr example, see my article on scientific studies on chemo/radiation: http://blogs.naturalnews.com/should-one-use-conventional-cancer-treatments-chemotheraphy-or-radiation/)

NOTEs:

1.Take your nutrients from ORGANIC WHOLE FOODS rather than supplements

2.The impoverishment of vitamin and pro-vitamin complexes no longer present in food, with the consequent increase in degenerative and deficient diseases such as cancer. The deliberate attempt to deactivate the natural substances contained in the plants is very serious: in this way fresh fruit and vegetables – greatly impoverished of many vitamins – can be carried over long distances and long periods of time because their oxidation does not take place.This vitamin impoverishment will ensure commercial profits and represents a serious act of deliberate damage inflicted on the Ecosystem by means of GMOs.

It’s heavy the possible disappearance of anti-cancer vitamins, that induce apoptosis (suicide) of the tumors (Anthocyanin, Flavonoids (1122), Polyphenols (1123), sesquiterpene lactone Parthenolide (701), penta-acetyl Geniposide (1061), Camelliin B (698), beta-Cryptoxantin (1063), Hesperidin (1063), Emodin (247,333,715), ursolic acid (700),allyl Sulfur (694,696), Eriodictoyol (693), hibiscus protocatechin acid (692), Indoles (809), Isothiocyanates (809), Resverarol (695), Elemene (690), Acutiaporberine (711), Capsaicin (719), Wagonin (713), Fisetin (713), carnosic acid (1062), Germanium sesquioxide (269), epigallocatechin Gallate (173,1124), Axerophthol palmitate, alpha and beta Carotene, trans-Retinoic acid, Tocopherols, Limonene (693), Cynaropicrin, Lycopene (633,1359), Proanthocyanidin, Damnacanthal (1043), Baicalin (718), Baicalein (718), hydrocinnamic acid (693), sesquiterpenoids as Atractylon (704), as Atractylenolides I, II, III (704), gelsemium alkaloids (699), tartary buckwheat flavonoid (1064), Sinigrin, ferulic acid, ellagic acid, cumarinic acid, …)

SEE: http://www.erbeofficinali/dati/nacci/allpdf.php

The disappearance of these natural anti-cancer vitamins is a grave threat.

See also a FREE EBOOK detailing Thousand Plants against Cancer without Chemo-Therapy ,May 2010 ,650 pages

EVIDENCE BASED MEDICINE:  2,050 official scientific publications ,2,100 various bibliographical references BONUS in my book, next to other 4 free ebooks(Dr. W .Kelley Dr. Binzel, Dr. Matias Rath , Johanna Brandt. )

In this book the plants are identified by their Latin names – according to the modern scientific classification (see Chapter 20)

– and 2,050 official scientific publications are quoted (out of 2,100 various bibliographical references (see Chapter 21), useful to in depth studies, which confirm the various arguments indicated there.

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Alimente utile in cancerul functie de tip de cancer

iul.6

 

Cancer san

Care a împiedicat mai bine tumorile, struguri negrii sau ceaiul verde?

Cred eu ca am raspuns deja la acest lucru dar haideti sa vedem ce spun studiile .
Un mai 2006 studiul a constatat ca DOAR polifenolul resveratrol, găsit în pielita de struguri negri/mov/rosii/roze,
este mai eficientă decât polifenolul, epigallocatechin-3-galat (EGCG), gasit in ceaiul verde in prevenirea tumorilor mamare la sobolani. Inca de la naștere, sobolanilor li s-au administrat fie resveratrol fie EGCG regulat.. La vechi 50 zile ” sobolanilor li s-au dat cancerigen, DMBA. Șobolanii cu resveratrol au avut mai putine tumori și a existat o întârziere în timp a  dezvoltarilor tumorale.

Analiza țesutului mamar a arătat că tratamentul cu resveratrol a rezultat structuri lobulare mai diferențiate. În plus, a existat o reducere semnificativă în celule proliferative în structurile ductal mamare, facand tesutul mamar mai puțin sensibil la daune de la agenți cancerigeni. (A se vedea Whitsett TG et al., Resveratrol, dar nu EGCG, în dieta suprima cancer mamare DMBA induse  la sobolani, J Carcinog 2006.)

Alte studii spun ca ceai verde este mai potent decat DOAR resveratrol.

Dar ambele sunt foarte bune, deci includeti atat struguri negrii(contin multi alti anticancerigeni puternici, nutrienti si antioxidanti) pe stomacol gol cat si ceai verde in dieta dvs.

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Capsuni si fructe de padure ajuta la lupta impotriva cancerului de san

Un studiu de la Harvard a urmărit dieta și sănătatea de 1271 de persoane iubitoare de căpșuni găsit o scădere generală de 70% din toate cazurile de cancer. Un studiu celulă 2004 a investigat efectele specifice ale zece extracte diferite de fructe și fructe de padure,  inclusiv macese, afine, coacaze negre, aronia negru, mere, cătină, ligonberries, cireșe, zmeură  pe celule de cancer de san si celulelor cancerului de colon. Extractele au scăzut proliferarea atât celulele canceroase sân  cat si a celulelor cancerului de colon. Efectul de inhibare a variat cu concentrația de fructe si boabe variate – o medie de 52% pentru celulele cancer de san. Deoarece această rată de anti-proliferare nu a putut fi găsită prin vitamina C standard de ascorbat singura, a existat o sugestie a unei sinergii între  vitamina C și alte substanțe. Pentru celulele de cancer mamar, antocianii, care sunt pigmentii roșu  albastru  din fructe și aparțin clasei de compuși cunoscuți ca flavonoide, poate contribui puternic  la inhibarea celulelor canceroase. (A se vedea Olsson M. și colab., Inhibarea Cancer Cell proliferarii in vitro de legume si fructe Extracte și corelații cu nivelele de antioxidanti, J Agric Food Chem 2004.)

Murele contin rutina, flavonoide ce poate bloca efectele unei enzime ce este responsabila de cheagurilor de sange. Acesta reduce considerabil riscul atacului de cord sau de  accident vascular cerebral.
Căpșuni cultivate ecologic, cu condiția niveluri de antioxidanti mai mari și mai bune au inhibat mai bine proliferarea celulelor canceroase decat căpșuni cultivate in mod conventional in celulele canceroase san . Într-un studiu din 2006, nivel mai ridicat de ascorbat (vitamina C) si antioxidanti gasiti in căpșuni organice au fost corelate cu o inhibare mai mare de proliferarea celulelor cancerului de san. Semnificația efectului de ascorbat asupra proliferării celulelor canceroase ar putea fi într-o acțiune sinergică cu alte compuși. (A se vedea Olsson ME și colab., Nivelele de antioxidant și inhibarea cancerului Proliferarea celulelor in vitro prin extrase din organic si  căpșuni cultivate convențional, J Agric Food Chem 2006.)
Acum e sezon de cirese, visine, afine, mure, zmeura, fructe de padure,caise, piersici, nectarine pepeni si tomate si toate acestea sunt deosebit de recomandate si anticancerigene, daca sunt consumate pe stomacul gol(ex: dimineata), MINIM 1 kg zilnic.

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Portocale.

Anchetatorii au descoperit acum că portocale conțin mai mult de 170 chimicate foto, inclusiv mai mult de 20 din familia puternica a  carotenoidelor . In plus, compusi numite limonoids – care dau citricelor gust  ușor amar  – par a fi agenti foarte activi anti- cancer , de asemenea.

oranges

oranges (Photo credit: WGyuri)

Tomatele

Hot News: carotenoide Deși au fost bine cunoscut ca fiind radical liber necrofagi, un studiu din 2006 a cautat sa determine mecanismul de acțiune al  licopenului – carotenoid din rosii (si pepene verde si struguri si grapefruit, etc) și acid retinoic asupra inhibarii IGFs  – factori de crestere  ca insulina- in proliferarea celulelor canceroase, inclusiv celule de cancer de san . În studiul celulelor, nivelurile D1 ciclina, care acționează ca un senzor de factor de creștere
părea să fie ținta de acțiune licopen lui. Slăbirea  nivelurilor D1 ciclina de catre licopen și acidul retinoic este un mecanism important reducerea rolului IGFs „în proliferarea celulelor maligne. (A se vedea Nahum A et al.,
Inhibarea Licopenul de IGF-induse de Cancer Cell crestere economica depinde de nivelul de Cyclin D1, Eur J Nutr 2006.)

Vinetele.

Coaja violet a vinetelor(pe care de obicei lumea o arunca) este dovada puterii antioxidantilor ce ii contine. Vinetele sunt una din cele mai bune surse de nasunin, antioxidant ce blocheaza raspandirea celulelor canceroase. Nasuninul poate incetini evolutia bolii Alzheimer pe principiul inlaturarii efectelor radicalilor liberi la nivelul neuronilor.

Mecanisme anti-cancer de san ale cruciferelor si   I3C 

Cruciferele inclusiv varza, conopida, broccoli  conțin fitochimicale care acționează împotriva cancerului în mai multe moduri diferite. Varza, singura,are peste 200 de produse chimice.De exemplu, indol-3-carbinol (I3C), care este derivat din cruciferee,  influențează gene de cancer I3C  si un site de receptor. Plus, fitochimicale din familia verzei sunt capabile de a induce activarea enzime faza 2 pentru a proteja împotriva carcinogenii chimici.

Într-un studiu de la Universitatea Georgetown 2006, fitochimicale indol-3-carbinol (I3C) dîn broccoli, conopidă, varză și, s-au găsit pentru a stimula producția de proteine cu ADN-ul  ​​BRCA 1 și BRCA 2 – ce repara ADN-ul deteriorate, care sunt scăzute în celulele canceroase. (A se vedea Rosen E et al., Legume pot proteja impotriva cancerului,
British Journal of Cancer 2006.)

Dr. Eliot Rosen, cercetator de plumb in studiu Georgetown, a comentat:

„Este acum clar că funcția de gene cruciale de cancer  poate fi influențată de compușii din lucrurile pe care le mâncam. Descoperirile noastre sugereaza un proces molecular clar  care va explica legatura dintre alimentatie si  prevenirea cancerului. „

Un alt studiu I3C, un studiu noiembrie 2005, a explorarat proprietățile anti-tumorale a componentei alimentare indol-3-carbinol din crucifere si a constatat ca efectele anti-tumorale ale I3C in celulele canceroase umane pot reduce expresia receptorilor de estrogen-alfa. (Vezi Wang TT și colab., Receptorului de estrogen alfa ca o tinta de -3 indol – Carbinol, J Nutr Biochem 2005.)

Într-un studiu broccoli , varza „la sobolani, varza si broccoli s-au dovedit a fi o excepțional de bogată sursă de inductori de enzime care protejează împotriva chimicale cancerigene. Extracte de  trei zile vechi de varza de broccoli au fost extrem de eficiente în reducerea incidenței si multiplicarii si ratei de dezvoltare a tumori mamare  la șobolani. (A se vedea Fahey JW, broccoli Varza:. O sursă extrem de bogata de inductori ai enzimelor care protejeaza impotriva chimice cancerigene, Proc Natl Acad. Sci USA 1997.)

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Ardeiul rosu

Ardeiul rosu poate fi o vedeta a scris benficile pe de ingrijire le aduce sistemului imunitare, fiind o excelenta sursa de Vitamina C. Vitamina C Stimuleaza producerea de celule albe.

Un Studiu Publicat in Jurnalul american de Nutritie Clinica a constatat ca persoanele ce au o dieta bogata in Vitamina C au fost mai putin predispuse la aparitia ridurilor Vitamina C Este esentiala a scris Productia de colagen.

Usturoi.

Studiile arata compusi sulf  care dau o aroma puternica acum s-au dovedit a fi protejat împotriva cancer si neutralizat cancerigeni și incetinit cresterii tumorilor. Într-o recentă Iowa  Studiul de sanatate femei, anchetatorii
a constatat ca femeile care consuma usturoi cel puțin o dată pe săptămână au, de asemenea, un 32% mai mică incidenta cancerului de san. Sulful e responsabil si cu o buna detoxifiere.

In plus, usturoiul si ceapa sunt o sursa importanta de seleniu, un puternc tratament de cancer individual – voi reveni cu un articol despre tratarea cancerului cu seleniu.

Daca doriti sa primiti pe mail  articolul GRATUIT , cand il public, si orice tratament cancer nou apasati pe butonul de mai jos(introduceti si adresa mail):

Introdu adresa de email pentru a te abona la acest blog și vei primi notificări prin email când vor fi publicate articole noi.

(nu uitati sa apasati pe buton)Veti primi direct pe mail orice e nou.

Hrean.

Această rădăcină stimuleaza o dezintoxicare excelenta. Soiuri puternice au fost studiate pentru proprietăți anti-cancer .

LEGUME

Ardei gras rosu si verde,vinete, tomate, usturoi,ceapa, varza, dovlecel, etc.

Sparanghelul conține un număr de fitochimicale capabile antifungice, antimutagenice, citotoxice și   antivirale. Într-un studiu de laborator, brut saponine (din clasa de fitochimicale terpenoide – precum licopenul ), obținute din  sparanghel, s-au dovedit a avea activitate. anti-tumorala  (A se vedea Shao Y și colab., Antitumorale  Activitatea de saponine brute obținute din sparanghel, cancer Lett 1999.)

ROSII+ASPARGUS!

ROSII+SPARANGHEL (ASPARAGUS)!

Busuiocul

Busuiocul contine cantitati mari de eugenol, compus cu capacitatea de  a bloca celule canceroase din a se DIVIZA si stimuleaza autodistrugerea celulelor canceroase în cancerul de col uterin.

BUSUIOC

BUSUIOC

Spanac.

Universitatea din Minnesota Servicii de sanatate a mediului și altele au descoperit că persoanele care includ două
sau mai multe portii de spanac pe săptămână în hrana lor au considerabil mai mici  ratele de cancer de san si pulmonar.

SPANAC

SPANAC


Fasolea.

Cercetarea in stiintele alimentare a stabilit că toate tipurile de fasole sunt încărcate cu inhibitori de protează,
compusi care fac greu pentru cancer a invada tesuturile adiacente(deci previn si impiedica metastazarea).

Daca puteti  leguminoase verzi sau GERMINATE este excelent( alaturi de cereale integrale GERMINATE asigura proteine complete, precum si energie din carbohidrati complecsi si multi nutrienti  – faceti o salata cu legume, leguminoase si cereale incoltite)!

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Curcuma, cancer de san

Inflamația este asociata cu o mare varietate de tipuri de cancer,inclusiv cancerul de san.

Femeile cu hiperplazie atipica in tumori benigne ale sânilor, care au mers pe a dezvolta cancer de san, s-au dovedit a avea un nivel semnificativ mai ridicat de COX-2, care este produsă în organism atunci când există inflamație.Într-un studiu-cheie pentru 2005, curcumina, care este derivat din curcuma, a fost gasit a reduce dramatic COX-2. În India, unde femeile consuma Curcumina, 79 dintr-un milion de femei dezvolta cancer de san, in timp ce in SUA, unde
Femeile nu consuma curcumina, 660 de femei per milion dezvolta de san.
Seminte de si ulei de in bogate in OMEGA 3

Omega-3 grasimi, gasite in seminte si ulei de in, nuci, avocado, catina si uleiul de peste, inhiba cresterea celulelor cancerului de san in cultură și în grefe la soareci.  Moartea celulară crescută este atribuită inhibarii COX-2, enzimă care promovează procesul de cancer. În plus, omega 3 activează PPAR, un regulator al metabolismului lipidic capabil a  modula proliferarea. Semintele de in, pe langa omega 3 contin si lignani anticancerigeni.

Grasimile omega 3 sunt singurele grasimi antitumorale.In plus, combinate corespunzator cu proteine sulfurice, cresc oxigenarea celulara si combat astfel cauza primara a cancerului(exista alt premiu Nobel acordat acestei descoperiri   precum si un tratament cancer foarte eficient bazat pe grasimi omega 3).

Am descris in carte exact cum pot fi folosite grasimile omega 3 ca tratament cancer foarte eficient 

Pina si Dr Gerson si-a reconsiderat opinia despre grasimile omega3 , dupa ce initial le-a disconsiderat.
Activitatea în celulele de san. (A se vedea Stoll BA, acizi grasi omega3 si peroxidarea lipidelor în  Inhibarea cancer de san, Br J Nutr 2002.)

Alaturi de grasimi din nuca de cocos, masline si migdale sunt singurele grasimi permise in cancer.

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Acestea sunt cateva alimente bine de inclus in alimentatia zilnica, pentru ca stiu ca va intereseaza.

Iodul (inclusiv solutia Logol)

Femeile din Japonia, care consumă  fructe de mare bogate in iod au o incidenta mai mica de cancer de san (revin cu un articol despre iod.)

Daca doriti sa primiti pe mail  articolul GRATUIT , cand il public, si orice tratament cancer nou apasati pe butonul de mai jos(introduceti si adresa mail):

Introdu adresa de email pentru a te abona la acest blog și vei primi notificări prin email când vor fi publicate articole noi.

(nu uitati sa apasati pe buton)Veti primi direct pe mail orice e nou.

 

Cancer ovarian

 
Dincolo consuma o varietate bogată de produse proaspete și limitarea produse lactate, carne și zahăr, anumite alimente vizeaza in special celulele cancer ovarian – au demonstrat succes extraordinar în înfrângerea acestei boli ce va pune in pericol viata.
Ghimbir

Radacina de ghimbir este un aliment excelent pentru anihilarea celulelor cancerului ovarian.

Când cercetătorii au dizolvat pudra de ghimbir într-o soluție care conține culturi de cancer ovarian, celulele mutante au murit. Ghimbirul distruge celulele de cancer ovarian în două moduri. 

Mai întâi printr-un proces de auto-distrugere celulară numit apoptoza apoi prin autofagie, cazul în care celulele se auto-digera. Oamenii de stiinta de la Universitatea din Michigan au descoperit ca ghimbirul a provocat aceeasi rata de apoptoza ca medicamente comune de chimioterapie, dar fără efecte secundare. Rădăcină ghimbir controlează, de asemenea, inflamația, care este un precursor al cancerului ovarian .

Ginkgo biloba

Cercetările au arătat că planta Ginkgo Biloba reduce semnificativ riscul de a dezvolta cancer ovarian. Mai mult de 600 de femei cu cancer ovarian și 640 subiecti sanatosi de control au fost studiate. Participanții au avut o istorie de a folosi fie ginkgo, echinacea, sunătoare, ginseng sau condroitina. Numai cei care au luat suplimente de Ginkgo au avut rate mai mici de ovarian cancer – o impresionantă scădere cu 60 la suta a riscului. 

Ceai verde 

Băut o doar doua cani pe zi de ceai verde poate reduce riscul de cancer ovarian la jumătate.

Cercetatorii au urmat 61057 de femei, variind de la varsta 40 – 76, pe parcursul a 15 ani. Pentru cei care au baut o ceasca de ceai verde pe zi, riscul de cancer ovarian a fost redus cu 24 la sută, în timp ce două sau mai multe cesti redus riscul cu 46 la suta. Și pentru femeile care au consumat băuturi în mod constant de peste 30 de ani, ratele de cancer ovarian a scazut cu 75 la suta. Oamenii de stiinta cred ca nivelul ridicat de antioxidanti gasit in ceaiul verde sunt responsabili pentru rezultate. Nu numai ca acesti fitonutrienti puternici ajuta la prevenirea și repararea daunelor ADN-ului, dar ele împiedică, de asemenea, creșterea și răspândirea celulelor canceroase prin cresterea apoptoza.

Semintele de in

Un studiu de caz-control a descoperit ca femeile din SUA care au avut cel mai mare aport de lignani(continuti si in seminte de in, caise  si in alte plante) au avut, de asemenea, cele mai mici rate de cancer ovarian. Lignani, gasiti in semintele de in sunt considerati fitoestrogeni. Acești compuși sunt „conectați” în receptori de estrogen, blocand forme mai puternice de hormon care agravează cancer ovarian. Lignani din semințe de in, de asemenea, acționează ca un antioxidant.

Într-o anchetă care implică surprinzător  puii de găină hraniti cu in, cercetatorii de la Universitatea din Illinois au descoperit ca de cancer ovarian a fost redus în mod semnificativ la găinile care au consumat semințe. Potrivit profesorului Janice Bahr, „la găini hrănite de seminte de in, am constatat ca mai multe tumori au fost limitate la ovar și au răspândit mai puțin metastatic. Aceasta este o constatare importanta deoarece metastaze care insotesc cancer ovarian stadiu tardiv sunt principala cauză de deces de boală. ” 

Sursele pentru acest articol includ:

„Ceaiul verde pentru prevenirea cancerului ovarian si de tratament: o analiza sistematica a in vitro, in vivo și studii epidemiologice” Trudel D, Labbe DP, Bairati eu, Fradet V, Bazinet L, Tetu B, Laval University Cancer Research Center, Pub Med , septembrie 2012. Adus de la 5 noiembrie 2012 de la: http://www.ncbi.nlm.nih.gov/pubmed/22564714

„Consumul de ceai verde imbunatateste supravietuirea de cancer ovarian epitelial” Zhang M, Lee AH, Binns CW, Xie X, Scoala de Sanatate Publica, Universitatea de Tehnologie Curtin, Australia, Pub Med, 10 noiembrie 2010. Adus de la 5 noiembrie 2012 de la: http://www.ncbi.nlm.nih.gov/pubmed/15382073

„Ceaiul verde lupta impotriva cancerului ovarian” David Liu, dr., de consum ale alimentelor, 09 mai 2012. Adus de la 5 noiembrie 2012 de la: http://www.foodconsumer.org

„Vitamine cancer ovarian, suplimente, plante și tratament naturist” Ray Sahelian, MD. Adus de la 5 noiembrie 2012 de la: http://www.raysahelian.com/ovariancancer.html

„Cure naturale pentru cancer ovarian” Thomas rege. Adus de la 5 noiembrie 2012 de la: http://www.ehow.com/about_5480292_natural-cures-ovarian-cancer.html

„Consumul de ceai verde poate reduce riscul de cancer ginecologica” Jonathan Benson, Natural News, 08 mai 2012. Adus de la 5 noiembrie 2012 de la: http://www.naturalnews.com

„Litri de beneficii in doar doua cesti de ceai” Karen Collins, RD, NBC News. Adus de la 5 noiembrie 2012 de la: http://www.msnbc.msn.com

„Lignani” Linus Pauling Institute. Adus de la 5 noiembrie 2012 de la: http://lpi.oregonstate.edu/infocenter/phytochemicals/lignans/

„Pui de seminte de in-Fed pune in lumina cancer ovarian” Știința Daily, 11 mai 2010. Adus de la 10 noiembrie 2012 de la: http://www.sciencedaily.com/releases/2010/05/100504124740.htm

„Lignani” NYU Langone Medical Center. Adus de la 5 noiembrie 2012 de la: http://www.med.nyu.edu/content?ChunkIID=21801

 

 

Multa sanatate!

Cristian

Acum as vrea sa aud si de la dumneavoastra:

Ati incercat oricare din cele de mai sus? Ce efecte au avut asupra sanatatii dumneavoastra? Lasati un comentariu mai jos!

CONSIDERATI UTILE CELE DE AICI? 

SPUNETI SI ALTORA! ( sunt butoane sub aceasta pagina precum si in DREAPTA SUS!). 

Legume crucifere, cancer san BCRA si cancer prostata

iun.8

Femeile care sunt BRCA (breast cancer susceptibility protein)pozitive sunt speriate de mastectomii duble inutile – o procedura din care nu beneficiază nimeni, cu excepția chirurgului. Ceea ce nimeni nu spune este ca legumele crucifere(varza, conopida, brocoli) contin nutrienti anti-cancer care in mod specific tintesc BRCA1 si BRCA2, protejand aceste femei de cancer de san.

Tot ce trebuie este un putin suc de broccoli proaspăt în fiecare zi sau de varza/conopida proaspete sau alte alimente crucifere (gulii, varza chinezeasca , etc) nutritive-dense sau sucuri consumate zi cu zi.

Medicii oncologi, desigur, uita să spuna femeilor despre aceste fapte „nesemnificative”. Aceasta ar strica unele lucruri  în cazul în care femeile ar ști cum să prevină cancerul pe cont propriu, acasa, cu alimente de zi cu zi și ierburi simple.

Iată textul dintr-un studiu care s-ar putea să vă intereseze. Acesta arată că I3C (de la broccoli) și genisteina (din soia fermentate) inhiba activitatea stimulata a receptorilor estrogen  într-un mod dependent de doză:

„… Am aratat ca I3C induce expresia BRCA1 și că atât I3C și BRCA1 inhiba activitatea receptorilor stimulati (ER-) de estrogen (E2)  in celulele umane cancer de san. Acum am raportat ca atât I3C și genisteina induc expresia atât cancerelor de san  cu sensibilitate de gene (BRCA1 si BRCA2) in san (MCF-7 și T47D) și de prostata (DU-145 și LNCaP), ambele tipuri de celule canceroase, într-un mod  dependent de timp și de doză.”

http://www.nature.com/bjc/journal/v94/n3/full/6602935a.html

 

Atentie: INTERZIS soia modificata genetic(GM)! 

Daca puteti face singuri din boabe intregi de soia Nemodificate genetic, in regula, daca nu EVITATI SOIA!

 

Medicii oncologi, desigur, uita să spuna femeilor despre aceste dovezi stiintifice.

Această prezentare necesită JavaScript.

 

Alte cercetări medicale privind legătura dintre alcool- vinul rosu şi cancerul la sân aduc noi perspective asupra problemei, dar riscurile de dezvoltare a acestei boli devin din ce în ce mai puţin clare. Un nou studiu a descoperit că vinul rosu consumat în cantităţi moderate poate proteja populaţia feminină de cancerul mamar. Dar acest lucru se întâmplă doar în cazul femeilor cu BCRA1 . Pe de altă parte, femeile care au BCRA2 pot avea un risc crescut de dezvoltare a cancerului din cauza consumului de alcool din vinul rosu.  Alcoolul este oricum acid si nu este indicat (chiar interzis in cancer!) .Beneficiile dse datoreaza „resurilor” anticancerigene din strugrui prezente  in vin din struguri inchis colorati, precum resveratrol etc.

Atentie: Vinul pastreaza doar 6% din proprietatile strugurilor.Propritatile anticancerigene ale strugurilor inchis colorati le-am descris la cura de struguri click aici Consumati struguri intregi, intens colorati sau suc de struguri intregi intens colorati si bine spalati cu apa filtrata de chimicale.

Cancerul de sân este a doua cauza de deces a femeilor din Canada. Obiectivul cercetătorilor a fost de a valida raportul Fundaţie Mondiale de Cercetare a Cancerului din 2007, care a găsit o legătură convingătoare între consumul de alcool şi rata crescută de dezvoltare a cancerului mamar. Studiile anterioare sugerează de asemenea că mutaţiile genelor BRCA contribuie la creşterea riscului de dezvoltare a bolii.

Genele BRCA funcţionează, în mod normal, ca supresor al tumorii, însă mutaţiile acestor gene se pot dovedi a fi dăunătoare. Aceste mutaţii sunt ereditare şi pot fi detectate doar cu ajutorul unor teste genetice.

Studiul condus de Jessica Dennis, cercetător şi student la Şcoala Dalla Lana de Sănătate Publică din cadrul Universităţii Toronto, susţine că mutaţia este în general rară. Însă anumite etnii, precum evreii ashkenazi, par să aibă un risc mai mare de dezvoltare a cancerului. Dar nu toate femeile care au această mutaţie genetică dăunătoare vor avea cancer la sân, avertizează doctorii.

Un total de 857 de paciente care aveau cancer la sân au participat la experiment, inclusiv 10 persoane care aveau mutaţia genetică BRCA1 şi 33 de persoane care prezentau mutaţia genetică BRCA2. Stilul lor de viaţă a fost notat, inclusiv cantitatea de alcool -vin rosu pe care acestea o consumă. Cercetătorii au examinat vârsta la care femeile au fost diagnosticate cu cancer mamar şi au început să dezvolte teorii despre patologia bolii şi modul în care se poate asocia cu un stil de viaţă care include consumul de alcool – vin rosu.

Aceştia au descoperit că femeile cu mutaţia BRCA1 au arătat o probabilitate cu 62% mai mică de dezvoltare a cancerului de sân, în comparaţie cu restul populaţiei, în cazul în care au băut vin rosu.

Pe de altă parte, femeile cu mutaţia genetică BRCA2 au avut un risc cu 58% mai crescut de a dezvolta boala.

Cercetătorii consideră că impactul pe care l-au observat se datorează prezenţei polifenolului găsit în struguri, numit resveratrol. Acesta se leagă de receptorii de estrogen şi ajută la reglarea activităţii genei mutante BRCA1, consideră cercetătorii. De asemenea, ei sunt de părere că BRCA2 nu răspunde la resveratrol. Cercetări suplimentare sunt necesare pentru a explica legătura dintre consumul de alcool şi dezvoltare cancerului mamar.

Studiul a fost efectuat la centrul de cercetare din cadrul Universităţii din Montreal, Toronto şi Ottawa şi va fi publicat în „The Breast Journal”.

Retineti 2 lucruri simple: legume crucifere si struguri intens colorati, intregi,  bine spalati!

 

Multa sanatate,

Cristian

Capsuni si fructe de padure lupta activ cu cancerul

mai13
Ca tot vine sezon si stiu ca pe multi dintre dvs va intereseaza ce sa mai mancati daca aveti cancer…
Scriu un mic articol „din inima” 🙂 50500_452696485598_3508230_n
slideshow-strawberries_476x357
fructe-de-padureCapsuni, afine, coacaze, mure, fragi, zmeura – fructe de padure aproape toată lumea le iubește si pot furniza compusi puternici impotriva cancerului.

Aceasta este concluzia Christine Sardo, care gestionează studiile clinice privind consumul de fructe și de prevenire a cancerului de la Colegiul de Medicina Ohio State University:

 „Promovam conceptul de” farmacie pe baza de fructe „, spre deosebire de produse farmaceutice pentru cancer, si subliniind prevenirea vs tratament”, a declarat ea in fata aproximativ 300 de practicieni de sanatate la Conferința de Nutriție și Sănătate în New York în luna mai. Conferința anuală, sponsorizată de Colegiul Columbia University a Medicilor si Chirurgilor si la Universitatea din Scoala de Medicina Arizona, reuneste oameni de stiinta in nutritie de top din toata lumea  pentru a discuta despre ultimele descoperiri lor.

Apocalipsa Sardo a fost printre cele mai importante conferințe. Ea a detaliat un studiu publicat în numărul 1 martie 2006 de Cercetare a Cancerului, în care  profesorul Gary Stoner și patru co-autori(OSU de Sanatate Publica) au hranit sobolani cu produse chimice cauzatoare de cancer, produse chimice ca N-nitrosomethylbenzylamine de trei ori pe saptamana, timp de cinci saptamani. După 20 de săptămâni suplimentare, sobolanii care au mancat o dieta constând din 10% mure au aratat reduceri in cazurile de cancer oral, de esofag și de colon de aproximativ 50 %, comparativ cu sobolanii care nu au mâncat fructe de padure.

„Fructele de padure împiedicat întregul spectru de tumori de a fi inițiat și promovat”, a spus Sardo.

Ideea de fructe de padure ca anticarcinogeni a început la sfârșitul anilor 1980, când Stoner a descoperit că acidul elagic, găsit si în multe alte fructe și legume, a inhibat geneza tumorilor. Apoi, el a constatat că fructele de padure conține cantități mari de acid elagic, și că murea, în special, a avut mai mult din acest compus decât toate celelalte fructe de padure.

Fructe de padure, a declarat Sardo, pot fi omologi naturali de droguri sintetice, cum ar fi tamoxifen.

 „Studiile arata Tamoxifen poate reduce riscul de cancer de san, dar studiile nu au evoluat să se uite la acțiunea chemopreventiva a alimentelor integrale(intregi) in dieta noastra – lucrurile pe care le mâncam zi cu zi.”

” E o greșeală, deoarece este posibil ca o combinație de compuși, cum ar fi cele găsite în  alimete integrale ( intregi ) , ar putea fi mai eficiente decât un singur agent. Într-adevăr, există și alte componente din boabe care pot preveni cancerul de asemenea,inclusiv calciu, acid folic, fibre și diverse fitochimicale.”

„Acționând împreună, TOTI compușii din mure încetinesc rata de creștere a celulelor canceroase pre-maligne, si stimuleaza aceste celule sa moara, un proces numit apatoza.”

Următorul pas sunt studiile umane, pe care Sardo le desfășoară în prezent. Ea se concentrează pe oameni cu leziunile pre-canceroase ale esofagului, gurii și colonului, deoarece acestea sunt locurile în care compușii din mure pot fi absorbite cel mai bine. Ea hrănește subiectii ei umani aproximativ cu  jumătate de kilogram de mure proaspătă .

In timp ce pacientii ei cred că sunt pur și simplu mănâncă gustos,  „ceea ce face cu adevărat este hrănirea lor cu o doză puternică de antociani, acizi fenolici, vitamine și minerale, de trei ori pe zi.”

Este prea devreme pentru a judeca dacă studiile umane sunt un succes, a spus ea. Dar daca fructele de padure se dovedesc a avea aceeași acțiune chimiopreventiva la om, la fel ca în sobolani, ar putea ajuta la prevenirea multor boli tragice. „Cancerul esofagian are o rată de supraviețuire foarte mica, doar aproximativ 10 la suta”, a spus ea.

„Dacă putem preveni aceste tipuri de cancer în față, ar fi minunat.”

 „Avem o oportunitate cu fructele de padure pentru a preveni sau controla carcinogeneza”, a spus ea.

 „Este o abordare naturală. Este o abordare cu totul-alimentara. „

Și la Dr. Weil, unul dintre directorii de curs la conferințe, a spus ca este o linie extrem de promitatoare de cercetare.

 „Acesta este doar un alt exemplu de acțiune uimitor de sinergica a compușilor plantelor integrale(intregi), care sunt de multe ori atât mai sigure și mai eficiente decât medicamentele sintetice cu un singur component„, a declarat el după prezentarea Sardo lui.

 „Acesta este exact genul de cercetare care are nevoie de mult mai multe fonduri și sprijin. În cele din urmă, cred că am descoperi că o întreagă serie de alimente de zi cu zi au utilitati uimitoare terapeutice impotriva a o varietate de condiții de sănătate. „

Totusi, voi adauga:

Cei mai mult bolnavi abia asteapta rezultate ale cercetarilor si acestea cine stie cand vor fi publicate(daca nu vor fi impiedicate de alte interese…).

Profitati acum de ce ofera viata. Iar capsunile, murele si fructele de padure nu fac decat bine!

EXEMPLU „RETETA „ANTICANCER:

Capsuni si/sau fructe de padure, miere (nu exagerat), scortisoara( in raport egal cu mierea) si/sau cuisoare si /sau ghimibir si/sau vanilie (alte arome naturale) si de ce nu, menta:

Capsuni_cu_miere

berries

mure

De asemenea,puteti adauga nuci , migdale, miez de samburi caise(intregi sau maruntite) pentru un plus de vitamina B17 si nutrienti(grasimi esentiale omega 3, proteine, energie,etc.)

ATENTIE:

Se serveste NUMAI pe STOMACUL GOL, pentru a fi EFICIENTA.

De ce?

Celulele canceroase  TREBUIE SA FIE INFOMETATE, pentru a  INTERCEPTA GLUCOZA si ODATA CU EA, ANTICANCERIGENII DIN FRUCTE.ALTI NUTRIENTI DIN ALTE ALIMENTE POT INTERFERA.

Ce ANTICANCERIGENI contin fructele de padure?

vitamina C, acid elagic, vitamina B17(laetrille) si multe altele,chiar si  resveratrol ( ca in struguri) si licopen(ca in rosii),antociani, acizi fenolici plus o sumedenie de alti nutrienti (vitamine, minerale  si multe altele inclusiv enzime ce dizolva invelisul tumorilor si ajuta sistemul imunitar sa le atace) si antioxidanti care protejeaza in cazuri de chimio/radioterapie.

Contin multi agenti anticancerigeni ca cei din struguri si rosii.De ce?Pentru ca atat  strugurii si tomatele(rosiile, care sunt tot fructe) fac parte din aceeasi familie cu capsunile si fructele de padure!

Pe baza de struguri negri,violet sau rosii, exista un tratament ce inca din 1920 a vindecat toate cancerele terminale, in special colorectale(click aici).Totusi, atunci nu aveam nici chimio nici radio…

purple-grapes-closeup

w560xh316_mure_si_afine

Bune si in boli de inima(scad colesterolul rau), detoxifica ficatul, si multe altele.

UN LUCRU IMPORTANT(legat de intoxicare/detoxificare):

CAPSUNI,AFINE,COACAZE, ZMEURA,MURE,STRUGURI,TOATE SUNT STROPITE(sa fim realisti, ce nu e?)

SPALATI SI CLATITI IN VAS CU APA FILTRATA!

“Suplimentele trebuie să fie testate pentru puritate de catre dumneavoastra. Dacă acest lucru nu se poate face, nu le luati. Suplimente poluate fac mult mai mult rău decât bine. Obtineti super-nutrițienți prin stoarcerea legumelor de toate tipurile și din ceaiuri de plante”.– Dr. Hulda Clark

DOZE : 

CAT DE MULT POFTITI(puteti face si o cura de cateva zile – sezonul nu tine mult, dar daca da,mancati, nu va infometati)!

fructe_de_padure_2_51739600



Cum Hipocrate a spus: „Alimentele sa fie medicamente, și medicamente fie hrana ta.”

In limita timpului, voi mai publica articole din gama, de sezon, pentru ca stiu ca va intereseaza in mod deosebit.

Cei ce au apasat pe butonul de FOLLOW sau pe caseta din DREAPTA SUS le vor primi automat pe mail.

Insa repet: SUNT MULTE ALTE LUCRUI MAI IMPORTANTE PE CARE TREBUIE SA LE AVETI IN VEDERE!

POFTA BUNA !

Cristian

CONSIDERATI INTERESANTE CELE DE AICI?
SPUNETI SI ALTORA!(butoane sub aceasta pagina sau in dreapta sus)

Antioxidanţi exogeni importanţi

mai8

RESVERATROLUL (alimente culoare neagra)

•        Este cel mai puternic anti-oxidant natural cunoscut

•          Există într-o cantitate de 50-100 mg / g pieliţă de strugure, mai mult decât dublul oricărei alte surse identificate

•          Se găseşte în general în fructele de culoare violet -neagră (dar nu numai) : sucul de struguri negri, sâmburii de struguri, dude, mure, coacăze, prune, dar şi din varza de Bruxelles (care poate fi consumată şi fiartă), fragi

•          Are un efect direct de distrugere tumorală, acţionând împotriva oricărui tip de localizare tumorală, dar şi asupra celor hormono-dependente (sân, ovar, testicul, ficat, stomac)

•          Blochează formarea de vase de sânge în jurul tumorii, dar şi metastazarea celulelor maligne

•          Conferă o protecţie deosebită materialului genetic nuclear (ADN), ferindu-l de mutaţii

•          Are un potenţial anti-oxidant de 50 de ori superior vitaminelor C şi E la un loc

•          Este de 10-20 de ori mai puternic decât vitamina E în protecţia anti-oxidativă a LDL-colesterolului

•          Scade nivelul sangvin al colesterolului total şi al trigliceridelor

•          Este un vasodilatator arterial

•          Se opune expansiunii fibroase a cicatricei post-infarct miocardic

•          Încă din 1985 se ştie că are capacitatea de a inhiba agregarea plachetară indusă de trombină şi ADP (Kimura) => efect anti-trombotic

•          Are efecte anti-SIDA, antivirale (virusurile hepatitice, dar nu numai !), antialergice (inhibând eliberarea Histaminei), antibacteriene şi antiinflamatoare

•          Măreşte elasticitatea articulaţiilor, stimulând sinteza fibrelor de colagen (astfel având şi un rol cosmetic)

•          Preîntâmpină ridarea şi îmbătrânirea pielii, menţinându-i elasticitatea şi tinereţea

•          Efect protectiv faţă de boala Alzheimer prin blocarea proteinei NF-Kb, împiedicând astfel microglia să distrugă neuronii

•          Există studii încurajatoare referitoare la potenţialul terapeutic al său în ceea ce priveşte şi alte boli neuro-degenerative

•          Resveratrolul poate reduce dezvoltarea melanomului malign, poate distruge cancerul de sân şi poate micşora nivelul colesterolului total sangvin

•          Creşte durata de viaţă şi potenţialul reproductiv la animalele de experienţă pe care a fost testat (15-30%)

•          Se comportă şi ca un fito-estrogen (vezi soia)

•          Previne şi combate eficient osteoporoza

Acum sper ca intelegeti de ce strugurii negrii se consuma intregi, cu tot cu pielite si samburi!

Mai mult , strugurii negrii au si multi lti antioxidanti si agenti anticancerigeni.

LICOPENUL(alimente culoare roşie)

•          (Alte denumiri : licopena, licopina)

•          Este cel mai important reprezentant al familiei carotenoizilor

•          Este singurul anti-oxidant a cărui cantitate sporeşte de circa 4-6 ori prin fierbere !!! (bulionul / pasta de roşii de ex.)(dar se distrug alte vitamine precum C si enzime prin fierbere, deci nu e un lucru recomandat!)

•          Licopen întâlnim în aproape orice aliment de culoare roşie : rosii, căpşuni, grape-fruit roşu, ardei iute şi capia, gogoşari, guava, papaya, ulei de cătină, dar şi-n struguri

•          Cea mai mare cantitate de licopen se găseşte în rosii (300-400 mg/kg) ; pentru calităţile cromatice, gustative şi medicinale ale tomatelor, italienii le-au denumit  „pomo d’oro“ (măr de aur), iar germanii „paradiesapfel“ (măr al paradisului)( de fapt rosiile sunt din aceeasi familie cu strugurii si fructele de padure: „berries”)

•          Datorită înapoierii culturale, cât şi a conservatorismului prost înţeles şi aplicat, tomatele au fost introduse şi cultivate la noi în ţară pe scară largă abia în urmă cu un secol !!!

•        Uleiul de măsline amplifică substanţial absorbţia licopenului ; prezintă biodisponibilitate şi efect antioxidant scăzut în medii apoase, în timp ce mediile lipidice îl fac puternic reactiv şi biodisponibil

•        Licopenul modifică profilul acizilor graşi din plasma umană

•        La concentraţii relativ scăzute de licopen, acesta are efecte antioxidante în protecţia celulelor, a membranelor celulare şi ADN

•        Are o capacitate anti-oxidantă de 10 ori mai puternică comparativ cu vitamina E

•        Este o substanţă cu efecte anti-tumorale marcate în general, şi specific în cancerul de prostată, sân, vezică urinară, pancreas, cervical, ovarian, uterin, intestinal, plămâni, piele

•        Unii cercetători merg până acolo încât afirmă că forţa licopenului este aşa de mare încât ajunge o singură roşie de dimensiuni medii consumată zilnic, pentru a ne da o protecţie sigură şi totală anti-tumorală pentru tot restul vieţii

•        Reduce semnificativ riscul aterosclerozei (incidenta infarctului miocardic scade cu 20-50% la persoanele ce consumă frecvent fructe şi legume bogate în licopen) şi procesele de îmbătrânire celulară

•        Alături de vitaminele C şi E, previne degenerescenţa maculară a retinei şi diminuează riscul de cataractă cu 50%

•        În consumul de licopen se pun speranţe mari pentru prevenirea bolilor neoplazice, degenerative şi a maladiei Alzheimer

B-CAROTENUL( alimente culoare galbenă)

–     beta-carotenul aparţine familiei carotenoidelor

•    (apocarotenalul şi nu b-carotenul este responsabil de colorarea în galben-portocaliu a alimentelor care-i conţin !)

•          A fost asociat decenii întregi cu vitamina A deoarece în organism este transformat rapid în aceasta. Deşi este o coincidenţă de denumire, nu cred că este greşit ca această vitamină să se bucure de o consideraţie deosebită din partea noastră, ca fiind vitamina…A !

•          Astfel s-a purces la utilizarea b-carotenului ca supliment, iar astăzi este de departe cea mai cunoscută şi cea mai cercetată carotenoidă, dar toate suplimentele studiate nu au avut acţiunea b-carotenului, dpdv teoretic

•          Este posibil ca, indiferent de conţinutul suplimentelor, acestea să interacţioneze cu absorbţia b-carotenului natural şi cu carotenoidele conţinute în dietă. Este de asemenea posibil ca, în loc de a avea loc un efect antioxidant, să existe unul pro-oxidant

•          Vitamina A luată constant perioade îndelungate la doze mari prezintă riscuri notabile, însă precursorul său, b-carotenul se pare că nu prezintă nici un risc, chiar la doze mamut (x 100 doza zilnică) ; majoritatea fructelor şi legumelor conţin cantităţi mult mai mari de b-caroten decât de vitamină A

•          Carotenoizii au efecte identice cu ale vitaminei A, dar riscul dezvoltării unei intoxicaţii este aproape nul la doze enorme

•          Necesar : 5000-8000 UI = 2-3 mg/zi (un morcov mediu conţine ceva mai mult de 10.000 UI)

Funcţii :

•          Antiinfecţioasă

•          Substanţă anti-oxidantă redutabilă

•          Atenuează mult simptomele şi efectele secundare ale curelor citostatice şi / sau radioterapice( de aceea sucuri de morcov sunt bune daca faceti chimio/radio)

•          Reglementează somnul şi tensiunea arterială

•          Creşte numărul şi stimulează activitatea limfocitelor T „ajutătoare” (LTh)

•          Frenator folicular în sindromul premenstrual

•          Stimulează şi creşte sinteza progesteronului

•          Ajută la formarea smalţului dentar

•          Utilă în tratamentul retinitei pigmentare

•          Asigură vederea normală (participă la sinteza rodopsinei, pigment fotosensibil din ochi) şi protecţia epiteliilor. Determină inducţia, diferenţierea şi creşterea ţesuturilor epiteliale, le menţine integritatea şi previne keratinizarea

•          Rol important în reproducere

•          Stabilizează membranele celulare

•          Stimulează ARN-ul mesager, cât şi sinteza unor proteine şi glicoproteine

•          Determină secreţia lizozimului salivar

•          Stimulează creşterea osoasă şi dentară

•          Este un antagonist tiroidian

•          Protector împotriva radiaţiilor de orice fel

•          Împreună cu vitamina C, reduce mult secreţia de mucus bronşic la astmatici şi la bronşiticii cronici (BPCO)

•          I s-a demonstrat eficienţa şi-n SIDA, studiile fiind încă în curs

•          Utilă în tratamentul calviţiei androgenice, a ridurilor şi a acneei juvenile

•          Îmbunătăţeşte toleranţa corpului la grefe

•          Scade riscul dezvoltării unor boli cardio-vasculare la persoanele care asociază şi un stil de viaţă sănătos ; reduce semnificativ frecvenţa infarctului miocardic, iar recuperarea post-infarct este de mai scurtă durată, iar riscul recidivelor este mai mic. Acelaşi efect îl prezintă şi Coenzima Q10

•          Este vitamina longevităţii întârziind mult apariţia senilităţii

•          Protejează ADN-ul celular de acţiunea nocivă a toxinelor

•          Surse (mg / 100 g produs) : lucernă (4,818), morcov (3-9), migdale (5-6), salată (4-8), măceşe (5), alune de padure (4,4), spanac (2,5), varză (2), sfeclă roşie (1,78), mango (1,454), papaya (1,25), pătrunjel, nucă (1,2), pepene galben (1,03) caisă (0,606), măsline (0,2), tomate (0,133), ulei de cătină, germeni de grâu, leguminoase, rădăcinoase, citrice, prune, usturoi, ceapă, fasole verde, tot ce-i verde, zmeură, pere, mere, smochine, creson, mazăre, bostan, dude, gutui, avocado, castane, cireşe, banane, nap, castravete, ananas, coacăze, mei, ovăz, orez, păpădie, struguri, ţelină, aloe…

•          Diareea cronică, medicaţia de scădere a colesterolului, uleiul mineral, contraceptivele orale, alcoolul, fumatul, stresul, sarcina şi alăptarea, hepatitele şi ciroza hepatică generează deficite semnificative de vitamină A

LUTEINA

•          Este un alt membru al familiei carotinoizilor (“lutheus” = galben)

•        Surse de luteină : loboda, salata, spanacul, dovleacul galben, morcov, rebarbarum, praz, mazăre, vegetale verzi şi orice fruct sau legumă care are culori intense

•          Se fixează în mod special la nivelul retinei, în special a maculei (pata galbenă) şi la nivelul cristalinului

•          Cercetările privind degenerarea maculei la vârste înaintate au dovedit rolul protector important al luteinei (6 mg/zi luteină timp de 6 luni, scade incidenţa degenerării maculei cu 43%)

•          Există posibilitatea prevenirii cataractei prin utilizarea de AO, dar mai ales prin luteină (scăzând la o 1/3 riscul apariţiei acesteia)

•          La diabetici şi hipertensivi protecţia prin luteină este excepţională la nivelul arterelor retiniene

•          Efectul antioxidant al luteinei se manifestă nu numai la nivelul aparatului vizual, dar şi la nivelul altor organe, precum şi în cadrul unor lanţuri metabolice putând fi utilizată cu rezultate bune de către toţi cei cărora li s-a recomandat consumul de AO (pentru prevenirea bolilor cardiovasculare, cancerului prostatic etc.)

•          Oxidarea grăsimilor este inhibată în cea mai mare măsură de luteină, cu consecinţe deosebite în serul sangvin şi la nivelul ochiului ; scade colesterolul sangvin

•        Efectul luteinei este amplificat de licopen

Alţi carotenoizi mai puţin cunoscuţi

Zeaxantina

•          Are culoarea galbenă

•        Surse : avocado, varza,morcov,boabele de porumb, ardeii roşii, mango, portocale, spanac, gălbenuşul de ou (şi-n general acolo unde există şi b-carotenul)

•          Previne degenerescenţa maculară a retinei alături de luteină (în special datorită capacităţii de a filtra lumina ultravioletă şi cea albastră) şi cataracta

 

Cantaxantina

•          Are o culoare roşie intensă

•        Surse : ciupercile comestibile

Este un colorant alimentar, cu termostabilitate ridicată şi nu este fotosensibilă

 

Apocarotenal

•          Imprimă culoarea portocalie spre roşu a alimentelor

•        Surse : citrice (în special in mandarine), legume verzi (în special în spanac)

•          Este o provitamină A, ca şi b-carotenul. Are jumatate din activitatea vitaminei A şi a b-carotenului

 

(Acidul-)b–apo-8-carotenal

•          Nuanţele de culoare obţinute de esterul acidului apocarotenal din alimente variază de la galben-lămâie până la galben-orange

•        Surse : este larg răspândit în natură, în special în plante, cum ar fi citricele, legumele verzi, iarba, lucerna, dar şi-n gălbenuşul de ou

•          În organismul uman este parţial convertit în vitamina A prin oxidare, contribuind la furnizarea de vitamina A

E demonstrat faptul ca avocado creste efectul carotenoizilor intre 200-400%(de 2-4 ori)(deci puteti creste  eficienta sucurilor de legume adaugand PUTIN avocado in sucuri)

Picnogenolii

•          “Picnogenolii” este o denumire generică mai corectă decât “picnogenolul”, deoarece defineşte un grup de substanţe înrudite (şi nu una singură), cu efecte sinergice, înmănunchiate

•          Aparţin familiei chimice a polifenolilor, clasei flavonoidelor. Este un complex de substanţe (proantocianine), printre care se menţionează : acidul cafeic, ferulic, fenolic, catechina, epicatechina etc.

•        Surse : seminţele de struguri, extractul de pin maritim, scoarţa de salcie, aloe vera, ceai verde, viţa nobilă, unele fructe şi verdeţuri

•          Picnogenolii au demonstrat o putere de peste 30 de ori superioară vitaminelor A, C şi E la un loc în combaterea radicalilor liberi, în menţinerea integrităţii membranelor celulare, a ADN-ului, împiedicând peroxidarea lipidică

•        Au efect antioxidant excepţional faţă de ionul superoxid, inhibând şi enzima generatoare a acestui RL (xantin-oxidaza)

•          Picnogenolii împreună cu vitaminele A,C şi E conduc la o puternică acţiune antioxidantă

•          Contribuie la reglarea tonusului muscular al arterelor, combătând vaso-spasmul

•          Participă la sinteza lichidului biliar şi la eliminarea bilei din vezica biliară (efect coleretic-colecistokinetic)

•          Reduc formarea nitrozaminelor

•          Efect hepatoprotector în caz de intoxicaţie prin expunere la substanţe toxice (solvenţi organici)

•          Inhibă formarea leucotrienelor, care sunt printre mediatorii cei mai importanţi ai reacţiilor alergice, astmului bronşic şi ai inflamaţiilor acute

•          Întăresc peretele capilar, menţinându-i supleţea (elasticitatea) şi integritatea

•          Posedă o activitate anti-mutagenă, de protejare a materialului genetic, dar şi anti-tumorală directă

•          Imunostimulator de excepţie

•          Efectele sale benefice au fost studiate în bolile degenerative cardio-vasculare, fragilitatea capilară, insuficienţa venoasă periferică

•          Nu prezintă efecte adverse pe termen lung, fiind lipsit de toxicitate

•          Protejează împotriva căderii părului

•          Previne şi combate retinopatia (microangiopatia retiniană) diabetică şi non-diabetică

•          Acţiune antienzimatică (în vitro) împotriva : elastazei, hialuronidazei, colagenazei, a1-antitripsinei, xantinoxidazei, b-glucuronidazei

 

Acidul ascorbic (vitamina C)

•          Întăreşte peretele vascular

•          Fixator de Calciu mai puternic decât vitaminele D

•          Scade colesterolul total şi creşte HDL-C

•          Previne şi distruge placa de aterom (la peste 300 mg/zi în prezenţa unui CT<160 mg%)

•          Previne cataracta, îi opreşte evoluţia şi chiar determină regresia ei

•          Creşte longevitatea şi scade numărul deceselor de orice cauză

•          Indispensabilă pentru absorbţia Fierului

•          Funcţie depurativ-detoxifiantă

•          Măreşte rezistenţa organismului la efort

•          Cresc performanţele intelectuale şi indicele IQ (alături de vitamina B1)

•          Asigură integritatea tegumentelor şi mucoaselor

•          Stimulează atât imunitatea anti-cancer, cât şi pe cea antiinfecţioasă

•          Contribuie la buna funcţionare a glandelor suprarenale

•          Fortifică musculatura şi ţesutul conjunctiv

•          Stimulează eliminarea Pb din oase

•          Participă la sinteza colagenului

•          Combate sterilitatea masculină

•          Rol desensibilizant (anti-alergic)

•          Grăbeşte vindecarea hepatitelor acute şi opreşte evoluţia celor cronice spre ciroză sau cancer hepatic

In dozele adecvate(peste 10 grame zilnic) poate prelungi viata bolnavilor decancer de pina la 16 ori

Complexul vitaminic E

•        Nu este vorba de o singură substanţă, ci de… (cel puţin) 8 : (a,b,g,d-) tocoferol şi (a,b,g,d-) tocotrienol + bioflavonoide

•        Surse (mg la 100 g / ml produs) :  migdale (25,8), ulei de măsline, nuci (12,3), germenii de grâu, măsline (8), zmeura (4,5), salata (4), ardei (3,1), avocado (3), spanac (1,7), piersici (0,6), uleiul de cătină, creson, polen, pătrunjel, aloe vera, mazăre, ridiche neagră, seminţele de in, bostan şi de floarea soarelui, roşii, alune de padure

•        Necesar : 20-30 mg / zi (eficienţa sa însă va creşte exponenţial la doze de >100 mg/zi)

•        Observaţie : orice aliment care conţine vitamina E, va conţine automat şi vitamina D şi F !

•          Clorul, pastilele cu fier anorganic şi anticoncepţionalele orale necesită cantităţi mari de vitamină E, deoarece o inactivează ; medicaţia hipocolesterolemiantă, uleiul mineral (folosit ca laxativ), fumatul, sarcina şi alăptarea, pancreatitele, hepatitele, boala Crohn etc. se însoţesc de deficite ale vitaminei E !

•          Este un anti-oxidant excepţional, “ocrotind” de oxidare acizii graşi nesaturaţi, vitaminele A şi C din lumenul intestinal, dar şi membranele celulare. Ne protejează şi de efectele oxidante remarcabile ale ozonului, smogului, de radiaţii şi de efectele nocive ale chimioterapiei (alături de vitamina A)

•          Protejează vitamina A de oxidare şi globulele roşii de factorii hemolitici

•          Potenţează funcţiile vitaminei C (evident în cataractă)

•          Grăbeşte vindecarea arsurilor şi a rănilor

•          Are calităţi diuretice şi hipotensoare

•          Diminuă frecvenţa crizelor epileptice la copii ; se pare că ar fi utilă şi în tratamentul bolii Parkinson

•          Vitamină anti-tumorală redutabilă în general, dar şi specifică pentru cancerele prostatic, col uterin, sân  şi pulmonar

•          Intervine în metabolismul şi-n sinteza acizilor nucleici şi a proteinelor

•          Măreşte capacitatea funcţională a muşchilor, ameliorând circulaţia capilară şi utilizând optim oxigenul la acest nivel. Este implicată şi în producerea de energie la nivel celular

•          Asigură buna funcţionare a aparatului reproducător şi este esenţială pentru sistemul nervos central

•          Reduce problemele legate de ciclul menstrual (tratând eficient sindromul premenstrual) şi de menopauză

•          Intervine şi-n eritropoeza (formarea globulelor roşii ale sângelui) fiziologică şi protejează eritrocitele împotriva distrugerii (hemoliză)

•          Are şi proprietăţi anti-coagulante, inhibând agregarea plachetară

•          Funcţiile acestei vitamine sunt potenţate în mare măsură de prezenţa Seleniului şi asta preponderent în cancer

•          Alături de Seleniu grăbeşte liza pigmentului de uzură neuronal – lipofuscina

•          Creşte producţia de interleukină 2, la rându-i stimulatoare a producţiei de limfocite T

•          Scade VLDL şi LDL-C (pe acesta din urmă în special în prezenţa vitaminei A), crescând în schimb HDL-C. Împiedică oxidarea LDL-C

•          Aportul corespunzător de vitamină E reduce semnificativ frecvenţa şi amplitudinea crizelor de angină pectorală

Acizii graşi omega 3

•        Surse : ulei de in,  nucă, spirulină,avocado,ulei ficat cod sau somon

•          Sursele de origine vegetală conţin doar reprezentantul inferior al clasei (ALA), în vreme ce uleiurile de peşte conţin toţi reprezentanţii (ALA, EPA şi DHA), alături de cantităţi importante de colesterol

•          Scad Colesterolul Total sangvin şi LDL-C cu densitate mică (care este extrem de aterogen !)

•          Au  un efect anti-trombotic

•          Produc o creştere uşoară a HDL-C

•          Scad fibrinogenul şi agregarea plachetară şi cresc timpul de sângerare

•          Reduc întinderea zonei de necroză cardiacă post-infarct recent

•          DHA este esenţial pentru dezvoltarea sistemului nervos, a retinei şi a sistemului imunitar al copilului

•          DHA şi ALA sunt  constituenţi importanţi ai membranei neuronale şi a vaselor de sânge din creier. În stările asociate cu deficitul lor, se întâlneşte o încetinire a creşterii staturo-ponderale, leziuni ale pielii, degenerescenţă  a organelor interne, o funcţie vizuală anormală şi chiar neuropatie periferică

•          Întârzie şi reduce apariţia simptomelor senilităţii prin blocarea generării de radicali liberi de natură lipidică

•          Acţiune anti-mutagenă şi de protejare a materialului genetic

•          Efect antiinflamator mediu

•          Reduc simptomele şi blochează acţiunea citokinelor (TNFa, PAF, IL1-8 etc.)

•          Modulatori deosebit de puternici ai răspunsului imun

•          Efecte importante în bolile auto-imune, infecţii virale şi / sau bacteriene, cancer, SIDA

•          Au capacitatea de a distruge vasele care alimentează cu sânge tumora

•          Previn apariţia preeclamsiei şi a eclamsiei gravidice. Previn apariţia depresiei de post-partum. Efect antidepresiv general

•          Prezintă efecte benefice şi-n sindromul Raynaud, după o utilizare îndelungată

•          Un raport w3 / w6 > 1/3 provoacă vasodilataţie arteriolară şi prevenind o eventuală HTA

•          În bolile glomerulare renale, aportul de AG w 3 a redus pierderile de proteinuria

•          Vindecă ulcerul gastric şi duodenal ; efecte excelente au fost raportate şi-n terapia colonului iritabil

•          Regularizează ciclul menstrual, diminuă frecvenţa şi intensitatea durerilor menstruale

•          Sunt substanţe anti-alergice, reducând frecvenţa şi intensitatea crizelor de astm bronşic

•          Au efect hipoglicemiant (util şi la diabetici), transformând glucoza sangvină în glicogen de depozit ; reduc rezistenţa la insulină

•          Previn şi combat eficient migrenele

•          Rol calmant şi de mărire a rezistenţei sistemului nervos la stres. Somnul se instalează mai repede la cei care au în alimentaţie surse bogate de AG w 3, iar frecvenţa insomniilor scade semnificativ

•          Stimulează sinteza colagenului din piele

Acizii graşi omega 6

 

•        Surse :  germeni de grâu, dovleac, rapiţă, susan

•          Extrem de sensibili la lumină, aer şi termic (prăjire), în prezenţa cărora putând suferi procese de izomerizare cis-trans (devenind din anti-aterogene, pro-aterogene), cât şi oxidări multiple la dublele legături, devenind din anti-oxidante, pro-oxidante

•          Reprezentanţi : acidul arahidonic, acidul g-linolenic şi acidul linoleic

•          Indispensabili pentru producerea de energie, pentru transferul oxigenului din aer până la nivelul hemoglobinei

•          Precursori ai prostaglandinelor

•          Anti-aterosclerotice “per se”

•          Asigură buna funcţionare a sistemului nervos central, intrând în structura membranelor neuronale

•          Ameliorează simptomele ulcerului gastric şi duodenal

•          Menţin tonicitatea şi troficitatea pielii

•          Carenţa acestor acizi determină astenie, piele uscată, deficit imunitar, retard al creşterii şi sterilitate

•          Un raport w6 / w3 > 1/3 are efecte pro-inflamatorii (raportul optim este < 1/3)!!!!!!!!!!

 

Coenzima Q10

•          Este un anti-oxidant exo-, dar şi endogen

•        Surse : frunzele de tutun, uleiul de cătină, alune de padure, varză, conopidă, broccoli, spanac, germenii de grâu, orez integral, uleiurile vegetale

•          Exerciţiul fizic, vitamina E şi Seleniul îi stimulează sinteza

•        Necesar : (se presupune că ar fi în jurul valorii de) 30-90 mg/zi (1 mg pentru fiecare an vârstă / zi)

•          Se concentrează în organele cu metabolism intens (creier, miocard, ficat…)

•          Cei care au o dietă vegan, aduc mai multă ubiquinonă prin alimentaţie decât omnivorii

•        Normo- şi subponderalii prezintă concentraţii mai ridicate de CoQ10 comparativ cu cei care au supragreutate

•          Sinteza ubiquinonei se reduce odată cu vârsta

•          Catalizator în procesul de formare a energiei celulare, răspunzătoare de 95% din energia ce se formează în corp ; menţine integritatea membranelor mitocondriale

•          Previne oxidarea LDL-C şi scade riscul aterosclerotic

•          Adjuvant extrem de util în tratamentul insuficienţei cardiace şi al cardiopatiei ischemice. Determină rărirea frecvenţei atacurilor anginoase cu 45-50%, mărind capacitatea de efort a pacienţilor cardiaci. Reduce hipertrofia miocardică şi-i satisface necesarul energetic. Creşte fluxul sangvin coronarian, îmbunătăţeşte metabolismul şi asigură furnizarea de energie pentru miocard, coboară TA

•          Determină producerea de anticorpi şi creşte concentraţia plasmatică a imunoglobulinelor G

•          Boala Parkinson prezintă concentraţii mici de ubiquinonă în creier, iar în SIDA există concentraţii plasmatice extrem de reduse ; pacienţii HIV pozitivi, vor rămâne asimptomatici dacă au o concentraţie optimă a CoQ10 în sânge

•          Utilă în distrofia musculară progresivă, ameliorând în bună măsură simptomatologia

•          Anti-oxidant puternic, imuno-stimulator (sporind numărul de limfocite TK) ; substanţă cu proprietăţi anti-tumorale (absorbind radicalii liberi), anti-SIDA şi antileucemică

•          Îmbunătăţeşte funcţia cerebrală şi creşte capacitatea de memorizare

•          Diminuă depozitele de grăsime

•          Măreşte rezistenţa musculară la efort

•          Grăbeşte vindecarea plăgilor, menţine supleţea, elasticitatea şi tinereţea tegumentelor

•          Capabilă să vindece ulcerul gastroduodenal

•          Adjuvant important, util şi extrem de eficace în refacerea ficatului (hepatite A, B, C etc., acute sau cronice)

•          Utilă în tratamentul schizofreniei, a bolii Alzheimer şi a sclerozei multiple

•          Întârzie procesele de îmbătrânire şi se opune celor degenerative

•          Medicaţia statinică, prin inhibarea enzimei HMG-CoA reductazei, determină o diminuare a producţiei de CoQ10 , iar  medicaţia b-blocantă inhibă enzimele activate de către CoQ10 şi produce o scădere a concentraţiei sale

Bioflavonoidele

•          Sunt cunoscute mai ales ca vitamina C2, P, sau flavone

•          Au fost descoperite de către omul de ştiinţă maghiar Albert Szent-Gyorgyi, descoperitorul vitaminei C, care a observat că bioflavonoidele au un efect sinergic cu vitamina C, având o mare importanţă în întărirea peretelui capilar

•          Se găsesc în multe fructe (coaja de măr şi pară, pieliţa internă a citricelor, fructele care au culori intense) şi verdeţuri

•          Bioflavonoidele diferă de la fruct la fruct, de la frunză la frunză, atât ca tip, cât şi ca şi cantitate şi putere antioxidantă

•          Cele mai cunoscute bioflavonoide sunt quercetina, rutina, hesperidina, naringina, baicalina şi picnogenolul

•          Substanţe potenţatoare de efect pentru minerale şi vitamine (mărind efectul acestora de 20-200 de ori)

•          Cresc rezistenţa capilarelor, reglându-le permeabilitatea ; se opun formării de varice şi hemoroizi

•          Efect antianginos şi tonicardiac ; anti-aterosclerotice de primă mână şi anti-trombotice

•          Sunt esenţiale pentru protecţia în calea oxidării vitaminei C

•          Au activitate majoră antivirală şi anticancerigenă

•          Efect antiinflamator moderat şi desensibilizant (maladii alergice şi astm bronşic) ; reduc cantitatea de Histamină din sânge

•          Acţiune marcată împotriva virusurilor poliomielitei, hepatitelor A şi B, influenţei şi HIV

•          Tonice-trofice şi regeneratoare hepatice

•          In vitro quercetina şi picnogenolul inhibă complet replicarea virusului HIV

•          Reduc problemele legate de ciclul menstrual (dureri, durata sângerării, neregularităţi etc.) ; au şi efect anti-abortiv

•          Tulburările de natură aterosclerotică ale vaselor urechii interne de care suferă diabeticii, par să răspundă tratamentului combinat vitamină C + bioflavonoide

•          Administrate împreună prezintă efecte benefice în tratamentul distrofiei musculare şi al depresiei cronice

•          Studii legate de administrarea lor concomitentă, cu rezultate benefice sunt în curs, în tratamentul schizofreniei

•          Bioflavonoidele din afine sunt eficace în tulburările de vedere, putând ameliora vederea crepusculară, reducând fenomenele de neacomodare la întuneric ; se opun degenerărilor retiniene de origine hipertensivă, diabetică şi miopiei evolutive

•          Rănile se vindecă mai repede şi fără cicatrici

•          Preîntâmpină ridarea şi îmbătrânirea pielii, menţinându-i elasticitatea şi tinereţea

•          Carenţa de bioflavonoide este asemănătoare cu carenţa de vitamină C : pierderi de sânge, fragilitate capilară, hematoame ; constituie un factor predispozant pentru reumatism

•          Antagonişti : fumatul, stresul, antiinflamatoarele steroidiene şi nesteroidiene, antibioticele, cafeaua

•          Cresc absorbţia bioflavonoidelor : vitamina C, Calciul şi Magneziul

Niacina (vitamina B3, PP, NAD)

•          Este o vitamină relativ stabilă termic, la lumină şi oxigen

•        Surse (mg%) :  caise  (6,7), cartof (1), piersica (0,9), germenii şi tărâţele de grâu, nuci, orez, polen, grape-fruit, anason, ovăz, varza, gutui, lămâi, mere, pere, vinete, roşii, sfeclă roşie, smochine, seminţele de in, aloe

•        Necesar : 15-20 mg/zi. Dacă dieta conţine suficient Triptofan şi vitamină B6, corpul şi-o poate sintetiza şi singur

•          Cel mai important factor de creştere al HDL-C. Reduce şi nivelul trigliceridelor

•          Creşte capacitatea de memorizare

•          Intensifică metabolizarea glucozei, rol important în diabetul zaharat

•          Participă la integritatea mucoaselor, prevenind instalarea a multiple dermatoze

•          Ameliorează simptomele artritei

•          Carenţa sa dă pelagra (cei 3 “D” : dermatită, demenţă, diaree)

•          Participă la producerea energiei în corp

•          Ajută la sinteza unor hormoni : insulină, testosteron, estrogeni

•          Combate un eventual miros neplăcut al gurii (halena)

•          Combate şi / sau ameliorează durerile ulceroase

•          În doze mari stimulează eliberarea de Histamină

•          În sarcină, alăptare, sau în cazurile în care se prestează un exerciţiu fizic intens, se suplimentează dieta cu cantităţi corespunzătoare de vitamină B3 Alcoolul este şi el răspunzător de scăderea nivelului plasmatic al acestei vitamine !

Germaniul (organic !)

Este un mineral alcalin(ceeaza alcalinitate), la fel ca potasiu, cesiu, etc.

–          necesar : 0,4 – 1,5 mg/zi(mult mai mult in cancere- detalii in carte)

–          funcţii : util în prevenţia şi tratamentul multor boli :

– cancere cu diverse localizări : colon, prostată, sân, plămâni, ovar, col uterin. Este un element cu proprietăţi anti-tumorale importante. Stimulează concomitent superoxid-dismutaza, glutation-peroxidaza şi catalaza !!!

– leucemii, SIDA

– astm bronşic

– gastrite şi ulcere

– diabet

– angină pectorală, HTA, ATS, infarct miocardic, sd. Raynaud

– boli psihice : psihoze depresive, schizofrenie, boala Parkinson, epilepsie, autism

– boli oculare : cataractă, glaucom, inflamaţii şi dezlipire de retină

– are o acţiune anti-virală şi anti-fungică

                   – stimulează imunitatea : creşte producţia de gama-interferon şi de limfokine, cât şi numărul de macrofage, limfocite Tk şi de supresoare

– combate osteoporoza şi artrita reumatoidă

– suprimă durerile menstruale

– rol fundamental în cura de dezintoxicare după acumularea de Mercur în corp

– element anti-oxidant puternic şi anti-mutagen

– scade concentraţia colesterolului sangvin

– măreşte biodisponibilitatea oxigenului la nivel celular

–          surse : usturoi, tărâţele de cereale şi cerealele integrale, aloe, nuci, uleiuri vegetale, fasole, morcovi, broccolli, conopidă, roşii, rădăcina de Ginseng.

Seleniul

–          necesar : 100 micrograme/zi. Carnea, alcoolul şi fumatul îi blochează absorbţia! Prin ejaculare se pierd cantităţi sporite de Seleniu !

–          funcţii : – element anti-oxidant cu proprietăţi anti-tumorale excepţionale

– previne acumularea unor metale grele în corp şi le grăbeşte eliminarea : Mercur, Arsen, Cupru (dacă acesta riscă să ajungă la niveluri plasmatice toxice !), Cadmiu

                    – stimulează sinteza şi efectele glutation-peroxidazei, enzimă extrem de potentă anti-tumoral, care nu poate funcţiona în absenţa Seleniului

– stimulează sinteza de imunoglobuline

– împiedică degenerarea musculaturii striate

– ameliorează simptomele legate de menopauză, în special bufeurile de căldură

– anti-ATS de forţă

– protejează Fe2+ din hemoglobină împotriva oxidării la Fe3+

– anti-reumatic puternic

– măreşte apărarea imună

– protejează ficatul de infiltraţia grasă

– controlează funcţia secretorie normală a pancreasului

– previne şi tratează eficient mătreaţa

–          surse : usturoi, ceapă, praz, afine, cereale integrale, grâu încolţit, aloe vera, seminţe de susan şi fistic, sparanghel, leguminoase, zarzavaturi, roşii.

Zincul

–          necesar : 15-20 mg/zi. Atenţie : stresul poate produce eliminarea a peste 8 mg de Zinc pe zi pe cale urinară, în timp ce cura citostatică îi reduce absorbţia şi-i măreşte eliminarea ! Medicaţia diuretică, alcoolismul cronic, dieta bogată în Fosfor (carne şi lactate) şi fibre vegetale (la un aport de peste 50 g pe zi !),  sarcina şi alăptarea sunt stări însoţite de pierderi mari de Zinc.

–          funcţii : – grăbeşte vindecarea şi cicatrizarea rănilor

– potenţează alături de Cupru şi Mangan efectele enzimei SOD

– intră în compoziţia a peste 70 de metalo-proteine (printre care şi a insulinei, heparinei) şi a unor enzime

– este un anti-oxidant redutabil pentru radicalii liberi

– previne şi tratează eficient depresiile, alături de Cupru

– metal cu efecte puternice anti-tumorale

– este un antagonist al Calciului

– intervine în formarea normală a globulelor sangvine (rol anti-anemic şi anti-leucemic). Stimulează creşterea numărului de leucocite (globule albe) în periferie

– este esenţial pentru maturarea limfocitelor T din timus

– stimulează hipofiza şi glandele sexuale, reglându-le în acelaşi timp şi funcţia

– previne şi combate eficient degenerarea maculară (petei galbene de pe retină)

– creşte potenţa şi măreşte dorinţa sexuală (prin stimularea secreţiei testosteronului – pe care prolactina l-ar inhiba – la ambele sexe)

– reduce semnificativ frecvenţa răcelilor

– este extrem de util în boala Wilson, ajutând la eliminarea excesului de Cupru

– protejează organismul de efectele toxice ale Cadmiului şi Plumbului, inhibându-le absorbţia lor din intestin

– creşte apetitul

– participă la metabolismul energetic, la sinteza şi degradarea proteinelor, cât şi la sinteza acizilor nucleici. Ajută la metabolismul vitaminei A

– intervine şi-n menţinerea echilibrului acido-bazic

– favorizează eliminarea CO2-ului din celule

– participă la sinteza colagenului

– asigură sensibilitatea gustativă, olfactivă şi tactilă normală

– ajută la dispariţia petelor galbene şi a striurilor unghiale

– favorizează contracţiile musculare

– creşte concentraţia testosteronului şi a hormonului FSH

– sunt studii în curs referitoare la utilitatea sa în tratamentul schizofreniei, acneei juvenile şi al ulcerului gastric şi duodenal. Rezultatele preliminare însă sunt promiţătoare

– intensifică activitatea enzimei alcool-ehidrogenaza şi o inhibă pe cea a anhidrazei carbonice

– anti-artritic bun

– inhibă secreţia de prolactină, care dacă ar stimula producţia de testosteron, ar determina o hipertrofie prostatică. Menţine astfel glanda la dimensiuni normale şi se opune adenomului de prostată

– este un inductor enzimatic pentru enzimele care contribuie la transcrierea corectă a informaţiei genetice de la nivelul ADN şi ARN. S-a descoperit că în sângele bolnavilor de SIDA cantitatea de Zinc este foarte redusă, şi se presupune că suplimentarea cu Zinc a dietei acestor pacienţilor ar avea rezultate notabile împotriva bolii

– participă la metabolismul vitaminei A

– asocierea Zinc + Cupru realizează beneficii notabile în dereglările hipofizo-ovariene şi testiculare

– asocierea Zinc + Cobalt + Nichel este utilă în tulburări pancreatice şi hipofizare

– asocierea Zinc + Magneziu + Fier contribuie la creşterea capacităţii de memorizare

– asocierea Zinc + Magneziu + vitamina B6 determină creşterea concentraţiei plasmatice a testosteronului

–          surse : nucile, castanele, stridiile, afinele, germenii de grâu, cereale integrale, piersici, portocale, banane, cireşe, ciuperci, pere, mere, smochine, susan, migdale, aloe vera, cerealele integrale, sfecla roşie, roşia, spanac, varză, salată, usturoi, caisă, vinete, seminţe de dovleac, migdale.

   Organele corpului uman care concentrează Zincul sunt : prostata, rinichii, ficatul, oasele, creierul, retina şi muşchii. S-a constatat că în SIDA şi diabetul zaharat există concentraţii sangvine foarte scăzute ale Zincului, iar suplimentarea alimentaţiei cu acest metal a adus beneficii semnificative.

Cuprul

–          necesar : 2,5 – 3 mg/zi

–          funcţii : – anti-oxidant puternic şi anti-cancerigen

– previne alterarea şi oxidarea AG nesaturaţi şi-n special a celor 3 AG w 3

– contribuie la integritatea membranelor celulare

– previne şi tratează eficient depresiile alături de Zinc

– determină creşterea uşoară a HDL-C

– asigură pigmentarea normală a părului

– limitează formarea radicalilor liberi

– asigură creşterea şi dezvoltarea armonioasă a organelor şi celulelor

– creşte apărarea imună

– menţine vasele arteriale curate (de ateroscleroză) şi elastice

– are şi efect anti-coagulant

– implicat în formarea globulelor roşii, ajutând la transferul Fierului pe Hemoglobină şi prin aceea că intervine în absorbţia şi-n utilizarea Fierului pentru hematopoeză

– ajută la formarea calusului în fracturi

– menţine integritatea mielinei (beneficii în boala numită “scleroză în plăci” ?)

– participă la sinteza colagenului alături de vitamina C

– reduce simptomele artritei

Deficitul de cupru antrenează şi următoarele tulburări : defecte de absorbţie şi metabolizare ale Fierului, anemia refractară la Fier, apariţia enteropatiei specifice cu pierderi consecutive de Cupru, creşte rata apariţiei de sugari distrofici şi prematuri, a sindromului mielodisplazic, a osteoporozei, se constată anomalii neurologice, reducerea diferenţierilor celulare, aritmii cardiace, hipotiroidie, transformare megaloblastică a seriei albe.

–          surse : nuci, castane, varză, migdale, alune, cireşe, mere, portocale, struguri, grape-fruit, polen, gutui, lămâi, pere, piersici, smochine, caise, măsline, cereale integrale, sfeclă roşie, nap, ceapă, spanac, cicoare, praz, cartof, roşii.

Manganul

–          necesar : 3 mg/zi. Un aport crescut de Fier este responsabil uneori de un deficit al Manganului

–          funcţii : – anti-oxidant puternic, având proprietăţi anti-tumorale marcate

            – împreună cu Zincul şi Cuprul, este metalul care stimulează funcţia enzimei SOD

– necesar structurii osoase normale şi a cartilajului articular

– este implicat în sinteza hormonilor sexuali

– asigură funcţionarea optimă a creierului, stimulând sinteza DOPA-minei. Această substanţă, în afara faptului că este un puternic anti-reumatic, este în stare să amelioreze simptomele bolii Parkinson (boală caracterizată tocmai prin scăderea numărului neuronilor producători de DOPA-mină)

– util în tratamentul schizofreniei şi al unor boli neurologice

– stimulează absorbţia vitaminelor C, H şi B1

– anti-alergic şi desensibilizant redutabil

– asocierea Mangan + Cobalt este utilă în tratamentul tulburărilor de memorie, sindromul premenstrual, anxietate, colite spastice, tulburărilor de menopauză

–          surse : nuci, castane, aloe vera, tărâţe, sparanghel, spanac, vinete, pere, mere, cereale integrale, usturoi, ceapă, praz, varză, sfeclă roşie, ţelină, morcov, păpădie, polen, caisă, cartof, ciuperci, cicoare, pătrunjel, portocale, smochine, căpşuni, struguri, uleiul de cătină.

Molibdenul

•          Este un mineral care se găseşte în cantităţi extrem de reduse în aproape toate ţesuturile vegetale şi animale

•          Prezintă efecte AO, fiind deci important în tratamentul maladiilor degenerative şi a îmbătrânirii

•        Surse : legumele, cerealele integrale şi verdeţurile cu frunze verde închis, salată, fasole

•        Necesar : 75-500 mg/zi

•          > 500 mg/zi există riscul pierderilor de Cu, diaree, anemie şi întârzierea creşterii ; la 15 mg/zi poate apărea guta

•          Carenţa este consecinţa acumulării de SO32-, radical toxic pentru sistemul nervos ; alimentele rafinate şi conservate consumate perioade mai lungi conduc inexorabil la carenţe de Mo

•          Intră în compoziţia a 2 enzime : xantinoxidaza (care ajută la mobilizarea Fe din rezervele hepatice, favorizând transformarea Fe2+ în Fe3+) şi aldehidoxidaza (necesară pentru oxidarea grăsimilor). Ambele enzime sunt implicate în transferul de electroni

•          Mo are un rol important în metabolismul Cu şi al N

•          Este implicat în faza finală a formării urinei

•          Previne anemia feriprivă

•          Smalţul dentar conţine Mo şi s-a descoperit că mineralul previne cariile dentare

•          Anumite studii au arătat o legătură între o cantitate optimă de Mo din alimentaţie şi incidenţa redusă a cancerului esofagian (asociat şi unei doze optime de vitamină C)

•          Combate impotenţa

MSM (Metil-sulfonil-metanul)

•        Este un AO puternic, capabil să împiedice acţiunea RL, dezintegrându-i ; acţionează atât direct, cât şi prin faptul că este o sursă de sulf ; MSM furnizează Sulful necesar AA sulfuraţi (MET, CYS, TAU), consideraţi la rându-le drept AO puternici

•          Se găseşte în cantităţi importante în spirulină şi aloe vera

•          Reacţionează la nivelul mucoaselor cu toxinele, contribuind la dezactivarea şi eliminarea acestora

•          Ameliorează permeabilitatea membranelor celulare, favorizând intrarea în celule a substanţelor nutritive şi a vitaminelor, dar şi eliminarea reziduurilor (este printre cele mai puternice substanţe cu efect dezintoxicant cunoscute)

•          Este un analgezic natural, blocând conducerea impulsurilor dureroase de-a lungul fibelor nervoase (fibrele C)

•          Blochează inflamaţia şi procesele inflamatorii, potenţând efectele cortizolului

•          Joacă un rol fundamental în menţinerea integrităţii articulaţiilor şi elasticităţii ţesutului conjunctiv

•          Dilată vasele de sânge, ameliorând circulaţia

•          Accelerează procesele de vindecare şi de reparaţie celulară

•          Reprezintă un bun miorelaxant în diverse forme de durere cronică

•          Este un adjuvant al mecanismelor naturale de apărare ale corpului, reglând metabolismul prostaglandinelor, participând la formarea anticorpilor

•          Este considerat un element sinergic pentru vitaminele A, B, C, D şi E, CoQ10, amino-acizi, Se, Ca, Mg

•          Diminuează simptomele unui mare număr de reacţii alergice, în special cele alimentare, dar şi cele prin mecanism de contact, sau prin inhalare. A fost stabilită o relaţie directă între cantitatea de MSM şi rezistenţa la alergeni ; este un inhibitor de Histamină

•          Controlează reacţiile inflamatorii în cadrul reacţiilor auto-imune

•          Reduce necesarul de medicamente anti-H2 în tratamentul ulcerului gastro-duodenal ; combate constipaţia asociată ulcerului

•          Măreşte rezistenţa organismului la stres (obiectiv şi subiectiv)

•          Toate tipurile de afecţiuni dermatologice, mai ales cele de natură alergică, răspund pozitiv la un regim dietetic integrat cu MSM ; s-a demonstrat că administrarea de MSM pe cale orală este eficace contra acneei, a pielii uscate, iritate şi a descuamărilor cutanate (sub formă de ungvent)

Alţi antioxidanţi exogeni importanţi

 

Betanina

•          Este colorantul roşu din sfecla roşie

•          Imuno-stimulator important

•          Are predilecţie pentru cancerele hormono-dependente

 

Sulforafanul

•          Izotiocianat, prezent din abundenţă în vegetalele aparţinând familiei crucifere, ceai verde, ceapă

•          Antioxidant puternic, mai puţin studiat

•          Capabil de distrugere tumorală directă, în special asupra tumorilor hormono-dependente : sân, col uterin, prostată

•          Imunostimulator

•          Prezintă şi efecte antiinflamatoare

•          Hepatoprotector şi detoxifiant

 

Indol-3-carbinolul

•          Prezent mai ales în vegetalele crucifere(varza, conopida, etc.)

•          Împiedică dezvoltarea tumorală malignă

•          Împiedică angiogeneza tumorală

 

Capsicaina (capsaicina)

•          Se găseşte şi se extrage şi ardeiul iute şi capia

•          Substanţă puternic iritantă pentru mucoase (uneori şi pentru tegumente)

•          I s-au descoperit proprietăţi anti-tumorale gastrice

•          Anti-reumatic de excepţie (există ungvente cu capsicaină)

 

Limonena

•          O întâlnim în citrice, dar mai ales în grape-fruit

•          Inhibă dezvoltarea tumorilor mamare

 

Antocianinele

•          Sunt coloranţi naturali roşii-albăstrui

•          Se găsesc în fructele de pădure, struguri, sfecla roşie, grape-fruit

•          Reduc frecvenţa tuturor cancerelor, indiferent de localizare, atât prin acţiune directă de distrugere tumorală, cât şi prin reciclarea glutationului

 

Acidul elagic

•          Există în din struguri, căpşuni şi cireşe

•          Este capabil să neutralizeze acţiunea substanţelor pro-carcinogene

 

Sulfidele

•          Le întâlnim la reprezentanţii familiei liliacee (usturoi, ceapă, praz)

•          Inhibă creşterea tumorală, fiind şi captatori excepţionali ai RL de oxigen

 

(Tri-)terpenele

•          Surse : crucifere(varza conopida,etc.), cereale integrale şi citrice

•          Diminuă multiplicările rapide, particulare celulelor tumorale

 

Substanţele indolice

•          Există aproape exclusiv în vegetalele crucifere

•          Utili în prevenţia şi terapia cancerului de sân, blocând acţiunea excesului de estrogen natural, factor implicat în creşterea tumorală

 

N-acetil-cisteina

•          Este un medicament fluidifiant al secreţiilor bronşice

•          Reprezintă un precursor, dar şi un stimulator al sintezei Glutationului

 

EDTA (Acidul etilen-diamino-tetraacetic)

•          Este un medicament utilizat drept kelator în ordine descrescătoare pentru : Cr,  Fe3+, Hg, Cu, Pb, Zn, Al, Fe2+, Mn, Ca, Mg

 

Ionul de H–

•          Există în apa unor izvoare de munte, din câteva zone ale lumii ; persoanele care beau acea apă fac parte dintre marii longevivi

•          A fost puţin studiat, dar se pare că este pe cale să detroneze resveratrolul din poziţia sa de lider al substanţelor AO

 

Nota:

Dozele de mai sus sunt recomandarile pentru persoane sanatoase.

Un pacient cu cancer are nevoie de doze de 10 ori mai mari, si nu glumesc.

Vedeti exemplul cu coenzima(click aici).

Niciodata nu se incepe cu dozele maxime ci cu doze mici si se cresc dozele pe masura ce organismul se adapteaza

 

Nu recomand suplimente antioxidante deoarece pot contine si multe substante chmice adaugate.Pulsa ca pot fi mai scumpe decat ce puteti obtine pe cale alimentara. Luati-va antioxidantii din fructe legume ierburi si verdeturi bine spalate cu apa filtrata.

 

Multa sanatate,

Cristian

 

CONSIDERATI UTILE CELE DE AICI?
SPUNETI SI ALTORA!(butoane sub aceasta pagina si in DREAPTA SUS!)

Ceai verde tratament cancer

mart.14

Aproximativ 40% din greutatea frunzelor uscate de ceai verde sunt polifenoli.

Cel mai puternic dintre acestia este EGCG.

 

Studii si cercetari interesante au fost publicate despre ceai verde si calitatile sale anti-cancer.

Un studiu recent din Japonia demonstrează că ceaiul verde merge dincolo de rolul său de  antioxidant bine-cunoscut.

Unul din factorii care diferentiaza celulele canceroase de celulele normale, este că au telomeraza, o enzima care menține telomerii aflati la capetele ADN. Celor mai multe celule normale, nu le trebuie telomeraza pentru a mentine telomerii lor. De fiecare data cand o celula normala se divide, telomerii sunt pierduti. Când toti telomerii dispar, celula moare. Capacitatea celulelor canceroase de a-si menține telomerii poate fi secretul nemuririi lor. Prin urmare, inhibarea enzimei telomeraza  și scurtarea  telomerilor celulelor canceroase a devenit un accent de terapie de cancer. Primul inhibitor telomeraza natural a fost descoperit ca fiind ceai verde. Cercetatorii japonezi au fost in masura sa demonstreze ca extract de ceai verde (EGCG) inhiba telomeraza din celulele canceroase în două tipuri diferite de cancer in eprubeta: leucemie și tipul de tumori solide.

Într-o lună de tratament, unele dintre celulele canceroase a început sa moara.

In trei luni, cele mai multe erau moarte. Experimentul a fost repetat de mai multe ori cu același rezultat.

Curios, telomerii de celulele normale vor rămâne neafectati.

 

 

O echipa de oameni de stiinta de la Universitatea Purdue a determinat:

„În prezența EGCG, celulele canceroase literalmente nu au reușit să crească/se mărească după diviziune. Probabil că nu au ajuns la dimensiunea minimă necesară pentru diviziune si au suferit moartea celulelor programate, sau apoptoza.”

Polifenolii de ceai verde , în special EGCG, inhibă o enzimă necesară pentru cresterea celulelor canceroase si ucid celulele canceroase, cu nici un efect negativ asupra celulelor sanatoase. EGCG, un antioxidant, este considerat de multe ori mai puternic decat vitamina E sau vitamina C in proprietati antioxidante. Într-un studiu din anul 1997, cercetatorii de la Universitatea din Kansas a stabilit că EGCG este de doua ori mai puternic ca resveratrolul din struguri negrii – recunoscut pentru a distruge celulele canceroase (a se vedea Cura cu struguri Negri, Violet, Rosii).

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Cura Johanna BRANDT cu struguri inchis colorati( Negrii, Violet, Rosii ) – tratament cancer ETAPA IV

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Strugurii colorati (rosii, violet, negrii, orice soi numai nu albi) (cu tot cu pielea lor și semințe),  sunt cunoscuti pentru a distruge celulele canceroase. Aceste tipuri de struguri contin substante nutritive pentru a ucide microbii din interiorul celulelor de  cancer(acestea redevenind celule sanatoase) dar sunt si alcalini – opresc raspandirea cancerului.

Detoxifica organismul( in special ficatul ).

Strugurii intens colorati(negri,violet,rosii ) conțin foarte mai mulți nutrienți ucigasi majori de canceri:

Acid elagic, catesine, quercetin, proantocianidine oligomerice (OPC) sau oligomeri procyanidolic (PCO), numit inițial: Pycnogenol (in semințe), resveratrol (culorarea pielii din struguri roșii), pterostilbene, seleniu, licopen, luteina, laetrile (amigdalină sau Vitamina B17) (in semințe), beta-caroten, acid cafeic și / sau acid ferulic (împreună ucide celulele canceroase), acid galic, vitamina C si multi antioxidanti si nutrienti (vitamine precum E-grasimi omega, minerale, enzime, etc)!

 

Un arsenal incredibil! Aproximativ 15 agenti anticancerigeni DEMONSTRATI de studii stiintifice (click aici pentru a consulta baza de date cu studii stiintifice referitoare la fiecare dintre anticancerigenii mentionati anterior ), cu fiecare cu importanta  in tratarea cancerului .

In plus, strugurii sunt in marea lor parte un glucid,si celulele canceroase intercepteaza  glucoza (cu ajutorul  invelisului proteic specific acestora ) si  au nevoie de15-17 ori mai multa decat celulele normale pentru a supravietui (cititi cauzele cancerului -click aici)  .

 

Iata de ce suplimente extract precum resveratrol nu vor egala in eficienta alimentul integral- sturgurele inchis colorat(ar trebui un extracvt de15 X15 ori mai concentrat; in plus, cu banii cheltuiti pe achizitionarea uni flacon resveratrol achizitionati zeci de  kg de struguri chair si cand nu e sezon  .alegrea ramane totusi a dvs.)  

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